Abstract:
:DNA sequence analysis has revealed that the gene coding for the human cytomegalovirus (HCMV) DNA polymerase is present within the long unique region of the virus genome. Identification is based on extensive amino acid homology between the predicted HCMV open reading frame HFLF2 and the DNA polymerase of herpes simplex virus type 1. We present here a 5280-base-pair DNA sequence containing the HCMV pol gene, along with the analysis of transcripts encoded within this region. Since HCMV pol also shows homology to the predicted Epstein-Barr virus pol, we were able to analyze the extent of homology between the DNA polymerases of three distantly related herpesviruses, HCMV, Epstein-Barr virus, and herpes simplex virus. The comparison shows that these DNA polymerases exhibit considerable amino acid homology and highlights a number of highly conserved regions; two such regions show homology to sequences within the adenovirus type 2 DNA polymerase. The HCMV pol gene is flanked by open reading frames with homology to those of other herpesviruses; upstream, there is a reading frame homologous to the glycoprotein B gene of herpes simplex virus type 1 and Epstein-Barr virus, and downstream there is a reading frame homologous to BFLF2 of Epstein-Barr virus.
journal_name
J Viroljournal_title
Journal of virologyauthors
Kouzarides T,Bankier AT,Satchwell SC,Weston K,Tomlinson P,Barrell BGdoi
10.1128/JVI.61.1.125-133.1987subject
Has Abstractpub_date
1987-01-01 00:00:00pages
125-33issue
1eissn
0022-538Xissn
1098-5514journal_volume
61pub_type
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journal_title:Journal of virology
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doi:10.1128/JVI.33.2.866-876.1980
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abstract::A cloned DNA copy of simian rotavirus SA11 genomic segment 10 was used to confirm the assignment of the nonstructural glycoprotein NCVP5 to this gene. Determination of the nucleotide sequence for gene 10 indicated that NCVP5 is 175 amino acids in length and has an N-terminal hydrophobic region with the characteristics...
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pub_type: 杂志文章
doi:10.1128/JVI.48.2.335-339.1983
更新日期:1983-11-01 00:00:00
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abstract::SERINC3 (serine incorporator 3) and SERINC5 are recently identified host cell inhibitors of HIV-1 particle infectivity that are counteracted by the viral pathogenesis factor Nef. Here we confirm that HIV-1 Nef, but not HIV-1 Vpu, antagonizes the particle infectivity restriction of SERINC5. SERINC5 antagonism occurred ...
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pub_type: 杂志文章
doi:10.1128/jvi.78.2.995-998.2004
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.55.1.60-66.1985
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pub_type: 杂志文章
doi:10.1128/JVI.63.9.3974-3982.1989
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00724-19
更新日期:2019-06-28 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01172-07
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pub_type: 杂志文章
doi:10.1128/JVI.01273-08
更新日期:2008-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-10-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01771-17
更新日期:2018-03-28 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00638-09
更新日期:2009-12-01 00:00:00
abstract::Infection of HeLa cells with adenovirus serotype 2 causes rearrangements in nuclear matrix morphology which can best be seen by gentle cell extraction and embedment-free section electron microscopy. We used these techniques to examine the nuclear matrices and cytoskeletons of cells at 6, 13, 28, and 44 h after infecti...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.61.4.1007-1018.1987
更新日期:1987-04-01 00:00:00
abstract:UNLABELLED:Noroviruses are the leading cause of acute gastroenteritis outbreaks worldwide. The majority of norovirus outbreaks are caused by genogroup II.4 (GII.4). Novel GII.4 strains emerge every 2 to 4 years and replace older variants as the dominant norovirus. Novel variants emerge through a combination of recombin...
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pub_type: 杂志文章
doi:10.1128/jvi.74.19.8876-8883.2000
更新日期:2000-10-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.10.6763-6766.1994
更新日期:1994-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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更新日期:2010-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2017-09-27 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02210-10
更新日期:2011-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01044-08
更新日期:2008-09-01 00:00:00
abstract:UNLABELLED:Type I IFN signaling, which is initiated through activation of the alpha interferon receptor (IFNAR), regulates the expression of proteins that are crucial contributors to immune responses. Paramyxoviruses, including human metapneumovirus (HMPV), have evolved mechanisms to inhibit IFNAR signaling, but the sp...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.03275-14
更新日期:2015-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.8.4722-4731.1993
更新日期:1993-08-01 00:00:00
abstract::Inhibition of hepatitis B virus (HBV) replication and viral clearance from an infected host requires both the innate and adaptive immune responses. Expression of interferon (IFN)-inducible proteasome catalytic and regulatory subunits correlates with the IFN-alpha/beta- and IFN-gamma-mediated noncytopathic inhibition o...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01779-06
更新日期:2007-01-01 00:00:00
abstract::The mechanism by which simian virus 40 converts the abortive adenovirus type 7 infection of monkey cells into an efficient lytic infection has been investigated. Analysis of ribonucleic acid (RNA) synthesis during unenhanced and enhanced infection of monkey cells has shown that adenovirus RNA synthesized in the aborti...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.10.2.220-227.1972
更新日期:1972-08-01 00:00:00
abstract:UNLABELLED:Human metapneumovirus (hMPV) is a respiratory paramyxovirus that is distributed worldwide and induces significant airway morbidity. Despite the relevance of hMPV as a pathogen, many aspects of the immune response to this virus are still largely unknown. In this report, we focus on the antiviral immune respon...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02897-14
更新日期:2015-01-01 00:00:00