Differential contribution of herpes simplex virus type 1 gene products and cellular factors to the activation of human immunodeficiency virus type 1 provirus.

abstract：:A gene encoding a polypeptide with homology to mammalian vascular endothelial growth factors (VEGFs) has been discovered in the genome of orf virus (OV), a parapoxvirus that affects sheep and goats and, occasionally, humans. The gene is transcribed abundantly early in infection and is found immediately outside the inv...

journal_title：Journal of virology

authors： Lyttle DJ,Fraser KM,Fleming SB,Mercer AA,Robinson AJ

更新日期：1994-01-01 00:00:00

abstract：:Borna disease virus (BDV) is a neurotropic virus with a broad host and geographic range. Lewis rats were immunized against BDV with a recombinant vaccinia virus expressing the BDV nucleoprotein and were later infected with BDV to evaluate protection against Borna disease (BD). Relative to animals that were not immuniz...

journal_title：Journal of virology

authors： Lewis AJ,Whitton JL,Hatalski CG,Weissenböck H,Lipkin WI

更新日期：1999-03-01 00:00:00

abstract：:Following the initial detection of viral infection, innate immune responses trigger the induction of numerous interferon-stimulated genes (ISGs) to inhibit virus replication and dissemination. One such ISG encodes cholesterol-25-hydroxylase (CH25H), an enzyme that catalyzes the oxidation of cholesterol to form a solub...

journal_title：Journal of virology

authors： Doms A,Sanabria T,Hansen JN,Altan-Bonnet N,Holm GH

更新日期：2018-08-29 00:00:00

abstract：:The vaccinia virus H2R gene (VACWR 100) is conserved in all sequenced members of the poxvirus family and encodes a protein with a predicted transmembrane domain and four invariant cysteines. A recombinant vaccinia virus, in which expression of the H2 protein is stringently regulated, was unable to replicate without in...

journal_title：Journal of virology

authors： Senkevich TG,Moss B

更新日期：2005-04-01 00:00:00

abstract：:Avian reovirus, an important avian pathogen, expresses eight structural and four nonstructural proteins. The structural sigmaA protein is a major component of the inner capsid, clamping together lambdaA building blocks. sigmaA has also been implicated in the resistance of avian reovirus to the antiviral action of inte...

journal_title：Journal of virology

authors： Guardado-Calvo P,Vazquez-Iglesias L,Martinez-Costas J,Llamas-Saiz AL,Schoehn G,Fox GC,Hermo-Parrado XL,Benavente J,van Raaij MJ

更新日期：2008-11-01 00:00:00

abstract：:Functional defects in cytotoxic CD8(+) T cell responses arise in chronic human viral infections, but the mechanisms involved are not well understood. In mice, CD4 cell-mediated interleukin-21 (IL-21) production is necessary for the maintenance of CD8(+) T cell function and control of persistent viral infections. To in...

journal_title：Journal of virology

authors： Chevalier MF,Jülg B,Pyo A,Flanders M,Ranasinghe S,Soghoian DZ,Kwon DS,Rychert J,Lian J,Muller MI,Cutler S,McAndrew E,Jessen H,Pereyra F,Rosenberg ES,Altfeld M,Walker BD,Streeck H

更新日期：2011-01-01 00:00:00

abstract：:The family Bunyaviridae is the most diversified family of RNA viruses. We describe a novel prototypic bunyavirus, tentatively named Gouléako virus, isolated from various mosquito species trapped in Côte d'Ivoire. The S segment comprised 1,087 nucleotides (nt), the M segment 3,188 nt, and the L segment 6,358 nt, consti...

journal_title：Journal of virology

authors： Marklewitz M,Handrick S,Grasse W,Kurth A,Lukashev A,Drosten C,Ellerbrok H,Leendertz FH,Pauli G,Junglen S

更新日期：2011-09-01 00:00:00

abstract：:Adeno-associated virus serotype 9 (AAV9) vectors show promise for gene therapy of a variety of diseases due to their ability to transduce multiple tissues, including heart, skeletal muscle, and the alveolar epithelium of the lung. In addition, AAV9 is unique compared to other AAV serotypes in that it is capable of sur...

journal_title：Journal of virology

authors： Bell CL,Gurda BL,Van Vliet K,Agbandje-McKenna M,Wilson JM

更新日期：2012-07-01 00:00:00

abstract：:Molecularly cloned proviral DNA of avian oncogenic retrovirus CMII was isolated by screening a genomic library of a CMII-transformed quail cell line with a myc-specific probe. On a 10.4-kilobase EcoRI fragment, the cloned DNA contained 4.4 kilobases of CMII proviral sequences extending from the 5' long terminal repeat...

journal_title：Journal of virology

authors： Walther N,Lurz R,Patschinsky T,Jansen HW,Bister K

更新日期：1985-05-01 00:00:00

abstract：:Cottontail rabbit papillomavirus induces strictly epithelial tumors in both cottontail and domestic rabbits. A high proportion of the initial benign papillomas progress within 8 to 14 months to invasive carcinomas. With the help of mRNA-specific riboprobes for E6, E7, E1, E2, L1 and L2, we investigated by in situ hybr...

journal_title：Journal of virology

authors： Zeltner R,Borenstein LA,Wettstein FO,Iftner T

更新日期：1994-06-01 00:00:00

abstract：:Host cell-mediated proteolytic cleavage of the human immunodeficiency virus type 1 (HIV-1) gp160 precursor glycoprotein into gp120 and gp41 subunits is required to generate fusion-competent envelope glycoprotein (Env) spikes. The gp120-directed broadly neutralizing monoclonal antibodies (bNabs) isolated from HIV-infec...

journal_title：Journal of virology

authors： Chakrabarti BK,Feng Y,Sharma SK,McKee K,Karlsson Hedestam GB,Labranche CC,Montefiori DC,Mascola JR,Wyatt RT

更新日期：2013-12-01 00:00:00

abstract：:Herpes simplex virus (HSV) has often been suggested for development as a vector, particularly for the nervous system. Considerable evidence has shown that for use of HSV as a vector, immediate-early (IE) gene expression must be minimized or abolished, otherwise such vectors are likely to be highly cytotoxic. Mutations...

journal_title：Journal of virology

authors： Thomas SK,Lilley CE,Latchman DS,Coffin RS

更新日期：1999-09-01 00:00:00

abstract：:The widespread presence of endogenous retroviruses in the genomes of animals and humans has suggested that these viruses may be involved in both normal and abnormal developmental processes. Previous studies have indicated the involvement of endogenous ecotropic murine leukemia virus (MuLV) in the development of age-de...

journal_title：Journal of virology

authors： Contag CH,Plagemann PG

更新日期：1989-10-01 00:00:00

abstract：:In earlier studies, we have shown that superinfection of an interleukin-2 (IL-2)-dependent, Moloney murine leukemia virus (MoMuLV)-induced rat T-cell lymphoma line (4437A) with mink cell focus-forming (also called polytropic) murine retroviruses induces rapid progression to IL-2-independent growth. In this report, we ...

journal_title：Journal of virology

authors： Flubacher MM,Bear SE,Tsichlis PN

更新日期：1994-12-01 00:00:00

abstract：:Varicella-zoster virus (VZV) is a highly species-specific herpesvirus that targets sensory ganglionic neurons. This species specificity has limited the study of many aspects of VZV pathogenesis, including neuronal infection. We report development of a highly efficient neuroblastoma cell model to study productive VZV i...

journal_title：Journal of virology

authors： Christensen J,Steain M,Slobedman B,Abendroth A

更新日期：2011-08-01 00:00:00

abstract：:Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA-3C) is one of five viral nuclear proteins that are essential for EBV-induced immortalization of primary human B lymphocytes in vitro. Previous studies have implied that EBNA-3C acts as a transcription factor. Using transient transfection assays, we demonstrate that EBN...

journal_title：Journal of virology

authors： Marshall D,Sample C

更新日期：1995-06-01 00:00:00

abstract：:Ground squirrel hepatitis virus (GSHV) is a small DNA virus, structurally and antigenically related to the human hepatitis B virus, which occurs naturally among certain wild populations of ground squirrels (P. L. Marion et al., Proc. Natl. Acad. Sci. U.S.A. 77:2941-2945, 1980). Serum from naturally infected animals wa...

journal_title：Journal of virology

authors： Ganem D,Weiser B,Barchuk A,Brown RJ,Varmus HE

更新日期：1982-10-01 00:00:00

abstract：:The phenotypic defects of two mutants of vaccinia virus, the lesions of which map to gene G2R, were characterized in vivo, and the results suggest a role for the G2R protein in viral transcription elongation. Both a temperature-sensitive mutant, Cts56, and an isatin-beta-thiosemicarbazone-dependent deletion mutant, G2...

journal_title：Journal of virology

authors： Black EP,Condit RC

更新日期：1996-01-01 00:00:00

abstract：:Apoptosis of infected cells is critically involved in antiviral defense. Apoptosis, however, may also support the release and spread of viruses. Although the elimination of infected hepatocytes is required to combat hepatitis B virus (HBV) infection, it is still unknown which consequences hepatocyte apoptosis has for ...

journal_title：Journal of virology

authors： Arzberger S,Hösel M,Protzer U

更新日期：2010-11-01 00:00:00

abstract：:The Cas-Br-E murine leukemia virus is a nondefective retrovirus that induces non-T-, non-B-cell lymphomas in susceptible NIH/Swiss mice. By using a DNA probe derived from Cas-Br-E provirus-flanking sequences, we identified a DNA region, originally called Sic-1, rearranged in 16 of 24 tumors analyzed (67%). All proviru...

journal_title：Journal of virology

authors： Bergeron D,Poliquin L,Kozak CA,Rassart E

更新日期：1991-01-01 00:00:00

abstract：UNLABELLED:Tetherin (BST2, CD317, or HM1.24) is a host cellular restriction factor that prevents the release of enveloped viruses by mechanically linking virions to the plasma membrane. The precise arrangement of tetherin molecules at the plasma membrane site of HIV-1 assembly, budding, and restriction is not well unde...

journal_title：Journal of virology

authors： Strauss JD,Hammonds JE,Yi H,Ding L,Spearman P,Wright ER

更新日期：2015-11-18 00:00:00

abstract：:Hypoviruses Cryphonectria hypovirus 1 (CHV-1)/EP713, CHV-1/Euro7, and CHV-1/EP721, which infect the chestnut blight fungus Cryphonectria parasitica, differ in their degrees of virulence attenuation (hypovirulence), symptom expression, and viral RNA accumulation, even though they share between 90% and 99% amino acid se...

journal_title：Journal of virology

authors： Zhang X,Shi D,Nuss DL

更新日期：2012-12-01 00:00:00

abstract：:Proteolytic processing of the Rous sarcoma virus (RSV) Gag precursor was altered in vivo through the introduction of amino acid substitutions into either the polyprotein cleavage junctions or the PR coding sequence. Single amino acid substitutions (V(P2)S and P(P4)G), which are predicted from in vitro peptide substrat...

journal_title：Journal of virology

authors： Xiang Y,Ridky TW,Krishna NK,Leis J

更新日期：1997-03-01 00:00:00

abstract：:Defining a macrophage-tropic phenotype for HIV-1 to assess a role in pathogenesis is complicated by the fact that HIV-1 isolates vary continuously in their ability to enter monocyte-derived macrophages (MDMs) in vitro, and MDMs vary in their ability to support HIV-1 entry. To overcome these limitations, we identified ...

journal_title：Journal of virology

authors： Joseph SB,Arrildt KT,Swanstrom AE,Schnell G,Lee B,Hoxie JA,Swanstrom R

更新日期：2014-02-01 00:00:00

abstract：:A technique of continuous filtration of T4-infected Escherichia coli has been devised to study the phenomenon of lysis inhibition. Studies using this technique revealed that the length of the lysis delay caused by superinfection can attain only certain discrete values, which for low average multiplicity of superinfect...

journal_title：Journal of virology

authors： Bode W

更新日期：1967-10-01 00:00:00

abstract：:A general theme that has emerged from studies of DNA tumor viruses is that otherwise unrelated oncoproteins encoded by these viruses often target the same important cellular factors. Major oncogenic determinants for human adenovirus type 9 (Ad9) and high-risk human papillomaviruses (HPV) are the E4-ORF1 and E6 oncopro...

journal_title：Journal of virology

authors： Lee SS,Glaunsinger B,Mantovani F,Banks L,Javier RT

更新日期：2000-10-01 00:00:00

abstract：:The sole immediate-early (IE) gene of equine herpesvirus 1 encodes a 1,487-amino-acid (aa) regulatory phosphoprotein that independently activates expression of early viral genes. Coimmunoprecipitation assays demonstrated that the IE protein physically interacts with the general transcription factor TFIIB. Using a vari...

journal_title：Journal of virology

authors： Jang HK,Albrecht RA,Buczynski KA,Kim SK,Derbigny WA,O'Callaghan DJ

更新日期：2001-11-01 00:00:00

abstract：:Plasma from a small subset of subjects chronically infected with HIV-1 shows remarkable magnitude and breadth of neutralizing activity. From one of these individuals (CH0219), we isolated two broadly neutralizing antibodies (bnAbs), CH01 and VRC-CH31, from two clonal lineages of memory B cells with distinct specificit...

journal_title：Journal of virology

authors： Bonsignori M,Montefiori DC,Wu X,Chen X,Hwang KK,Tsao CY,Kozink DM,Parks RJ,Tomaras GD,Crump JA,Kapiga SH,Sam NE,Kwong PD,Kepler TB,Liao HX,Mascola JR,Haynes BF

更新日期：2012-04-01 00:00:00

abstract：:Adenovirus E1B 55K protein cooperates with E1A gene products to induce cell transformation. E1B 55K mediates its effects by binding to and inhibiting the transcriptional activation and growth-suppression functions of the tumor suppressor p53. Previous studies in vivo have suggested that E1B 55K has an active role in r...

journal_title：Journal of virology

authors： Martin ME,Berk AJ

更新日期：1998-04-01 00:00:00

abstract：:We recently discovered an expanded family of adeno-associated viruses (AAVs) that show promise as improved gene therapy vectors. In this study we evaluated the potential of vectors based on several of these novel AAVs as vaccine carriers for human immunodeficiency virus type 1 Gag. Studies with mice indicated that vec...

journal_title：Journal of virology

authors： Lin J,Zhi Y,Mays L,Wilson JM

更新日期：2007-11-01 00:00:00