Production of a monospecific antiserum against the early region 1A proteins of adenovirus 12 and adenovirus 5 by an adenovirus 12 early region 1A-beta-galactosidase fusion protein antigen expressed in bacteria.

abstract：:Herpes simplex virus 1 (HSV-1) capsids leave the nucleus by a process of envelopment and de-envelopment at the nuclear envelope (NE) that is accompanied by structural alterations of the NE. As capsids translocate across the NE, transient primary enveloped virions form in the perinuclear space. Here, we provide evidenc...

journal_title：Journal of virology

authors： Maric M,Shao J,Ryan RJ,Wong CS,Gonzalez-Alegre P,Roller RJ

更新日期：2011-10-01 00:00:00

abstract：:A polypeptide (p40) of approximately 40,000 molecular weight was isolated from herpes simplex virus type 1 and 2 nucleocapsids by gel filtration and ion exchange chromatography. This protein appears to be the same as protein 22a described previously (Gibson and Roizman, J. Virol. 10:1044--1052, 1972). Competition immu...

journal_title：Journal of virology

authors： Heilman CJ Jr,Zweig M,Stephenson JR,Hampar B

更新日期：1979-01-01 00:00:00

abstract：:The large (L) protein of Ebola virus is a key protein for virus replication. Its N-terminal region harbors the RNA-dependent RNA polymerase activity, and its C terminus contains a cap assembling line composed of a capping domain and a methyltransferase domain (MTase) followed by a C-terminal domain (CTD) of unknown fu...

journal_title：Journal of virology

authors： Valle C,Martin B,Debart F,Vasseur JJ,Imbert I,Canard B,Coutard B,Decroly E

更新日期：2020-06-01 00:00:00

abstract：:The terminal 500-base-pair alpha sequence of the herpes simplex virus 1 genome contains signals for cleavage (Pac1 and Pac2) of unit-length DNA molecules from concatemers in unique stretches of sequences designated Ub and Uc, respectively, and a cis site for cleavage designated DR1. We report that nuclear extracts fro...

journal_title：Journal of virology

authors： Chou J,Roizman B

更新日期：1989-03-01 00:00:00

abstract：:T-even bacteriophages were grown and purified in bulk quantities. The protein coats were disrupted into their component substructures by treatment with 67% dimethyl sulfoxide (DMSO). Tail fibers and tubes were purified on glycerol-CsCl-D(2)O gradients and examined with respect to sedimentation properties, subunit mole...

journal_title：Journal of virology

authors： Cummings DJ,Kusy AR,Chapman VA,DeLong SS,Stone KR

更新日期：1970-10-01 00:00:00

abstract：:The foot-and-mouth disease virus (FMDV) capsid protein precursor, P1-2A, is cleaved by 3C(pro) to generate VP0, VP3, VP1, and the peptide 2A. The capsid proteins self-assemble into empty capsid particles or viruses which do not contain 2A. In a cell culture-adapted strain of FMDV (O1 Manisa [Lindholm]), three differen...

journal_title：Journal of virology

authors： Gullberg M,Polacek C,Bøtner A,Belsham GJ

更新日期：2013-11-01 00:00:00

abstract：:Posttranslational modification-oligomerization, phosphorylation, and proteolytic cleavage-of the human papillomavirus (HPV) E4 protein occurs as the infected keratinocytes migrate up through the suprabasal wart layers. It has been postulated that these events modify E4 function during the virus life cycle. In HPV type...

journal_title：Journal of virology

authors： Knight GL,Grainger JR,Gallimore PH,Roberts S

更新日期：2004-12-01 00:00:00

abstract：UNLABELLED:Hepadnaviruses (hepatitis B viruses [HBVs]) are the only animal viruses that replicate their DNA by reverse transcription of an RNA intermediate. Until recently, the known host range of hepadnaviruses was limited to mammals and birds. We obtained and analyzed the first amphibian HBV genome, as well as severa...

journal_title：Journal of virology

authors： Dill JA,Camus AC,Leary JH,Di Giallonardo F,Holmes EC,Ng TF

更新日期：2016-08-12 00:00:00

abstract：:Immunosuppressed patients are at risk for developing Epstein-Barr Virus (EBV)-positive lymphomas that express the major EBV oncoprotein, LMP1. Although increasing evidence suggests that a small number of lytically infected cells may promote EBV-positive lymphomas, the impact of enhanced lytic gene expression on the ab...

journal_title：Journal of virology

authors： Ma SD,Yu X,Mertz JE,Gumperz JE,Reinheim E,Zhou Y,Tang W,Burlingham WJ,Gulley ML,Kenney SC

更新日期：2012-08-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) Nef interferes with the endocytic machinery to modulate the cell surface expression of CD4. However, the basal trafficking of CD4 is governed by different rules in the target cells of HIV-1: whereas CD4 is rapidly internalized from the cell surface in myeloid cells, CD4 is s...

journal_title：Journal of virology

authors： Laguette N,Brégnard C,Bouchet J,Benmerah A,Benichou S,Basmaciogullari S

更新日期：2009-07-01 00:00:00

abstract：:The UL3 protein of equine herpesvirus 1 (EHV-1) KyA strain is a homolog of the ICP27 alpha regulatory protein of herpes simplex virus type 1 (HSV-1) and the ORF 4 protein of varicella-zoster virus. To characterize the regulatory function of the UL3 gene product, a UL3 gene expression vector (pSVUL3) and a vector expre...

journal_title：Journal of virology

authors： Zhao Y,Holden VR,Smith RH,O'Callaghan DJ

更新日期：1995-05-01 00:00:00

abstract：:Echovirus 1 (EV1) is a human pathogen which belongs to the Picornaviridae family of RNA viruses. We have analyzed the early events of infection after EV1 binding to its receptor alpha 2 beta 1 integrin and elucidated the route by which EV1 gains access to the host cell. EV1 binding onto the cell surface and subsequent...

journal_title：Journal of virology

authors： Marjomäki V,Pietiäinen V,Matilainen H,Upla P,Ivaska J,Nissinen L,Reunanen H,Huttunen P,Hyypiä T,Heino J

更新日期：2002-02-01 00:00:00

abstract：:Hpt-13 is a Chinese hamster cell line deficient in hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) and sensitive to a medium containing 10(-4) M hypoxanthine, 5.5 X 10(-6) M aminopterin, and 10(-4) M thymidine. In this cell line there is a high incidence of cells resistant to this selective medium after an incubat...

journal_title：Journal of virology

authors： Marengo C,Mbikay M,Weber J,Thirion JP

更新日期：1981-04-01 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) is a common human pathogen that causes lifelong latent infection of sensory neurons. Non-nucleoside inhibitors that can limit HSV-1 recurrence are particularly useful in treating immunocompromised individuals or cases of emerging acyclovir-resistant strains of herpesvirus. We report that...

journal_title：Journal of virology

authors： Lin LT,Chen TY,Chung CY,Noyce RS,Grindley TB,McCormick C,Lin TC,Wang GH,Lin CC,Richardson CD

更新日期：2011-05-01 00:00:00

abstract：:Chinese hamster ovary (CHO) cells have recently been used for identification of receptors for several alphaherpesviruses, including pseudorabies virus (PrV) (R. J. Geraghty, C. Krummenacher, G. H. Cohen, R. J. Eisenberg, and P. G. Spear, Science 280:1618-1620, 1998). The experiments were based on the fact that CHO cel...

journal_title：Journal of virology

authors： Nixdorf R,Schmidt J,Karger A,Mettenleiter TC

更新日期：1999-10-01 00:00:00

abstract：:Many viruses have evolved mechanisms to evade the repression of translation mediated by protein kinase R (PKR). In the case of murine cytomegalovirus (MCMV), the protein products of two essential genes, m142 and m143, bind to double-stranded RNA (dsRNA) and block phosphorylation of PKR and eukaryotic initiation factor...

journal_title：Journal of virology

authors： Child SJ,Geballe AP

更新日期：2009-02-01 00:00:00

abstract：:White spot syndrome virus (WSSV) occurs worldwide and causes high mortality and considerable economic damage to the shrimp farming industry. No adequate treatments against this virus are available. It is generally accepted that invertebrates such as shrimp do not have an adaptive immune response system such as that pr...

journal_title：Journal of virology

authors： Witteveldt J,Cifuentes CC,Vlak JM,van Hulten MC

更新日期：2004-02-01 00:00:00

abstract：:We report several biological activities of a synthetic peptide whose sequence contains the highly conserved region of feline leukemia virus transmembrane protein (TM) synthetically linked to another short TM-derived sequence particularly rich in polar positive residues. This 29-amino-acid peptide blocked [3H]thymidine...

journal_title：Journal of virology

authors： Wegemer DE,Kabat KG,Kloetzer WS

更新日期：1990-04-01 00:00:00

abstract：:Recently, we showed that the Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) VP80 protein is essential for the formation of both virion types, budded virus (BV) and occlusion-derived virus (ODV). Deletion of the vp80 gene did not affect assembly of nucleocapsids. However, these nucleocapsids were not ...

journal_title：Journal of virology

authors： Marek M,Merten OW,Galibert L,Vlak JM,van Oers MM

更新日期：2011-06-01 00:00:00

abstract：:A soluble polymerase-template complex prepared from poliovirus-infected cells was found to incorporate radioactive UTP into trichloroacetic acid-insoluble RNA linearly for 8 h in the presence of ATP and Mg2+. Radioactive CTP or GTP was not incorporated under identical conditions. Nearest-neighbor analysis of the in vi...

journal_title：Journal of virology

authors： Yin FH

更新日期：1977-01-01 00:00:00

abstract：:Hydroxyurea, an inhibitor of ribonucleotide reductase, blocks replication of vaccinia virus. However, when medium containing hydroxyurea and dialyzed serum was supplemented with deoxyadenosine, the block to viral reproduction was circumvented, provided that an inhibitor of adenosine deaminase was also present. Deoxygu...

journal_title：Journal of virology

authors： Slabaugh MB,Howell ML,Wang Y,Mathews CK

更新日期：1991-05-01 00:00:00

abstract：:Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for chikungunya fever. Nonstructural protein 2 (nsP2), a multifunctional protein essential for viral replication, has an N-terminal helicase region (nsP2h), which as both nucleotide triphosphatase and RNA triphosphatase activities, as well as a C-ter...

journal_title：Journal of virology

authors： Law YS,Wang S,Tan YB,Shih O,Utt A,Goh WY,Lian BJ,Chen MW,Jeng US,Merits A,Luo D

更新日期：2020-12-16 00:00:00

abstract：:Cytolytic T-lymphocyte (CTL) activity specific for respiratory syncytial (RS) virus was investigated after intranasal infection of mice with RS virus, after intraperitoneal infection of mice with a recombinant vaccinia virus expressing the F glycoprotein, and after intramuscular vaccination of mice with Formalin-inact...

journal_title：Journal of virology

authors： Nicholas JA,Rubino KL,Levely ME,Adams EG,Collins PL

更新日期：1990-09-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) B capsids are composed of seven proteins, designated VP5, VP19C, 21, 22a, VP23, VP24, and VP26 in order of decreasing molecular weight. Three proteins (21, 22a, and VP24) are encoded by a single open reading frame (ORF), UL26, and include a protease whose structure and function have...

journal_title：Journal of virology

authors： Desai P,Watkins SC,Person S

更新日期：1994-09-01 00:00:00

abstract：:Human respiratory syncytial virus (HRSV) is the leading cause of serious pediatric acute respiratory tract infections, and a better understanding is needed of the host response to HRSV and its attenuated vaccine derivatives. It has been shown previously that HRSV nonstructural proteins 1 and 2 (NS1 and NS2) inhibit th...

journal_title：Journal of virology

authors： Spann KM,Tran KC,Collins PL

更新日期：2005-05-01 00:00:00

abstract：:Natural Killer (NK) cells are important in the immune response to a number of viruses; however, the mechanisms used by NK cells to discriminate between healthy and virus-infected cells are only beginning to be understood. Infection with vaccinia virus provokes a marked increase in the susceptibility of target cells to...

journal_title：Journal of virology

authors： Chisholm SE,Reyburn HT

更新日期：2006-03-01 00:00:00

abstract：:Nidoviruses (arteriviruses, coronaviruses, and roniviruses) are a phylogenetically compact but diverse group of positive-strand RNA viruses that includes important human and animal pathogens. Nidovirus RNA synthesis is mediated by a cytoplasmic membrane-associated replication/transcription complex that includes up to ...

journal_title：Journal of virology

authors： Nedialkova DD,Ulferts R,van den Born E,Lauber C,Gorbalenya AE,Ziebuhr J,Snijder EJ

更新日期：2009-06-01 00:00:00

abstract：:The ability of viruses to control and/or evade the host antiviral response is critical to the establishment of a productive infection. We have previously shown that West Nile virus NY (WNV-NY) delays activation of interferon regulatory factor 3 (IRF-3), a transcription factor critical to the initiation of the antivira...

journal_title：Journal of virology

authors： Fredericksen BL,Gale M Jr

更新日期：2006-03-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) is a 1,162-amino-acid protein that mediates episome persistence of viral genomes. LANA binds the KSHV terminal-repeat (TR) sequence through its carboxy-terminal domain to mediate DNA replication. LANA simultaneously binds mitotic ...

journal_title：Journal of virology

authors： Juillard F,De León Vázquez E,Tan M,Li S,Kaye KM

更新日期：2019-03-05 00:00:00

abstract：:The rate of transcription in isolated nuclei of primary mouse kidney cells increases by a factor of about 1.5 between 5 and 8 h after infection with polyoma virus or simian virus 40. This process requires intact virus and is inhibited by cycloheximide and actinomycin D. It appears to involve the activity of all three ...

journal_title：Journal of virology

authors： Pöckl E,Wintersberger E

更新日期：1980-07-01 00:00:00