Functional antagonism of chemokine receptor CCR1 reduces mortality in acute pneumovirus infection in vivo.

Abstract:

:We present an antiviral-immunomodulatory therapeutic strategy involving the chemokine receptor antagonist Met-RANTES, which yields significant survival in the setting of an otherwise fatal respiratory virus infection. In previous work, we demonstrated that infection with the natural rodent pathogen pneumonia virus of mice involves robust virus replication accompanied by cellular inflammation modulated by the CC chemokine macrophage inflammatory protein 1alpha (MIP-1alpha). We found that the antiviral agent ribavirin limited virus replication in vivo but had no impact on morbidity and mortality associated with this disease in the absence of immunomodulatory control. We show here that ribavirin reduces mortality, from 100% to 10 and 30%, respectively, in gene-deleted CCR1(-/-) mice and in wild-type mice treated with the small-molecule chemokine receptor antagonist, Met-RANTES. As MIP-1alpha-mediated inflammation is a common response to several distantly related respiratory virus pathogens, specific antiviral therapy in conjunction with blockade of the MIP-1alpha/CCR1 inflammatory cascade may ultimately prove to be a useful, generalized approach to severe respiratory virus infection and its pathological sequelae in human subjects.

journal_name

J Virol

journal_title

Journal of virology

authors

Bonville CA,Lau VK,DeLeon JM,Gao JL,Easton AJ,Rosenberg HF,Domachowske JB

doi

10.1128/JVI.78.15.7984-7989.2004

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

7984-9

issue

15

eissn

0022-538X

issn

1098-5514

pii

78/15/7984

journal_volume

78

pub_type

杂志文章
  • Panels of HIV-1 Subtype C Env Reference Strains for Standardized Neutralization Assessments.

    abstract::In the search for effective immunologic interventions to prevent and treat HIV-1 infection, standardized reference reagents are a cost-effective way to maintain robustness and reproducibility among immunological assays. To support planned and ongoing studies where clade C predominates, here we describe three virus pan...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00991-17

    authors: Hraber P,Rademeyer C,Williamson C,Seaman MS,Gottardo R,Tang H,Greene K,Gao H,LaBranche C,Mascola JR,Morris L,Montefiori DC,Korber B

    更新日期:2017-09-12 00:00:00

  • The Host DHX9 DExH-Box Helicase Is Recruited to Chikungunya Virus Replication Complexes for Optimal Genomic RNA Translation.

    abstract::Beyond their role in cellular RNA metabolism, DExD/H-box RNA helicases are hijacked by various RNA viruses in order to assist replication of the viral genome. Here, we identify the DExH-box RNA helicase 9 (DHX9) as a binding partner of chikungunya virus (CHIKV) nsP3 mainly interacting with the C-terminal hypervariable...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01764-18

    authors: Matkovic R,Bernard E,Fontanel S,Eldin P,Chazal N,Hassan Hersi D,Merits A,Péloponèse JM Jr,Briant L

    更新日期:2019-02-05 00:00:00

  • The human papillomavirus type 16 E6 gene alone is sufficient to induce carcinomas in transgenic animals.

    abstract::High-risk human papillomaviruses (HPVs) are the causative agents of certain human cancers. HPV type 16 (HPV16) is the papillomavirus most frequently associated with cervical cancer in women. The E6 and E7 genes of HPV are expressed in cells derived from these cancers and can transform cells in tissue culture. Animal e...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.73.7.5887-5893.1999

    authors: Song S,Pitot HC,Lambert PF

    更新日期:1999-07-01 00:00:00

  • Instability of large direct repeats in retrovirus vectors.

    abstract::Retrovirus vectors were constructed with large (0.85- to 1.3-kilobase-pair) direct repeats in their genomes. Deletions involving the direct repeats occurred at a high frequency. Deletions occurred both when the direct repeats were in tandem and when they were separated by additional sequences. These deletions occurred...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.61.3.925-927.1987

    authors: Rhode BW,Emerman M,Temin HM

    更新日期:1987-03-01 00:00:00

  • Isolation of episomal bovine papillomavirus chromatin and identification of a DNase I-hypersensitive region.

    abstract::The investigation of papillomavirus chromatin has been hampered by the unavailability of a tissue culture system for vegetative growth of these viruses. We have used, therefore, bovine papillomavirus type 1-transformed hamster embryo fibroblasts containing 200 to 250 episomal genome equivalents per cell as a source of...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.46.2.567-574.1983

    authors: Rösl F,Waldeck W,Sauer G

    更新日期:1983-05-01 00:00:00

  • Truncation of the human immunodeficiency virus type 1 transmembrane glycoprotein cytoplasmic domain blocks virus infectivity.

    abstract::Human immunodeficiency virus type 1 contains a transmembrane glycoprotein with an unusually long cytoplasmic domain. To determine the role of this domain in virus replication, a series of single nucleotide changes that result in the insertion of premature termination codons throughout the cytoplasmic domain has been c...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.66.11.6616-6625.1992

    authors: Dubay JW,Roberts SJ,Hahn BH,Hunter E

    更新日期:1992-11-01 00:00:00

  • Characterization of tissue tropism determinants of adeno-associated virus type 1.

    abstract::Muscle is an attractive target for gene delivery because of its mass and because vectors can be delivered in a noninvasive fashion. Adeno-associated virus (AAV) has been shown to be effective for muscle-targeted gene transfer. Recent progress in characterization of AAV serotype 1 (AAV1) and AAV6 demonstrated that thes...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.77.4.2768-2774.2003

    authors: Hauck B,Xiao W

    更新日期:2003-02-01 00:00:00

  • Differential induction of antiviral effects against West Nile virus in primary mouse macrophages derived from flavivirus-susceptible and congenic resistant mice by alpha/beta interferon and poly(I-C).

    abstract::A cell model of primary macrophages isolated from the peritoneal cavity of flavivirus-susceptible and congenic resistant mice has been used to study the extent and kinetics of antiviral effects against West Nile virus upon priming with alpha/beta interferon (IFN-alpha/beta) or poly(I-C) (pIC). The pattern of flaviviru...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.79.3.1753-1764.2005

    authors: Pantelic L,Sivakumaran H,Urosevic N

    更新日期:2005-02-01 00:00:00

  • Neurodegeneration induced by PVC-211 murine leukemia virus is associated with increased levels of vascular endothelial growth factor and macrophage inflammatory protein 1 alpha and is inhibited by blocking activation of microglia.

    abstract::PVC-211 murine leukemia virus (MuLV) is a neuropathogenic retrovirus that has undergone genetic changes from its nonneuropathogenic parent, Friend MuLV, that allow it to efficiently infect rat brain capillary endothelial cells (BCEC). To clarify the mechanism by which PVC-211 MuLV expression in BCEC induces neurologic...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.02343-08

    authors: Li X,Hanson C,Cmarik JL,Ruscetti S

    更新日期:2009-05-01 00:00:00

  • Variation in antagonism of the interferon response to rotavirus NSP1 results in differential infectivity in mouse embryonic fibroblasts.

    abstract::Rotavirus NSP1 has been shown to function as an E3 ubiquitin ligase that mediates proteasome-dependent degradation of interferon (IFN) regulatory factors (IRF), including IRF3, -5, and -7, and suppresses the cellular type I IFN response. However, the effect of rotavirus NSP1 on viral replication is not well defined. P...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00585-09

    authors: Feng N,Sen A,Nguyen H,Vo P,Hoshino Y,Deal EM,Greenberg HB

    更新日期:2009-07-01 00:00:00

  • Antigenic structure of envelope glycoprotein E1 of hog cholera virus.

    abstract::Envelope glycoprotein E1 (gp51 to gp54) is the most antigenic protein of hog cholera virus or classical swine fever virus (CSFV). Four antigenic domains, A to D, have been mapped on E1 with a panel of monoclonal antibodies (MAbs) raised against CSFV strain Brescia. The boundaries of these domains have been established...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.68.6.3934-3942.1994

    authors: van Rijn PA,Miedema GK,Wensvoort G,van Gennip HG,Moormann RJ

    更新日期:1994-06-01 00:00:00

  • Conditional repression of the E2 transcription unit in E1-E3-deleted adenovirus vectors is correlated with a strong reduction in viral DNA replication and late gene expression in vitro.

    abstract::An E1-E3-deleted recombinant adenovirus vector expressing the hybrid protein TetR-KRAB has been produced. In this virus, AdTG9562, the E2 transcription is regulated by TetR-KRAB and tetO sequences inserted in cis. In the absence of tetracycline, a strong reduction in E2A gene expression, viral DNA replication, and lat...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.71.4.3307-3311.1997

    authors: Rittner K,Schultz H,Pavirani A,Mehtali M

    更新日期:1997-04-01 00:00:00

  • 1-beta-D-arabinofuranosylcytosine inhibits borna disease virus replication and spread.

    abstract::Borna disease virus (BDV) is a nonsegmented, negative-strand RNA virus that causes neurological diseases in a variety of warm-blooded animal species. There is general consensus that BDV can also infect humans, being a possible zoonosis. Although the clinical consequences of human BDV infection are still controversial,...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.76.12.6268-6286.2002

    authors: Bajramovic JJ,Syan S,Brahic M,de la Torre JC,Gonzalez-Dunia D

    更新日期:2002-06-01 00:00:00

  • Identification of closely spaced but distinct transcription initiation sites for the murine gammaherpesvirus 68 latency-associated M2 gene.

    abstract::Murine gammaherpesvirus 68 (MHV68) infection of mice provides a tractable small-animal system for assessing viral requirements for establishment of and reactivation from latency. The M2 gene product has no homology to any known proteins but has been shown to play a role in both the establishment of MHV68 latency and r...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00651-08

    authors: DeZalia M,Speck SH

    更新日期:2008-08-01 00:00:00

  • The Src family kinase c-Yes is required for maturation of West Nile virus particles.

    abstract::The role of cellular genes in West Nile virus (WNV) replication is not well understood. Examination of cellular transcripts upregulated during WNV infection revealed an increase in the expression of the src family kinase (SFK) c-Yes. WNV-infected cell lines treated with the SFK inhibitor PP2 demonstrated a 2- to 4-log...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.79.18.11943-11951.2005

    authors: Hirsch AJ,Medigeshi GR,Meyers HL,DeFilippis V,Früh K,Briese T,Lipkin WI,Nelson JA

    更新日期:2005-09-01 00:00:00

  • Unique peptide maps of the three largest proteins specified by the flavivirus Kunjin.

    abstract::Tryptic digests of four polypeptides found in Kunjin virus-infected Vero cells, NV5, NV4, V3, and NV3, were compared by peptide mapping. The polypeptides to be analyzed were labeled with radioactive methionine and separated by electrophoresis through polyacrylamide gels containing sodium dodecyl sulfate. Because infec...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.24.2.651-661.1977

    authors: Wright PJ,Bowden DS,Westaway EG

    更新日期:1977-11-01 00:00:00

  • Vertical transmission of bovine spongiform encephalopathy prions evaluated in a transgenic mouse model.

    abstract::In this work we show evidence of mother-to-offspring transmission in a transgenic mouse line expressing bovine PrP (boTg) experimentally infected by intracerebral administration of bovine spongiform encephalopathy (BSE) prions. PrP(res) was detected in brains of newborns from infected mothers only when mating was allo...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.79.13.8665-8668.2005

    authors: Castilla J,Brun A,Díaz-San Segundo F,Salguero FJ,Gutiérrez-Adán A,Pintado B,Ramírez MA,del Riego L,Torres JM

    更新日期:2005-07-01 00:00:00

  • Cell killing by simian virus 40: variation in the pattern of lysosomal enzyme release, cellular enzyme release, and cell death during productive infection of normal and simian virus 40-transformed simian cell lines.

    abstract::Simian virus 40 (SV40) growth on rhesus kidney cells and on the T-22 line of SV40-transformed green monkey kidney (GMK) cells is largely limited by the low plating efficiency of SV40 on these cells. In addition, a fraction of the rhesus kidney and T-22 cells are resistant to infection by SV40. Nevertheless, 72-h viral...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.18.1.48-57.1976

    authors: Norkin LC,Ouellette J

    更新日期:1976-04-01 00:00:00

  • VPg gene amplification correlates with infective particle formation in foot-and-mouth disease virus.

    abstract::In order to analyze the function of VPg amplification in aphthoviruses, we have undertaken the first mutational analysis of the repetitive VPg-coding region using an improved foot-and-mouth disease virus (FMDV) cDNA clone from which infective viral RNA was synthesized. A set of VPg mutants was constructed by site-dire...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.66.4.2251-2260.1992

    authors: Falk MM,Sobrino F,Beck E

    更新日期:1992-04-01 00:00:00

  • Long-term latent murine Gammaherpesvirus 68 infection is preferentially found within the surface immunoglobulin D-negative subset of splenic B cells in vivo.

    abstract::Murine gammaherpesvirus 68 (gammaHV68; also known as MHV-68) can establish a latent infection in both inbred and outbred strains of mice and, as such, provides a tractable small-animal model to address mechanisms and cell types involved in the establishment and maintenance of chronic gammaherpesvirus infection. Latenc...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.77.15.8310-8321.2003

    authors: Willer DO,Speck SH

    更新日期:2003-08-01 00:00:00

  • Viral ribonuclei acid synthesis by Newcastle disease virus mutants isolated from persistently infected L cells: effect of interferon.

    abstract::The synthesis of different viral ribonucleic acid (RNA) species was studied in chick embryo (CE) and mouse L-cell cultures infected with the Herts strain of Newcastle disease virus (NDV(o)) and a mutant isolated from persistently infected L cells (NDV(pi)). In CE cell cultures, both viruses synthesized significant amo...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.9.3.503-509.1972

    authors: Thacore HR,Youngner JS

    更新日期:1972-03-01 00:00:00

  • Characterization of a human immunodeficiency virus type 1 V3 deletion mutation that confers resistance to CCR5 inhibitors and the ability to use aplaviroc-bound receptor.

    abstract::The human immunodeficiency virus type 1 (HIV-1) V3 loop is essential for coreceptor binding and principally determines tropism for the CCR5 and CXCR4 coreceptors. Using the dual-tropic virus HIV-1(R3A), we previously made an extensive panel of V3 deletions and identified subdomains within V3 that could differentially ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01751-08

    authors: Nolan KM,Del Prete GQ,Jordan AP,Haggarty B,Romano J,Leslie GJ,Hoxie JA

    更新日期:2009-04-01 00:00:00

  • Chromosomal localization of the Moloney sarcoma virus mouse cellular (c-mos) sequence.

    abstract::The Moloney sarcoma virus-specific onc gene, referred to as v-mos, was used as probe to hybridize to restricted DNAs from various mouse-Chinese hamster hybrid cell lines. These hybrid cells contain, in addition to all of the Chinese hamster chromosomes, various numbers (less than a full complement) of mouse chromosome...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.44.2.752-754.1982

    authors: Swan D,Oskarsson M,Keithley D,Ruddle FH,D'Eustachio P,Vande Woude GF

    更新日期:1982-11-01 00:00:00

  • Cellular chaperonin CCTγ contributes to rabies virus replication during infection.

    abstract::Rabies, as the oldest known infectious disease, remains a serious threat to public health worldwide. The eukaryotic cytosolic chaperonin TRiC/CCT complex facilitates the folding of proteins through ATP hydrolysis. Here, we investigated the expression, cellular localization, and function of neuronal CCTγ during neurotr...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.03186-12

    authors: Zhang J,Wu X,Zan J,Wu Y,Ye C,Ruan X,Zhou J

    更新日期:2013-07-01 00:00:00

  • LANA and hnRNP A1 Regulate the Translation of LANA mRNA through G-Quadruplexes.

    abstract::During the latent phase, Kaposi's sarcoma-associated herpes virus (KSHV) maintains itself inside the host by escaping the host immune surveillance mechanism through restricted protein expression. Latency-associated nuclear antigen (LANA), the most abundantly expressed protein, is essential for viral persistence, as it...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01508-19

    authors: Dabral P,Babu J,Zareie A,Verma SC

    更新日期:2020-01-17 00:00:00

  • A strong negative transcriptional regulatory region between the human cytomegalovirus UL127 gene and the major immediate-early enhancer.

    abstract::The region of the human cytomegalovirus (CMV) genome between the UL127 open reading frame and the major immediate-early (MIE) enhancer is referred to as the unique region. DNase I protection analysis with human cell nuclear extracts demonstrated multiple protein binding sites in this region of the viral genome (P. Gha...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.73.11.9039-9052.1999

    authors: Lundquist CA,Meier JL,Stinski MF

    更新日期:1999-11-01 00:00:00

  • Dynamics of persistent TT virus infection, as determined in patients treated with alpha interferon for concomitant hepatitis C virus infection.

    abstract::TT virus (TTV) is a recently identified widespread DNA virus of humans that produces persistent viremia in the absence of overt clinical manifestations. In an attempt to shed light on the dynamics of chronic infection, we measured the levels of TTV in the plasma of 25 persistently infected patients during the first 3 ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.75.24.11999-12004.2001

    authors: Maggi F,Pistello M,Vatteroni M,Presciuttini S,Marchi S,Isola P,Fornai C,Fagnani S,Andreoli E,Antonelli G,Bendinelli M

    更新日期:2001-12-01 00:00:00

  • In vivo and in vitro synthesis of human rhinovirus type 2 ribonucleic acid.

    abstract::HeLa cells infected with human rhinovirus type 2 synthesize a mixture of single-and double-stranded ribonucleic acid (RNA). The RNA synthesized by the membrane-bound RNA polymerase complex in vitro is also a mixture of single- and double-stranded RNA, whereas the deoxycholate-treated RNA polymerase complex synthesized...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.10.1.93-98.1972

    authors: Yin FH,Knight E Jr

    更新日期:1972-07-01 00:00:00

  • Hierarchy of polyadenylation site usage by bovine papillomavirus in transformed mouse cells.

    abstract::The great majority of viral mRNAs in mouse C127 cells transformed by bovine papillomavirus type 1 (BPV) have a common 3' end at the early polyadenylation site which is 23 nucleotides (nt) downstream of a canonical poly(A) consensus signal. Twenty percent of BPV mRNA from productively infected cells bypasses the early ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.67.12.7705-7710.1993

    authors: Andrews EM,DiMaio D

    更新日期:1993-12-01 00:00:00

  • cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus Infection.

    abstract:UNLABELLED:Several innate sensing pathways contribute to the control of early cytomegalovirus (CMV) infection, leading to a multiphasic type I interferon (IFN-I) response that limits viral replication and promotes host defenses. Toll-like receptor (TLR)-dependent pathways induce IFN-I production in CMV-infected plasmac...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01040-16

    authors: Lio CW,McDonald B,Takahashi M,Dhanwani R,Sharma N,Huang J,Pham E,Benedict CA,Sharma S

    更新日期:2016-08-12 00:00:00