Apoptosis induced by infection of primary brain cultures with diverse human immunodeficiency virus type 1 isolates: evidence for a role of the envelope.

abstract：:Chronic hepatitis B affects over 300 million people who are at risk of developing liver cancer. The basis for the persistence of hepatitis B virus (HBV) in hepatocytes, even in the presence of available antiviral therapies, lies in the accumulation of covalently closed circular DNA (cccDNA) in nuclei of infected cells...

journal_title：Journal of virology

authors： Li M,Sohn JA,Seeger C

更新日期：2017-12-14 00:00:00

abstract：:We present an antiviral-immunomodulatory therapeutic strategy involving the chemokine receptor antagonist Met-RANTES, which yields significant survival in the setting of an otherwise fatal respiratory virus infection. In previous work, we demonstrated that infection with the natural rodent pathogen pneumonia virus of ...

journal_title：Journal of virology

authors： Bonville CA,Lau VK,DeLeon JM,Gao JL,Easton AJ,Rosenberg HF,Domachowske JB

更新日期：2004-08-01 00:00:00

abstract：:With the rationale that the neuropathological similarities between scrapie and Alzheimer's disease reflect convergent pathological mechanisms involving altered gene expression, we set out to identify molecular events involved in both processes, using scrapie as a model to study the time course of these changes. We dif...

journal_title：Journal of virology

authors： Diedrich JF,Minnigan H,Carp RI,Whitaker JN,Race R,Frey W 2nd,Haase AT

更新日期：1991-09-01 00:00:00

abstract：:Hepatitis C virus (HCV) core protein is suggested to localize to the endoplasmic reticulum (ER) through a C-terminal hydrophobic region that acts as a membrane anchor for core protein and as a signal sequence for E1 protein. The signal sequence of core protein is further processed by signal peptide peptidase (SPP). We...

journal_title：Journal of virology

authors： Okamoto K,Moriishi K,Miyamura T,Matsuura Y

更新日期：2004-06-01 00:00:00

abstract：:Transcription of the terminal protein (TP) gene of Epstein-Barr virus (EBV) in Burkitt's lymphoma cells, in EBV-negative Burkitt's lymphoma cells converted with transformation-defective (P3HR1) and transformation-competent (B95-8, AG876) EBV strains, and in EBV-immortalized cell lines was studied. A TP1 cDNA probe spa...

journal_title：Journal of virology

authors： Zimber-Strobl U,Suentzenich KO,Laux G,Eick D,Cordier M,Calender A,Billaud M,Lenoir GM,Bornkamm GW

更新日期：1991-01-01 00:00:00

abstract：:A unique feature of the large hepadnavirus envelope protein (L) is its mixed transmembrane topology, resulting from partial posttranslational translocation of the pre-S domain. Using protease protection analysis, we demonstrate for duck hepatitis B virus an essential role for the small envelope protein (S) in this pro...

journal_title：Journal of virology

authors： Grgacic EV,Kuhn C,Schaller H

更新日期：2000-03-01 00:00:00

abstract：:An in vitro system for production of hepatitis B virus (HBV) was established by infection of human hepatoma (HepG2) cells. HBV particles obtained from the serum of a chronic hepatitis B surface antigen (subtype ad) carrier were used to inoculate HepG2 cells. HBV envelope and core proteins were synthesized de novo by t...

journal_title：Journal of virology

authors： Bchini R,Capel F,Dauguet C,Dubanchet S,Petit MA

更新日期：1990-06-01 00:00:00

abstract：:The immunosuppressant drug rapamycin blocks progression of the cell cycle at G1 in mammalian cells and yeast. We recently showed that rapamycin inhibits both in vitro and in vivo cap-dependent, but not cap-independent, translation. This inhibition is causally related to reduced phosphorylation and consequent activatio...

journal_title：Journal of virology

authors： Beretta L,Svitkin YV,Sonenberg N

更新日期：1996-12-01 00:00:00

abstract：UNLABELLED:The latent HIV reservoir is a major impediment to curing HIV infection. The contribution of CD4(+) T cell activation status to the establishment and maintenance of the latent reservoir was investigated by enumerating viral DNA components in a cohort of 12 individuals commencing antiretroviral therapy (ART) c...

journal_title：Journal of virology

authors： Murray JM,Zaunders JJ,McBride KL,Xu Y,Bailey M,Suzuki K,Cooper DA,Emery S,Kelleher AD,Koelsch KK,PINT Study Team.

更新日期：2014-03-01 00:00:00

abstract：:Retroviral genomes are dimeric, comprised of two sense-strand RNAs linked at their 5' ends by noncovalent base pairing and tertiary interactions. Viral maturation involves large-scale morphological changes in viral proteins and in genomic RNA dimer structures to yield infectious virions. Structural studies have largel...

journal_title：Journal of virology

authors： Gherghe C,Leonard CW,Gorelick RJ,Weeks KM

更新日期：2010-01-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) pathogenesis is dependent on the hematogenous spread of the virus to host tissue. While data suggest that infected monocytes are required for viral dissemination from the blood to the host organs, infected endothelial cells are also thought to contribute to this key step in viral pathogene...

journal_title：Journal of virology

authors： Bentz GL,Jarquin-Pardo M,Chan G,Smith MS,Sinzger C,Yurochko AD

更新日期：2006-12-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) Vif recruits a cellular ubiquitin ligase complex to degrade antiviral APOBEC3 enzymes (APOBEC3C-H) and PP2A phosphatase regulators (PPP2R5A to PPP2R5E). While APOBEC3 antagonism is the canonical function of HIV-1 Vif, this viral accessory protein is also known to trigger G2/...

journal_title：Journal of virology

authors： Salamango DJ,McCann JL,Demir Ö,Becker JT,Wang J,Lingappa JR,Temiz NA,Brown WL,Amaro RE,Harris RS

更新日期：2020-10-14 00:00:00

abstract：:Murine gammaherpesvirus 68 (MHV68) infection of mice provides a tractable small-animal system for assessing viral requirements for establishment of and reactivation from latency. The M2 gene product has no homology to any known proteins but has been shown to play a role in both the establishment of MHV68 latency and r...

journal_title：Journal of virology

authors： DeZalia M,Speck SH

更新日期：2008-08-01 00:00:00

abstract：:Latent membrane protein 2A (LMP2A) is one of only two viral proteins expressed during latent Epstein-Barr virus (EBV) infections in human peripheral B cells. LMP2A blocks B-cell receptor (BCR) signal transduction in vitro by modulation of the Syk and Lyn protein tyrosine kinases. Five genetically unique LMP2A transgen...

journal_title：Journal of virology

authors： Caldwell RG,Brown RC,Longnecker R

更新日期：2000-02-01 00:00:00

abstract：:V3-glycan-targeting broadly neutralizing antibodies (bNAbs) are a focus of HIV-1 vaccine development. Understanding the viral dynamics that stimulate the development of these antibodies can provide insights for immunogen design. We used a deep-sequencing approach, together with neutralization phenotyping, to investiga...

journal_title：Journal of virology

authors： Anthony C,York T,Bekker V,Matten D,Selhorst P,Ferreria RC,Garrett NJ,Karim SSA,Morris L,Wood NT,Moore PL,Williamson C

更新日期：2017-08-24 00:00:00

abstract：:The internal structural proteins of retroviruses are proteolytically processed from the Gag polyprotein, which alone is able to assemble into virus-like particles when expressed in cells. All Gag proteins contain domains corresponding to the three structural proteins MA, CA, and NC. We have expressed the CA and NC dom...

journal_title：Journal of virology

authors： Campbell S,Vogt VM

更新日期：1995-10-01 00:00:00

abstract：:Subgenomic RNAs of both polarities corresponding to rice hoja blanca virus (RHBV) ambisense RNA4 were detected in RHBV-infected rice tissues. Total RNA extracted from RHBV-infected and noninfected rice tissues and RNA4 purified from RHBV ribonucleoprotein particles were used as templates for primer extension studies. ...

journal_title：Journal of virology

authors： Ramirez BC,Garcin D,Calvert LA,Kolakofsky D,Haenni AL

更新日期：1995-03-01 00:00:00

abstract：:West Nile virus has spread rapidly across the United States, and there is currently no approved human vaccine or therapy to prevent or treat disease. Passive immunization with antibodies against the envelope protein represents a promising means to provide short-term prophylaxis and treatment for West Nile virus infect...

journal_title：Journal of virology

authors： Gould LH,Sui J,Foellmer H,Oliphant T,Wang T,Ledizet M,Murakami A,Noonan K,Lambeth C,Kar K,Anderson JF,de Silva AM,Diamond MS,Koski RA,Marasco WA,Fikrig E

更新日期：2005-12-01 00:00:00

abstract：:Borna disease virus infection is diagnosed by the presence of serum antibodies reactive with the major viral proteins, p40 and p23. Although p40 and p23 are unrelated in amino acid sequence structure, cross-reactive antibodies are described. Protein fragments and synthetic peptides were analyzed to characterize the sp...

journal_title：Journal of virology

authors： Kliche S,Stitz L,Mangalam H,Shi L,Binz T,Niemann H,Briese T,Lipkin WI

更新日期：1996-11-01 00:00:00

abstract：:A limited period of chemotherapy during primary immunodeficiency virus infection might provide a long-term clinical benefit even if treatment is initiated at a time point when virus is already detectable in plasma. To evaluate this strategy, we infected rhesus macaques with the pathogenic simian/human immunodeficiency...

journal_title：Journal of virology

authors： Rosenwirth B,ten Haaft P,Bogers WM,Nieuwenhuis IG,Niphuis H,Kuhn EM,Bischofberger N,Heeney JL,Uberla K

更新日期：2000-02-01 00:00:00

abstract：:The bovine herpesvirus 1 (BHV-1) UL49 gene encodes a viral tegument protein termed VP22. UL49 homologs are conserved among alphaherpesviruses. Interestingly, the BHV-1 VP22 deletion mutant virus is asymptomatic and avirulent in infected cattle but produces only a slight reduction in titer in vitro. Attenuation of the ...

journal_title：Journal of virology

authors： Ren X,Harms JS,Splitter GA

更新日期：2001-09-01 00:00:00

abstract：:The adenovirus major late transcription unit (MLTU) encodes five families of mRNAs, L1 to L5, each distinguished by a unique poly(A) site. Use of the promoter-proximal L1 poly(A) site predominates during early infection, whereas poly(A) site choice shifts to the promoter-distal sites during late infection. A mini-MLTU...

journal_title：Journal of virology

authors： Gilmartin GM,Hung SL,DeZazzo JD,Fleming ES,Imperiale MJ

更新日期：1996-03-01 00:00:00

abstract：:Recent studies have demonstrated that influenza A virus infection activates the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway by binding of influenza NS1 protein to the p85 regulatory subunit of PI3K. Our previous study proposed that two polyproline motifs in NS1 (amino acids 164 to 167 [PXXP], SH3 bindin...

journal_title：Journal of virology

authors： Shin YK,Li Y,Liu Q,Anderson DH,Babiuk LA,Zhou Y

更新日期：2007-12-01 00:00:00

abstract：:Molluscum contagiosum virus (MCV), a member of the human poxvirus family, encodes the MC159 protein that inhibits Fas-, tumor necrosis factor (TNF)-, and TNF-related apoptosis-inducing ligant (TRAIL)-induced apoptosis. We used site-directed mutagenesis to change charged or hydrophobic amino acid residues to alanines t...

journal_title：Journal of virology

authors： Garvey TL,Bertin J,Siegel RM,Wang GH,Lenardo MJ,Cohen JI

更新日期：2002-01-01 00:00:00

abstract：:Although picornavirus RNA genomes contain a 3'-terminal poly(A) tract that is critical for their replication, the impact of encephalomyocarditis virus (EMCV) infection on the host poly(A)-binding protein (PABP) remains unknown. Here, we establish that EMCV infection stimulates site-specific PABP proteolysis, resulting...

journal_title：Journal of virology

authors： Kobayashi M,Arias C,Garabedian A,Palmenberg AC,Mohr I

更新日期：2012-10-01 00:00:00

abstract：:Mengovirus 14S subviral protein particles generated in infected L cells and in a cell-free translation system primed with mengovirus RNA were purified by sucrose gradient centrifugation and immunoaffinity chromatography. The preparations from both sources contained essentially pure proteins epsilon, alpha, and gamma, ...

journal_title：Journal of virology

authors： Boege U,Ko DS,Scraba DG

更新日期：1986-01-01 00:00:00

abstract：:Friend murine spleen focus-forming virus (SFFV) encodes a glycoprotein designated gp52, which is responsible for the leukemogenic properties of the virus. gp52 lacks a cytoplasmic domain and is defective in its transport to the cell surface. We constructed a chimeric envelope gene which codes for a molecule with an ex...

journal_title：Journal of virology

authors： Srinivas RV,Kilpatrick DR,Compans RW

更新日期：1987-12-01 00:00:00

abstract：:Epstein-Barr virus (EBV)-associated membrane antigens have been purified from the plasma membranes of the producer cell line P3HR-1 NONO. The antigens were assayed with a specific rabbit anti-ebv antiserum using an 125I-labeled staphylococcal protein A binding assay. The antigens have been shown to be present on purif...

journal_title：Journal of virology

authors： Thorley-Lawson DA,Edson CM

更新日期：1979-11-01 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) genomes are associated with the repressive heterochromatic marks H3K9me2/me3 and H3K27me3 during latency. Previous studies have demonstrated that inhibitors of H3K9me2/me3 histone demethylases reduce the ability of HSV-1 to reactivate from latency. Here we demonstrate that GSK-J4, a spec...

journal_title：Journal of virology

authors： Messer HG,Jacobs D,Dhummakupt A,Bloom DC

更新日期：2015-03-01 00:00:00

abstract：:The uncoating of adenovirus type 2 and a temperature-sensitive mutant, tsl, was studied. HEp-2 cells were infected with 32P- OR 125I-labeled purified virions for various lengths of time, and the nuclear and cytoplasmic fractions were analyzed by sucrose gradient velocity sedimentation and sodium dodecyl sulfate-polyac...

journal_title：Journal of virology

authors： Mirza MA,Weber J

更新日期：1979-05-01 00:00:00