Induction of a major histocompatibility complex class I-restricted cytotoxic T-lymphocyte response to a highly conserved region of human immunodeficiency virus type 1 (HIV-1) gp120 in seronegative humans immunized with a candidate HIV-1 vaccine.

abstract：:The long terminal repeat U3 sequences were determined for multiple feline leukemia virus proviruses isolated from naturally occurring T-cell tumors. Heterogeneity was evident, even among proviruses cloned from individual tumors. Proviruses with one, two, or three repeats of the long terminal repeat enhancer sequences ...

journal_title：Journal of virology

authors： Fulton R,Plumb M,Shield L,Neil JC

更新日期：1990-04-01 00:00:00

abstract：:We report the complete genome sequence of Pseudomonas aeruginosa siphophage MP1412, which displays synteny to those of P. aeruginosa phages M6 and YuA. However, the presence of two homing endonucleases of the GIY-YIG family is unique to MP1412, suggesting their unique role in the phage life cycle of the bacterial host...

journal_title：Journal of virology

authors： Bae HW,Chung IY,Sim N,Cho YH

更新日期：2012-09-01 00:00:00

abstract：:In the influenza H5N1 virus incident in Hong Kong in 1997, viruses that are closely related to H5N1 viruses initially isolated in a severe outbreak of avian influenza in chickens were isolated from humans, signaling the possibility of an incipient pandemic. However, it was not possible to prepare a vaccine against the...

journal_title：Journal of virology

authors： Takada A,Kuboki N,Okazaki K,Ninomiya A,Tanaka H,Ozaki H,Itamura S,Nishimura H,Enami M,Tashiro M,Shortridge KF,Kida H

更新日期：1999-10-01 00:00:00

abstract：:Simian immunodeficiency virus (SIV) of macaques isolate SIVmac239 is highly resistant to neutralization by polyclonal antisera or monoclonal antibodies, a property that it shares with most primary isolates of human immunodeficiency virus type 1 (HIV-1). This resistance is important for the ability of the virus to pers...

journal_title：Journal of virology

authors： Johnson WE,Sanford H,Schwall L,Burton DR,Parren PW,Robinson JE,Desrosiers RC

更新日期：2003-09-01 00:00:00

abstract：:Previous in vitro analyses have shown that the human immunodeficiency virus type 1 (HIV-1) integrase uses either manganese or magnesium to assemble as a stable complex on the donor substrate and to catalyze strand transfer. We now demonstrate that subsequent to assembly, catalysis of both 3' end processing and strand ...

journal_title：Journal of virology

authors： Hazuda DJ,Felock PJ,Hastings JC,Pramanik B,Wolfe AL

更新日期：1997-09-01 00:00:00

abstract：:Currently there is limited information about the quality of immune responses elicited by candidate human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env)-based immunogens in primates. Here we describe a comprehensive analysis of neutralizing antibody and T-cell responses obtained in cynomolgus macaque...

journal_title：Journal of virology

authors： Mörner A,Douagi I,Forsell MN,Sundling C,Dosenovic P,O'Dell S,Dey B,Kwong PD,Voss G,Thorstensson R,Mascola JR,Wyatt RT,Karlsson Hedestam GB

更新日期：2009-01-01 00:00:00

abstract：:Transgene expression after the administration of recombinant adenovirus with E1 deleted is constantly transient. It is admitted that E1A-substituting activities of cellular or viral origin allow viral antigen synthesis and trigger cytotoxic lymphocyte-mediated clearance of the recipient cells. Our approach to solving ...

journal_title：Journal of virology

authors： Yeh P,Dedieu JF,Orsini C,Vigne E,Denefle P,Perricaudet M

更新日期：1996-01-01 00:00:00

abstract：UNLABELLED:Paramyxoviruses and other negative-strand RNA viruses encode matrix proteins that coordinate the virus assembly process. The matrix proteins link the viral glycoproteins and the viral ribonucleoproteins at virus assembly sites and often recruit host machinery that facilitates the budding process. Using a co-...

journal_title：Journal of virology

authors： Sun W,McCrory TS,Khaw WY,Petzing S,Myers T,Schmitt AP

更新日期：2014-11-01 00:00:00

abstract：:Abnormal prion protein (PrP(Sc)) plays a central role in the transmission of prion diseases, but the molecular basis of prion strains with distinct biological characteristics remains to be elucidated. We analyzed the characteristics of prion disease by using mice inoculated with the Chandler and Fukuoka-1 strains prop...

journal_title：Journal of virology

authors： Arima K,Nishida N,Sakaguchi S,Shigematsu K,Atarashi R,Yamaguchi N,Yoshikawa D,Yoon J,Watanabe K,Kobayashi N,Mouillet-Richard S,Lehmann S,Katamine S

更新日期：2005-06-01 00:00:00

abstract：:Vesicular stomatitis virus (VSV) vectors that express heterologous antigens have shown promise as vaccines in preclinical studies. The efficacy of VSV-based vaccines can be improved by engineering vectors that enhance innate immune responses. We previously generated a VSV vaccine vector that incorporates two enhancing...

journal_title：Journal of virology

authors： Smedberg JR,Westcott MM,Ahmed M,Lyles DS

更新日期：2014-01-01 00:00:00

abstract：:The first 86 residues of the Rous sarcoma virus (RSV) Gag protein form a membrane-binding (M) domain that directs Gag to the plasma membrane during budding. Unlike other retroviral Gag proteins, RSV Gag is not myristylated; however, the RSV M domain does contain 11 basic residues that could potentially interact with a...

journal_title：Journal of virology

authors： Callahan EM,Wills JW

更新日期：2000-12-01 00:00:00

abstract：:Retrovirus infection is normally limited to cells within a specific host range which express a cognate receptor that is recognized by the product of the env gene. We describe retrovirus infection of cells outside of their normal host range when the infection is performed in the presence of a replication-defective aden...

journal_title：Journal of virology

authors： Adams RM,Wang M,Steffen D,Ledley FD

更新日期：1995-03-01 00:00:00

abstract：:Dengue virus (DEN) causes dengue fever and dengue hemorrhagic fever/dengue shock syndrome, which are major public health problems worldwide. The immune factors that control DEN infection or contribute to severe disease are neither well understood nor easy to examine in humans. In this study, we used wild-type and cong...

journal_title：Journal of virology

authors： Shresta S,Kyle JL,Snider HM,Basavapatna M,Beatty PR,Harris E

更新日期：2004-03-01 00:00:00

abstract：:Cytolytic T-lymphocyte (CTL) activity specific for respiratory syncytial (RS) virus was investigated after intranasal infection of mice with RS virus, after intraperitoneal infection of mice with a recombinant vaccinia virus expressing the F glycoprotein, and after intramuscular vaccination of mice with Formalin-inact...

journal_title：Journal of virology

authors： Nicholas JA,Rubino KL,Levely ME,Adams EG,Collins PL

更新日期：1990-09-01 00:00:00

abstract：:Many viruses express inhibitors of programmed cell death (apoptosis), thereby countering host defenses that would otherwise rapidly clear infected cells. To counter this, viruses such as adenoviruses and herpesviruses express recognizable homologs of the mammalian prosurvival protein Bcl-2. In contrast, the majority o...

journal_title：Journal of virology

authors： Okamoto T,Campbell S,Mehta N,Thibault J,Colman PM,Barry M,Huang DC,Kvansakul M

更新日期：2012-11-01 00:00:00

abstract：:The major histocompatibility complex (MHC) class I region of humans, chimpanzees (Pan troglodytes), and bonobos (Pan paniscus) is highly similar, and orthologues of HLA-A, -B, and -C are present in both Pan species. Based on functional characteristics, the different HLA-A allotypes are classified into different supert...

journal_title：Journal of virology

authors： de Groot NG,Heijmans CMC,de Ru AH,Otting N,Koning F,van Veelen PA,Bontrop RE

更新日期：2020-04-16 00:00:00

abstract：:3-O-(3',3'-Dimethysuccinyl) betulinic acid (PA-457) has been shown to potently inhibit human immunodeficiency virus (HIV) replication in culture. In contrast to inhibitors that act upon the viral proteinase, PA-457 appears to block only the final maturational cleavage of p25CA-p2 to p24CA. However, attempts to replica...

journal_title：Journal of virology

authors： Sakalian M,McMurtrey CP,Deeg FJ,Maloy CW,Li F,Wild CT,Salzwedel K

更新日期：2006-06-01 00:00:00

abstract：:The large-particle fraction from the cytoplasm of chick embryo fibroblasts infected with Semliki Forest virus was found to catalyze the incorporation of the 5'-triphosphates of guanosine, adenine, cytidine, and uridine into an acid-insoluble alkali-labile product. The conditions affecting the preparation and assay of ...

journal_title：Journal of virology

authors： Martin EM,Sonnabend JA

更新日期：1967-02-01 00:00:00

abstract：:We examined cellular components which associate with p40tax, the viral transactivation molecule of human T-cell leukemia virus type I. Such molecules were searched by immunoprecipitation with polyclonal and monoclonal antibodies specific for p40tax. Two cellular proteins with molecular masses of 95 kDa (p95) and 60 kD...

journal_title：Journal of virology

authors： Nagata K,Ide Y,Takagi T,Ohtani K,Aoshima M,Tozawa H,Nakamura M,Sugamura K

更新日期：1992-02-01 00:00:00

abstract：:Thirty-six monoclonal antibodies from mice and three from rats were raised against a peptide corresponding to the immunodominant domain of the transmembrane gp41 protein of human immunodeficiency virus (HIV) type 1 (LGLWGCSGKLIC; amino acid residues 598 to 609). Of these, three monoclonal antibodies from the mice and ...

journal_title：Journal of virology

authors： Oldstone MB,Tishon A,Lewicki H,Dyson HJ,Feher VA,Assa-Munt N,Wright PE

更新日期：1991-04-01 00:00:00

abstract：:After corneal inoculation, herpes simplex virus type 1 replicates in the mouse eye, trigeminal ganglia, and brainstem, producing first an acute and then a latent infection. Previous work from this laboratory focused on the structure of the viral DNA in this system. We have now examined the structure of the viral genom...

journal_title：Journal of virology

authors： Muggeridge MI,Fraser NW

更新日期：1986-09-01 00:00:00

abstract：:We previously described a monoclonal antibody (Y8-10C2) that binds influenza virus hemagglutinin (HA) monomers but not native trimers. In this study, we demonstrated that Y8-10C2 binds to the globular domain of HA and found evidence that its epitope is located at the interface of adjacent subunits. We further showed t...

journal_title：Journal of virology

authors： Yewdell JW,Taylor A,Yellen A,Caton A,Gerhard W,Bächi T

更新日期：1993-02-01 00:00:00

abstract：:Adenovirus infection affects the nuclear distribution of host splicing factors. Late phase-infected cells contain discrete clusters of small nuclear ribonucleoproteins (snRNPs) that are separate from centers containing the viral 72-kilodalton DNA-binding protein (72K protein). In the present study, we demonstrate that...

journal_title：Journal of virology

authors： Bridge E,Xia DX,Carmo-Fonseca M,Cardinali B,Lamond AI,Pettersson U

更新日期：1995-01-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) normally assembles into particles of 100 to 120 nm in diameter by budding through the plasma membrane of the cell. The Gag polyprotein is the only viral protein that is required for the formation of these particles. We have used an in vitro assembly system to examine the ass...

journal_title：Journal of virology

authors： Campbell S,Rein A

更新日期：1999-03-01 00:00:00

abstract：:The vaccinia virus F10 protein is one of two virally encoded protein kinases. A phenotypic analysis of infections involving a tetracycline-inducible recombinant (vDeltaiF10) indicated that F10 is involved in the early stages of virion morphogenesis, as previously reported for the mutants ts28 and ts15. The proteins en...

journal_title：Journal of virology

authors： Punjabi A,Traktman P

更新日期：2005-02-01 00:00:00

abstract：:Bacterial lipopolysaccharide (LPS) induces interferon (IFN) secretion and an antiviral state in murine peritoneal macrophages (PM). These cells secrete predominantly IFN-beta, as shown by neutralization assays with monoclonal antibodies. Secretion of IFN-beta is also induced in PM by IFN-gamma. LPS and IFN-gamma syner...

journal_title：Journal of virology

authors： Gessani S,Belardelli F,Pecorelli A,Puddu P,Baglioni C

更新日期：1989-06-01 00:00:00

abstract：:African swine fever virus (ASFV) is the etiological agent of a contagious and often lethal viral disease of domestic pigs that has significant economic consequences for the swine industry. The control of African swine fever (ASF) has been hampered by the unavailability of vaccines. Successful experimental vaccines hav...

journal_title：Journal of virology

authors： O'Donnell V,Risatti GR,Holinka LG,Krug PW,Carlson J,Velazquez-Salinas L,Azzinaro PA,Gladue DP,Borca MV

更新日期：2016-12-16 00:00:00

abstract：:The STP-C488 open reading frame of herpesvirus saimiri encodes an oncoprotein that has transforming and tumor-inducing activities independent of the rest of the herpesvirus genome. STP-C488 protein has an unusual, membrane-associated, fibrous structure and is located primarily in perinuclear compartments. We now repor...

journal_title：Journal of virology

authors： Jung JU,Desrosiers RC

更新日期：1992-03-01 00:00:00

abstract：:Apoptosis of neurons and astrocytes is induced by human immunodeficiency type 1 (HIV-1) infection in vitro and has been demonstrated in brain tissue from patients with AIDS. We analyzed a panel of diverse HIV-1 primary isolates for the ability to replicate and induce neuronal and astrocyte apoptosis in primary human b...

journal_title：Journal of virology

authors： Ohagen A,Ghosh S,He J,Huang K,Chen Y,Yuan M,Osathanondh R,Gartner S,Shi B,Shaw G,Gabuzda D

更新日期：1999-02-01 00:00:00

abstract：:Heterologous viral infections have been shown to impact the preexisting memory CD8(+)-T-cell repertoire. Bacterial superantigens are products of common human pathogenic bacteria, including staphylococci and streptococci, that are potent T-cell-stimulatory molecules. In this report, we show that exposure to staphylococ...

journal_title：Journal of virology

authors： Huang CC,Shah S,Nguyen P,Altman JD,Blackman MA

更新日期：2002-07-01 00:00:00