Abstract:
:To investigate the role of the hepatitis C virus internal ribosome entry site (HCV IRES) domain IV in translation initiation and regulation, two chimeric IRES elements were constructed to contain the reciprocal domain IV in the otherwise HCV and classical swine fever virus IRES elements. This permitted an examination of the role of domain IV in the control of HCV translation. A specific inhibitor of the HCV IRES, vitamin B(12), was shown to inhibit translation directed by all IRES elements which contained domain IV from the HCV and the GB virus B IRES elements, whereas the HCV core protein could only suppress translation from the wild-type HCV IRES. Thus, the mechanisms of translation inhibition by vitamin B(12) and the core protein differ, and they target different regions of the IRES.
journal_name
J Viroljournal_title
Journal of virologyauthors
Li D,Lott WB,Martyn J,Haqshenas G,Gowans EJdoi
10.1128/JVI.78.21.12075-12081.2004subject
Has Abstractpub_date
2004-11-01 00:00:00pages
12075-81issue
21eissn
0022-538Xissn
1098-5514pii
78/21/12075journal_volume
78pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
abstract::The effect of herpes simplex virus type 2 (HSV-2) infection on the synthesis of DNA in human embryonic fibroblast cells was determined at temperatures permissive (37 C) and nonpermissive (42 C) for virus multiplication. During incubation of HSV-2 infected cultures at 42 C for 2 to 4 days or after shift-down from 42 to...
journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00134-16
更新日期:2016-04-14 00:00:00
abstract::The complete genomic sequence of a new Muscovy duck-origin reovirus (N-MDRV), strain J18 from China, was determined. The virus has a tricistronic S1 genome segment that is distinct from the originally described MDRV, which possesses a bicistronic S4 genome segment. Pairwise comparisons and phylogenetic analyses sugges...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02230-12
更新日期:2012-11-01 00:00:00
abstract::Autographa californica nuclear polyhedrosis virus (AcMNPV) is a double-stranded DNA virus that expresses several immediate-early genes under the control of different promoters. The expression of one of these transcription units, IE-N, is shown here, by a transient expression assay, to be regulated by both cis- and tra...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.2.945-951.1991
更新日期:1991-02-01 00:00:00
abstract::Influenza viruses and rhinoviruses are responsible for a large number of acute respiratory viral infections in human populations and are detected as copathogens within hosts. Clinical and epidemiological studies suggest that coinfection by rhinovirus and influenza virus may reduce disease severity and that they may al...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00881-18
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journal_title:Journal of virology
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.9.5912-5916.1995
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更新日期:2013-07-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1979-10-01 00:00:00
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journal_title:Journal of virology
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1972-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1989-10-01 00:00:00
abstract::Previous studies in our laboratory showed that the RNA debranching enzyme (DBR1) is not required for early steps in HIV cDNA formation but is necessary for synthesis of intermediate and late cDNA products. To further characterize this effect, we evaluated the topology of the 5' end of the HIV-1 RNA genome during early...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01377-17
更新日期:2017-11-14 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2017-10-27 00:00:00
abstract::3-O-(3',3'-Dimethysuccinyl) betulinic acid (PA-457) has been shown to potently inhibit human immunodeficiency virus (HIV) replication in culture. In contrast to inhibitors that act upon the viral proteinase, PA-457 appears to block only the final maturational cleavage of p25CA-p2 to p24CA. However, attempts to replica...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02743-05
更新日期:2006-06-01 00:00:00