Abstract:
:The rate of transcription in isolated nuclei of primary mouse kidney cells increases by a factor of about 1.5 between 5 and 8 h after infection with polyoma virus or simian virus 40. This process requires intact virus and is inhibited by cycloheximide and actinomycin D. It appears to involve the activity of all three nuclear RNA polymerases, and evidence was obtained for an increase in the rate of synthesis of most, if not all, species of RNA that were already produced in resting cells before infection. The additional synthesis of a few new RNA species not made in uninfected cells, however, cannot be excluded. The increase in the rate of transcription seems to precede an increase in the rate of translation in infected cells. Our additional finding that large and small tumor antigens (T-antigens) are synthesized at the same time after infection suggests that these cellular reactions are early consequences of the action of one or both of these T-antigens in the infected cell. Experiments with simian virus 40 mutants provided strong evidence for an involvement of large-T-antigen but not of small t-antigen. These studies furthermore indicate that the increase in the transcription rate is a prerequisite for the induction of DNA replication in simian virus 40-infected mouse kidney cells.
journal_name
J Viroljournal_title
Journal of virologyauthors
Pöckl E,Wintersberger Edoi
10.1128/JVI.35.1.8-19.1980subject
Has Abstractpub_date
1980-07-01 00:00:00pages
8-19issue
1eissn
0022-538Xissn
1098-5514journal_volume
35pub_type
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pub_type: 杂志文章
doi:10.1128/JVI.02639-07
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pub_type: 杂志文章
doi:10.1128/JVI.75.16.7384-7391.2001
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abstract:UNLABELLED:Testudinid herpesvirus 3 (TeHV-3) is the causative agent of a lethal disease affecting several tortoise species. The threat that this virus poses to endangered animals is focusing efforts on characterizing its properties, in order to enable the development of prophylactic methods. We have sequenced the genom...
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1128/JVI.22.3.608-618.1977
更新日期:1977-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.13.6.1254-1262.1974
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pub_type: 杂志文章
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更新日期:2003-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.69.9.5445-5454.1995
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.2.1236-1240.1992
更新日期:1992-02-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00170-07
更新日期:2007-07-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.12.7900-7908.1994
更新日期:1994-12-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.2.772-781.2001
更新日期:2001-01-01 00:00:00
abstract::The restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ovine TRIM5α effectively restricted the lentivirus visna/maedi virus DNA synthesis. Proteasome inhib...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00440-12
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journal_title:Journal of virology
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.3.1195-1202.1993
更新日期:1993-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2002-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2003-10-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.5.4475-4480.1999
更新日期:1999-05-01 00:00:00
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更新日期:2002-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1997-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.1.270-280.1999
更新日期:1999-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01867-07
更新日期:2008-03-01 00:00:00