A new group of hepadnaviruses naturally infecting orangutans (Pongo pygmaeus).

abstract：:Antigen-presenting cells are a heterogeneous group of cells that are characterized by their functional specialization. Consequently, targeting specific antigen-presenting cell subsets offers opportunities to induce distinct T cell responses. Here we report on the generation and use of nanobodies (Nbs) to target lentiv...

journal_title：Journal of virology

authors： Goyvaerts C,Dingemans J,De Groeve K,Heirman C,Van Gulck E,Vanham G,De Baetselier P,Thielemans K,Raes G,Breckpot K

更新日期：2013-10-01 00:00:00

abstract：:A closed circular, double-stranded infectious DNA of Moloney leukemia virus has been described previously. The present report characterizes a second type of infectious, unintegrated viral DNA which is linear, largely double stranded, and of mass comparable to that of the closed circular viral DNA. The linear form is o...

journal_title：Journal of virology

authors： Smotkin D,Yoshimura FK,Weinberg RA

更新日期：1976-12-01 00:00:00

abstract：:The cloned transcription factor hepatocyte nuclear factor 1 (HNF1) transactivates transcription from the hepatitis B virus (HBV) large surface antigen promoter but does not influence the transcriptional activities of the other three HBV promoters. This indicates that this transcription factor can differentially influe...

journal_title：Journal of virology

authors： Raney AK,Easton AJ,Milich DR,McLachlan A

更新日期：1991-11-01 00:00:00

abstract：:The UL3 protein of equine herpesvirus 1 (EHV-1) KyA strain is a homolog of the ICP27 alpha regulatory protein of herpes simplex virus type 1 (HSV-1) and the ORF 4 protein of varicella-zoster virus. To characterize the regulatory function of the UL3 gene product, a UL3 gene expression vector (pSVUL3) and a vector expre...

journal_title：Journal of virology

authors： Zhao Y,Holden VR,Smith RH,O'Callaghan DJ

更新日期：1995-05-01 00:00:00

abstract：:Transcriptional stimulatory properties of virus-encoded transactivators appear to be critical for viral gene expression and may be linked to cellular transformation in certain cases. Recently, the simian virus 40 (SV40) 17-kDa small-t antigen was shown to stimulate transcription of polymerase II and III genes in trans...

journal_title：Journal of virology

authors： Rajan P,Dhamankar V,Rundell K,Thimmapaya B

更新日期：1991-12-01 00:00:00

abstract：:To examine the prerequisites for cleavage activation of the hemagglutinin of human influenza viruses, a cDNA clone obtained from strain A/Port Chalmers/1/73 (serotype H3) was subjected to site-directed mutagenesis and expressed in CV-1 cells by using a simian virus 40 vector. The number of basic residues at the cleava...

journal_title：Journal of virology

authors： Ohuchi R,Ohuchi M,Garten W,Klenk HD

更新日期：1991-07-01 00:00:00

abstract：:To investigate the role of the hepatitis C virus internal ribosome entry site (HCV IRES) domain IV in translation initiation and regulation, two chimeric IRES elements were constructed to contain the reciprocal domain IV in the otherwise HCV and classical swine fever virus IRES elements. This permitted an examination ...

journal_title：Journal of virology

authors： Li D,Lott WB,Martyn J,Haqshenas G,Gowans EJ

更新日期：2004-11-01 00:00:00

abstract：:One hundred thirty-eight new Epstein-Barr virus (EBV) genome sequences have been determined. One hundred twenty-five of these and 116 from previous reports were combined to produce a multiple-sequence alignment of 241 EBV genomes, which we have used to analyze variation within the viral genome. The type 1/type 2 class...

journal_title：Journal of virology

authors： Correia S,Bridges R,Wegner F,Venturini C,Palser A,Middeldorp JM,Cohen JI,Lorenzetti MA,Bassano I,White RE,Kellam P,Breuer J,Farrell PJ

更新日期：2018-10-29 00:00:00

abstract：:Immunity to human immunodeficiency virus virion-like structures or a polyprotein has been examined after DNA immunization with Rev-independent expression vectors. A Gag-Pol fusion protein stimulated cytotoxic T lymphocyte and antibody responses to Gag and Pol, while a Gag-Pol pseudoparticle did not elicit substantial ...

journal_title：Journal of virology

authors： Huang Y,Kong WP,Nabel GJ

更新日期：2001-05-01 00:00:00

abstract：:The first step in the replication of the plus-stranded poliovirus RNA is the synthesis of a complementary minus strand. This process is initiated by the covalent attachment of UMP to the terminal protein VPg, yielding VPgpU and VPgpUpU. We have previously shown that these products can be made in vitro in a reaction th...

journal_title：Journal of virology

authors： Paul AV,Rieder E,Kim DW,van Boom JH,Wimmer E

更新日期：2000-11-01 00:00:00

abstract：:Cell cycle progression during cytomegalovirus infection was investigated by fluorescence-activated cell sorter (FACS) analysis of the DNA content in growth-arrested as well as serum-stimulated human fibroblasts. Virus-infected cells maintained in either low (0.2%) or high (10%) serum failed to progress into S phase an...

journal_title：Journal of virology

authors： Dittmer D,Mocarski ES

更新日期：1997-02-01 00:00:00

abstract：:Severe acute respiratory syndrome (SARS), caused by a novel coronavirus (CoV) known as SARS-CoV, is a contagious and life-threatening respiratory illness with pneumocytes as its main target. A full understanding of how SARS-CoV would interact with lung epithelial cells will be vital for advancing our knowledge of SARS...

journal_title：Journal of virology

authors： Tseng CT,Tseng J,Perrone L,Worthy M,Popov V,Peters CJ

更新日期：2005-08-01 00:00:00

abstract：:The C-terminal half of the replicase ORF1a polyprotein of the arterivirus equine arteritis virus is processed by a chymotrypsinlike serine protease (SP) (E. J. Snijder et al., J. Biol. Chem. 271:4864-4871, 1996) located in nonstructural protein 4 (nsp4). Three probable SP cleavage sites had previously been identified ...

journal_title：Journal of virology

authors： Wassenaar AL,Spaan WJ,Gorbalenya AE,Snijder EJ

更新日期：1997-12-01 00:00:00

abstract：UNLABELLED:The first discovered and sequenced hepatitis C virus (HCV) genome and the first in vivo infectious HCV clones originated from the HCV prototype strains HCV-1 and H77, respectively, both widely used in research of this important human pathogen. In the present study, we developed efficient infectious cell cult...

journal_title：Journal of virology

authors： Li YP,Ramirez S,Mikkelsen L,Bukh J

更新日期：2015-01-01 00:00:00

abstract：:We recently demonstrated that members of the c-ets proto-oncogene family, Ets1 and Ets2, are sequence-specific transcriptional activators of the human T-lymphotropic virus type I (HTLV-I) long terminal repeat (LTR). We now report that the HTLV-I LTR contains two distinct Ets1-responsive regions, ERR-1 and ERR-2. Expre...

journal_title：Journal of virology

authors： Gitlin SD,Bosselut R,Gégonne A,Ghysdael J,Brady JN

更新日期：1991-10-01 00:00:00

abstract：:The nucleotide and deduced amino acid sequences of the P1 region of the genomes of 10 independent equine rhinitis A virus (ERAV) isolates were determined and found to be very closely related. A panel of seven monoclonal antibodies to the prototype virus ERAV.393/76 that bound to nonneutralization epitopes conserved am...

journal_title：Journal of virology

authors： Varrasso A,Drummer HE,Huang JA,Stevenson RA,Ficorilli N,Studdert MJ,Hartley CA

更新日期：2001-11-01 00:00:00

abstract：:Analysis of purified simian rotavirus has shown that it contains fewer structural polypeptide classes than previously reported. Two polypeptides (molecular weights, 62,000 and 28,000) commonly found in purified rotaviruses were, in fact, produced by cleavage of a larger structural polypeptide (molecular weight, about ...

journal_title：Journal of virology

authors： Espejo RT,López S,Arias C

更新日期：1981-01-01 00:00:00

abstract：:Simian immunodeficiency virus (SIV) of macaques isolate SIVmac239 is highly resistant to neutralization by polyclonal antisera or monoclonal antibodies, a property that it shares with most primary isolates of human immunodeficiency virus type 1 (HIV-1). This resistance is important for the ability of the virus to pers...

journal_title：Journal of virology

authors： Johnson WE,Sanford H,Schwall L,Burton DR,Parren PW,Robinson JE,Desrosiers RC

更新日期：2003-09-01 00:00:00

abstract：:Herpesvirus lytic DNA replication requires both the cis-acting element, the origin, and trans-acting factors, including virally encoded origin-binding protein, DNA replication enzymes, and auxiliary factors. Two lytic DNA replication origins (ori-Lyt) of Kaposi's sarcoma-associated herpesvirus (KSHV) have been identif...

journal_title：Journal of virology

authors： Wang Y,Li H,Tang Q,Maul GG,Yuan Y

更新日期：2008-03-01 00:00:00

abstract：:Nevirapine forms the mainstay of our efforts to curtail the pediatric AIDS epidemic through prevention of mother-to-child transmission of HIV-1. A key limitation, however, is the rapid selection of HIV-1 strains resistant to nevirapine following the administration of a single dose. This rapid selection of resistance s...

journal_title：Journal of virology

authors： Gadhamsetty S,Dixit NM

更新日期：2010-10-01 00:00:00

abstract：:The full repertoire of hepatitis B virus (HBV) peptides that bind to the common HLA class I molecules found in areas with a high prevalence of chronic HBV infection has not been determined. This information may be useful for designing immunotherapies for chronic hepatitis B. We identified amino acid residues under pos...

journal_title：Journal of virology

authors： Abbott WG,Tsai P,Leung E,Trevarton A,Ofanoa M,Hornell J,Gane EJ,Munn SR,Rodrigo AG

更新日期：2010-01-01 00:00:00

abstract：:Progressive multifocal leukoencephalopathy (PML) is an often-fatal demyelinating disease of the central nervous system. PML results when oligodendrocytes within immunocompromised individuals are infected with the human JC virus (JCV). We have identified an oligodendrocyte precursor cell line, termed G144, that support...

journal_title：Journal of virology

authors： Peterson JN,Lin B,Shin J,Phelan PJ,Tsichlis P,Schwob JE,Bullock PA

更新日期：2017-09-27 00:00:00

abstract：:Chicken embryo fibroblasts and NIH 3T3 mouse cells were transformable by DNAs of chicken cells infected with avian myelocytomatosis virus strain MC29 or with avian erythroblastosis virus. Transfection of chicken cells appeared to require replication of MC29 or avian erythroblastosis virus in the presence of a nontrans...

journal_title：Journal of virology

authors： Copeland NG,Cooper GM

更新日期：1980-03-01 00:00:00

abstract：:Cell fractionation and protein electrophoresis were used to study the intracellular sites of synthesis and intermediate structures in the assembly of the virion proteins of vesicular stomatitis virus. Each of the three major virion proteins assembled into virions through a separable pathway. The nucleocapsid (N) prote...

journal_title：Journal of virology

authors： Knipe DM,Baltimore D,Lodish HF

更新日期：1977-03-01 00:00:00

abstract：:Expression of human papillomavirus late genes encoding L1 and L2 capsid proteins is restricted to terminally differentiated epithelial cells. We have previously identified and characterized an AU-rich, cis-acting negative regulatory element in the 3' untranslated region of human papillomavirus type 1 late mRNAs. This ...

journal_title：Journal of virology

authors： Zhao C,Tan W,Sokolowski M,Schwartz S

更新日期：1996-06-01 00:00:00

abstract：:Phosphonoformate (foscarnet) is a pyrophosphate (PP(i)) analogue and a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), acting through the PP(i) binding site on the enzyme. HIV-1 RT can unblock a chain-terminated DNA primer by phosphorolytic transfer of the terminal residue t...

journal_title：Journal of virology

authors： Meyer PR,Matsuura SE,Zonarich D,Chopra RR,Pendarvis E,Bazmi HZ,Mellors JW,Scott WA

更新日期：2003-06-01 00:00:00

abstract：:We have previously demonstrated that two mouse cell lines that are poorly infectible by reovirus become highly susceptible upon transfection with the gene encoding the epidermal growth factor receptor (EGFR) (J. E. Strong, D. Tang, and P. W. K. Lee, Virology 197:405-411, 1993). This enhancement of infection efficiency...

journal_title：Journal of virology

authors： Strong JE,Lee PW

更新日期：1996-01-01 00:00:00

abstract：:Duck hepatitis B virus mutants containing frameshift or stop codon mutations in a portion of the viral pol gene separating the terminal protein and reverse transcriptase domains had a leaky phenotype and, depending on the location and type of mutation, synthesized up to 10% as much viral DNA as did the wild type. This...

journal_title：Journal of virology

authors： Wu TT,Condreay LD,Coates L,Aldrich C,Mason W

更新日期：1991-05-01 00:00:00

abstract：:The herpesvirus saimiri genome encodes a complement control protein homolog (CCPH). Stable mammalian cell transfectants expressing a recombinant transmembrane form of CCPH (mCCPH) or a 5'FLAG epitope-tagged mCCPH (5'FLAGmCCPH) conferred resistance to complement-mediated cell damage by inhibiting the lytic activity of ...

journal_title：Journal of virology

authors： Fodor WL,Rollins SA,Bianco-Caron S,Rother RP,Guilmette ER,Burton WV,Albrecht JC,Fleckenstein B,Squinto SP

更新日期：1995-06-01 00:00:00

abstract：:Two poliovirus mutants were isolated that contain an oligonucleotide linker insertion in the 2C-coding region of the viral genome. One, 2C-31, has a strongly temperature-sensitive phenotype and the other, 2C-32, forms small plaques on HeLa cell monolayers at all temperatures. Both mutants have a severe temperature-sen...

journal_title：Journal of virology

authors： Li JP,Baltimore D

更新日期：1988-11-01 00:00:00