Abstract:
:The human immunodeficiency virus type 1 (HIV-1) readily infects both humans and chimpanzees, but the pathologic outcomes of infection in these two species differ greatly. In attempts to identify virus-cell interactions that might account for this differential pathogenicity, chimpanzee peripheral blood lymphocytes and bone marrow macrophages were assessed in vitro for their ability to support the replication of several HIV-1 isolates. Although the IIIb, RF, and MN isolates did not readily infect chimpanzee peripheral blood lymphocytes, an isolate of HIV-1 passaged in vivo in chimpanzees not only replicated well in both chimpanzee peripheral blood lymphocytes and bone marrow macrophages but also was cytopathic for chimpanzee CD4+ lymphocytes. Because no evidence of HIV-induced disease has been observed in chimpanzees infected with this isolate, in vitro replication to high titers with concomitant loss of CD4+ cells is not, in this instance, a correlate of pathogenicity. These observations, therefore, indicate that caution must be used when making extrapolations from in vitro data to in vivo pathogenesis.
journal_name
J Viroljournal_title
Journal of virologyauthors
Watanabe M,Ringler DJ,Fultz PN,MacKey JJ,Boyson JE,Levine CG,Letvin NLdoi
10.1128/JVI.65.6.3344-3348.1991subject
Has Abstractpub_date
1991-06-01 00:00:00pages
3344-8issue
6eissn
0022-538Xissn
1098-5514journal_volume
65pub_type
杂志文章abstract::The adenovirus tripartite leader is a 200-nucleotide 5' noncoding region that is found on all late viral mRNAs. This segment is required for preferential translation of viral mRNAs at late times during infection. Most tripartite leader-containing mRNAs appear to exhibit little if any requirement for intact cap-binding...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.62.6.2059-2066.1988
更新日期:1988-06-01 00:00:00
abstract::Although recombinant human adenovirus (HAV)-based vectors offer several advantages for somatic gene therapy and vaccination over other viral vectors, it would be desirable to develop alternative vectors with prolonged expression and decreased toxicity. Toward this objective, a replication-defective bovine adenovirus t...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.11.9137-9144.1999
更新日期:1999-11-01 00:00:00
abstract::To study the role of the biochemical and physiological activities of simian virus 40 (SV40) large T antigen in the lytic and transformation processes, we have analyzed DNA replication-defective, transformation-competent T-antigen mutants. Here we describe two such mutants, C8/SV40 and T22/SV40, and also summarize the ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.53.1.120-127.1985
更新日期:1985-01-01 00:00:00
abstract:UNLABELLED:Many viruses have the capacity to prevent a cell from being infected by a second virus, often termed superinfection exclusion. Alphaherpesviruses, including the human pathogen herpes simplex virus 1 (HSV-1) and the animal herpesvirus pseudorabies virus (PRV), encode a membrane-bound glycoprotein, gD, that ca...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00089-16
更新日期:2016-03-28 00:00:00
abstract::Envelope glycoprotein E1 (gp51 to gp54) is the most antigenic protein of hog cholera virus or classical swine fever virus (CSFV). Four antigenic domains, A to D, have been mapped on E1 with a panel of monoclonal antibodies (MAbs) raised against CSFV strain Brescia. The boundaries of these domains have been established...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.6.3934-3942.1994
更新日期:1994-06-01 00:00:00
abstract::The L1 and L2 capsid genes of human papillomavirus type 31 (HPV-31) are expressed upon keratinocyte differentiation from a promoter located in the E7 open reading frame (ORF) of the early region. Late transcripts must therefore pass through and ignore the early polyadenylation sequences to use the downstream late AAUA...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.75.17.8147-8157.2001
更新日期:2001-09-01 00:00:00
abstract::To determine which sequences or structures in the poliovirus 5' noncoding region (5'NCR) are involved in binding proteins used for internal ribosome binding and protein synthesis initiation, translation competition assays were performed in rabbit reticulocyte lysates in the presence and absence of HeLa cell extract. T...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.5.3101-3109.1992
更新日期:1992-05-01 00:00:00
abstract::Antisera were prepared against the amino acid sequences encoded within the N-terminal half of the adenovirus 12 (Ad12) early region 1A (E1A) gene. This was accomplished by construction of a plasmid vector which encoded the N-terminal 131 amino acids of Ad12 E1A joined in frame to the coding sequence of beta-galactosid...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.50.3.895-903.1984
更新日期:1984-06-01 00:00:00
abstract::Autophagy is now known to be an essential component of host innate and adaptive immunity. Several herpesviruses have developed various strategies to evade this antiviral host defense. Herpes simplex virus 1 (HSV-1) blocks autophagy in fibroblasts and in neurons, and the ICP34.5 protein is important for the resistance ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01158-12
更新日期:2013-01-01 00:00:00
abstract::A sequence of polyadenylic acid, homogeneous in composition but heterogeneous in length, was isolated from complete pancreatic RNase digests of both middle and bottom RNAs of cowpea mosaic virus. The polyadenylic acid was 3'-terminal and occurred once per molecule. A fragment consisting of the polyadenylic acid and ap...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.26.2.243-248.1978
更新日期:1978-05-01 00:00:00
abstract::The Rep78 and Rep68 proteins of adeno-associated virus type 2 (AAV) are multifunctional proteins which are required for viral replication, regulation of AAV promoters, and preferential integration of the AAV genome into a region of human chromosome 19. These proteins bind the hairpin structures formed by the AAV inver...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.3.2084-2093.1999
更新日期:1999-03-01 00:00:00
abstract::Preferential integration into transcriptionally active regions of genomes has been observed for retroviral vectors based on gamma-retroviruses and lentiviruses. However, differences in the integration site preferences were detected, which might be explained by differences in viral components of the preintegration comp...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00373-06
更新日期:2006-08-01 00:00:00
abstract::Friend virus induces an erythroleukemia in susceptible mice that is initiated by the interaction of the Friend virus-encoded glycoprotein gp55 with the erythropoietin (Epo) receptor and the product of the host Fv2 gene, a naturally occurring truncated form of the Stk receptor tyrosine kinase (Sf-Stk). We have previous...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02090-09
更新日期:2010-03-01 00:00:00
abstract::Following infection by pairs of reovirus isolates consisting of combinations of reovirus T1 Lang, T2 Jones, or T3 Dearing, we found that one of the isolates interfered with the yield of progeny RNA derived from the other parents. The most significant interference was produced by T2 Jones or T3 Dearing, when mixed with...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.10.6667-6671.1994
更新日期:1994-10-01 00:00:00
abstract::The Chinese hamster cell lines E36 and CHOK1 dramatically differ in susceptibility to amphotropic murine leukemia virus (A-MuLV) and gibbon ape leukemia virus (GALV); E36 cells are highly susceptible to both viruses, CHOK1 cells are not. We have previously shown that GALV can infect E36 cells by using both its own rec...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.4.2916-2920.1999
更新日期:1999-04-01 00:00:00
abstract::Adeno-associated virus serotype 9 (AAV9) vectors show promise for gene therapy of a variety of diseases due to their ability to transduce multiple tissues, including heart, skeletal muscle, and the alveolar epithelium of the lung. In addition, AAV9 is unique compared to other AAV serotypes in that it is capable of sur...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00448-12
更新日期:2012-07-01 00:00:00
abstract::HIV-1 Nef promotes virus spread and disease progression by altering host cell transport and signaling processes through interaction with multiple host cell proteins. The N-terminal region in HIV-1 Nef encompassing residues 12 to 39 has been implicated in many Nef activities, including disruption of CD4 T lymphocyte po...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01398-19
更新日期:2019-12-12 00:00:00
abstract::Friend murine leukemia virus (F-MuLV) is a replication-competent, ecotropic, NB-tropic retrovirus which produces a rapidly fatal erythroleukemia in susceptible strains of mice. We previously molecularly cloned the entire F-MuLV genome. Transfection of this cloned DNA into NIH 3T3 mouse fibroblasts produces a virus wit...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.46.3.718-725.1983
更新日期:1983-06-01 00:00:00
abstract::Borna disease virus (BDV) uses a unique strategy of replication and transcription which takes place in the nucleus, unlike other known, nonsegmented, negative-stranded RNA viruses of animal origin. In this process, viral constituents necessary for replication must be transported to the nucleus from the cytoplasm. We r...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.12.9755-9762.1998
更新日期:1998-12-01 00:00:00
abstract::Bacteriophages of the C3 morphotype, characterized by very long heads that exceed their width several times, are extremely rare among the Podoviridae family members and constitute only 0.5% of over 5,500 phages that have been examined by the electron microscope (H. W. Ackermann, Arch. Virol. 152:227-243, 2007; H. W. A...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02727-12
更新日期:2012-12-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.58.1.212-215.1986
更新日期:1986-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00524-17
更新日期:2017-08-24 00:00:00
abstract::Functions of viral proteins can be regulated through phosphorylation by serine/threonine kinases in plants, but little is known about the involvement of tyrosine kinases in plant virus infection. In this study, TGBp3, one of the three movement proteins encoded by a triple gene block (TGB) of Potato mop-top virus (PMTV...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.03388-12
更新日期:2013-04-01 00:00:00
abstract::Human immunodeficiency virus (HIV) infections in sub-Saharan Africa represent about 56% of global infections. Study of active-site mutations (the V82A single mutation and the V82F I84V double mutation) in the less-studied South African HIV type 1 subtype C (C-SA) protease indicated that neither mutation had a signific...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00726-08
更新日期:2008-11-01 00:00:00
abstract::Senecavirus A (SVA) is a picornavirus that causes acute vesicular disease (VD), that is clinically indistinguishable from foot-and-mouth disease (FMD), in pigs. Notably, SVA RNA has been detected in lymphoid tissues of infected animals several weeks following resolution of the clinical disease, suggesting that the vir...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00819-19
更新日期:2019-10-15 00:00:00
abstract::The inbred mouse strain RIII has long been known for shedding large amounts of mouse mammary tumor virus (MMTV) particles in milk and for the development of hormone-dependent early mammary tumors at a very high incidence (>90%). We have established one RIII subline (RIII/Sa) that shows a pattern of virus expression an...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.78.2.1055-1062.2004
更新日期:2004-01-01 00:00:00
abstract::The retinoblastoma tumor suppressor protein (pRb) can associate with the transforming proteins of several DNA tumor viruses, including the large T antigen encoded by polyomavirus (Py T Ag). Although pRb function is critical for regulating progression from G1 to S phase, a role for pRb in S phase has not been demonstra...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.4.3004-3013.1999
更新日期:1999-04-01 00:00:00
abstract::The transforming proteins of the small DNA tumor viruses, simian virus 40 (SV40), adenovirus, and human papillomavirus (HPV) target a number of identical cellular regulators whose functional abrogation is required for transformation. However, while both adenovirus E1A and SV40 large T transforming properties also depe...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.8.6209-6219.1999
更新日期:1999-08-01 00:00:00
abstract::Neurons of the sensory ganglia are the major site of varicella-zoster virus (VZV) latency and may undergo productive infection during reactivation. Although the VZV glycoprotein E/glycoprotein I (gE/gI) complex is known to be critical for neurovirulence, few studies have assessed the roles of these proteins during inf...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02293-13
更新日期:2013-12-01 00:00:00
abstract::Two hundred forty pyridazinamine derivatives were tested for the ability to stabilize the antigenicity and infectivity of oral poliovirus vaccine subjected to 45 degrees C for 2 h. Seven compounds stabilized the antigenicity of all three vaccine strains and neutralized the viral particles in a way that is reversible b...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.5.3397-3400.1994
更新日期:1994-05-01 00:00:00