Pol-specific CD8+ T cells recognize simian immunodeficiency virus-infected cells prior to Nef-mediated major histocompatibility complex class I downregulation.

abstract：:Lassa fever (LF) is a potentially lethal human disease that is caused by the arenavirus Lassa virus (LASV). Annually, around 300,000 infections with up to 10,000 deaths occur in regions of Lassa fever endemicity in West Africa. Here we demonstrate that mice lacking a functional STAT1 pathway are highly susceptible to ...

journal_title：Journal of virology

authors： Yun NE,Seregin AV,Walker DH,Popov VL,Walker AG,Smith JN,Miller M,de la Torre JC,Smith JK,Borisevich V,Fair JN,Wauquier N,Grant DS,Bockarie B,Bente D,Paessler S

更新日期：2013-10-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) plays a significant role in the development of Kaposi's sarcoma, primary effusion lymphoma, and some forms of multicentric Castleman's disease. The KSHV open reading frame K9 encodes the viral interferon (IFN) factor 1 (vIRF1), which downregulates IFN- and IRF-mediated tr...

journal_title：Journal of virology

authors： Seo T,Lee D,Shim YS,Angell JE,Chidambaram NV,Kalvakolanu DV,Choe J

更新日期：2002-09-01 00:00:00

abstract：:RNA packaging signals (psi) from the 5' ends of murine and avian retroviral genomes have previously been shown to direct encapsidation of heterologous mRNA into the retroviral virion. The avian 5' packaging region has now been further characterized, and we have defined a 270-nucleotide sequence, A psi, which is suffic...

journal_title：Journal of virology

authors： Aronoff R,Hajjar AM,Linial ML

更新日期：1993-01-01 00:00:00

abstract：:The positive-strand RNA bromoviruses encode two nonstructural proteins, 1a and 2a, involved in RNA-dependent RNA replication. These proteins have extensive sequence similarities with methyltransferase, helicase, and polymerase proteins of other plant and animal viruses. 1a and 2a can also form a complex in vitro. To e...

journal_title：Journal of virology

authors： Dinant S,Janda M,Kroner PA,Ahlquist P

更新日期：1993-12-01 00:00:00

abstract：:A covalently closed circular form of unintegrated viral DNA obtained from NIH 3T3 cells freshly infected with Moloney murine leukemia virus (M-MLV) and a port of the endogenous M-MLV from the BALB/Mo mouse strain have been cloned in bacteriophage lambda. The unintegrated viral DNA was cleaved with restriction endonucl...

journal_title：Journal of virology

authors： Berns AJ,Lai MH,Bosselman RA,McKennett MA,Bacheler LT,Fan H,Maandag EC,van der Putten HV,Verma IM

更新日期：1980-10-01 00:00:00

abstract：UNLABELLED:Hepatitis B virus (HBV)-specific cytotoxic T lymphocytes (CTLs) are critical in eliminating infection. We developed an animal model in which HBV-infected human hepatocytes are targeted by HBV-specific CTLs. After HBV inoculation in human hepatocyte-transplanted herpes simplex virus type-1 thymidine kinase-NO...

journal_title：Journal of virology

authors： Uchida T,Hiraga N,Imamura M,Tsuge M,Abe H,Hayes CN,Aikata H,Ishida Y,Tateno C,Yoshizato K,Ohdan H,Murakami K,Chayama K

更新日期：2015-10-01 00:00:00

abstract：:Three fish retroviruses infecting walleyes constitute the recently recognized genus called epsilonretrovirus. The founding member of this group, walleye dermal sarcoma virus (WDSV), induces benign skin tumors in the infected fish and replicates near 4 degrees C. While the viral genomic sequence is known, biochemical c...

journal_title：Journal of virology

authors： Fodor SK,Vogt VM

更新日期：2002-05-01 00:00:00

abstract：:Equine herpesvirus 1 (EHV1) replicates in the respiratory epithelium and disseminates through the body via a cell-associated viremia in leukocytes, despite the presence of neutralizing antibodies. "Hijacked" leukocytes, previously identified as monocytic cells and T lymphocytes, transmit EHV1 to endothelial cells of t...

journal_title：Journal of virology

authors： Poelaert KCK,Van Cleemput J,Laval K,Favoreel HW,Couck L,Van den Broeck W,Azab W,Nauwynck HJ

更新日期：2019-03-21 00:00:00

abstract：:Higher-order RNA structures in the 3' untranslated region (3'UTR) of enteroviruses are thought to play a pivotal role in viral negative-strand RNA synthesis. The structure of the 3'UTR was predicted by thermodynamic calculations using the STAR (structural analysis of RNA) computer program and experimentally verified u...

journal_title：Journal of virology

authors： Melchers WJ,Hoenderop JG,Bruins Slot HJ,Pleij CW,Pilipenko EV,Agol VI,Galama JM

更新日期：1997-01-01 00:00:00

abstract：:Two hundred seventeen field isolates of cucumber mosaic cucumovirus (CMV), sampled from 11 natural populations, were typed by RNase protection assay (RPA) using probes from the genomic RNAs of strains in subgroup I and in subgroup II of CMV strains. Most (85%) of the analyzed isolates belonged to subgroup I. For these...

journal_title：Journal of virology

authors： Fraile A,Alonso-Prados JL,Aranda MA,Bernal JJ,Malpica JM,García-Arenal F

更新日期：1997-02-01 00:00:00

abstract：:Three mRNAs from the murine polyomavirus early region encode the three well-characterized tumor antigens. We report the existence of a fourth alternatively spliced mRNA which encodes a fourth tumor antigen, tiny T antigen, which comprises the amino-terminal domain common to all of the T antigens but is extended by six...

journal_title：Journal of virology

authors： Riley MI,Yoo W,Mda NY,Folk WR

更新日期：1997-08-01 00:00:00

abstract：:The infected cell polypeptide 4 (ICP4) of herpes simplex virus 1 (HSV-1) is a regulator of viral transcription that is required for productive infection. Since viral genes are transcribed by cellular RNA polymerase II (RNA pol II), ICP4 must interact with components of the pol II machinery to regulate viral gene expre...

journal_title：Journal of virology

authors： Lester JT,DeLuca NA

更新日期：2011-06-01 00:00:00

abstract：:The Kaposi's sarcoma-associated herpesvirus nuclear egress complex is composed of two proteins, ORF67 and ORF69. In this study, we have recapitulated the KSHV complex by coexpression of these two proteins in insect cells using expression from recombinant baculoviruses. The proteins form a complex at the nuclear membra...

journal_title：Journal of virology

authors： Desai PJ,Pryce EN,Henson BW,Luitweiler EM,Cothran J

更新日期：2012-01-01 00:00:00

abstract：:Functions of viral proteins can be regulated through phosphorylation by serine/threonine kinases in plants, but little is known about the involvement of tyrosine kinases in plant virus infection. In this study, TGBp3, one of the three movement proteins encoded by a triple gene block (TGB) of Potato mop-top virus (PMTV...

journal_title：Journal of virology

authors： Samuilova O,Santala J,Valkonen JP

更新日期：2013-04-01 00:00:00

abstract：:RNA-dependent RNA polymerase activity was found in mouse hepatitis virus strain A59 (MHV-A59)-infected cells. The enzyme was induced in the infected cells and could not be detected in the MHV-A59 virion. Two peaks of RNA polymerase activity, one early and the other late in infection, were detected. These polymerase ac...

journal_title：Journal of virology

authors： Brayton PR,Lai MM,Patton CD,Stohlman SA

更新日期：1982-06-01 00:00:00

abstract：:The herpes simplex virus type 1 gamma(1)34.5 gene product precludes the host-mediated protein shutoff response induced by activated protein kinase R (PKR). Earlier studies demonstrated that recombinant viruses lacking the gamma(1)34.5 gene (Deltagamma(1)34.5) developed secondary mutations that allowed earlier U(S)11 e...

journal_title：Journal of virology

authors： Cassady KA,Gross M

更新日期：2002-03-01 00:00:00

abstract：:Nevirapine forms the mainstay of our efforts to curtail the pediatric AIDS epidemic through prevention of mother-to-child transmission of HIV-1. A key limitation, however, is the rapid selection of HIV-1 strains resistant to nevirapine following the administration of a single dose. This rapid selection of resistance s...

journal_title：Journal of virology

authors： Gadhamsetty S,Dixit NM

更新日期：2010-10-01 00:00:00

abstract：:Human papillomavirus type 1 (HPV1) E4 protein is associated with cytoplasmic and nuclear inclusions in productively infected keratinocytes. Here we have used transient expression of HPV1 E4 (also known as E1E4) protein in keratinocytes to reproduce formation of E4 inclusions. Immunofluorescence analysis showed that pr...

journal_title：Journal of virology

authors： Roberts S,Hillman ML,Knight GL,Gallimore PH

更新日期：2003-01-01 00:00:00

abstract：:Recombinant poxvirus vectors are undergoing intensive evaluation as vaccine candidates for a variety of infectious pathogens. Avipoxviruses, such as canarypox virus, are replication deficient in mammalian cells by virtue of a poorly understood species-specific restriction. Highly attenuated vaccinia virus strains such...

journal_title：Journal of virology

authors： Zhang X,Cassis-Ghavami F,Eller M,Currier J,Slike BM,Chen X,Tartaglia J,Marovich M,Spearman P

更新日期：2007-07-01 00:00:00

abstract：:Caprine arthritis encephalitis virus (CAEV) is a lentivirus closely related to visna virus and more distantly to other lentiviruses, such as human immunodeficiency virus. The genomes of visna virus and CAEV contain a tat gene encoding a protein able to weakly transactivate its own long terminal repeat, suggesting that...

journal_title：Journal of virology

authors： Harmache A,Vitu C,Russo P,Bouyac M,Hieblot C,Peveri P,Vigne R,Suzan M

更新日期：1995-09-01 00:00:00

abstract：:The v-rel oncogene encoded by reticuloendotheliosis virus strain T is the acutely transforming member of the Rel/NF-kappaB family of transcription factors. In v-Rel-transformed cells, v-Rel exists as homodimers or heterodimers with the endogenous Rel/NF-kappaB proteins c-Rel, NF-kappaB1, NF-kappaB2, and RelA. To exami...

journal_title：Journal of virology

authors： Liss AS,Bose HR Jr

更新日期：2002-05-01 00:00:00

abstract：:Human rhinoviruses (HRVs) were discovered as common cold pathogens over 50 years ago. Recent advances in molecular viral diagnostics have led to an appreciation of their role in more-significant respiratory illnesses, including bronchiolitis in infancy, childhood pneumonia, and acute exacerbations of chronic respirato...

journal_title：Journal of virology

authors： Gern JE

更新日期：2010-08-01 00:00:00

abstract：:Previous analyses have demonstrated that adenovirus DNA is packaged into virions in vivo in a polar, left-to-right fashion. The packaging of viral DNA is dependent on cis-acting elements at the left end of the genome. In this report, we describe a genetic analysis of the sequences that are required for efficient packa...

journal_title：Journal of virology

authors： Gräble M,Hearing P

更新日期：1990-05-01 00:00:00

abstract：:Epstein-Barr virus (EBV) establishes a persistent latent infection in B lymphocytes and is associated with the development of numerous human tumors. Epstein-Barr nuclear antigen 3C (EBNA 3C) is essential for B-cell immortalization, has potent cell cycle deregulation capabilities, and functions as a regulator of both v...

journal_title：Journal of virology

authors： McClellan MJ,Khasnis S,Wood CD,Palermo RD,Schlick SN,Kanhere AS,Jenner RG,West MJ

更新日期：2012-05-01 00:00:00

abstract：:Highly active antiretroviral therapy (HAART) enables long-term suppression of plasma HIV-1 loads in infected persons, but low-level virus persists and rebounds following cessation of therapy. During HAART, this virus resides in latently infected cells, such as resting CD4(+) T cells, and in other cell types that may s...

journal_title：Journal of virology

authors： North TW,Higgins J,Deere JD,Hayes TL,Villalobos A,Adamson L,Shacklett BL,Schinazi RF,Luciw PA

更新日期：2010-03-01 00:00:00

abstract：:Infection of primary or secondary cultures of Chinese hamster embryo cells with simian virus 40 at a multiplicity of 20 to 50 induced synthesis of the virus-specific intranuclear T antigen in 80 to 90% of the cells within 48 to 72 hr. In the infected cultures, 30 to 50% more cells were recruited into deoxyribonucleic ...

journal_title：Journal of virology

authors： Lehman JM,Defendi V

更新日期：1970-12-01 00:00:00

abstract：:The Kaposi's sarcoma-associated herpesvirus (KSHV) (or human herpesvirus 8) open reading frame (ORF) K15 encodes a putative integral transmembrane protein in the same genomic location as latent membrane protein 2A of Epstein-Barr virus. Ectopic expression of K15 in cell lines revealed the presence of several different...

journal_title：Journal of virology

authors： Sharp TV,Wang HW,Koumi A,Hollyman D,Endo Y,Ye H,Du MQ,Boshoff C

更新日期：2002-01-01 00:00:00

abstract：:Human metapneumovirus (hMPV) is a recently discovered paramyxovirus that is a major cause of lower-respiratory-tract disease. hMPV is associated with more severe disease in infants and persons with underlying medical conditions. Animal studies have shown that the hMPV fusion (F) protein alone is capable of inducing pr...

journal_title：Journal of virology

authors： Williams JV,Chen Z,Cseke G,Wright DW,Keefer CJ,Tollefson SJ,Hessell A,Podsiad A,Shepherd BE,Sanna PP,Burton DR,Crowe JE Jr,Williamson RA

更新日期：2007-08-01 00:00:00

abstract：:Human papillomaviruses (HPVs) infect squamous epithelium and establish their genomes as episomes in proliferating basal cells. As infected cells differentiate, the viral DNA is amplified to high copy number and infectious virus is produced. Viral production has not yet been observed in vitro due to the inability of st...

journal_title：Journal of virology

authors： Bedell MA,Hudson JB,Golub TR,Turyk ME,Hosken M,Wilbanks GD,Laimins LA

更新日期：1991-05-01 00:00:00

abstract：:Hepatitis C virus (HCV) is an important human pathogen associated with chronic liver disease. Recently, based on a genotype 2a isolate, tissue culture systems supporting complete replication and infectious virus production have been developed. In this study, we used cell culture-produced infectious HCV to analyze the ...

journal_title：Journal of virology

authors： Tscherne DM,Jones CT,Evans MJ,Lindenbach BD,McKeating JA,Rice CM

更新日期：2006-02-01 00:00:00