Human cytomegalovirus (HCMV) infection of endothelial cells promotes naive monocyte extravasation and transfer of productive virus to enhance hematogenous dissemination of HCMV.

abstract：:Polyomavirus small t antigen was purified from genetically engineered Escherichia coli and used as the immunogen for the production of polyclonal and monoclonal antibodies. A new series of plasmids for increased expression of polyomavirus T antigens or a T antigen-beta-galactosidase fusion protein was constructed by r...

journal_title：Journal of virology

authors： Pallas DC,Schley C,Mahoney M,Harlow E,Schaffhausen BS,Roberts TM

更新日期：1986-12-01 00:00:00

abstract：:The products of the A33R and A36R genes of vaccinia virus are incorporated into the membranes of intracellular enveloped virions (IEV). When extracts of cells that had been infected with vaccinia virus and labeled with H(3)(32)PO(4) were immunoprecipitated with antibodies against the A33R protein, two prominent bands ...

journal_title：Journal of virology

authors： Wolffe EJ,Weisberg AS,Moss B

更新日期：2001-01-01 00:00:00

abstract：:Evidence is presented that the herpes simplex virus type 2 glycoprotein previously designated gF is antigenically related to herpes simplex virus type 1 gC (gC-1). An antiserum prepared against type 1 virion envelope proteins immunoprecipitated gF of type 2 (gF-2), and competition experiments revealed that the anti-gC...

journal_title：Journal of virology

authors： Zezulak KM,Spear PG

更新日期：1983-09-01 00:00:00

abstract：:This study describes a method for increasing the immunogenicity of influenza virus vaccines by exploiting the natural anti-Gal antibody to effectively target vaccines to antigen-presenting cells (APC). This method is based on enzymatic engineering of carbohydrate chains on virus envelope hemagglutinin to carry the alp...

journal_title：Journal of virology

authors： Abdel-Motal UM,Guay HM,Wigglesworth K,Welsh RM,Galili U

更新日期：2007-09-01 00:00:00

abstract：:Approximately 10% of gastric carcinomas (GC) are comprised of cells latently infected with Epstein-Barr virus (EBV); however, the mechanism by which EBV contributes to the development of this malignancy is unclear. We have investigated the cellular effects of the only EBV nuclear protein expressed in GC, EBNA1, focusi...

journal_title：Journal of virology

authors： Sivachandran N,Dawson CW,Young LS,Liu FF,Middeldorp J,Frappier L

更新日期：2012-01-01 00:00:00

abstract：:Reverse transcription in hepatitis B viruses is initiated through a unique protein priming mechanism whereby the viral reverse transcriptase (RT) first assembles into a ribonucleoprotein (RNP) complex with its RNA template and then initiates DNA synthesis de novo using the RT itself as a protein primer. RNP formation ...

journal_title：Journal of virology

authors： Hu J,Anselmo D

更新日期：2000-12-01 00:00:00

abstract：:The hepatitis B virus (HBV) capsid or core protein (Cp) can self-assemble to form an icosahedral capsid. It is now being pursued as a target for small-molecule antivirals that enhance the rate and extent of its assembly to yield empty and/or aberrant capsids. These small molecules are thus called core protein alloster...

journal_title：Journal of virology

authors： Ruan L,Hadden JA,Zlotnick A

更新日期：2018-09-26 00:00:00

abstract：:The pneumopathogenicity of a trypsin-sensitive revertant of Sendai virus, TSrev-58, which was derived from a trypsin-resistant mutant, TR-5, was examined in mice. In comparison with TR-5, the revertant had a single amino acid substitution at residue 116 (Ile----Arg) on F protein, which was the cleavage site, and had t...

journal_title：Journal of virology

authors： Mochizuki Y,Tashiro M,Homma M

更新日期：1988-08-01 00:00:00

abstract：:We have purified the seven virus-specific RNAs which were previously shown to be induced in Sac(-) cells upon infection with mouse hepatitis virus strain A59 (W. J. M. Spaan, P. J. M. Rottier, M. C. Horzinek, and B. A. M. van der Zeijst, Virology 108:424-434, 1981). The individual RNAs, prepared by agarose gel electro...

journal_title：Journal of virology

authors： Rottier PJ,Spaan WJ,Horzinek MC,van der Zeijst BA

更新日期：1981-04-01 00:00:00

abstract：:Persistent infection with oncogenic human papillomaviruses (HPVs) causes cervical cancer, accompanied by the accumulation of somatic mutations into the host genome. There are concomitant genetic changes in the HPV genome during viral infection; however, their relevance to cervical carcinogenesis is poorly understood. ...

journal_title：Journal of virology

authors： Hirose Y,Onuki M,Tenjimbayashi Y,Mori S,Ishii Y,Takeuchi T,Tasaka N,Satoh T,Morisada T,Iwata T,Miyamoto S,Matsumoto K,Sekizawa A,Kukimoto I

更新日期：2018-05-29 00:00:00

abstract：:The first step in the replication of the plus-stranded poliovirus RNA is the synthesis of a complementary minus strand. This process is initiated by the covalent attachment of UMP to the terminal protein VPg, yielding VPgpU and VPgpUpU. We have previously shown that these products can be made in vitro in a reaction th...

journal_title：Journal of virology

authors： Paul AV,Rieder E,Kim DW,van Boom JH,Wimmer E

更新日期：2000-11-01 00:00:00

abstract：:Effective, vaccine-induced CD8+ T-cell responses should recognize infected cells early enough to prevent production of progeny virions. We have recently shown that Gag-specific CD8+ T cells recognize simian immunodeficiency virus-infected cells at 2 h postinfection, whereas Env-specific CD8+ T cells do not recognize i...

journal_title：Journal of virology

authors： Sacha JB,Chung C,Reed J,Jonas AK,Bean AT,Spencer SP,Lee W,Vojnov L,Rudersdorf R,Friedrich TC,Wilson NA,Lifson JD,Watkins DI

更新日期：2007-11-01 00:00:00

abstract：:The Us11 protein of herpes simplex virus 1 (HSV-1) is an accessory factor with multiple functions. In virus-infected cells, it inhibits double-stranded RNA-dependent protein kinase (PKR), 2',5'-oligoadenylate synthetase, RIG-I, and MDA-5. However, its precise role is incompletely defined. By screening a human cDNA lib...

journal_title：Journal of virology

authors： Liu X,Main D,Ma Y,He B

更新日期：2018-06-29 00:00:00

abstract：:BALB/c mice treated with pristane and Abelson virus have been used as an animal model system for the rapid induction of plasmacytomas. Myelomonocytic tumors with helper Moloney murine leukemia virus clonally inserted into the c-myb locus were observed in about 10% of pristane-primed BALB/c mice infected with Abelson v...

journal_title：Journal of virology

authors： Shen-Ong GL,Wolff L

更新日期：1987-12-01 00:00:00

abstract：:Longitudinal studies of T cell immune responses during viral infections in humans are essential for our understanding of how effector T cell responses develop, clear infection, and provide long-lasting immunity. Here, following an outbreak of a Puumala hantavirus infection in the human population, we longitudinally an...

journal_title：Journal of virology

authors： Lindgren T,Ahlm C,Mohamed N,Evander M,Ljunggren HG,Björkström NK

更新日期：2011-10-01 00:00:00

abstract：:We analyzed control sequences of the human papovavirus JC virus (JCV) to define the cis-acting elements that regulate specific expression of the viral early region genes in glial cells. Nuclear run-on transcription, S1 analysis, and chloramphenicol acetyltransferase enzyme activity in a transient transfection assay es...

journal_title：Journal of virology

authors： Tada H,Lashgari M,Rappaport J,Khalili K

更新日期：1989-01-01 00:00:00

abstract：:Seasonal influenza viruses are a major cause of human disease worldwide. Most neutralizing antibodies (Abs) elicited by influenza viruses target the head domain of the hemagglutinin (HA) protein. Anti-HA head Abs can be highly potent, but they have limited breadth since the HA head is variable. There is great interest...

journal_title：Journal of virology

authors： Christensen SR,Toulmin SA,Griesman T,Lamerato LE,Petrie JG,Martin ET,Monto AS,Hensley SE

更新日期：2019-04-03 00:00:00

abstract：:Both CD4(+) and CD8(+) T cells are required for clearance of the murine coronavirus mouse hepatitis virus (MHV) during acute infection. We investigated the effects of an epitope-specific CD8(+) T-cell response on acute infection of MHV, strain A59, in the murine CNS. Mice with CD8(+) T cells specific for gp33-41 (an H...

journal_title：Journal of virology

authors： Chua MM,MacNamara KC,San Mateo L,Shen H,Weiss SR

更新日期：2004-02-01 00:00:00

abstract：:The recent yellow fever virus (YFV) epidemic in Brazil in 2017 and Zika virus (ZIKV) epidemic in 2015 serve to remind us of the importance of flaviviruses as emerging human pathogens. With the current global flavivirus threat, there is an urgent need for antivirals and vaccines to curb the spread of these viruses. How...

journal_title：Journal of virology

authors： Miorin L,Laurent-Rolle M,Pisanelli G,Co PH,Albrecht RA,García-Sastre A,Morrison J

更新日期：2019-06-28 00:00:00

abstract：:In less than 3 months after the first cases of swine origin 2009 influenza A (H1N1) virus infections were reported from Mexico, WHO declared a pandemic. The pandemic virus is antigenically distinct from seasonal influenza viruses, and the majority of human population lacks immunity against this virus. We have studied ...

journal_title：Journal of virology

authors： Osterlund P,Pirhonen J,Ikonen N,Rönkkö E,Strengell M,Mäkelä SM,Broman M,Hamming OJ,Hartmann R,Ziegler T,Julkunen I

更新日期：2010-02-01 00:00:00

abstract：:The E3 complex transcription unit of adenovirus encodes four major mRNAs (a, c, f, and h) and two minor (d and e) mRNAs with overlapping exons, alternative splice sites, and two polyadenylation sites, termed E3A (upstream) and E3B (downstream). mRNAs a and d use the E3A polyadenylation site, and mRNAs c, e, f, and h u...

journal_title：Journal of virology

authors： Brady HA,Scaria A,Wold WS

更新日期：1992-10-01 00:00:00

abstract：:Circoviruses are small, nonenveloped icosahedral animal viruses characterized by circular single-stranded DNA genomes. Their genomes are the smallest possessed by animal viruses. Infections with circoviruses, which can lead to economically important diseases, frequently result in virus-induced damage to lymphoid tissu...

journal_title：Journal of virology

authors： Crowther RA,Berriman JA,Curran WL,Allan GM,Todd D

更新日期：2003-12-01 00:00:00

abstract：:The sheep genome harbors approximately 20 endogenous retroviruses (enJSRVs) highly related to the exogenous Jaagsiekte sheep retrovirus (JSRV). One of the enJSRV loci, enJS56A1, acts as a unique restriction factor by blocking JSRV in a transdominant fashion at a late stage of the retroviral cycle. To better understand...

journal_title：Journal of virology

authors： Murcia PR,Arnaud F,Palmarini M

更新日期：2007-02-01 00:00:00

abstract：:To further define the transcriptional regulation of the P38 promoter in the minute virus of mice (MVM) genome, we constructed a series of internal deletion and linker scanning mutations. The mutant P38 constructs were assayed for transcriptional activity in vitro by primer extension analysis with nuclear extracts from...

journal_title：Journal of virology

authors： Ahn JK,Pitluk ZW,Ward DC

更新日期：1992-06-01 00:00:00

abstract：:Parapoxviruses can be morphologically distinguished from other poxviruses in conventional negative staining electron microscopy (EM) by their ovoid appearance and the spiral tubule surrounding the virion's surface. However, this technique may introduce artifacts. We have examined Orf virus (ORFV; the prototype species...

journal_title：Journal of virology

authors： Spehner D,De Carlo S,Drillien R,Weiland F,Mildner K,Hanau D,Rziha HJ

更新日期：2004-08-01 00:00:00

abstract：:Borna disease virus (BDV) is a nonsegmented, negative-strand RNA virus that causes neurological diseases in a variety of warm-blooded animal species. There is general consensus that BDV can also infect humans, being a possible zoonosis. Although the clinical consequences of human BDV infection are still controversial,...

journal_title：Journal of virology

authors： Bajramovic JJ,Syan S,Brahic M,de la Torre JC,Gonzalez-Dunia D

更新日期：2002-06-01 00:00:00

abstract：:Noroviruses account for 96% of viral gastroenteritis cases worldwide, with GII.4 strains responsible >80% of norovirus outbreaks. Histo-blood group antigens (HBGAs) are norovirus binding ligands, and antigenic and preferential HBGA binding profiles vary over time as new GII.4 strains emerge. The capsid P2 subdomain fa...

journal_title：Journal of virology

authors： Debbink K,Donaldson EF,Lindesmith LC,Baric RS

更新日期：2012-01-01 00:00:00

abstract：:The recent identification of coreceptors that mediate efficient entry of human immunodeficiency virus type 1 (HIV-1) suggests new therapeutic and preventive strategies. We analyzed simian immunodeficiency virus (SIV) entry cofactors to investigate whether the macaque SIV model can be used as an experimental model to e...

journal_title：Journal of virology

authors： Kirchhoff F,Pöhlmann S,Hamacher M,Means RE,Kraus T,Uberla K,Di Marzio P

更新日期：1997-09-01 00:00:00

abstract：:Human herpesvirus 8 (HHV-8) (also known as Kaposi's sarcoma-associated herpesvirus) encodes a novel noncoding polyadenylated nuclear (PAN) RNA (also known as T1.1 or nut-1) during the early phase of lytic replication. PAN RNA is the most abundant transcript of HHV-8, comprising 80% of total poly(A)-selected transcript...

journal_title：Journal of virology

authors： Song MJ,Brown HJ,Wu TT,Sun R

更新日期：2001-04-01 00:00:00

abstract：:The Moloney sarcoma virus-specific onc gene, referred to as v-mos, was used as probe to hybridize to restricted DNAs from various mouse-Chinese hamster hybrid cell lines. These hybrid cells contain, in addition to all of the Chinese hamster chromosomes, various numbers (less than a full complement) of mouse chromosome...

journal_title：Journal of virology

authors： Swan D,Oskarsson M,Keithley D,Ruddle FH,D'Eustachio P,Vande Woude GF

更新日期：1982-11-01 00:00:00