Human respiratory coronavirus OC43: genetic stability and neuroinvasion.

abstract：:Nonglucosylated and fragmented T4 DNA shows a gene-specific variation in transformation efficiency. ...

journal_title：Journal of virology

authors： McNicol LA

更新日期：1973-08-01 00:00:00

abstract：:The dengue type 4 virus (DEN4) genome contains a 384-nucleotide (nt) 3' noncoding sequence in which the last 81 nt, predicted to form a secondary structure, are thought to be essential for virus replication. Immediately upstream of the secondary structure, short RNA sequences that are conserved among mosquito-borne fl...

journal_title：Journal of virology

authors： Men R,Bray M,Clark D,Chanock RM,Lai CJ

更新日期：1996-06-01 00:00:00

abstract：:Budding of retroviruses from cell membranes requires ubiquitination of Gag and recruitment of cellular proteins involved in endosome sorting, including endosome sorting complex required for transport III (ESCRT-III) protein complex and vacuolar protein sorting 4 (VPS4) and its ATPase. In response to infection, a cellu...

journal_title：Journal of virology

authors： Kuang Z,Seo EJ,Leis J

更新日期：2011-07-01 00:00:00

abstract：:The papillomavirus E2 protein is a critical viral regulatory protein with transcription, DNA replication, and genome maintenance functions. We have previously identified the cellular bromodomain protein Brd4 as a major E2-interacting protein and established that it participates in tethering bovine papillomavirus type ...

journal_title：Journal of virology

authors： Schweiger MR,Ottinger M,You J,Howley PM

更新日期：2007-09-01 00:00:00

abstract：:The vaccinia virus A16L open reading frame encodes a 378-amino-acid protein with a predicted C-terminal transmembrane domain and 20 invariant cysteine residues that is conserved in all sequenced members of the poxvirus family. The A16 protein was expressed late in infection and incorporated into intracellular virus pa...

journal_title：Journal of virology

authors： Ojeda S,Senkevich TG,Moss B

更新日期：2006-01-01 00:00:00

abstract：:Murine monoclonal antibodies directed against the structural proteins p17 and p24 of human immunodeficiency virus type 1 were investigated in an epitope mapping system. Overlapping peptides consisting of 15 amino acids of the p17 and p24 protein, respectively, were used as competitors in an enzyme-linked immunosorbent...

journal_title：Journal of virology

authors： Niedrig M,Hinkula J,Weigelt W,L'age-Stehr J,Pauli G,Rosen J,Wahren B

更新日期：1989-08-01 00:00:00

abstract：:Antibodies directed to Sindbis virus (SV) envelope protein E2 are able to control virus replication in vivo and in persistently infected cultures of neurons in vitro. We investigated the mechanisms by which anti-E2 monoclonal antibody (MAb) alters virus replication by using AT3 rat prostatic carcinoma cells expressing...

journal_title：Journal of virology

authors： Després P,Griffin JW,Griffin DE

更新日期：1995-11-01 00:00:00

abstract：:Cytolytic T-lymphocyte (CTL) activity specific for respiratory syncytial (RS) virus was investigated after intranasal infection of mice with RS virus, after intraperitoneal infection of mice with a recombinant vaccinia virus expressing the F glycoprotein, and after intramuscular vaccination of mice with Formalin-inact...

journal_title：Journal of virology

authors： Nicholas JA,Rubino KL,Levely ME,Adams EG,Collins PL

更新日期：1990-09-01 00:00:00

abstract：:The unique region of the capsid protein VP1 (VP1u) of human parvovirus B19 (B19) elicits a dominant immune response and has a phospholipase A(2) (PLA(2)) activity, which is necessary for the infection. In contrast to the rest of the parvoviruses, the VP1u of B19 is thought to occupy an external position in the virion,...

journal_title：Journal of virology

authors： Ros C,Gerber M,Kempf C

更新日期：2006-12-01 00:00:00

abstract：:The effect of monoclonal antibodies on the growth of herpes simplex virus type 1 in trigeminal ganglia was investigated. Four-week-old mice were infected on an abrased cornea with herpes simplex virus type 1. Forty-eight hours after infection, trigeminal ganglia ipsilateral with infected eyes were removed and placed i...

journal_title：Journal of virology

authors： Oakes JE,Lausch RN

更新日期：1984-09-01 00:00:00

abstract：:HIV circumvents HLA class I-restricted CD8+ T-cell responses through selection of escape mutations that leave characteristic mutational "footprints," also known as HLA-associated polymorphisms (HAPs), on HIV sequences at the population level. While many HLA footprints are universal across HIV subtypes and human popula...

journal_title：Journal of virology

authors： Soto-Nava M,Avila-Ríos S,Valenzuela-Ponce H,García-Morales C,Carlson JM,Tapia-Trejo D,Garrido-Rodriguez D,Alva-Hernández SN,García-Tellez TA,Murakami-Ogasawara A,International HIV Adaptation Collaborative.,Mallal SA,John M,Broc

更新日期：2018-01-02 00:00:00

abstract：:The features of herpes simplex virus 1 (HSV-1) strain 129 (H129), including natural neurotropism and anterograde transneuronal trafficking, make it a potential tool for anterograde neural circuitry tracing. Recently anterograde polysynaptic and monosynaptic tracers were developed from H129 and have been applied for th...

journal_title：Journal of virology

authors： Dong X,Zhou J,Qin HB,Xin B,Huang ZL,Li YY,Xu XM,Zhao F,Zhao CJ,Liu JJ,Luo MH,Zeng WB

更新日期：2020-03-31 00:00:00

abstract：:Plasmacytoid dendritic cells (pcDC) and myeloid dendritic cells (myDC) are shown to express CD4 and low levels of CCR5 and CXCR4, but only myDC express DC SIGN, a C-type lectin that binds human immunodeficiency virus but does not mediate virus entry. Both DC types were more susceptible to infection with a macrophage t...

journal_title：Journal of virology

authors： Patterson S,Rae A,Hockey N,Gilmour J,Gotch F

更新日期：2001-07-01 00:00:00

abstract：:Herpes simplex virus (HSV) glycoprotein B (gB) is an integral part of the multicomponent fusion system required for virus entry and cell-cell fusion. Here we investigated the mechanism of viral neutralization by the monoclonal antibody (MAb) 2c, which specifically recognizes the gB of HSV type 1 (HSV-1) and HSV-2. Bin...

journal_title：Journal of virology

authors： Krawczyk A,Krauss J,Eis-Hübinger AM,Däumer MP,Schwarzenbacher R,Dittmer U,Schneweis KE,Jäger D,Roggendorf M,Arndt MA

更新日期：2011-02-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) has emerged as a clinically opportunistic pathogen that targets multiple types of ocular cells and tissues, including the iris region of the uveal tract during anterior uveitis. In this report, we used primary cultures of human iris stroma (HIS) cells derived from human eye donors to inves...

journal_title：Journal of virology

authors： Baldwin J,Maus E,Zanotti B,Volin MV,Tandon R,Shukla D,Tiwari V

更新日期：2015-05-01 00:00:00

abstract：:The Epstein-Barr virus (EBV)-induced membrane antigen (MA) was successfully solubilized from the membranes of viable EBV-infected Raji cells by treatment with papain (5 to 6 U per 1 X 10(7) to 2 X 10(7) cells). The loss of MA from viable cells was monitored by membrane immunofluorescence and antibody-dependent cellula...

journal_title：Journal of virology

authors： Pearson GR,Qualtiere LF

更新日期：1978-10-01 00:00:00

abstract：:We previously reported that the cellular transcription factor hypoxia-inducible factor 1α (HIF-1α) binds a hypoxia response element (HRE) located within the promoter of Epstein-Barr virus's (EBV's) latent-lytic switch BZLF1 gene, Zp, inducing viral reactivation. In this study, EBV-infected cell lines derived from gast...

journal_title：Journal of virology

authors： Kraus RJ,Cordes BA,Sathiamoorthi S,Patel P,Yuan X,Iempridee T,Yu X,Lee DL,Lambert PF,Mertz JE

更新日期：2020-08-31 00:00:00

abstract：:Proteolytic processing of the dengue virus polyprotein is mediated by host cell proteases and the virus-encoded NS2B-NS3 two-component protease. The NS3 protease represents an attractive target for the development of antiviral inhibitors. The three-dimensional structure of the NS3 protease domain has been determined, ...

journal_title：Journal of virology

authors： Niyomrattanakit P,Winoyanuwattikun P,Chanprapaph S,Angsuthanasombat C,Panyim S,Katzenmeier G

更新日期：2004-12-01 00:00:00

abstract：:Epstein-Barr virus (EBV)-induced B-cell growth transformation, a central feature of the virus' strategy for colonizing the human B-cell system, requires full virus latent gene expression and is initiated by transcription from the viral promoter Wp. Interestingly, when EBV accesses other cell types, this growth-transfo...

journal_title：Journal of virology

authors： Tierney R,Kirby H,Nagra J,Rickinson A,Bell A

更新日期：2000-11-01 00:00:00

abstract：:Treatment of human immunodeficiency virus type 1 (HIV-1)-infected CEM cell cultures with escalating concentrations of the quinoxaline S-2720 resulted in an ordered appearance of single and multiple mutant virus strains that gradually became resistant to the quinoxaline and other nonnucleoside reverse transcriptase (RT...

journal_title：Journal of virology

authors： Pelemans H,Esnouf R,Dunkler A,Parniak MA,Vandamme AM,Karlsson A,De Clercq E,Kleim JP,Balzarini J

更新日期：1997-11-01 00:00:00

abstract：:Clink, a 20-kDa protein of faba bean necrotic yellows virus, a single-stranded DNA plant virus, interacts with pRB family members and a SKP1 homologue from Medicago sativa. An LxCxE motif and an F-box of Clink mediate the interactions with the respective proteins. The capacity of Clink to bind pRB correlates with its ...

journal_title：Journal of virology

authors： Aronson MN,Meyer AD,Györgyey J,Katul L,Vetten HJ,Gronenborn B,Timchenko T

更新日期：2000-04-01 00:00:00

abstract：:Infection of cells with poliovirus induces a massive intracellular membrane reorganization to form vesicle-like structures where viral RNA replication occurs. The mechanism of membrane remodeling remains unknown, although some observations have implicated components of the cellular secretory and/or autophagy pathways....

journal_title：Journal of virology

authors： Belov GA,Altan-Bonnet N,Kovtunovych G,Jackson CL,Lippincott-Schwartz J,Ehrenfeld E

更新日期：2007-01-01 00:00:00

abstract：:We report that adaptation to infect the guinea pig did not modify the capacity of foot-and-mouth disease virus (FMDV) to kill suckling mice and to cause an acute and transmissible disease in the pig, an important natural host for this pathogen. Adaptive amino acid replacements (I(248)-->T in 2C, Q(44)-->R in 3A, and L...

journal_title：Journal of virology

authors： Núñez JI,Molina N,Baranowski E,Domingo E,Clark S,Burman A,Berryman S,Jackson T,Sobrino F

更新日期：2007-08-01 00:00:00

abstract：:Viruses cause about 15% of the cancers that are still the leading causes of human mortality. The discovery of viral oncogenes has enhanced our understanding of viral oncogenesis. However, the underlying molecular mechanisms of virus-induced cancers are complex and require further investigation. The present study has a...

journal_title：Journal of virology

authors： Xu S,Xue C,Li J,Bi Y,Cao Y

更新日期：2011-01-01 00:00:00

abstract：:Hepatitis C virus (HCV) replicates through an error-prone process that may support the evolution of genetic variants resistant to the host cell antiviral response and interferon (IFN)-based therapy. We evaluated HCV-IFN interactions within a long-term culture system of Huh7 cell lines harboring different variants of a...

journal_title：Journal of virology

authors： Sumpter R Jr,Wang C,Foy E,Loo YM,Gale M Jr

更新日期：2004-11-01 00:00:00

abstract：:Aphid transmission of poleroviruses is highly specific, but the viral determinants governing this specificity are unknown. We used a gene exchange strategy between two poleroviruses with different vectors, Beet western yellows virus (BWYV) and Cucurbit aphid-borne yellows virus (CABYV), to analyze the role of the majo...

journal_title：Journal of virology

authors： Brault V,Périgon S,Reinbold C,Erdinger M,Scheidecker D,Herrbach E,Richards K,Ziegler-Graff V

更新日期：2005-08-01 00:00:00

abstract：:Vaccinia virus replication is inhibited by etoposide and mitoxantrone even though poxviruses do not encode the type II topoisomerases that are the specific targets of these drugs. Furthermore, one can isolate drug-resistant virus carrying mutations in the viral DNA ligase and yet the ligase is not known to exhibit sen...

journal_title：Journal of virology

authors： Lin YC,Li J,Irwin CR,Jenkins H,DeLange L,Evans DH

更新日期：2008-06-01 00:00:00

abstract：:Recent environmental and metagenomic studies have considerably increased the repertoire of archaeal viruses and suggested that they play important roles in nutrient cycling in the biosphere. However, very little is known about how they regulate their life cycles and interact with their hosts. Here, we report that the ...

journal_title：Journal of virology

authors： Chen B,Chen Z,Wang Y,Gong H,Sima L,Wang J,Ouyang S,Gan W,Krupovic M,Chen X,Du S

更新日期：2020-07-30 00:00:00

abstract：:Recently it has been shown that kaposica, an immune evasion protein of Kaposi's sarcoma-associated herpesvirus, inactivates complement by acting on C3-convertases by accelerating their decay as well as by acting as a cofactor in factor I-mediated inactivation of their subunits C3b and C4b. Here, we have mapped the fun...

journal_title：Journal of virology

authors： Mullick J,Singh AK,Panse Y,Yadav V,Bernet J,Sahu A

更新日期：2005-05-01 00:00:00

abstract：:Different tombusviruses were able to support the replication of either homologous or heterologous defective interfering (DI) RNAs, and those infected plants usually developed typical attenuated symptoms. However, in some helper virus-DI RNA combinations the inoculated plants were necrotized, although they contained a ...

journal_title：Journal of virology

authors： Havelda Z,Szittya G,Burgyán J

更新日期：1998-07-01 00:00:00