1-beta-D-arabinofuranosylcytosine inhibits borna disease virus replication and spread.

abstract：:RNA structures play key roles in the replication of RNA viruses. Sequence alignment software, thermodynamic RNA folding programs, and classical comparative phylogenetic analysis were used to build models of six RNA elements in the coding region of the hepatitis C virus (HCV) RNA-dependent RNA polymerase, NS5B. The imp...

journal_title：Journal of virology

authors： You S,Stump DD,Branch AD,Rice CM

更新日期：2004-02-01 00:00:00

abstract：:Antisera produced in mice recognize primarily type-specific antigenic determinants on both the major core protein, p30, and the major envelope proteins, gp70 and p15(E), of the endogenous leukemia viruses (MuLV) of BALB/c mice. Three different mouse sera were investigated in detail. (i) Antisera prepared in C57BL/6 mi...

journal_title：Journal of virology

authors： Brown JP,Boiocchi M,Nowinski RC

更新日期：1979-10-01 00:00:00

abstract：:Capsids of polyomaviruses--small, nonenveloped DNA viruses--consist of the major structural protein VP1 and the minor structural proteins VP2 and VP3. The contributions of the individual capsid proteins to functions of the viral particle, such as DNA encapsidation, cell receptor attachment, entry, and uncoating, are s...

journal_title：Journal of virology

authors： Pawlita M,Müller M,Oppenländer M,Zentgraf H,Herrmann M

更新日期：1996-11-01 00:00:00

abstract：:Therapeutic strategies for the treatment of acute retroviral infections have relied mainly on antiviral drugs. In this study we used the Friend virus model system to demonstrate that enhancement of the immune system can also have dramatic therapeutic effects. Since resistance to Friend virus-induced leukemia in mice i...

journal_title：Journal of virology

authors： Olbrich AR,Schimmer S,Heeg K,Schepers K,Schumacher TN,Dittmer U

更新日期：2002-11-01 00:00:00

abstract：:It has been shown previously in the severe acute respiratory syndrome coronavirus (SARS-CoV) that two point mutations, N15A and V25F, in the transmembrane domain (TMD) of the envelope (E) protein abolished channel activity and led to in vivo attenuation. Pathogenicity was recovered in mutants that also regained E prot...

journal_title：Journal of virology

authors： To J,Surya W,Fung TS,Li Y,Verdià-Bàguena C,Queralt-Martin M,Aguilella VM,Liu DX,Torres J

更新日期：2017-02-14 00:00:00

abstract：:trans activation of the human immunodeficiency virus type 1 long terminal repeat requires that the viral trans activator Tat interact with the trans-acting responsive region (TAR) RNA. Although the N-terminal 47 amino acids represent an independent activation domain that functions via heterologous nucleic acid-binding...

journal_title：Journal of virology

authors： Luo Y,Peterlin BM

更新日期：1993-06-01 00:00:00

abstract：:The transmission bottleneck is defined as the number of viral particles that transmit from one host to establish an infection in another. Genome sequence data have been used to evaluate the size of the transmission bottleneck between humans infected with the influenza virus; however, the methods used to make these est...

journal_title：Journal of virology

authors： Ghafari M,Lumby CK,Weissman DB,Illingworth CJR

更新日期：2020-06-16 00:00:00

abstract：:tsAF8 cells are temperature-sensitive (ts) mutants of BHK-21 cells that arrest at the nonpermissive temperature in the G1 phase of the cell cycle. When made quiescent by serum restriction, they can be stimulated to enter the S phase by 10% serum at 34 degrees C, but not at 40.6 degrees C. Infection by adenovirus type ...

journal_title：Journal of virology

authors： Rossini M,Jonak GJ,Baserga R

更新日期：1981-06-01 00:00:00

abstract：:The adenovirus type 5 mutant dl1520 was engineered previously to be completely defective for E1B-55K functions. Recently, this mutant (also known as ONYX-015) has been suggested to replicate preferentially in p53(-) and some p53(+) tumor cell lines but to be attenuated in primary cultured cells (C. Heise, A. Sampson-J...

journal_title：Journal of virology

authors： Harada JN,Berk AJ

更新日期：1999-07-01 00:00:00

abstract：:We generated Chinese hamster ovary cell lines that stably express wild-type, secreted, and glycosylphosphatidylinositol (GPI)-anchored envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1). The cells expressing wild-type Env (WT cells) express both the precursor gp160 and the mature gp120/gp41 and readi...

journal_title：Journal of virology

authors： Weiss CD,White JM

更新日期：1993-12-01 00:00:00

abstract：:Despite being able to use the Bonzo coreceptor as efficiently as CCR5 in transfected cells, pediatric human immunodeficiency virus type 1 isolate P6 was unable to replicate in peripheral blood mononuclear cells (PBMC) lacking the CCR5 receptor. Furthermore, its replication in wild-type PBMC was completely inhibited by...

journal_title：Journal of virology

authors： Zhang YJ,Moore JP

更新日期：1999-04-01 00:00:00

abstract：:Coinfection with HIV-1 and Kaposi's sarcoma-associated herpesvirus (KSHV) often leads to AIDS-related malignancies, including Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). The interaction between HIV and KSHV plays a pivotal role in the progression of these malignancies. We have previously demonstrated th...

journal_title：Journal of virology

authors： Yan Q,Zhao R,Shen C,Wang F,Li W,Gao SJ,Lu C

更新日期：2018-08-29 00:00:00

abstract：:A gene encoding a polypeptide with homology to mammalian vascular endothelial growth factors (VEGFs) has been discovered in the genome of orf virus (OV), a parapoxvirus that affects sheep and goats and, occasionally, humans. The gene is transcribed abundantly early in infection and is found immediately outside the inv...

journal_title：Journal of virology

authors： Lyttle DJ,Fraser KM,Fleming SB,Mercer AA,Robinson AJ

更新日期：1994-01-01 00:00:00

abstract：:Adenovirus deletion mutants were studied to examine the influence of the 5' untranslated sequence on the translation of early region 1A mRNAs. Alterations of the 5' untranslated sequence, including complete deletion of the wild-type 5' untranslated sequence, did not significantly affect the rate of translation. ...

journal_title：Journal of virology

authors： Spindler KR,Berk AJ

更新日期：1984-09-01 00:00:00

abstract：:The herpesvirus tegument is a layer of viral and cellular proteins located between the capsid and envelope of the virion. The VP1/2 tegument protein is critical for the propagation of all herpesviruses examined. Using an infectious clone of the alphaherpesvirus pseudorabies virus, we have made a collection of truncati...

journal_title：Journal of virology

authors： Lee JI,Luxton GW,Smith GA

更新日期：2006-12-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) primary infection is characterized by the use of CCR5 as a coreceptor for viral entry, which is associated with the non-syncytium-inducing (NSI) phenotype in lymphoid cells. Syncytium-inducing (SI) variants of HIV-1 appear in advanced stages of HIV-1 infection and are charac...

journal_title：Journal of virology

authors： Llano A,Barretina J,Gutiérrez A,Blanco J,Cabrera C,Clotet B,Esté JA

更新日期：2001-11-01 00:00:00

abstract：:Although the genetic organization of tobacco mosaic virus (TMV) differs considerably from that of the tripartite viruses (alfalfa mosaic virus [AlMV] and brome mosaic virus [BMV]), all of these RNA plant viruses share three domains of homology among their nonstructural proteins. One such domain, common to the AlMV and...

journal_title：Journal of virology

authors： Ahlquist P,Strauss EG,Rice CM,Strauss JH,Haseloff J,Zimmern D

更新日期：1985-02-01 00:00:00

abstract：:Sterile alpha motif domain- and HD domain-containing protein 1 (SAMHD1) is a deoxynucleoside triphosphohydrolase that restricts the replication of lentiviruses in myeloid cells by hydrolyzing the cellular deoxynucleotide triphosphates to a level below that which is required for reverse transcription. Human immunodefic...

journal_title：Journal of virology

authors： Hofmann H,Logue EC,Bloch N,Daddacha W,Polsky SB,Schultz ML,Kim B,Landau NR

更新日期：2012-12-01 00:00:00

abstract：:The 104-S monoclonal antibody immunoprecipitated from herpes simplex virus type 2 (HSV-2)-infected cell extracts the 75,000-molecular-weight glycoprotein gF and its 65,000-molecular-weight precursor (pgF). The precursor pgF was sensitive to endoglycosidase H digestion, indicating the presence of high mannose-type olig...

journal_title：Journal of virology

authors： Zweig M,Showalter SD,Bladen SV,Heilman CJ Jr,Hampar B

更新日期：1983-07-01 00:00:00

abstract：:To combat emerging coronaviruses, developing safe and efficient platforms to evaluate viral protease activities and the efficacy of protease inhibitors is a high priority. Here, we exploit a biosafety level 2 (BSL-2) chimeric Sindbis virus system to evaluate protease activities and the efficacy of inhibitors directed ...

journal_title：Journal of virology

authors： Deng X,Agnihothram S,Mielech AM,Nichols DB,Wilson MW,StJohn SE,Larsen SD,Mesecar AD,Lenschow DJ,Baric RS,Baker SC

更新日期：2014-10-01 00:00:00

abstract：:Two second-site mutations in Moloney murine leukemia virus envelope surface protein (SU) were previously shown to rescue infection of two different SU mutants, a fusion-defective point mutant and a fusion-defective modified SU that exhibits weak subunit association. We report here that they also rescue infection of a ...

journal_title：Journal of virology

authors： Kizhatil K,Gromley A,Albritton LM

更新日期：2001-12-01 00:00:00

abstract：:The membrane-proximal region of the human immunodeficiency virus type 1 (HIV-1) transmembrane protein (TM) is critical for envelope (Env)-mediated membrane fusion and contains the target for broadly reactive neutralizing antibody 2F5. It has been proposed that 2F5 neutralization might involve interaction of its long, ...

journal_title：Journal of virology

authors： Ou W,Lu N,Yu SS,Silver J

更新日期：2006-03-01 00:00:00

abstract：:CD8(+) cytotoxic T lymphocytes (CTL) play a key role in the control of many virus infections, and the need for vaccines to elicit strong CD8(+) T-cell responses in order to provide optimal protection in such infections is increasingly apparent. However, the mechanisms involved in the induction and maintenance of CD8(+...

journal_title：Journal of virology

authors： Borrow P,Tough DF,Eto D,Tishon A,Grewal IS,Sprent J,Flavell RA,Oldstone MB

更新日期：1998-09-01 00:00:00

abstract：:We previously showed that murine polyomavirus mutants that lack both middle T (MT) and small T (ST) functions have a severe pleiotropic defect in early and late viral gene expression as well as genome amplification. The respective contribution of MT and ST to this phenotype was unclear. This work separates the roles o...

journal_title：Journal of virology

authors： Chen L,Wang X,Fluck MM

更新日期：2006-08-01 00:00:00

abstract：:pp60v-src is a nonreceptor protein tyrosine kinase that can transform both chicken and rodent fibroblasts. The src homology 2 (SH2) domain of this protein serves a critical role in the regulation of protein tyrosine kinase activity. The host range proteins pp60v-src-L, which contains a deletion of a highly conserved r...

journal_title：Journal of virology

authors： Woods KM,Verderame MF

更新日期：1994-11-01 00:00:00

abstract：:Norovirus (NV) gastroenteritis is a major contributor to global morbidity and mortality, yet little is known about immune mechanisms leading to NV control. Previous studies using the murine norovirus (MNV) model have established a key role for T cells in MNV clearance. Despite these advances, important questions remai...

journal_title：Journal of virology

authors： Tomov VT,Osborne LC,Dolfi DV,Sonnenberg GF,Monticelli LA,Mansfield K,Virgin HW,Artis D,Wherry EJ

更新日期：2013-06-01 00:00:00

abstract：:The matrix (MA) protein of human immunodeficiency virus type 1 (HIV-1) forms the outer protein shell directly underneath the lipid envelope of the virion. The MA protein has a key role in different aspects of virus assembly, including the incorporation of the HIV-1 Env protein complex, which contains a transmembrane g...

journal_title：Journal of virology

authors： Mammano F,Kondo E,Sodroski J,Bukovsky A,Göttlinger HG

更新日期：1995-06-01 00:00:00

abstract：:RIG-I is a major cytoplasmic sensor of viral pathogen-associated molecular pattern (PAMP) RNA and induces type I interferon (IFN) production upon viral infection. A double-stranded RNA (dsRNA)-binding protein, PACT, plays an important role in potentiating RIG-I function. We have shown previously that arenaviral nucleo...

journal_title：Journal of virology

authors： Shao J,Huang Q,Liu X,Di D,Liang Y,Ly H

更新日期：2018-06-13 00:00:00

abstract：:Replication and assembly of hepatitis C virus (HCV) depend on the host's secretory and lipid-biosynthetic machinery. Viral replication occurs on endoplasmic reticulum (ER)-derived modified membranes, while viral assembly is thought to occur on lipid droplets (LDs). A physical association and coordination between the v...

journal_title：Journal of virology

authors： Nevo-Yassaf I,Yaffe Y,Asher M,Ravid O,Eizenberg S,Henis YI,Nahmias Y,Hirschberg K,Sklan EH

更新日期：2012-06-01 00:00:00

abstract：:The antiviral activity of the double-stranded complex poly(rI) . poly(rC) in cell culture was restored or even surpassed if the constituent homopolymers were administered separately. Poly(rI) primed the cells for the antiviral activity of poly(rC) and poly(rC) primed for poly(rI), but neither poly(rI) nor poly(rC) pri...

journal_title：Journal of virology

authors： De Clercq E,De Somer P

更新日期：1972-05-01 00:00:00