Human polymorphonuclear leukocyte-mediated cytotoxicity against varicella-zoster virus-infected fibroblasts.

abstract：:The virus-encoded proteins of tobacco etch virus (TEV), a plant potyvirus, arise by proteolytic processing of a large polyprotein precursor. The TEV genome codes for two proteinases, a 49-kilodalton proteinase and helper component proteinase (HC-Pro), which cleave the polyprotein at specific sites. The only known clea...

journal_title：Journal of virology

authors： Carrington JC,Freed DD,Sanders TC

更新日期：1989-10-01 00:00:00

abstract：:Presumably due to the capability of the hepatitis C virus (HCV) to evade the antiviral effects of alpha interferon, treatment is ineffective in more than half of chronically genotype HCV type 1 (HCV-1)-infected patients. Previous approaches to correlate the number of amino acid mutations within regions of HCV nonstruc...

journal_title：Journal of virology

authors： Sarrazin C,Herrmann E,Bruch K,Zeuzem S

更新日期：2002-11-01 00:00:00

abstract：:Our ability to rapidly respond to an emerging influenza pandemic is hampered somewhat by the lack of a susceptible small-animal model. To develop a more sensitive model, we pathotyped 18 low-pathogenic non-mouse-adapted influenza A viruses of human and avian origin in DBA/2 and C57BL/6 mice. The majority of the isolat...

journal_title：Journal of virology

authors： Boon AC,deBeauchamp J,Krauss S,Rubrum A,Webb AD,Webster RG,McElhaney J,Webby RJ

更新日期：2010-08-01 00:00:00

abstract：:Infection with human papillomavirus (HPV) is a critical factor in the pathogenesis of most cervical cancers and some aerodigestive cancers. The HPV E6 oncoprotein from high-risk HPV types contributes to the immortalization and transformation of cells by multiple mechanisms, including degradation of p53, transcriptiona...

journal_title：Journal of virology

authors： James MA,Lee JH,Klingelhutz AJ

更新日期：2006-06-01 00:00:00

abstract：UNLABELLED:Virions vary in size by at least 4 orders of magnitude, yet the evolutionary forces responsible for this enormous diversity are unknown. We document a significant allometric relationship, with an exponent of approximately 1.5, between the genome length and virion volume of viruses and find that this relation...

journal_title：Journal of virology

authors： Cui J,Schlub TE,Holmes EC

更新日期：2014-06-01 00:00:00

abstract：:To investigate E7-dependent biochemical changes which are involved in cellular transformation, we analyzed the influence of human papillomavirus type 16 (HPV-16) E7 on the expression of cell cycle regulatory proteins. Expression of E7 in established rodent fibroblasts (NIH 3T3), which was shown to be sufficient for tr...

journal_title：Journal of virology

authors： Zerfass K,Schulze A,Spitkovsky D,Friedman V,Henglein B,Jansen-Dürr P

更新日期：1995-10-01 00:00:00

abstract：:The route of internalization of the pestivirus bovine viral diarrhea virus (BVDV) was studied by using different chemical and biophysical inhibitors of endocytosis. Expression of the dominant-negative mutant Dyn(K44A) of the GTPase dynamin in MDBK cells, as well as the treatment of the cells with chlorpromazine and be...

journal_title：Journal of virology

authors： Krey T,Thiel HJ,Rümenapf T

更新日期：2005-04-01 00:00:00

abstract：:The HIV-1 spike is composed of three protomeric units, each containing a peripheral gp120 and a transmembrane gp41 subunit. Binding to the CD4 and the chemokine receptors triggers them to mediate virus entry into cells by membrane fusion. The spikes also represent the major target for neutralizing antibodies (Abs) aga...

journal_title：Journal of virology

authors： Löving R,Sjöberg M,Wu SR,Binley JM,Garoff H

更新日期：2013-06-01 00:00:00

abstract：:For viruses with segmented genomes, genetic diversity is generated by genetic drift, reassortment, and recombination. Recombination produces RNA populations distinct from full-length gene segments and can influence viral population dynamics, persistence, and host immune responses. Viruses in the Reoviridae family, inc...

journal_title：Journal of virology

authors： Smith SC,Gribble J,Diller JR,Wiebe MA,Thoner TW Jr,Denison MR,Ogden KM

更新日期：2021-01-20 00:00:00

abstract：:We used a transfected L cell and a vaccinia vector carrying the herpes simplex virus type 1 (HSV-1) gene coding for glycoprotein D (gD) to characterize HSV-specific T-cell responses. Various studies with mice revealed that the vectors could stimulate some HSV-specific T-cell responses. Although the majority of the T c...

journal_title：Journal of virology

authors： Martin S,Moss B,Berman PW,Laskey LA,Rouse BT

更新日期：1987-03-01 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) is a common human pathogen that causes lifelong latent infection of sensory neurons. Non-nucleoside inhibitors that can limit HSV-1 recurrence are particularly useful in treating immunocompromised individuals or cases of emerging acyclovir-resistant strains of herpesvirus. We report that...

journal_title：Journal of virology

authors： Lin LT,Chen TY,Chung CY,Noyce RS,Grindley TB,McCormick C,Lin TC,Wang GH,Lin CC,Richardson CD

更新日期：2011-05-01 00:00:00

abstract：:While RNA silencing is a potent antiviral defense in plants, well-adapted plant viruses are known to encode suppressors of RNA silencing (VSR) that can neutralize the effectiveness of RNA silencing. As a result, most plant genes involved in antiviral silencing were identified by using debilitated viruses lacking silen...

journal_title：Journal of virology

authors： Zhang X,Zhang X,Singh J,Li D,Qu F

更新日期：2012-06-01 00:00:00

abstract：:Infectious bursal disease virus (IBDV) is a nonenveloped virus with an icosahedral capsid composed of two proteins, VP2 and VP3, that derive from the processing of the polyprotein NH(2)-pVP2-VP4-VP3-COOH. The virion contains VP1, the viral polymerase, which is both free and covalently linked to the two double-stranded...

journal_title：Journal of virology

authors： Chevalier C,Lepault J,Da Costa B,Delmas B

更新日期：2004-04-01 00:00:00

abstract：:To study fundamental aspects of RNA recombination, an in vivo RNA recombination system was established. This system allowed the efficient generation of recombinant cytopathogenic pestiviruses after transfection of synthetic, nonreplicatable, subgenomic transcripts in cells infected with a replicating noncytopathogenic...

journal_title：Journal of virology

authors： Gallei A,Pankraz A,Thiel HJ,Becher P

更新日期：2004-06-01 00:00:00

abstract：:A cloned DNA copy of simian rotavirus SA11 genomic segment 10 was used to confirm the assignment of the nonstructural glycoprotein NCVP5 to this gene. Determination of the nucleotide sequence for gene 10 indicated that NCVP5 is 175 amino acids in length and has an N-terminal hydrophobic region with the characteristics...

journal_title：Journal of virology

authors： Both GW,Siegman LJ,Bellamy AR,Atkinson PH

更新日期：1983-11-01 00:00:00

abstract：:A new temperate bacteriophage, rho11, isolated by J. Hoch, has been characterized. This new phage is very similar to the temperate phage phi3T in size (380 nm), host range, homoimmunity, DNA buoyant density (1.694 g/ml), antigenicity, and molecular weight (around 6.0 X 10(7)) as determined in gels. Like phi3T, rho11 c...

journal_title：Journal of virology

authors： Dean DH,Orrego JC,Hutchison KW,Halvorson HO

更新日期：1976-11-01 00:00:00

abstract：:Fluorosulfonylbenzoyl 5'-adenosine (FSBA) bound to one site in simian virus 40 large T antigen (T) and covalently modified greater than 95% of the molecules in a complete reaction. This analog for ATP specifically cross-links to the Mg-phosphate pocket in ATP-binding sites. Cyanogen bromide cleavage and tryptic digest...

journal_title：Journal of virology

authors： Bradley MK

更新日期：1990-10-01 00:00:00

abstract：:Phosphorylation of the expressed NS5A protein of hepatitis C virus (HCV), a member of the Hepacivirus genus of the family Flaviviridae, has been demonstrated in mammalian cells and in a cell-free assay by an associated kinase activity. In this report, phosphorylation is also shown for the NS5A and NS5 proteins, respec...

journal_title：Journal of virology

authors： Reed KE,Gorbalenya AE,Rice CM

更新日期：1998-07-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) exists as a complex population of multiple genotypic variants in persons with chronic infection. However, acute HIV-1 infection via sexual transmission is a low-probability event in which there is thought to be low genetic complexity in the initial inoculum. In order to asse...

journal_title：Journal of virology

authors： Ritola K,Pilcher CD,Fiscus SA,Hoffman NG,Nelson JA,Kitrinos KM,Hicks CB,Eron JJ Jr,Swanstrom R

更新日期：2004-10-01 00:00:00

abstract：:The Chinese hamster cell lines E36 and CHOK1 dramatically differ in susceptibility to amphotropic murine leukemia virus (A-MuLV) and gibbon ape leukemia virus (GALV); E36 cells are highly susceptible to both viruses, CHOK1 cells are not. We have previously shown that GALV can infect E36 cells by using both its own rec...

journal_title：Journal of virology

authors： Chaudry GJ,Farrell KB,Ting YT,Schmitz C,Lie SY,Petropoulos CJ,Eiden MV

更新日期：1999-04-01 00:00:00

abstract：:Ribonucleic acid extracted from the virions of two human rhinoviruses is infective and is similar in size to poliovirus ribonucleic acid. ...

journal_title：Journal of virology

authors： Nair CN,Lonberg-Holm KK

更新日期：1971-02-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) latently infects KS tumors, primary effusion lymphomas (PELs), and PEL cell lines. K12 (T0.7) is the most abundant transcript expressed in latent KSHV infection. We characterize here the K12 transcript from a PEL tumor prior to passage in cell culture. The PEL tumor KSHV ...

journal_title：Journal of virology

authors： Li H,Komatsu T,Dezube BJ,Kaye KM

更新日期：2002-12-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) alpha protein ICP27 regulates the transition between the delayed-early and late phases of the viral infection. Previous genetic analyses have suggested that the important functional domains of ICP27 map to its carboxyl-terminal half. One striking feature of the primary sequence ...

journal_title：Journal of virology

authors： Rice SA,Lam V,Knipe DM

更新日期：1993-04-01 00:00:00

abstract：:When human A431 cells, which carry high numbers of epidermal growth factor (EGF) receptors, are exposed to EGF, the total content of phosphotyrosine in cell protein is increased, the EGF receptor becomes phosphorylated at tyrosine, and new phosphotyrosine-containing 36,000- and 81,000-dalton proteins are detected. We ...

journal_title：Journal of virology

authors： Cooper JA,Scolnick EM,Ozanne B,Hunter T

更新日期：1983-12-01 00:00:00

abstract：:The influenza virus NS1 protein inhibits the nuclear export of a spliced viral mRNA, NS2 mRNA (F. V. Alonso-Caplen, M. E. Nemeroff, Y. Qiu, and R. M. Krug, Genes Dev. 6:255-267, 1992). To identify the sequence in NS2 mRNA that is recognized by the NS1 protein, we developed a gel shift assay for the formation of specif...

journal_title：Journal of virology

authors： Qiu Y,Krug RM

更新日期：1994-04-01 00:00:00

abstract：:Hepatitis C virus (HCV) is an important human pathogen affecting an estimated 3% of the world's population. Recent advances have enabled in vitro propagation of the virus and allow assembly and egress to be investigated for the first time. As a component of the virion, the HCV core protein likely functions primarily i...

journal_title：Journal of virology

authors： Murray CL,Jones CT,Tassello J,Rice CM

更新日期：2007-10-01 00:00:00

abstract：:Walleye dermal sarcoma virus (WDSV) is a complex retrovirus associated with dermal sarcomas in walleye fish. A WDSV accessory gene encodes a cyclin homolog or retroviral cyclin (rv-cyclin). WDSV rv-cyclin was found to be associated with transcription complexes and to affect transcription in a cell-type and promoter-de...

journal_title：Journal of virology

authors： Rovnak J,Quackenbush SL

更新日期：2006-12-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) infection results in the disruption of ND10 (also called nuclear bodies, PODs, or PML-associated bodies), which are nuclear matrix domains of unknown function present in mammalian cells. After ND10 disruption, viral transcription and DNA replication occur in globular nuclear domains...

journal_title：Journal of virology

authors： Burkham J,Coen DM,Weller SK

更新日期：1998-12-01 00:00:00

abstract：:Previous studies with simian virus 40-transformed mouse 3T3 cells which are temperature sensitive for the expression of the transformed phenotype (ts SV3T3 cells) have shown that T-antigen expression and viral DNA transcription are under cell cycle control. Using these ts SV3T3 cells, we studied the expression of the ...

journal_title：Journal of virology

authors： Zouzias D,Basilico C

更新日期：1979-06-01 00:00:00

abstract：:The endogenous transcriptase present in purified vesicular stomatitis (VS) virions was solubilized with a Triton X-100 high-salt solution. The polymerase activity was purified on glycerol gradients and by phosphocellulose column chromatography; the viral proteins present in the active enzyme fractions were identified ...

journal_title：Journal of virology

authors： Emerson SU,Wagner RR

更新日期：1973-12-01 00:00:00