Identification of an internal ribosome entry segment in the 5' region of the mouse VL30 retrotransposon and its use in the development of retroviral vectors.

abstract：:Chronic hepatitis C virus (HCV) infection is frequently associated with extrahepatic manifestations, including nonmalignant and malignant B-cell lymphoproliferative disorders. It has been reported that specific changes or recurring motifs in the amino acid sequence of the HCV hypervariable region 1 (HVR1) may be assoc...

journal_title：Journal of virology

authors： Bianchettin G,Bonaccini C,Oliva R,Tramontano A,Cividini A,Casato M,Merlini G,Silini E,Mondelli MU

更新日期：2007-05-01 00:00:00

abstract：:Lethal, amber mutations in T4 genes 46 and 47 cause incomplete degradation of host DNA, premature arrest of phage DNA synthesis, accumulation of abnormal DNA replication intermediates, and defective recombination. These phenotypes can be explained by the hypothesis that genes 46 and 47 control a DNA exonuclease, but i...

journal_title：Journal of virology

authors： Mickelson C,Wiberg JS

更新日期：1981-10-01 00:00:00

abstract：:Only a few archaeal viruses have been subjected to detailed structural analyses. Major obstacles have been the extreme conditions such as high salinity or temperature needed for the propagation of these viruses. In addition, unusual morphotypes of many archaeal viruses have made it difficult to obtain further informat...

journal_title：Journal of virology

authors： Pietilä MK,Laurinavicius S,Sund J,Roine E,Bamford DH

更新日期：2010-01-01 00:00:00

abstract：:Transient transfection experiments indicated (i) that E6 protein of non-cancer-associated cutaneous human papillomavirus type 1 (HPV-1) can inhibit p53-mediated transcriptional transactivation in both p53-deficient human cells (H358) and normal rat cells (3Y1), but those of cancer-associated cutaneous HPV-5, -8, and -...

journal_title：Journal of virology

authors： Kiyono T,Hiraiwa A,Ishii S,Takahashi T,Ishibashi M

更新日期：1994-07-01 00:00:00

abstract：:The trans-activator Tat proteins coded by human immunodeficiency virus type 1 (HIV-1) and HIV-2 appear to be similar in structure and function. However, the Tat protein of HIV-2 (Tat2) activates the HIV-1 long terminal repeat (LTR) less efficiently than Tat1 (M. Emerman, M. Guyader, L. Montagnier, D. Baltimore, and M....

journal_title：Journal of virology

authors： Elangovan B,Subramanian T,Chinnadurai G

更新日期：1992-04-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) vpr inhibits the replication of tumor cell lines and peripheral blood mononuclear cells. Here it is demonstrated that expression of vpr, either in the context of a provirus or from an independent genetic element, induces a discrete cell cycle arrest, with cells containing 4N...

journal_title：Journal of virology

authors： Re F,Braaten D,Franke EK,Luban J

更新日期：1995-11-01 00:00:00

abstract：UNLABELLED:The distribution of vesicular stomatitis virus (VSV) nucleocapsids in the cytoplasm of infected cells was analyzed by scanning confocal fluorescence microscopy using a newly developed quantitative approach called the border-to-border distribution method. Nucleocapsids were located near the cell nucleus at ea...

journal_title：Journal of virology

authors： Yacovone SK,Smelser AM,Macosko JC,Holzwarth G,Ornelles DA,Lyles DS

更新日期：2016-06-10 00:00:00

abstract：:The HIV-1 Rev response element (RRE) is a 351-base element in unspliced and partially spliced viral RNA; binding of the RRE by the viral Rev protein induces nuclear export of RRE-containing RNAs, as required for virus replication. It contains one long, imperfect double helix (domain I), one branched domain (domain II)...

journal_title：Journal of virology

authors： O'Carroll IP,Thappeta Y,Fan L,Ramirez-Valdez EA,Smith S,Wang YX,Rein A

更新日期：2017-10-13 00:00:00

abstract：:Herpes simplex virus (HSV) is an important human pathogen with a high worldwide seroprevalence. HSV enters epithelial cells, the primary site of infection, by a low-pH pathway. HSV glycoprotein B (gB) undergoes low pH-induced conformational changes, which are thought to drive membrane fusion. When neutralized back to ...

journal_title：Journal of virology

authors： Weed DJ,Dollery SJ,Komala Sari T,Nicola AV

更新日期：2018-08-16 00:00:00

abstract：:A porcine rotavirus (prv), variant 4F, isolated in tissue culture from the feces of a Chinese pig with diarrhea, was found to have become highly pathogenic when passaged in gnotobiotic piglets (J. C. Bridger, B. Burke, G. M. Beards, and U. Desselberger, J. Gen. Virol. 73:3011-3015, 1992). Comparison with the closely r...

journal_title：Journal of virology

authors： Tauscher GI,Desselberger U

更新日期：1997-01-01 00:00:00

abstract：:The reovirus core particle is a molecular machine that mediates synthesis, capping, and export of the viral plus strand RNA transcripts. Its assembly and structure-function relationships remain to be well understood. Following the lead of previous studies with other Reoviridae family members, most notably orbiviruses ...

journal_title：Journal of virology

authors： Kim J,Zhang X,Centonze VE,Bowman VD,Noble S,Baker TS,Nibert ML

更新日期：2002-12-01 00:00:00

abstract：:The VP24 protein plays an essential, albeit poorly understood role in the filovirus life cycle. VP24 is only 30% identical between Marburg virus and the ebolaviruses. Furthermore, VP24 from the ebolaviruses is immunosuppressive, while that of Marburg virus is not. The crystal structure of Marburg virus VP24, presented...

journal_title：Journal of virology

authors： Zhang AP,Bornholdt ZA,Abelson DM,Saphire EO

更新日期：2014-05-01 00:00:00

abstract：:Proteolytic processing of the Rous sarcoma virus (RSV) Gag precursor was altered in vivo through the introduction of amino acid substitutions into either the polyprotein cleavage junctions or the PR coding sequence. Single amino acid substitutions (V(P2)S and P(P4)G), which are predicted from in vitro peptide substrat...

journal_title：Journal of virology

authors： Xiang Y,Ridky TW,Krishna NK,Leis J

更新日期：1997-03-01 00:00:00

abstract：:Rhesus lymphocryptovirus (rLCV) and Epstein-Barr virus (EBV) are closely related gammaherpesviruses that infect and cause disease in rhesus monkeys and humans, respectively. Thus, rLCV is an important model system for EBV pathogenesis. Both rLCV and EBV express microRNAs (miRNAs), several conserved in sequence and gen...

journal_title：Journal of virology

authors： Riley KJ,Rabinowitz GS,Steitz JA

更新日期：2010-05-01 00:00:00

abstract：:Despite intensive study, the mechanism by which many retroviruses complete reverse transcription has remained unclear. Most retroviruses and all lentiviruses fail to synthesize a full-length second strand of the viral cDNA (plus strand) efficiently in infected cells. For human immunodeficiency virus type 1, we find in...

journal_title：Journal of virology

authors： Miller MD,Wang B,Bushman FD

更新日期：1995-06-01 00:00:00

abstract：:Targeted vectors will be necessary for many gene therapy applications. To target retroviruses to melanomas, we fused a single-chain variable fragment antibody (scFv) directed against the surface glycoprotein high-molecular-weight melanoma-associated antigen (HMW-MAA) to the amphotropic murine leukemia virus envelope. ...

journal_title：Journal of virology

authors： Martin F,Neil S,Kupsch J,Maurice M,Cosset F,Collins M

更新日期：1999-08-01 00:00:00

abstract：:The Epstein-Barr virus latent membrane protein (LMP) is an integral membrane protein that is expressed in cells latently infected with the virus. LMP is believed to play an important role in Epstein-Barr virus transformation and has been shown to induce expression of several cellular proteins. We performed a series of...

journal_title：Journal of virology

authors： Hammarskjöld ML,Simurda MC

更新日期：1992-11-01 00:00:00

abstract：:N(pro) is a multifunctional autoprotease unique to pestiviruses. The interacting partners of the N(pro) protein of classical swine fever virus (CSFV), a swine pestivirus, have been insufficiently defined. Using a yeast two-hybrid screen, we identified poly(C)-binding protein 1 (PCBP1) as a novel interacting partner of...

journal_title：Journal of virology

authors： Li D,Li S,Sun Y,Dong H,Li Y,Zhao B,Guo D,Weng C,Qiu HJ

更新日期：2013-02-01 00:00:00

abstract：:The structure of recombinant virus-like particles of malabaricus grouper nervous necrosis virus (MGNNV), a fish nodavirus isolated from the grouper Epinephelus malabaricus, was determined by electron cryomicroscopy (cryoEM) and three-dimensional reconstruction at 23-A resolution. The cryoEM structure, sequence compari...

journal_title：Journal of virology

authors： Tang L,Lin CS,Krishna NK,Yeager M,Schneemann A,Johnson JE

更新日期：2002-06-01 00:00:00

abstract：:Adeno-associated virus type 2 (AAV2) preferentially integrates its genome into the AAVS1 locus on human chromosome 19. Preferential integration requires the AAV2 Rep68 or Rep78 protein (Rep68/78), a Rep68/78 binding site (RBS), and a nicking site within AAVS1 and may also require an RBS within the virus genome. To obt...

journal_title：Journal of virology

authors： McAlister VJ,Owens RA

更新日期：2007-09-01 00:00:00

abstract：:The chimeric murine oncornavirus FrCas(E) causes a rapidly progressive paralytic disease associated with spongiform neurodegeneration throughout the neuroaxis. Neurovirulence is determined by the sequence of the viral envelope gene and by the capacity of the virus to infect microglia. The neurocytopathic effect of thi...

journal_title：Journal of virology

authors： Askovic S,Favara C,McAtee FJ,Portis JL

更新日期：2001-03-01 00:00:00

abstract：:Infectious bursal disease virus (IBDV) is a double-stranded RNA (dsRNA) virus of the Birnaviridae family. Its two genome segments are encapsidated together with multiple copies of the viral RNA-dependent RNA polymerase, VP1, in a single-shell capsid that is composed of VP2 and VP3. In this study we identified the doma...

journal_title：Journal of virology

authors： Tacken MG,Peeters BP,Thomas AA,Rottier PJ,Boot HJ

更新日期：2002-11-01 00:00:00

abstract：:This study describes a method for increasing the immunogenicity of influenza virus vaccines by exploiting the natural anti-Gal antibody to effectively target vaccines to antigen-presenting cells (APC). This method is based on enzymatic engineering of carbohydrate chains on virus envelope hemagglutinin to carry the alp...

journal_title：Journal of virology

authors： Abdel-Motal UM,Guay HM,Wigglesworth K,Welsh RM,Galili U

更新日期：2007-09-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) play an important role in the immune response against respiratory syncytial virus (RSV) infection. The cell surface molecule lymphocyte function-associated antigen 1 (LFA-1) is an important contributor to CTL activation, CTL-mediated direct cell lysis, and lymphocyte migration. In an att...

journal_title：Journal of virology

authors： Rutigliano JA,Johnson TR,Hollinger TN,Fischer JE,Aung S,Graham BS

更新日期：2004-03-01 00:00:00

abstract：:We present data that retroviral gene expression in early hematopoietic cells is subjected to transcriptional controls similar to those previously described for embryonic stem cells. Transient transfection experiments revealed that both the viral enhancer region in the U3 region of the long terminal repeat as well as a...

journal_title：Journal of virology

authors： Baum C,Hegewisch-Becker S,Eckert HG,Stocking C,Ostertag W

更新日期：1995-12-01 00:00:00

abstract：:The Tax protein from human T-cell leukemia virus type I (HTLV-I) is a 40-kDa phosphoprotein capable of activating transcription from its own long terminal repeat (LTR), as well as increasing the transcription of cellular genes. Transcriptional activation of the HTLV-I LTR has been demonstrated via a cyclic-AMP-respons...

journal_title：Journal of virology

authors： Fontes JD,Strawhecker JM,Bills ND,Lewis RE,Hinrichs SH

更新日期：1993-07-01 00:00:00

abstract：:A high prevalence (42.6%) of hepatitis B virus (HBV) infection was suspected in 195 formerly captive orangutans due to a large number of serum samples which cross-reacted with human HBV antigens. It was assumed that such viral infections were contracted from humans during captivity. However, two wild orangutans were i...

journal_title：Journal of virology

authors： Warren KS,Heeney JL,Swan RA,Heriyanto,Verschoor EJ

更新日期：1999-09-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The HTLV-1 genome encodes the Tax protein that plays essential regulatory roles in HTLV-1 replication and oncogenic transformation of T lymphocytes....

journal_title：Journal of virology

authors： Gao L,Harhaj EW

更新日期：2013-12-01 00:00:00

abstract：:The Gag proteins of retroviruses are the only viral products required for the release of membrane-enclosed particles by budding from the host cell. Particles released when these proteins are expressed alone are identical to authentic virions in their rates of budding, proteolytic processing, and core morphology, as we...

journal_title：Journal of virology

authors： Krishna NK,Campbell S,Vogt VM,Wills JW

更新日期：1998-01-01 00:00:00

abstract：:We have examined the exposure and conservation of antigenic epitopes on the surface envelope glycoproteins (gp120 and gp41) of 26 intact, native, primary human immunodeficiency virus type 1 (HIV-1) group M virions of clades A to H. For this, 47 monoclonal antibodies (MAbs) derived from HIV-1-infected patients were use...

journal_title：Journal of virology

authors： Nyambi PN,Mbah HA,Burda S,Williams C,Gorny MK,Nádas A,Zolla-Pazner S

更新日期：2000-08-01 00:00:00