Abstract:
:The mechanism by which simian virus 40 converts the abortive adenovirus type 7 infection of monkey cells into an efficient lytic infection has been investigated. Analysis of ribonucleic acid (RNA) synthesis during unenhanced and enhanced infection of monkey cells has shown that adenovirus RNA synthesized in the abortive infection contains both "early" and "late" sequences. In hybridization competition experiments, early adenovirus RNA from human cells prevented the hybridization of only 20% of the adenovirus RNA transcribed in unenhanced infection. Further, the RNA from unenhanced cells was able to completely block the hybridization of RNA synthesized during enhanced infection. Finally, virus-associated RNA, which is a late RNA transcribed in lytic adenovirus infection, is also produced in the unenhanced infection. An accompanying paper describes a marked deficiency in adenoviral capsid protein synthesis in the unenhanced infection. We conclude that RNA sequences, which are sufficient to code for the synthesis and assembly of structural proteins of adenovirus, are transcribed but are not efficiently translated in the unenhanced adenovirus infection of monkey cells.
journal_name
J Viroljournal_title
Journal of virologyauthors
Fox RI,Baum SGdoi
10.1128/JVI.10.2.220-227.1972subject
Has Abstractpub_date
1972-08-01 00:00:00pages
220-7issue
2eissn
0022-538Xissn
1098-5514journal_volume
10pub_type
杂志文章abstract::F111 rat cells transformed by simian virus 40 mutant tsA1499 are cold sensitive for the expression of transformation. Yet, unlike F111 cells transformed by tsA58, they do not lose the ability to stabilize the transformation-associated host cell protein p53 at the temperature at which transformation is extinguished. ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.49.3.997-1001.1984
更新日期:1984-03-01 00:00:00
abstract::Polymorphonuclear leukocytes (PMN) were studied for their ability to mediate cytotoxicity against varicella-zoster virus (VZV)-infected and uninfected human fibroblasts in 51Cr release assays. PMN were capable of mediating antibody-dependent cellular cytotoxicity (ADCC) against VZV-infected targets. Maximal ADCC was o...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.51.1.110-116.1984
更新日期:1984-07-01 00:00:00
abstract::Murine gammaherpesvirus 68 (gammaHV68; also known as MHV-68) can establish a latent infection in both inbred and outbred strains of mice and, as such, provides a tractable small-animal model to address mechanisms and cell types involved in the establishment and maintenance of chronic gammaherpesvirus infection. Latenc...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.15.8310-8321.2003
更新日期:2003-08-01 00:00:00
abstract::Reovirus virions are nonenveloped icosahedral particles consisting of two concentric protein shells, termed outer capsid and core. Outer-capsid protein sigma1 is the viral attachment protein and binds carbohydrate molecules on the surface of host cells. Monoclonal antibody (MAb) 4F2, which is specific for outer-capsid...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.14.6625-6634.2001
更新日期:2001-07-01 00:00:00
abstract::The HXLF (HindIII-X left reading frame) gene family is a group of five genes that share one or two regions of homology and are arranged in tandem within the short unique component of the human cytomegalovirus genome (K. Weston and B.G. Barrell, J. Mol. Biol. 192:177-208, 1986). These genes were cloned into an SP6 expr...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.62.6.1956-1962.1988
更新日期:1988-06-01 00:00:00
abstract::Gammaherpesviruses are ubiquitous pathogens that establish lifelong infections and are associated with a variety of malignancies, including lymphomas. Interferon regulatory factor 7 (IRF-7) is an innate immune transcription factor that restricts acute replication of diverse viruses, including murine gammaherpesvirus 6...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01554-20
更新日期:2020-11-23 00:00:00
abstract::The human foamy virus (HFV) contains within the U3 region of its long terminal repeat (LTR) three perfect consensus sequences for the binding of the inducible transcription factor AP-1. Results of DNase I footprint protection and gel retardation assays demonstrated that proteins in extracts of HeLa and BHK-21 cells as...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.11.6353-6357.1991
更新日期:1991-11-01 00:00:00
abstract::Antibody-dependent enhancement of flavivirus infection, which except for dengue virus is without clear proof in vivo, is still under debate. Recently, postexposure immunoglobulin prophylaxis against tick-borne encephalitis virus, a flavivirus, was claimed to possibly have worsened the outcome of infection due to antib...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.4.2921-2927.1997
更新日期:1997-04-01 00:00:00
abstract::Characterizations of genetic variations among hepatitis delta virus (HDV) isolates have focused principally on phylogenetic analysis of sequences, which vary by 30 to 40% among three genotypes and about 10 to 15% among isolates of the same genotype. The significance of the sequence differences has been unclear but cou...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.4.2806-2814.1998
更新日期:1998-04-01 00:00:00
abstract::The parameters governing the activity of the cloned T4 gene 23, which codes for the major T4 head protein, were analyzed. Suppressor-negative bacteria carrying wild-type T4 gene 23 cloned into plasmid pCR1 or pBR322 were infected with T4 gene 23 amber phage also carrying mutations in the following genes: (i) denA and ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.39.1.46-59.1981
更新日期:1981-07-01 00:00:00
abstract::Poliovirus-specific RNA-dependent RNA polymerase (3Dpol) was purified to apparent homogeneity. A single polypeptide of an apparent molecular weight of 63,000 catalyzes the synthesis of dimeric and monomeric RNA products in response to the poliovirion RNA template. Analysis of purified 3Dpol by two-dimensional electrop...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.11.4563-4568.1989
更新日期:1989-11-01 00:00:00
abstract:UNLABELLED:Due to a scarcity of immunocompetent animal models for viral hepatitis, little is known about the early innate immune responses in the liver. In various hepatotoxic models, both pro- and anti-inflammatory activities of recruited monocytes have been described. In this study, we compared the effect of liver in...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.03733-14
更新日期:2015-05-01 00:00:00
abstract::Adenovirus type 19 is a major cause of epidemic keratoconjunctivitis, the only ocular adenoviral infection associated with prolonged corneal inflammation. In this study, we investigated the role of phosphoinositide 3-kinase (PI3K) and Akt and their downstream targets in adenovirus infection, and here we report the nov...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.19.12332-12341.2005
更新日期:2005-10-01 00:00:00
abstract::The interaction of simian virus 40 (SV40) T antigen (T-ag) with the viral origin has served as a model for studies of site-specific recognition of a eukaryotic replication origin and the mechanism of DNA unwinding. These studies have revealed that a motif termed the "beta-hairpin" is necessary for assembly of T-ag on ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02451-06
更新日期:2007-05-01 00:00:00
abstract::Specific cleavage of BK virus (MM) DNA with restriction endonuclease MboI gives rise to 10 fragments. Two techniques were used to determine the location of these fragments on the viral genome with respect to the three known sites for HindIII cleavage. In the first method, reciprocal digestion, individual MboI fragment...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.27.3.700-712.1978
更新日期:1978-09-01 00:00:00
abstract::SF162 is a primary (PR), non-syncytium-inducing, macrophagetropic human immunodeficiency virus type 1 (HIV-1) clade B isolate which is resistant to antibody-mediated neutralization. Deletion of the first or second hypervariable envelope gp120 region (V1 or V2 loop, respectively) of this virus does not abrogate its abi...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.10.7840-7845.1998
更新日期:1998-10-01 00:00:00
abstract::Epstein-Barr virus (EBV) is a human herpesvirus capable of establishing a latent state in B lymphocytes. EBV's BZLF1 gene product plays a central role in regulating the switch from latency to productive infection. Here, we identify a sequence element, 5'-CAGGTA-3', called ZV, located at nucleotides -17 to -12 relative...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.2.867-877.2001
更新日期:2001-01-01 00:00:00
abstract::The biological and genetic characteristics of murine leukemia viruses (MuLV) derived from leukemic and normal HRS/J mice were studied. T1-oligonucleotide fingerprinting and mapping of viral RNAs from unpassaged isolates revealed the presence of complex mixtures of viral genomes. MuLV that were purified by endpoint dil...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.50.2.397-407.1984
更新日期:1984-05-01 00:00:00
abstract::We have previously shown that delivery of the porcine type I interferon gene (poIFN-α/β) with a replication-defective human adenovirus vector (adenovirus 5 [Ad5]) can sterilely protect swine challenged with foot-and-mouth disease virus (FMDV) 1 day later. However, the need of relatively high doses of Ad5 limits the ap...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.03462-12
更新日期:2013-05-01 00:00:00
abstract::Many viruses induce type I interferon responses by activating cytoplasmic RNA sensors, including the RIG-I-like receptors (RLRs). Although two members of the RLR family, RIG-I and MDA5, have been implicated in host control of virus infection, the relative role of each RLR in restricting pathogenesis in vivo remains un...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01403-13
更新日期:2013-11-01 00:00:00
abstract::The mechanism of lysis by in vivo-induced cytotoxic T lymphocytes (CTL) was examined with virus-specific CTL from mice infected with lymphocytic choriomeningitis virus (LCMV). LCMV-induced T cells were shown to have greater than 10 times the serine esterase activity of T cells from normal mice, and high levels of seri...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.8.3726-3733.1990
更新日期:1990-08-01 00:00:00
abstract::Three drug-dependent mutants of human rhinovirus 16 (HRV16) were characterized by sequence analyses of spontaneous mutant isolates and were genetically reconstructed from a parental cDNA plasmid. These mutants formed plaques in the presence but not in the absence of the selecting antiviral drug, WIN 52035, which binds...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.2.1210-1218.1998
更新日期:1998-02-01 00:00:00
abstract::In Escherichia coli B infected with phage T4 with mutations in gene 55 the shut-off of synthesis of two early enzymes was found to be delayed 10 to 15 min as compared to wild-type T4 infection. The kinetics of early enzyme formation was very similar to that obtained after DNA-negative mutant infection. The transcripti...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.12.1.49-57.1973
更新日期:1973-07-01 00:00:00
abstract:UNLABELLED:Multiple cellular pathways are regulated by small ubiquitin-like modifier (SUMO) modification, including ubiquitin-mediated proteolysis, signal transduction, innate immunity, and antiviral defense. In the study described in this report, we investigated the effects of SUMO on the replication of two members of...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00722-16
更新日期:2016-06-24 00:00:00
abstract::A specific endoribonucleolytic activity was detected when detergent-lysed vesicular stomatitis of Sendai virus was incubated with the precursor to Escherichia coli tRNA Tyr. The cleavage products produced and the characteristics of the reaction were similar to those previously reported for human KB cell RNase NU. Like...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.25.1.274-284.1978
更新日期:1978-01-01 00:00:00
abstract::Retroviral Gag proteins have the ability to induce budding and particle release from the plasma membrane when expressed in the absence of all of the other virus-encoded components; however, the locations of the functional domains within the Gag protein that are important for this process are poorly understood. It was ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.9.5550-5561.1993
更新日期:1993-09-01 00:00:00
abstract::The E4orf6 protein of group C adenovirus is an oncoprotein that, in association with the E1B 55-kDa protein and by E1B-independent means, promotes virus replication. An arginine-faced amphipathic alpha-helix in the E4orf6 protein is required for the E4orf6 protein to direct nuclear localization of the E1B 55-kDa prote...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.3.1475-1487.2002
更新日期:2002-02-01 00:00:00
abstract::The abilities to infect and transmit efficiently among humans are essential for a novel influenza A virus to cause a pandemic. To evaluate the pandemic potential of widely disseminated H5N1 influenza viruses, a ferret contact model using experimental groups comprised of one inoculated ferret and two contact ferrets wa...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00170-07
更新日期:2007-07-01 00:00:00
abstract::Nonenveloped viruses often invade membranes by exposing hydrophobic or amphipathic peptides generated by a proteolytic maturation step that leaves a lytic peptide noncovalently associated with the viral capsid. Since multiple copies of the same protein form many nonenveloped virus capsids, it is unclear if lytic pepti...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01089-12
更新日期:2012-09-01 00:00:00
abstract::We have examined the influence of the V1/V2 region of the human immunodeficiency virus type 1 (HIV-1) gp120 on certain biologic properties of the virus. We observed that on the genomic background of the T-cell-line-tropic strain, HIV-1SF2mc, both the V1 and V2 domains of the macrophage-tropic strain, HIV-1SF162mc, in ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.4.2253-2259.1994
更新日期:1994-04-01 00:00:00