Abstract:
:We isolated a simian virus 40 mutant, dl2194, which carried deletions in both early genes. One deletion removed 234 base pairs in the 54/59 region within the small-t-antigen coding sequence and the large-T-antigen gene intron. The second deletion removed 57 base pairs at the C terminus of the large-T-antigen coding sequence (0.20 map unit). dl2194 was a viable mutant, it carried a normal helper function for adenovirus growth on monkey cells, and it displayed the transformation properties of a small-t-antigen-negative single mutant. Therefore, none of the known large-T-antigen functions seemed to be altered by the C-terminal deletion.
journal_name
J Viroljournal_title
Journal of virologyauthors
Feunteun J,Carmichael G,Nicolas JC,Kress Mdoi
10.1128/JVI.40.3.625-634.1981subject
Has Abstractpub_date
1981-12-01 00:00:00pages
625-34issue
3eissn
0022-538Xissn
1098-5514journal_volume
40pub_type
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更新日期:1999-07-01 00:00:00