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Adenovirus-pulsed dendritic cells stimulate human virus-specific T-cell responses in vitro.

Abstract：

:Adenovirus infections cause significant morbidity and mortality in immunocompromised patients, yet little is known about the immune response to adenovirus infections. We established a system for the generation of a cytotoxic immune response to adenovirus in vitro. Cytotoxic T cells (CTLs) were derived from normal donors by using peripheral blood dendritic cells as antigen-presenting cells. The CTLs were found to contain a mixture of effector cells that recognized virus peptides in the context of both class I and class II antigens. Endogenous viral gene expression was not required to sensitize cells to lysis by adenovirus-specific CTLs. CTLs raised against subgroup C adenovirus type 5 can lyse cells infected with subgroup B adenovirus type 11, indicating that viruses of different subgroups have epitopes in common. This system holds promise for defining the human immune response to adenovirus, including characterization of the viral protein(s) against which the response is generated, and the identity of the effector cells. Such studies are in progress.

journal_name

J Virol

journal_title

Journal of virology

authors

Smith CA,Woodruff LS,Kitchingman GR,Rooney CM

doi

10.1128/JVI.70.10.6733-6740.1996

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

6733-40

issue

10

eissn

0022-538X

issn

1098-5514

journal_volume

70

pub_type

杂志文章

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