Complete genome sequence of a new circular DNA virus from grapevine.

abstract：:Previous studies have suggested that coxsackievirus B (CVB) activates CD8(+) T cells in vivo, but the extent of this activation and the antigen specificity of the CD8(+) T cells remain uncertain. Furthermore, CVB-induced CD4(+) T-cell responses have not been carefully investigated. Herein, we evaluate CD8(+) and CD4(+...

journal_title：Journal of virology

authors： Kemball CC,Harkins S,Whitton JL

更新日期：2008-05-01 00:00:00

abstract：:The Gag-Pol polyprotein of human immunodeficiency virus type 1 (HIV-1) is not required for efficient viral particle production. However, premature termination codons in pol, particularly in the integrase (IN)-coding region, can markedly impair HIV-1 particle formation, apparently due to the premature activation of the...

journal_title：Journal of virology

authors： Popov S,Strack B,Sanchez-Merino V,Popova E,Rosin H,Göttlinger HG

更新日期：2011-04-01 00:00:00

abstract：:Infection of domestic rabbits with cottontail rabbit papillomavirus (CRPV) causes local papillomas which progress to carcinomas in more than 80% of cases. This animal model system therefore allows the identification of molecular mechanisms required for the induction and progression of epithelial tumors. The viral E2 p...

journal_title：Journal of virology

authors： Jeckel S,Huber E,Stubenrauch F,Iftner T

更新日期：2002-11-01 00:00:00

abstract：:Genotype 1 hepatitis E viruses (HEVs) are restricted to primate hosts, whereas genotype 3 HEVs predominantly infect swine, in addition to primates. In order to identify possible determinants of the host range, infectious recombinant viruses and chimeras of a genotype 1 isolate and a genotype 3 isolate were compared fo...

journal_title：Journal of virology

authors： Nguyen HT,Shukla P,Torian U,Faulk K,Emerson SU

更新日期：2014-01-01 00:00:00

abstract：:RNA-dependent protein kinase PKR is an important regulator of gene expression in interferon (IFN)-treated and virus-infected cells. The 50-kb gene encoding human PKR kinase (pkr) is inducible by IFN. Transfection analyses, using chloramphenicol acetyltransferase (CAT) as the reporter in constructs possessing various 5...

journal_title：Journal of virology

authors： Kuhen KL,Vessey JW,Samuel CE

更新日期：1998-12-01 00:00:00

abstract：:Passive administration of porcine reproductive and respiratory syndrome virus (PRRSV) neutralizing antibodies (NAbs) can effectively protect pigs against PRRSV infection. However, after PRRSV infection, pigs typically develop a weak and deferred NAb response. One major reason for such a meager NAb response is the phen...

journal_title：Journal of virology

authors： Vu HL,Kwon B,Yoon KJ,Laegreid WW,Pattnaik AK,Osorio FA

更新日期：2011-06-01 00:00:00

abstract：:Some animal rotaviruses require the presence of sialic acid (SA) on the cell surface to infect the cell. We have isolated variants of rhesus rotavirus (RRV) whose infectivity no longer depends on SA. Both the SA-dependent and -independent interactions of these viruses with the cell are mediated by the virus spike prot...

journal_title：Journal of virology

authors： Zárate S,Espinosa R,Romero P,Méndez E,Arias CF,López S

更新日期：2000-01-01 00:00:00

abstract：:Cellular inhibitor of apoptosis protein 2 (cIAP2) is a potent suppressor of apoptotic cell death. We have shown previously that cIAP2 is involved in the tumor necrosis factor alpha (TNF-α)-induced anti-hepatitis B virus (HBV) response; however, the mechanism for this antiviral effect remains unclear. In the present st...

journal_title：Journal of virology

authors： Wang Z,Ni J,Li J,Shi B,Xu Y,Yuan Z

更新日期：2011-11-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) is a large (150-kb) double-stranded DNA virus that forms latent infections in neuronal cells of the human peripheral nervous system. Previous work determined that the HSV-1 genome is found in an ordered nucleosomal structure during latent infection. However, during lytic infection, ...

journal_title：Journal of virology

authors： Kent JR,Zeng PY,Atanasiu D,Gardner J,Fraser NW,Berger SL

更新日期：2004-09-01 00:00:00

abstract：:Parvovirus capsids are assembled from multiple forms of a single protein and are quite stable structurally. However, in order to infect cells, conformational plasticity of the capsid is required and this likely involves the exposure of structures that are buried within the structural models. The presence of functional...

journal_title：Journal of virology

authors： Nelson CD,Minkkinen E,Bergkvist M,Hoelzer K,Fisher M,Bothner B,Parrish CR

更新日期：2008-11-01 00:00:00

abstract：:The rat-derived Harvey murine sarcoma virus (Ha-MuSV) contains a transduced ras oncogene activated by two missense mutations and flanked by rat retroviruslike VL30 sequences. Ha-MuSV induces focal transformation of mouse NIH 3T3 cells in vitro and tumors (fibrosarcomas and splenic erythroleukemias) in newborn mice. We...

journal_title：Journal of virology

authors： Velu TJ,Vass WC,Lowy DR,Tambourin PE

更新日期：1989-03-01 00:00:00

abstract：:Polypeptides synthesized in Newcastle disease virus (NDV)-infected CHO cells in the absence of glycosylation were characterized. Incorporation of either [3H]mannose of [3H]glucosamine into NDV polypeptides was inhibited to greater than 99% by the antibiotic tunicamycin. Under these conditions, infected cells synthesiz...

journal_title：Journal of virology

authors： Morrison TG,Simpson D

更新日期：1980-10-01 00:00:00

abstract：:We isolated a simian virus 40 mutant, dl2194, which carried deletions in both early genes. One deletion removed 234 base pairs in the 54/59 region within the small-t-antigen coding sequence and the large-T-antigen gene intron. The second deletion removed 57 base pairs at the C terminus of the large-T-antigen coding se...

journal_title：Journal of virology

authors： Feunteun J,Carmichael G,Nicolas JC,Kress M

更新日期：1981-12-01 00:00:00

abstract：:Nonstructural protein 1 (NS1) of yellow fever virus (YF) is a glycoprotein localized to extracytoplasmic compartments within infected cells. We have previously shown that NS1 can be supplied in trans and is required for viral RNA replication, a process thought to occur in membrane-bound cytoplasmic complexes. Here we ...

journal_title：Journal of virology

authors： Lindenbach BD,Rice CM

更新日期：1999-06-01 00:00:00

abstract：:The ATP-dependent DNase activity of Escherichia coli disappeared or was markedly reduced after infection with double-stranded DNA phages, T2, T3, T4, T5, T6, T7, lambda, phi80, and P1, but not with the single-stranded DNA phage f1, or the RNA phage Qbeta. This DNase activity was not reduced when chloramphenicol was ad...

journal_title：Journal of virology

authors： Sakaki Y

更新日期：1974-12-01 00:00:00

abstract：:The Kaposi's sarcoma-associated herpesvirus (KSHV) (or human herpesvirus 8) open reading frame (ORF) K15 encodes a putative integral transmembrane protein in the same genomic location as latent membrane protein 2A of Epstein-Barr virus. Ectopic expression of K15 in cell lines revealed the presence of several different...

journal_title：Journal of virology

authors： Sharp TV,Wang HW,Koumi A,Hollyman D,Endo Y,Ye H,Du MQ,Boshoff C

更新日期：2002-01-01 00:00:00

abstract：:The genome of infectious bursal disease virus consists of two segments of double-stranded RNA of 2.5 X 10(6) and 2.2 X 10(6) molecular weight. Polyacrylamide gel electrophoresis of purified virus resolved four structural polypeptides: VP-1 (90,000), VP-2 (41,000), VP-3 (35,000), and VP-4 (28,000). Peptide map comparis...

journal_title：Journal of virology

authors： Dobos P

更新日期：1979-12-01 00:00:00

abstract：:HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/Ran-GTP nuclear export machinery through the activity of Rev's prototypical leucine-rich nuclear export signal (NES). In this study, we used a functional fluorescently tagged Rev fusion protein as a platform to study th...

journal_title：Journal of virology

authors： Behrens RT,Aligeti M,Pocock GM,Higgins CA,Sherer NM

更新日期：2017-01-18 00:00:00

abstract：:Recent studies of varicella-zoster virus (VZV) DNA sequence variation, involving large numbers of globally distributed clinical isolates, suggest that this virus has diverged into at least three distinct genotypes designated European (E), Japanese (J), and mosaic (M). In the present study, we determined and analyzed t...

journal_title：Journal of virology

authors： Norberg P,Liljeqvist JA,Bergström T,Sammons S,Schmid DS,Loparev VN

更新日期：2006-10-01 00:00:00

abstract：:ICP27 is a multifunctional protein that is required for herpes simplex virus 1 mRNA export. ICP27 interacts with the mRNA export receptor TAP/NXF1 and binds RNA through an RGG box motif. Unlike other RGG box proteins, ICP27 does not bind G-quartet structures but instead binds GC-rich sequences that are flexible in str...

journal_title：Journal of virology

authors： Corbin-Lickfett KA,Souki SK,Cocco MJ,Sandri-Goldin RM

更新日期：2010-07-01 00:00:00

abstract：:We present data that retroviral gene expression in early hematopoietic cells is subjected to transcriptional controls similar to those previously described for embryonic stem cells. Transient transfection experiments revealed that both the viral enhancer region in the U3 region of the long terminal repeat as well as a...

journal_title：Journal of virology

authors： Baum C,Hegewisch-Becker S,Eckert HG,Stocking C,Ostertag W

更新日期：1995-12-01 00:00:00

abstract：:The rotavirus nonstructural phosphoprotein NSP5 is encoded by a gene in RNA segment 11. Immunofluorescence analysis of fixed cells showed that NSP5 polypeptides remained confined to viroplasms even at a late stage when provirions migrated from these structures. When NSP5 was expressed in COS-7 cells in the absence of ...

journal_title：Journal of virology

authors： Blackhall J,Muñoz M,Fuentes A,Magnusson G

更新日期：1998-08-01 00:00:00

abstract：:Human norovirus (HuNoV) is a major causative agent of food-borne gastroenteritis worldwide. Currently, there are no vaccines or effective therapeutic interventions for this virus. Development of an attenuated vaccine for HuNoV has been hampered by the inability to grow the virus in cell culture. Thus, a vector-based v...

journal_title：Journal of virology

authors： Ma Y,Li J

更新日期：2011-03-01 00:00:00

abstract：:This paper describes Q beta noninfectious particles produced at 41 degrees C in a streptomycin-resistant Escherichia coli mutant which is temperature sensitive for suppression of a nonsense codon. The noninfectious particles resembled Q beta under the electron microscope and contained coat protein molecules in an amou...

journal_title：Journal of virology

authors： Engelberg-Kulka H,Israeli-Reches M,Dekel L,Friedmann A

更新日期：1979-03-01 00:00:00

abstract：:Human oncolytic adenoviruses have been used in clinical trials targeting cancers of epithelial origin. To gain a better understanding of the infectious cycle of adenovirus in normal human squamous tissues, we examined the viral infection process in organotypic cultures of primary human keratinocytes. We show that for ...

journal_title：Journal of virology

authors： Noya F,Balagué C,Banerjee NS,Curiel DT,Broker TR,Chow LT

更新日期：2003-06-01 00:00:00

abstract：:Most mammalian rotaviruses contain tripeptide amino acid sequences in outer capsid proteins VP4 and VP7 which have been shown to act as ligands for integrins alpha2beta1 and alpha4beta1. Peptides containing these sequences and monoclonal antibodies directed to these integrins block rotavirus infection of cells. Here w...

journal_title：Journal of virology

authors： Hewish MJ,Takada Y,Coulson BS

更新日期：2000-01-01 00:00:00

abstract：:Interferon (IFN) signal transduction involves interferon regulatory factors (IRF). Kaposi's sarcoma-associated herpesvirus (KSHV) encodes four IRF homologues: viral IRF 1 (vIRF-1) to vIRF-4. Previous functional studies revealed that the first exon of vIRF-2 inhibited alpha/beta interferon (IFN-alpha/beta) signaling. W...

journal_title：Journal of virology

authors： Fuld S,Cunningham C,Klucher K,Davison AJ,Blackbourn DJ

更新日期：2006-03-01 00:00:00

abstract：:Viruses in the family Coronaviridae, within the order Nidovirales, are etiologic agents of a range of human and animal diseases, including both mild and severe respiratory diseases in humans. These viruses encode conserved replicase and structural proteins as well as more diverse accessory proteins, encoded in the 3' ...

journal_title：Journal of virology

authors： Goldstein SA,Thornbrough JM,Zhang R,Jha BK,Li Y,Elliott R,Quiroz-Figueroa K,Chen AI,Silverman RH,Weiss SR

更新日期：2017-02-14 00:00:00

abstract：:The recent identification of coreceptors that mediate efficient entry of human immunodeficiency virus type 1 (HIV-1) suggests new therapeutic and preventive strategies. We analyzed simian immunodeficiency virus (SIV) entry cofactors to investigate whether the macaque SIV model can be used as an experimental model to e...

journal_title：Journal of virology

authors： Kirchhoff F,Pöhlmann S,Hamacher M,Means RE,Kraus T,Uberla K,Di Marzio P

更新日期：1997-09-01 00:00:00

abstract：:The vpr gene product of human immunodeficiency virus type (HIV-1) is a virion-associated regulatory protein. A transferable virion association motif for Vpr is located in the p6 domain of the HIV-1 Gag polyprotein. To map the sequences in p6 that are involved in Vpr incorporation, we analyzed the ability of mutant for...

journal_title：Journal of virology

authors： Kondo E,Göttlinger HG

更新日期：1996-01-01 00:00:00