Mutations in or near the fusion peptide of the influenza virus hemagglutinin affect an antigenic site in the globular region.

abstract：:The host structural maintenance of chromosomes 5/6 complex (Smc5/6) suppresses hepatitis B virus (HBV) transcription. HBV counters this restriction by expressing the X protein (HBx), which redirects the cellular DNA damage-binding protein 1 (DDB1)-containing E3 ubiquitin ligase to target Smc5/6 for degradation. Howeve...

journal_title：Journal of virology

authors： Ramakrishnan D,Xing W,Beran RK,Chemuru S,Rohrs H,Niedziela-Majka A,Marchand B,Mehra U,Zábranský A,Doležal M,Hubálek M,Pichová I,Gross ML,Kwon HJ,Fletcher SP

更新日期：2019-07-30 00:00:00

abstract：:A total of 51 restriction sites were recognized within the BK virus genome by the combination of 10 different restriction endonucleases. These sites were mapped and oriented relative to one another as well as to the five fragments generated by the digestion of BK virus DNA with HindIII and EcoRI. The result was a comp...

journal_title：Journal of virology

authors： Freund J,di Mayorca G,Subramanian KN

更新日期：1979-03-01 00:00:00

abstract：:Polyoma virus particles were purified by equilibrium centrifugation in CsCl. Particles from three regions of the density gradient were examined for infectivity, for their ability to induce expanded pools of deoxyribonucleic acid (DNA) precursors, and for their ability to stimulate the synthesis of DNA. The most infect...

journal_title：Journal of virology

authors： Skoog L,Nordenskjöld BA,Lindberg U

更新日期：1970-07-01 00:00:00

abstract：:Plus-strand RNA viruses characteristically replicate their genome in association with altered cellular membranes. In the present study, the capacity of hepatitis C virus (HCV) proteins to elicit intracellular membrane alterations was investigated by expressing, in tetracycline-regulated cell lines, a comprehensive pan...

journal_title：Journal of virology

authors： Egger D,Wölk B,Gosert R,Bianchi L,Blum HE,Moradpour D,Bienz K

更新日期：2002-06-01 00:00:00

abstract：:A number of options are available to modify and improve DNA vaccines. An interesting approach to improve DNA vaccines is to fuse bioactive domains, like cytotoxic-T-lymphocyte-associated protein 4 (CTLA-4), to an antigen. Such fusion antigens are expressed in vivo and directed to immune cells by the specific bioactive...

journal_title：Journal of virology

authors： Lu M,Isogawa M,Xu Y,Hilken G

更新日期：2005-05-01 00:00:00

abstract：:Mammalian cells infected with herpes simplex virus (HSV) express a novel ribonucleotide reductase which is biochemically and immunologically distinct from the uninfected-cell enzyme. Using polyvalent rabbit antiserum raised against partially purified HSV type 2 reductase as well as monoclonal antibodies to HSV type 1 ...

journal_title：Journal of virology

authors： Bacchetti S,Evelegh MJ,Muirhead B,Sartori CS,Huszar D

更新日期：1984-02-01 00:00:00

abstract：:Phosphorylation of the expressed NS5A protein of hepatitis C virus (HCV), a member of the Hepacivirus genus of the family Flaviviridae, has been demonstrated in mammalian cells and in a cell-free assay by an associated kinase activity. In this report, phosphorylation is also shown for the NS5A and NS5 proteins, respec...

journal_title：Journal of virology

authors： Reed KE,Gorbalenya AE,Rice CM

更新日期：1998-07-01 00:00:00

abstract：:Hepatitis E virus (HEV) replication is not well understood, mainly because the virus does not infect cultured cells efficiently. However, Huh-7 cells transfected with full-length genomes produce open reading frame 2 protein, indicative of genome replication (6). To investigate the role of 3'-terminal sequences in RNA ...

journal_title：Journal of virology

authors： Graff J,Nguyen H,Kasorndorkbua C,Halbur PG,St Claire M,Purcell RH,Emerson SU

更新日期：2005-01-01 00:00:00

abstract：:RNA recombination is a major process in promoting rapid virus evolution in an infected host. A previous genome-wide screen with the yeast single-gene deletion library of 4,848 strains, representing approximately 80% of all genes of yeast, led to the identification of 11 host genes affecting RNA recombination in Tomato...

journal_title：Journal of virology

authors： Serviene E,Jiang Y,Cheng CP,Baker J,Nagy PD

更新日期：2006-02-01 00:00:00

abstract：:The Epstein-Barr virus nuclear antigen 2 (EBNA-2) acidic domain is essential for B-lymphocyte growth transformation and can activate transcription when brought to a promoter by a sequence-specific DNA-binding domain. We now show that the EBNA-2 acidic domain has slightly less activity than the proteotypic acidic trans...

journal_title：Journal of virology

authors： Tong X,Wang F,Thut CJ,Kieff E

更新日期：1995-01-01 00:00:00

abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) infection of swine leads to a serious disease characterized by a delayed and defective adaptive immune response. It is hypothesized that a suboptimal innate immune response is responsible for the disease pathogenesis. In the study presented here we tested thi...

journal_title：Journal of virology

authors： Beura LK,Sarkar SN,Kwon B,Subramaniam S,Jones C,Pattnaik AK,Osorio FA

更新日期：2010-02-01 00:00:00

abstract：:Ten bacteriophages that attack and lyse saprophytic strains of Bdellovibrio bacteriovorus were isolated. Morphological, serological, and host-range studies revealed that there were four different bdellovibrio phages present among the isolates. One of the phages lysed a strain of B. bacteriovorus that requires the pres...

journal_title：Journal of virology

authors： Althauser M,Samsonoff WA,Anderson C,Conti SF

更新日期：1972-09-01 00:00:00

abstract：:Viral infectivity factor (Vif) is one of the human immunodeficiency virus (HIV) accessory proteins and is conserved in the primate lentivirus group. This protein is essential for viral replication in vivo and for productive infection of nonpermissive cells, such as peripheral blood mononuclear cells (PBMC). Vif counte...

journal_title：Journal of virology

authors： Ribeiro AC,Maia e Silva A,Santa-Marta M,Pombo A,Moniz-Pereira J,Goncalves J,Barahona I

更新日期：2005-01-01 00:00:00

abstract：:Hepatitis B virus particles contain three related viral envelope proteins, the small, middle, and large S (surface) proteins. All three proteins contain the small S amino acid sequence at their carboxyl terminus. It is not clear which of these S proteins functions as the viral attachment protein, binding to a target c...

journal_title：Journal of virology

authors： Pontisso P,Petit MA,Bankowski MJ,Peeples ME

更新日期：1989-05-01 00:00:00

abstract：:Serial passage at high multiplicity of pseudorabies virus generates defective interfering particles (DIPs) whose genomes consist at least in part of reiterations of segments of DNA in which sequences originating from different regions of the genome have become covalently linked (F. J. Rixon and T. Ben-Porat, Virology ...

journal_title：Journal of virology

authors： Wu CA,Harper L,Ben-Porat T

更新日期：1986-08-01 00:00:00

abstract：:Protein synthesis in adenovirus-infected cells is regulated during the late phase of infection. The rate of initiation is maintained by a small viral RNA, virus-associated (VA) RNAI, which prevents the phosphorylation of eukaryotic initiation factor eIF-2 by a double-stranded RNA-activated protein kinase, DAI. On the ...

journal_title：Journal of virology

authors： Pe'ery T,Mellits KH,Mathews MB

更新日期：1993-06-01 00:00:00

abstract：:Herpesviruses are capable of several types of infection of a host cell. To investigate the early events which ultimately determine the nature of the virus-host cell interaction, a system was established utilizing temperature-sensitive mutants of herpes simplex virus type 2. Four mutants have been isolated which fail t...

journal_title：Journal of virology

authors： Koment RW,Rapp F

更新日期：1975-04-01 00:00:00

abstract：:Measles virus (MV) infection causes an acute childhood disease, associated in certain cases with infection of the central nervous system and development of a severe neurological disease. We have generated transgenic mice ubiquitously expressing the human protein SLAM (signaling lymphocytic activation molecule), or CD1...

journal_title：Journal of virology

authors： Sellin CI,Davoust N,Guillaume V,Baas D,Belin MF,Buckland R,Wild TF,Horvat B

更新日期：2006-07-01 00:00:00

abstract：:Langat virus (LGT), the naturally attenuated member of the tick-borne encephalitis virus (TBEV) complex, was tested extensively in clinical trials as a live TBEV vaccine and was found to induce a protective, durable immune response; however, it retained a low residual neuroinvasiveness in mice and humans. In order to ...

journal_title：Journal of virology

authors： Rumyantsev AA,Murphy BR,Pletnev AG

更新日期：2006-02-01 00:00:00

abstract：:Recent environmental and metagenomic studies have considerably increased the repertoire of archaeal viruses and suggested that they play important roles in nutrient cycling in the biosphere. However, very little is known about how they regulate their life cycles and interact with their hosts. Here, we report that the ...

journal_title：Journal of virology

authors： Chen B,Chen Z,Wang Y,Gong H,Sima L,Wang J,Ouyang S,Gan W,Krupovic M,Chen X,Du S

更新日期：2020-07-30 00:00:00

abstract：:The inducible transcription factor NF-kappaB is commonly activated upon RNA virus infection and is a key player in the induction and regulation of the innate immune response. Borna disease virus (BDV) is a neurotropic negative-strand RNA virus, which replicates in the nucleus of the infected cell and causes a persiste...

journal_title：Journal of virology

authors： Bourteele S,Oesterle K,Pleschka S,Unterstab G,Ehrhardt C,Wolff T,Ludwig S,Planz O

更新日期：2005-05-01 00:00:00

abstract：:Vaccinia virus, a poxvirus, produces structurally distinct forms of virions for which the immediate events following cell entry are ill-defined. We provide evidence that intracellular mature virus (IMV) enters both permissive and nonpermissive T-cell lines and that introduction of CCR5 into nonpermissive mouse fibrobl...

journal_title：Journal of virology

authors： Rahbar R,Murooka TT,Hinek AA,Galligan CL,Sassano A,Yu C,Srivastava K,Platanias LC,Fish EN

更新日期：2006-07-01 00:00:00

abstract：UNLABELLED:The antiviral role of TRIM E3 ligases in vivo is not fully understood. To test the hypothesis that TRIM5α and TRIM22 have differential transcriptional regulation and distinct anti-HIV roles according to infection phase and compartment, we measured TRIM5α, TRIM22, and type I interferon (IFN-I)-inducible myxov...

journal_title：Journal of virology

authors： Singh R,Patel V,Mureithi MW,Naranbhai V,Ramsuran D,Tulsi S,Hiramen K,Werner L,Mlisana K,Altfeld M,Luban J,Kasprowicz V,Dheda K,Abdool Karim SS,Ndung'u T

更新日期：2014-04-01 00:00:00

abstract：:Hepatitis A virus (HAV) 3C proteinase expressed in Escherichia coli was purified to homogeneity, and its cleavage specificity towards various parts of the viral polyprotein was analyzed. Intermolecular cleavage of the P2-P3 domain of the HAV polyprotein gave rise to proteins 2A, 2B, 2C, 3ABC, and 3D, suggesting that i...

journal_title：Journal of virology

authors： Schultheiss T,Sommergruber W,Kusov Y,Gauss-Müller V

更新日期：1995-03-01 00:00:00

abstract：:CD81 has been described as a putative receptor for hepatitis C virus (HCV); however, its role in HCV cell entry has not been characterized due to the lack of an efficient cell culture system. We have examined the role of CD81 in HCV glycoprotein-dependent entry by using a recently developed retroviral pseudotyping sys...

journal_title：Journal of virology

authors： Zhang J,Randall G,Higginbottom A,Monk P,Rice CM,McKeating JA

更新日期：2004-02-01 00:00:00

abstract：:In search of an anti-transcriptase, antibody was raised in rabbits to partially purified, soluble NS protein present in cytoplasmic extracts of cells infected with the Indiana serotype of vesicular stomatitis (VSInd) virus. This antiserum gave specific reactions of identity by agar immunodiffusion with both cytoplasmi...

journal_title：Journal of virology

authors： Imblum RL,Wagner RR

更新日期：1975-06-01 00:00:00

abstract：:The distribtuion of various amino acid tRNA's in the 4S RNA components of avian myeloblastosis virus (AMV) and in 4S RNA prepared from chicken cmbryo cells, chicken myeloblasts, and chicken livers was determined. This was done by aminoacylating the 4S RNA samples with a mixture of 17 radioactive amino acids and subseq...

journal_title：Journal of virology

authors： Waters LC,Mullin BC,Bailiff EG,Popp RA

更新日期：1975-12-01 00:00:00

abstract：:The membrane-proximal region of the human immunodeficiency virus type 1 (HIV-1) transmembrane protein (TM) is critical for envelope (Env)-mediated membrane fusion and contains the target for broadly reactive neutralizing antibody 2F5. It has been proposed that 2F5 neutralization might involve interaction of its long, ...

journal_title：Journal of virology

authors： Ou W,Lu N,Yu SS,Silver J

更新日期：2006-03-01 00:00:00

abstract：:The transcription of human papillomavirus type 16 (HPV-16) is mediated by the viral enhancer. Epithelial cell-specific activation is achieved by the cooperative interaction of apparently ubiquitous transcriptional factors. One of them, nuclear factor I (NFI), binds seven sites within the HPV-16 enhancer. Point mutatio...

journal_title：Journal of virology

authors： Apt D,Chong T,Liu Y,Bernard HU

更新日期：1993-08-01 00:00:00

abstract：:In cell-free systems, 2-5A [ppp(A2'p)nA, n = 2 to greater than or equal to 4] activates a latent endoribonuclease, the 2-5A-dependent RNase, which cleaves rRNA in intact ribosomes into discrete and characteristic products (D. H. Wreschner et al., Nucleic Acids Res. 9:1571-1581, 1981). Here we present Northern blots wh...

journal_title：Journal of virology

authors： Silverman RH,Skehel JJ,James TC,Wreschner DH,Kerr IM

更新日期：1983-06-01 00:00:00