Cross-reactive neutralizing antibodies directed against pandemic H1N1 2009 virus are protective in a highly sensitive DBA/2 mouse influenza model.

abstract：:Reovirus virions are nonenveloped icosahedral particles consisting of two concentric protein shells, termed outer capsid and core. Outer-capsid protein sigma1 is the viral attachment protein and binds carbohydrate molecules on the surface of host cells. Monoclonal antibody (MAb) 4F2, which is specific for outer-capsid...

journal_title：Journal of virology

authors： Nason EL,Wetzel JD,Mukherjee SK,Barton ES,Prasad BV,Dermody TS

更新日期：2001-07-01 00:00:00

abstract：:Mus dunni endogenous virus (MDEV) is activated from cells of the Asian wild mouse M. dunni (also known as Mus terricolor) in response to treatment with either 5-iodo-2'-deoxyuridine or hydrocortisone. MDEV represents a new murine retrovirus interference group and thus appears to use a different receptor for entry into...

journal_title：Journal of virology

authors： Bonham L,Wolgamot G,Miller AD

更新日期：1997-06-01 00:00:00

abstract：:Partial deletion of the second hypervariable region from the envelope of the primary-like SF162 virus increases the exposure of certain neutralization epitopes and renders the virus, SF162DeltaV2, highly susceptible to neutralization by clade B and non-clade B human immunodeficiency virus (HIV-positive) sera (L. Stama...

journal_title：Journal of virology

authors： Barnett SW,Lu S,Srivastava I,Cherpelis S,Gettie A,Blanchard J,Wang S,Mboudjeka I,Leung L,Lian Y,Fong A,Buckner C,Ly A,Hilt S,Ulmer J,Wild CT,Mascola JR,Stamatatos L

更新日期：2001-06-01 00:00:00

abstract：:Human cytomegalovirus (CMV) is the leading cause of prenatal viral infection. Affected infants may suffer intrauterine growth retardation and serious neurologic impairment. Analysis of spontaneously aborted conceptuses shows that CMV infects the placenta before the embryo or fetus. In the human hemochorial placenta, m...

journal_title：Journal of virology

authors： Fisher S,Genbacev O,Maidji E,Pereira L

更新日期：2000-08-01 00:00:00

abstract：:Circulating interferon production, induced by Newcastle disease virus, is about seven times higher in C(57) Black mice than i Balb/c/Gif mice. A Mendelian analysis was carried out and circulating interferon production was measured in reciprocal F(1) hybrids, in the F(2) generation, in progeny of backcrosses of F(1) hy...

journal_title：Journal of virology

authors： de Maeyer E,de Maeyer-Guignard J

更新日期：1969-05-01 00:00:00

abstract：:Inbred LSH hamster brain cells were transformed in vitro by the GS strain of BK virus (BKV), and transplantable tumors classified as undifferentiated glioblastomas were induced in the syngeneic host. The viral status in the transformed cells, designated LSH-BR-BK, was established. About 46 genome equivalents per cell ...

journal_title：Journal of virology

authors： Beth E,Giraldo G,Schmidt-Ullrich R,Pater MM,Pater A,di Mayorca G

更新日期：1981-10-01 00:00:00

abstract：:Interspecies transmission of the transmissible spongiform encephalopathies (TSEs), or prion diseases, can result in the adaptation and selection of TSE strains with an expanded host range and increased virulence such as in the case of bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease. To investiga...

journal_title：Journal of virology

authors： Bartz JC,Bessen RA,McKenzie D,Marsh RF,Aiken JM

更新日期：2000-06-01 00:00:00

abstract：:The ability of certain vesicular stomatitis virus (VSV; Indiana serotype) temperature-sensitive (ts) mutants to synthesize intracellular viral complementary RNA (vcRNA) at permissive or nonpermissive temperatures for productive infections has been investigated. Mutants belonging to complementation groups II, III, and ...

journal_title：Journal of virology

authors： Repik P,Flamand A,Bishop DH

更新日期：1976-10-01 00:00:00

abstract：:Virus was isolated from the lumen of the calyx region of ovaries in the parasitoid wasp Campoletis sonorensis (Hymenoptera: Ichneumonidae), and the nature of the viral DNA was analyzed. DNA purified from a homogeneous band of virus contained double-stranded superhelical molecules which were polydisperse in molecular w...

journal_title：Journal of virology

authors： Krell PJ,Summers MD,Vinson SB

更新日期：1982-09-01 00:00:00

abstract：:Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA-2) is a key determinant in the EBV-driven B-cell growth transformation process. By activating an array of viral and cellular target genes, EBNA-2 initiates a cascade of events which ultimately cause cell cycle entry and the proliferation of the infected B cell. In order...

journal_title：Journal of virology

authors： Maier S,Staffler G,Hartmann A,Höck J,Henning K,Grabusic K,Mailhammer R,Hoffmann R,Wilmanns M,Lang R,Mages J,Kempkes B

更新日期：2006-10-01 00:00:00

abstract：:Growth of bacteriophage T7 is inhibited by the antibiotic coumermycin A1, an inhibitor of the Escherichia coli DNA gyrase. Since growth of the phage is insensitive to the antibiotic in strains containing a coumermycin-resistant DNA gyrase, this enzyme appears to be required for phage growth. We have investigated the e...

journal_title：Journal of virology

authors： De Wyngaert M,Hinkle DC

更新日期：1979-02-01 00:00:00

abstract：:Adenovirus type 35 (Ad35) is a group B adenovirus that has been isolated primarily from patients with acquired immunodeficiency syndrome and other immunodeficiency disorders. We have studied the interaction of this unique adenovirus with the immune system by analyzing Ad35 early viral proteins in infected HeLa cells. ...

journal_title：Journal of virology

authors： Flomenberg PR,Chen M,Horwitz MS

更新日期：1987-12-01 00:00:00

abstract：:Guinea pig antisera and mouse monoclonal antibodies against a 40,000-molecular-weight nucleocapsid protein (p40) of herpes simplex virus types 1 and 2 immunoprecipitated 40,000- and 80,000-molecular-weight classes of soluble proteins from infected cell extracts. The soluble 40,000-molecular-weight protein class (intra...

journal_title：Journal of virology

authors： Zweig M,Heilman CJ Jr,Rabin H,Hampar B

更新日期：1980-09-01 00:00:00

abstract：:The antibiotic tunicamycin, which blocks the synthesis of glycoproteins, inhibited the production of infectious herpes simplex virus. In the presence of this drug, [14C]glucosamine and [3H]mannose incorporation was reduced in infected cells, whereas total protein synthesis was not affected. Gel electrophoresis of [2-3...

journal_title：Journal of virology

authors： Pizer LI,Cohen GH,Eisenberg RJ

更新日期：1980-04-01 00:00:00

abstract：:Fluorescent retroviral envelope (Env) proteins were developed for direct visualization of viral particles. By fusing the enhanced green fluorescent protein (eGFP) to the N terminus of the amphotropic 4070A envelope protein, extracellular presentation of eGFP was achieved. Viruses incorporated the modified Env protein ...

journal_title：Journal of virology

authors： Spitzer D,Dittmar KE,Rohde M,Hauser H,Wirth D

更新日期：2003-05-01 00:00:00

abstract：:Influenza A virus encodes M2, a proton channel that has been shown to be important during virus entry and assembly. In order to systematically investigate the role of the membrane-proximal residues in the M2 cytoplasmic tail in virus replication, we utilized scanning and directed alanine mutagenesis in combination wit...

journal_title：Journal of virology

authors： Stewart SM,Pekosz A

更新日期：2011-12-01 00:00:00

abstract：:The 72-kDa immediate early 1 (IE1) protein encoded by human cytomegalovirus (hCMV) is a nuclearly localized promiscuous regulator of viral and cellular transcription. IE1 has long been known to associate with host mitotic chromatin, yet the mechanisms underlying this interaction have not been specified. In this study,...

journal_title：Journal of virology

authors： Mücke K,Paulus C,Bernhardt K,Gerrer K,Schön K,Fink A,Sauer EM,Asbach-Nitzsche A,Harwardt T,Kieninger B,Kremer W,Kalbitzer HR,Nevels M

更新日期：2014-01-01 00:00:00

abstract：:The cytoplasmic domains of the transmembrane (TM) envelope proteins (TM-CDs) of most retroviruses have a Tyr-based motif, YXXO, in their membrane-proximal regions. This signal is involved in the trafficking and endocytosis of membrane receptors via clathrin-associated AP-1 and AP-2 adaptor complexes. We have used CD8-...

journal_title：Journal of virology

authors： Berlioz-Torrent C,Shacklett BL,Erdtmann L,Delamarre L,Bouchaert I,Sonigo P,Dokhelar MC,Benarous R

更新日期：1999-02-01 00:00:00

abstract：:We show here that the white spot syndrome virus (WSSV) immediate-early protein IE1 interacts with the Penaeus monodon TATA box-binding protein (PmTBP) and that this protein-protein interaction occurs in the absence of any other viral or cellular proteins or nucleic acids, both in vitro and in vivo. Mapping studies usi...

journal_title：Journal of virology

authors： Liu WJ,Chang YS,Huang WT,Chen IT,Wang KC,Kou GH,Lo CF

更新日期：2011-07-01 00:00:00

abstract：:Pigs are permissive to both human and avian influenza viruses and have been proposed to be an intermediate host for the genesis of pandemic influenza viruses through reassortment or adaptation of avian viruses. Prospective virological surveillance carried out between March 1998 and June 2000 in Hong Kong, Special Admi...

journal_title：Journal of virology

authors： Peiris JS,Guan Y,Markwell D,Ghose P,Webster RG,Shortridge KF

更新日期：2001-10-01 00:00:00

abstract：:Several C/EBP binding sites within the Rous sarcoma virus (RSV) long terminal repeat (LTR) and gag enhancers were mutated, and the effect of these mutations on viral gene expression was assessed. Minimal site-specific mutations in each of three adjacent C/EBP binding sites in the LTR reduced steady-state viral RNA lev...

journal_title：Journal of virology

authors： Ryden TA,de Mars M,Beemon K

更新日期：1993-05-01 00:00:00

abstract：:DNA sequence analysis has revealed that the gene coding for the human cytomegalovirus (HCMV) DNA polymerase is present within the long unique region of the virus genome. Identification is based on extensive amino acid homology between the predicted HCMV open reading frame HFLF2 and the DNA polymerase of herpes simplex...

journal_title：Journal of virology

authors： Kouzarides T,Bankier AT,Satchwell SC,Weston K,Tomlinson P,Barrell BG

更新日期：1987-01-01 00:00:00

abstract：:A number of cDNA clones complementary to measles virus mRNA and 50S genome RNA have been generated. These clones have been mapped by restriction enzyme analysis and were subsequently sequenced by the method of Maxam and Gilbert (A. M. Maxam and W. Gilbert, Methods Enzymol. 65:499-560, 1980). Computer analysis of these...

journal_title：Journal of virology

authors： Richardson CD,Berkovich A,Rozenblatt S,Bellini WJ

更新日期：1985-04-01 00:00:00

abstract：UNLABELLED:Reactivation of human cytomegalovirus (HCMV) is a significant cause of disease and death in immunocompromised patients, underscoring the need to understand how latency is controlled. Here we demonstrate that HCMV has evolved to utilize cellular microRNAs (miRNAs) in cells that promote latency to regulate exp...

journal_title：Journal of virology

authors： O'Connor CM,Vanicek J,Murphy EA

更新日期：2014-05-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) readily infects both humans and chimpanzees, but the pathologic outcomes of infection in these two species differ greatly. In attempts to identify virus-cell interactions that might account for this differential pathogenicity, chimpanzee peripheral blood lymphocytes and ...

journal_title：Journal of virology

authors： Watanabe M,Ringler DJ,Fultz PN,MacKey JJ,Boyson JE,Levine CG,Letvin NL

更新日期：1991-06-01 00:00:00

abstract：:Small-t antigen of simian virus 40 renders CV-1 cells resistant to growth arrest induced by theophylline and other methylxanthines. Elevated levels of cyclic AMP are not involved in growth arrest of CV-1 cells by methylxanthines, and small-t antigen does not alter cyclic AMP levels dramatically after infection. ...

journal_title：Journal of virology

authors： Renz C,Rundell K

更新日期：1985-06-01 00:00:00

abstract：:The human immunodeficiency virus type 1 Tat protein binds to an RNA stem-loop structure called TAR which is present at the 5' end of all human immunodeficiency virus type 1 transcripts. This binding is centered on a bulge within the stem of TAR and is an essential step in the trans-activation process which results in ...

journal_title：Journal of virology

authors： Sumner-Smith M,Roy S,Barnett R,Reid LS,Kuperman R,Delling U,Sonenberg N

更新日期：1991-10-01 00:00:00

abstract：:West Nile virus (WNV), currently the cause of a serious U.S. epidemic, is a mosquito-borne flavivirus and member of the Japanese encephalitis (JE) serocomplex. There is currently no approved human WNV vaccine, and treatment options remain limited, resulting in significant mortality and morbidity from human infection. ...

journal_title：Journal of virology

authors： Petrovsky N,Larena M,Siddharthan V,Prow NA,Hall RA,Lobigs M,Morrey J

更新日期：2013-09-01 00:00:00

abstract：:The reticuloendotheliosis viruses (REVs), originally isolated from avian species, constitute a group of retroviruses which are more closely related to mammalian retroviruses than to other avian retroviruses. The envelope glycoproteins of members of the REV group display a striking amino acid sequence identity with a g...

journal_title：Journal of virology

authors： Koo HM,Gu J,Varela-Echavarria A,Ron Y,Dougherty JP

更新日期：1992-06-01 00:00:00

abstract：:Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8+ T-cell response to human parvovirus B19 in acutely infected individuals. We observed striking CD8+ T-ce...

journal_title：Journal of virology

authors： Norbeck O,Isa A,Pöhlmann C,Broliden K,Kasprowicz V,Bowness P,Klenerman P,Tolfvenstam T

更新日期：2005-09-01 00:00:00