RNA recombination in vivo in the absence of viral replication.

abstract：:Hemorrhage is a common clinical manifestation in dengue patients. However, the pathogenic mechanism of dengue virus (DV)-induced hemorrhage awaits clarification. We established a mouse model of DV hemorrhage using immunocompetent C57BL/6 mice by injecting DV serotype 2 strain 16681 intradermally. While inoculation of ...

journal_title：Journal of virology

authors： Chen HC,Hofman FM,Kung JT,Lin YD,Wu-Hsieh BA

更新日期：2007-06-01 00:00:00

abstract：:Utilization of internal ribosome entry segment (IRES) structures in the 5' noncoding region (5'NCR) of picornavirus RNAs for initiation of translation requires a number of host cell factors whose distribution may vary in different cells and whose requirement may vary for different picornaviruses. We have examined the ...

journal_title：Journal of virology

authors： Graff J,Cha J,Blyn LB,Ehrenfeld E

更新日期：1998-12-01 00:00:00

abstract：:Herpes simplex virus 1 genome consists of two covalently linked components, L and S, that invert relative to each other to yield four equimolar isomeric populations designated P (prototype), Is (inversion of S component), Il (inversion of L component), and Ils (inversion of L and S components) differing in the orienta...

journal_title：Journal of virology

authors： Jenkins FJ,Roizman B

更新日期：1986-08-01 00:00:00

abstract：:Generating durable humoral immunity through vaccination depends upon effective interactions of follicular helper T (Tfh) cells with germinal center (GC) B cells. Th1 polarization of Tfh cells is an important process shaping the success of Tfh-GC B cell interactions by influencing costimulatory and cytokine-dependent T...

journal_title：Journal of virology

authors： Verma A,Schmidt BA,Elizaldi SR,Nguyen NK,Walter KA,Beck Z,Trinh HV,Dinasarapu AR,Lakshmanappa YS,Rane NN,Matyas GR,Rao M,Shen X,Tomaras GD,LaBranche CC,Reimann KA,Foehl DH,Gach JS,Forthal DN,Kozlowski PA,Amara RR

更新日期：2020-02-28 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) and HSV-2 are large, double-stranded DNA viruses that cause lifelong persistent infections characterized by periods of quiescence and recurrent disease. How HSV evolves within an infected individual experiencing multiple episodes of recurrent disease over time is not known. We determined...

journal_title：Journal of virology

authors： Minaya MA,Jensen TL,Goll JB,Korom M,Datla SH,Belshe RB,Morrison LA

更新日期：2017-11-14 00:00:00

abstract：:Synthetic peptides containing portions of a highly conserved region of retroviral transmembrane proteins of human and animal retroviruses were tested for their ability to inhibit lymphoproliferation to determine the minimum amino acid sequence required. The previously reported immunosuppression mediated by the peptide...

journal_title：Journal of virology

authors： Ruegg CL,Monell CR,Strand M

更新日期：1989-08-01 00:00:00

abstract：:Mutations critical for the central nervous system (CNS) attenuation of the Sabin vaccine strains of poliovirus (PV) are located within the viral internal ribosome entry site (IRES). We examined the interaction of the IRESs of PV type 3 (PV3) and Sabin type 3 (Sabin3) with polypyrimidine tract-binding protein (PTB) and...

journal_title：Journal of virology

authors： Guest S,Pilipenko E,Sharma K,Chumakov K,Roos RP

更新日期：2004-10-01 00:00:00

abstract：:A virulent porcine epidemic diarrhea virus (PEDV) strain, DR13, was obtained from suckling pigs suspected of having porcine epidemic diarrhea in 1999 in Korea, and its attenuated counterpart was derived from virulent strain DR13 by serial propagation in Vero cells. This report describes the first complete genome seque...

journal_title：Journal of virology

authors： Park SJ,Kim HK,Song DS,An DJ,Park BK

更新日期：2012-05-01 00:00:00

abstract：:Viral recombination has been postulated to play two roles in the development of human immunodeficiency virus (HIV) resistance to antiretroviral drugs. First, recombination has the capacity to associate resistance mutations expressed by distinct viruses, thereby contributing to the development of viruses with improved ...

journal_title：Journal of virology

authors： Nora T,Charpentier C,Tenaillon O,Hoede C,Clavel F,Hance AJ

更新日期：2007-07-01 00:00:00

abstract：:A cyanophage, PaV-LD, has been isolated from harmful filamentous cyanobacterium Planktothrix agardhii in Lake Donghu, a shallow freshwater lake in China. Here, we present the cyanophage's genomic organization and major structural proteins. The genome is a 95,299-bp-long, linear double-stranded DNA and contains 142 pot...

journal_title：Journal of virology

authors： Gao EB,Gui JF,Zhang QY

更新日期：2012-01-01 00:00:00

abstract：:DNA sequence analysis has revealed that the gene coding for the human cytomegalovirus (HCMV) DNA polymerase is present within the long unique region of the virus genome. Identification is based on extensive amino acid homology between the predicted HCMV open reading frame HFLF2 and the DNA polymerase of herpes simplex...

journal_title：Journal of virology

authors： Kouzarides T,Bankier AT,Satchwell SC,Weston K,Tomlinson P,Barrell BG

更新日期：1987-01-01 00:00:00

abstract：:RNA-dependent protein kinase PKR is an important regulator of gene expression in interferon (IFN)-treated and virus-infected cells. The 50-kb gene encoding human PKR kinase (pkr) is inducible by IFN. Transfection analyses, using chloramphenicol acetyltransferase (CAT) as the reporter in constructs possessing various 5...

journal_title：Journal of virology

authors： Kuhen KL,Vessey JW,Samuel CE

更新日期：1998-12-01 00:00:00

abstract：:Growth of phage phi105 and its deoxyribonucleic acid (DNA) was studied in radiation-sensitive mutants of Bacillus subtilis. The recA gene is required for optimal prophage induction with mitomycin C and for infectivity of prophage DNA. rec B gene is required for marker rescue from mature DNA. The importance of bacteria...

journal_title：Journal of virology

authors： Rutberg B,Rutberg L

更新日期：1971-12-01 00:00:00

abstract：:Comparative surface feature analyses of the VP1 sequences of hepatitis A virus (HAV) and poliovirus type 1 allowed an alignment of the two sequences and an identification of probable HAV neutralization antigenic sites. A synthetic peptide containing the HAV-specific amino acid sequence of one of these sites induced an...

journal_title：Journal of virology

authors： Emini EA,Hughes JV,Perlow DS,Boger J

更新日期：1985-09-01 00:00:00

abstract：:We showed previously that retrovirus vector particles can encapsidate RNAs without retroviral cis-acting sequences, that such RNAs are reverse transcribed in infected target cells, and that the cDNA copies are inserted into the host genome resulting in cDNA genes (R. Dornburg and H. M. Temin, Mol. Cell. Biol. 8:2328-2...

journal_title：Journal of virology

authors： Dornburg R,Temin HM

更新日期：1990-02-01 00:00:00

abstract：:In gene therapy, the innate immune system is a significant barrier to the effective application of adenovirus (Ad) vectors. In kidney epithelium-derived (REC) cells, serotype 5 Ad vectors induce the expression of the chemokine CXCL10 (IP-10), a response that is dependent on NFkappaB. Compared to the parental vector Ad...

journal_title：Journal of virology

authors： Liu Q,White LR,Clark SA,Heffner DJ,Winston BW,Tibbles LA,Muruve DA

更新日期：2005-12-01 00:00:00

abstract：:Treatment of [3H]glucosamine-labeled Friend mink cell focus-forming virus (FrMCF) gp70 with excess peptide:N-glycanase F (PNGase F) resulted in removal of the expected seven N-linked oligosaccharide chains; however, approximately 10% of the glucosamine label was retained in the resulting 49,000-Mr (49K) product. For [...

journal_title：Journal of virology

authors： Pinter A,Honnen WJ

更新日期：1988-03-01 00:00:00

abstract：:Glycans on human immunodeficiency virus (HIV) envelope protein play an important role in infection and evasion from host immune responses. To examine the role of specific glycans, we introduced single or multiple mutations into potential N-linked glycosylation sites in hypervariable regions (V1 to V3) of the env gene ...

journal_title：Journal of virology

authors： Li Y,Cleveland B,Klots I,Travis B,Richardson BA,Anderson D,Montefiori D,Polacino P,Hu SL

更新日期：2008-01-01 00:00:00

abstract：:Extracts made from human respiratory syncytial virus (RSV)-infected Hep-2 cells synthesized mRNAs encoded by all known viral genes. In contrast, RSV ribonucleoproteins purified from infected cells failed to transcribe in vitro; transcription was restored by addition of a cytoplasmic extract of uninfected Hep-2 cells, ...

journal_title：Journal of virology

authors： Barik S

更新日期：1992-11-01 00:00:00

abstract：:A cloned DNA copy of simian rotavirus SA11 genomic segment 10 was used to confirm the assignment of the nonstructural glycoprotein NCVP5 to this gene. Determination of the nucleotide sequence for gene 10 indicated that NCVP5 is 175 amino acids in length and has an N-terminal hydrophobic region with the characteristics...

journal_title：Journal of virology

authors： Both GW,Siegman LJ,Bellamy AR,Atkinson PH

更新日期：1983-11-01 00:00:00

abstract：:Fluorosulfonylbenzoyl 5'-adenosine (FSBA) bound to one site in simian virus 40 large T antigen (T) and covalently modified greater than 95% of the molecules in a complete reaction. This analog for ATP specifically cross-links to the Mg-phosphate pocket in ATP-binding sites. Cyanogen bromide cleavage and tryptic digest...

journal_title：Journal of virology

authors： Bradley MK

更新日期：1990-10-01 00:00:00

abstract：:Initiation of the Epstein-Barr virus (EBV) lytic cycle is dependent on expression of the viral transactivator Zta, which is encoded by the BZLF1 gene. Described here is an initial mapping of the regions of Zta involved in activating transcription. The data indicate that the amino-terminal 153 amino acids of Zta are im...

journal_title：Journal of virology

authors： Flemington EK,Borras AM,Lytle JP,Speck SH

更新日期：1992-02-01 00:00:00

abstract：:The development of a reproducible model system for the study of hepatitis C virus (HCV) infection has the potential to significantly enhance the study of virus-host interactions and provide future direction for modeling the pathogenesis of HCV. While there are studies describing global gene expression changes associat...

journal_title：Journal of virology

authors： Jacobs JM,Diamond DL,Chan EY,Gritsenko MA,Qian W,Stastna M,Baas T,Camp DG 2nd,Carithers RL Jr,Smith RD,Katze MG

更新日期：2005-06-01 00:00:00

abstract：:We report the isolation and propagation of human papillomavirus type 16, the main agent of cervical cancer, using human foreskin fragments implanted in severe combined immunodeficiency mice. The infection produced viral particles, and with each passage of the virus it caused lesions identical to intraepithelial neopla...

journal_title：Journal of virology

authors： Bonnez W,DaRin C,Borkhuis C,de Mesy Jensen K,Reichman RC,Rose RC

更新日期：1998-06-01 00:00:00

abstract：:Influenza A virus matrix protein M1 is involved in multiple stages of the viral infectious cycle. Despite its functional importance, our present understanding of this essential viral protein is limited. The roles of a small subset of specific amino acids have been reported, but a more comprehensive understanding of th...

journal_title：Journal of virology

authors： Hom N,Gentles L,Bloom JD,Lee KK

更新日期：2019-06-14 00:00:00

abstract：:Walleye dermal sarcoma virus (WDSV) is a complex retrovirus associated with dermal sarcomas in walleye fish. A WDSV accessory gene encodes a cyclin homolog or retroviral cyclin (rv-cyclin). WDSV rv-cyclin was found to be associated with transcription complexes and to affect transcription in a cell-type and promoter-de...

journal_title：Journal of virology

authors： Rovnak J,Quackenbush SL

更新日期：2006-12-01 00:00:00

abstract：:The envelope glycoproteins of the human immunodeficiency virus (HIV) type 1 are synthesized as a precursor molecule, gp160, which is cleaved to generate the two mature envelope glycoproteins, gp120 and gp41. The cleavage reaction, which is mediated by a host protease, occurs at a sequence highly conserved in retrovira...

journal_title：Journal of virology

authors： Freed EO,Myers DJ,Risser R

更新日期：1989-11-01 00:00:00

abstract：:L2 cells infected with vesicular stomatitis virus under single-cycle conditions have been studied by scanning electron microscopy after preparation by the critical point drying technique. Three dimensional images of intact cells show bullet-shaped vesicular stomatitis virus virions budding singly and in radiating clus...

journal_title：Journal of virology

authors： Holmes KV

更新日期：1975-02-01 00:00:00

abstract：:Individuals infected with the human immunodeficiency virus (HIV) experience a marked loss of CD4+ T lymphocytes, leading to fatal immunodeficiency. The mechanisms causing the depletion of these cells are not yet understood. In this study, we observed that CD4+ T lymphocytes from HIV type 1 (HIV-1)-infected and uninfec...

journal_title：Journal of virology

authors： Heinkelein M,Sopper S,Jassoy C

更新日期：1995-11-01 00:00:00

abstract：:Mouse virus-like 30S RNAs (VL30m) constitute a family of retrotransposons, present at 100 to 200 copies, dispersed in the mouse genome. They display little sequence homology to Moloney murine leukemia virus (MoMLV), do not encode virus-like proteins, and have not been implicated in retroviral carcinogenesis. However, ...

journal_title：Journal of virology

authors： López-Lastra M,Ulrici S,Gabus C,Darlix JL

更新日期：1999-10-01 00:00:00