Pneumopathogenicity in mice of a Sendai virus mutant, TSrev-58, is accompanied by in vitro activation with trypsin.

abstract：:Simian immunodeficiency virus (SIV) infection of rhesus macaques causes immune depletion and disease closely resembling human AIDS and is well recognized as the most relevant animal model for the human disease. Experimental investigations of viral pathogenesis and vaccine protection primarily involve a limited set of ...

journal_title：Journal of virology

authors： Fischer W,Apetrei C,Santiago ML,Li Y,Gautam R,Pandrea I,Shaw GM,Hahn BH,Letvin NL,Nabel GJ,Korber BT

更新日期：2012-12-01 00:00:00

abstract：:Amphiphilic fatty acid derivatives having a 14- to 20-carbon cis-unsaturated alkyl chain were found to be potent inhibitors of the entry process of the lipid-containing bacteriophage PR4. ...

journal_title：Journal of virology

authors： Sands JA,Reinhardt A,Auperin D,Landin P

更新日期：1979-01-01 00:00:00

abstract：:Intragastric inoculation with whole-virion vaccine of inactivated influenza virus resulted in production of hemagglutinin (HA)-specific immunoglobulin A (IgA) and IgG both in lung lavage fluids and in serum samples of mice. HA-specific IgA was the predominant isotypic antibody secreted in the lung lavage fluids (avera...

journal_title：Journal of virology

authors： Chen KS,Burlington DB,Quinnan GV Jr

更新日期：1987-07-01 00:00:00

abstract：:A polymorphism in the gene encoding CCR2 is associated with a delay in progression to AIDS in human immunodeficiency virus (HIV)-infected individuals. The polymorphism, CCR2-64I, changes valine 64 of CCR2 to isoleucine. However, it is not clear whether the effect on AIDS progression results from the amino acid change ...

journal_title：Journal of virology

authors： Mariani R,Wong S,Mulder LC,Wilkinson DA,Reinhart AL,LaRosa G,Nibbs R,O'Brien TR,Michael NL,Connor RI,Macdonald M,Busch M,Koup RA,Landau NR

更新日期：1999-03-01 00:00:00

abstract：:The isolation and characterization of an adenovirus mutant, Ad5dl802r1, containing two independent deletions in the 72-kilodalton (kDa) DNA-binding protein (DBP) gene is described. The two deletions remove amino acids 23 through 105 of DBP, resulting in the production of a 50-kDa product. Expression of this truncated ...

journal_title：Journal of virology

authors： Cleghon V,Voelkerding K,Morin N,Delsert C,Klessig DF

更新日期：1989-05-01 00:00:00

abstract：:Resolution of virus infections depends on the priming of virus-specific CD8+ T cells by dendritic cells (DC). While this process requires major histocompatibility complex (MHC) class I-restricted antigen presentation by DC, the relative contribution to CD8+ T cell priming by infected DC is less clear. We have addresse...

journal_title：Journal of virology

authors： Whitney PG,Makhlouf C,MacLeod B,Ma JZ,Gressier E,Greyer M,Hochheiser K,Bachem A,Zaid A,Voehringer D,Heath WR,Wagle MV,Parish I,Russell TA,Smith SA,Tscharke DC,Gebhardt T,Bedoui S

更新日期：2018-01-17 00:00:00

abstract：:Polyomavirus large T antigen has an N-terminal domain of approximately 260 amino acids which can immortalize primary cells but lacks sequences known to be required for DNA binding and replication. Treatment of full-length large T with either V8 protease or chymotrypsin yields an N-terminal fragment of 36 to 40 kDa and...

journal_title：Journal of virology

authors： Holman PS,Gjoerup OV,Davin T,Schaffhausen BS

更新日期：1994-02-01 00:00:00

abstract：:Influenza A virus (IAV) remains a global health concern despite the availability of a seasonal vaccine. It is difficult to predict which strains will circulate during influenza season, and therefore, it is extremely challenging to test novel vaccines in the human population. To overcome this obstacle, new vaccines mus...

journal_title：Journal of virology

authors： Fay EJ,Aron SL,Stone IA,Waring BM,Plemper RK,Langlois RA

更新日期：2018-12-10 00:00:00

abstract：:Human oncolytic adenoviruses have been used in clinical trials targeting cancers of epithelial origin. To gain a better understanding of the infectious cycle of adenovirus in normal human squamous tissues, we examined the viral infection process in organotypic cultures of primary human keratinocytes. We show that for ...

journal_title：Journal of virology

authors： Noya F,Balagué C,Banerjee NS,Curiel DT,Broker TR,Chow LT

更新日期：2003-06-01 00:00:00

abstract：:Hepatitis B virus (HBV) DNA clones were propagated from 57 carriers with antibody to hepatitis B e antigen (HBeAg) and sequenced within nucleotides (nt) 1685 to 1926 including the core promoter (nt 1742 to 1849) and the pre-C region (nt 1814 to 1900). Mutations in the core promoter or those in the pre-C region, or bot...

journal_title：Journal of virology

authors： Okamoto H,Tsuda F,Akahane Y,Sugai Y,Yoshiba M,Moriyama K,Tanaka T,Miyakawa Y,Mayumi M

更新日期：1994-12-01 00:00:00

abstract：:Adeno-associated virus type 2 (AAV-2) gene expression is tightly controlled by functions of the helper virus as well as by the products of its own viral rep gene. Double-immunofluorescence studies of Rep and VP protein expression in cells coinfected with AAV-2 and adenovirus type 2 showed that a large proportion of th...

journal_title：Journal of virology

authors： Weger S,Wistuba A,Grimm D,Kleinschmidt JA

更新日期：1997-11-01 00:00:00

abstract：:We have investigated the species-specific replication of polyomavirus DNA in the cell-free system that was established previously (Y. Murakami, T. Eki, M. Yamada, C. Prives, and J. Hurwitz, Proc. Natl. Acad. Sci. USA 83:6347-6351, 1986). Extracts from various species of cells supported polyomavirus DNA replication in ...

journal_title：Journal of virology

authors： Eki T,Enomoto T,Masutani C,Miyajima A,Takada R,Murakami Y,Ohno T,Hanaoka F,Ui M

更新日期：1991-09-01 00:00:00

abstract：UNLABELLED:Capsid-associated tegument proteins have been identified in alpha- and betaherpesviruses to play an essential role in viral DNA packaging. Whether and how such tegument proteins exist in gammaherpesviruses have been mysteries. Here, we report a 6-Å-resolution cryo-electron microscopy (cryo-EM) structure of K...

journal_title：Journal of virology

authors： Dai X,Gong D,Wu TT,Sun R,Zhou ZH

更新日期：2014-11-01 00:00:00

abstract：:To evaluate host range differences between two different strains of feline leukemia virus subgroup B (FeLV-B), we compared the binding and infectivity patterns of retrovirus vectors bearing either FeLV-B-90Z or FeLV-B-GA envelopes. We report here that the ability of these envelopes to utilize different Pit1 orthologs ...

journal_title：Journal of virology

authors： Faix PH,Feldman SA,Overbaugh J,Eiden MV

更新日期：2002-12-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) does not replicate in murine cells. We investigated the basis of this block by infecting a murine NIH 3T3 reporter cell line that stably expressed human CD4, CCR5, and cyclin T1 and contained a transactivatable HIV-1 long terminal repeat (LTR)-green fluorescent protein (GFP)...

journal_title：Journal of virology

authors： Mariani R,Rutter G,Harris ME,Hope TJ,Kräusslich HG,Landau NR

更新日期：2000-04-01 00:00:00

abstract：:The human immunodeficiency virus type 1 Vpu protein is a 16-kDa phosphoprotein which enhances the efficiency of virion production and induces rapid degradation of CD4, the cellular receptor for human immunodeficiency virus. The topology of membrane-inserted Vpu was investigated by using in vitro-synthesized Vpu cotran...

journal_title：Journal of virology

authors： Maldarelli F,Chen MY,Willey RL,Strebel K

更新日期：1993-08-01 00:00:00

abstract：:Borna disease virus (BDV) uses a unique strategy of replication and transcription which takes place in the nucleus, unlike other known, nonsegmented, negative-stranded RNA viruses of animal origin. In this process, viral constituents necessary for replication must be transported to the nucleus from the cytoplasm. We r...

journal_title：Journal of virology

authors： Shoya Y,Kobayashi T,Koda T,Ikuta K,Kakinuma M,Kishi M

更新日期：1998-12-01 00:00:00

abstract：:Unintegrated linear and closed circular DNAs of B- and N-tropic endogenous BALB/c murine leukemia virus (MuLV) were extracted from newly infected mouse cells and cleaved with EcoRI, XhoI, PvuI, HindIII, SalI, XbaI, KpnI, SmaI, and PstI restriction endonucleases. The DNA fragments were separated by electrophoresis and ...

journal_title：Journal of virology

authors： Rassart E,Jolicoeur P

更新日期：1980-09-01 00:00:00

abstract：:RNA structures play key roles in the replication of RNA viruses. Sequence alignment software, thermodynamic RNA folding programs, and classical comparative phylogenetic analysis were used to build models of six RNA elements in the coding region of the hepatitis C virus (HCV) RNA-dependent RNA polymerase, NS5B. The imp...

journal_title：Journal of virology

authors： You S,Stump DD,Branch AD,Rice CM

更新日期：2004-02-01 00:00:00

abstract：:Feline calicivirus is a major causative agent of respiratory disease in cats. It is also one of the few cultivatable members of Caliciviridae. We have examined the entry process of feline calicivirus (FCV). An earlier study demonstrated that acidification in endosomes may be required. We have confirmed this observatio...

journal_title：Journal of virology

authors： Stuart AD,Brown TD

更新日期：2006-08-01 00:00:00

abstract：:Chimeric human immunodeficiency virus type 1 (HIV-1) molecular clones differing only in the envelope V3 region were constructed. The V3 regions were derived from two HIV-1 isolates with a non-syncytium-inducing, non-T-cell-tropic phenotype and from four HIV-1 isolates with a syncytium-inducing, T-cell-tropic phenotype...

journal_title：Journal of virology

authors： de Jong JJ,Goudsmit J,Keulen W,Klaver B,Krone W,Tersmette M,de Ronde A

更新日期：1992-02-01 00:00:00

abstract：:We evaluated the ability of human coronaviruses to infect primary cultures of human neural cells. Double immunofluorescence with antibodies to virus and cell markers showed infection of fetal astrocytes and of adult microglia and astrocytes by strain OC43. RNA amplification revealed infection of fetal astrocytes, adul...

journal_title：Journal of virology

authors： Bonavia A,Arbour N,Yong VW,Talbot PJ

更新日期：1997-01-01 00:00:00

abstract：:West Nile virus has spread rapidly across the United States, and there is currently no approved human vaccine or therapy to prevent or treat disease. Passive immunization with antibodies against the envelope protein represents a promising means to provide short-term prophylaxis and treatment for West Nile virus infect...

journal_title：Journal of virology

authors： Gould LH,Sui J,Foellmer H,Oliphant T,Wang T,Ledizet M,Murakami A,Noonan K,Lambeth C,Kar K,Anderson JF,de Silva AM,Diamond MS,Koski RA,Marasco WA,Fikrig E

更新日期：2005-12-01 00:00:00

abstract：:Cytomegaloviruses (CMVs) colonize blood-borne myeloid cells. Murine CMV (MCMV) spreads from the lungs via infected CD11c+ cells, consistent with an important role for dendritic cells (DC). We show here that MCMV entering via the olfactory epithelium, a natural transmission portal, also spreads via infected DC. They re...

journal_title：Journal of virology

authors： Farrell HE,Bruce K,Lawler C,Stevenson PG

更新日期：2019-07-17 00:00:00

abstract：:Natural Killer (NK) cells are important in the immune response to a number of viruses; however, the mechanisms used by NK cells to discriminate between healthy and virus-infected cells are only beginning to be understood. Infection with vaccinia virus provokes a marked increase in the susceptibility of target cells to...

journal_title：Journal of virology

authors： Chisholm SE,Reyburn HT

更新日期：2006-03-01 00:00:00

abstract：:Single-envelope human immunodeficiency virus (HIV) vaccines have been studied for more than a decade, with some successes in homologous challenge experiments in nonhuman primates but with no clear successes in clinical trials. To gain insight into the breadth of the immunity elicited by such vaccines, we have dissecte...

journal_title：Journal of virology

authors： Zhan X,Slobod KS,Surman S,Brown SA,Lockey TD,Coleclough C,Doherty PC,Hurwitz JL

更新日期：2003-04-01 00:00:00

abstract：:Artificial target sequences for tissue-specific miRNAs have recently been introduced as a new means for altering the tissue tropism of viral replication. This approach can be used to improve the safety of oncolytic viruses for cancer virotherapy by restricting their replication in unwanted tissues, such as the liver. ...

journal_title：Journal of virology

authors： Ylösmäki E,Martikainen M,Hinkkanen A,Saksela K

更新日期：2013-01-01 00:00:00

abstract：:A putative transcription factor, C/EBP, isolated from rat liver nuclei, has been shown to bind to at least two different sequence motifs: the CCAAT promoter domain and a core sequence [GTGG(T/A)(T/A)(T/A)G] common to many viral enhancers, including simian virus 40 and human hepatitis B virus. It has been proposed that...

journal_title：Journal of virology

authors： Pei DQ,Shih CH

更新日期：1990-04-01 00:00:00

abstract：:Our ability to rapidly respond to an emerging influenza pandemic is hampered somewhat by the lack of a susceptible small-animal model. To develop a more sensitive model, we pathotyped 18 low-pathogenic non-mouse-adapted influenza A viruses of human and avian origin in DBA/2 and C57BL/6 mice. The majority of the isolat...

journal_title：Journal of virology

authors： Boon AC,deBeauchamp J,Krauss S,Rubrum A,Webb AD,Webster RG,McElhaney J,Webby RJ

更新日期：2010-08-01 00:00:00

abstract：:We investigated properties of the rotavirus genome segment 11 protein. A rotavirus SA11 genome segment 11 cDNA which contains the entire coding region was sequenced and inserted into the baculovirus transfer vector pVL941. Recombinants containing gene 11 cDNA were selected, and the gene 11 product expressed in Spodopt...

journal_title：Journal of virology

authors： Welch SK,Crawford SE,Estes MK

更新日期：1989-09-01 00:00:00