Kaposi's sarcoma-associated herpesvirus ori-Lyt-dependent DNA replication: involvement of host cellular factors.

abstract：:The incorporation of (3)H-thymidine ((3)H-dT) into deoxyribonucleic acid (DNA) has been studied in uninfected confluent monolayer cultures of monkey kidney and mouse kidney cells, simian virus 40 (SV40)-infected cells, and in SV40-transformed mouse kidney cells. Radioautographic measurements revealed that during the p...

journal_title：Journal of virology

authors： Kit S,De Torres RA,Dubbs DR,Salvi ML

更新日期：1967-08-01 00:00:00

abstract：:The 5'-terminal nucleotide sequence from positions 50 to 130 of vesicular stomatitis virus RNA was determined indirectly by using a defective interfering particle RNA which contains covalently linked genomic minus and antigenomic plus sense RNAs. The last 18 nucleotides of the L gene coding for in the viral polymerase...

journal_title：Journal of virology

authors： Schubert M,Keene JD,Herman RC,Lazzarini RA

更新日期：1980-05-01 00:00:00

abstract：:ZEBRA is an Epstein-Barr virus (EBV) transcriptional activator that mediates a genetic switch between the latent and lytic states of the virus by binding to the promoters of genes involved in lytic DNA replication and activating their transcription. A computer survey revealed that 9 of 23 potential or known ZEBRA-resp...

journal_title：Journal of virology

authors： Carey M,Kolman J,Katz DA,Gradoville L,Barberis L,Miller G

更新日期：1992-08-01 00:00:00

abstract：:We have previously demonstrated that the human papillomavirus (HPV) genome replicates effectively in U2OS cells after transfection using electroporation. The transient extrachromosomal replication, stable maintenance, and late amplification of the viral genome could be studied for high- and low-risk mucosal and cutane...

journal_title：Journal of virology

authors： Reinson T,Toots M,Kadaja M,Pipitch R,Allik M,Ustav E,Ustav M

更新日期：2013-01-01 00:00:00

abstract：:The glycan shield of the human immunodeficiency virus type 1 (HIV-1) envelope (Env) protein serves as a barrier to antibody-mediated neutralization and plays a critical role in transmission and infection. One of the few broadly neutralizing HIV-1 antibodies, 2G12, binds to a carbohydrate epitope consisting of an array...

journal_title：Journal of virology

authors： Luallen RJ,Lin J,Fu H,Cai KK,Agrawal C,Mboudjeka I,Lee FH,Montefiori D,Smith DF,Doms RW,Geng Y

更新日期：2008-07-01 00:00:00

abstract：:The influenza A virus NS1 protein contains a conserved 4-amino-acid-residue PDZ-ligand binding motif (PBM) at the carboxyl terminus that can function as a virulence determinant by targeting cellular PDZ proteins. The NS1 proteins from avian and human viral isolates have consensus PBM sequences ESEV and RSKV, respectiv...

journal_title：Journal of virology

authors： Golebiewski L,Liu H,Javier RT,Rice AP

更新日期：2011-10-01 00:00:00

abstract：:The structure of VRC01 in complex with the HIV-1 gp120 core reveals that this broadly neutralizing CD4 binding site (CD4bs) antibody partially mimics the interaction of the primary virus receptor, CD4, with gp120. Here, we extended the investigation of the VRC01-gp120 core interaction to the biologically relevant vira...

journal_title：Journal of virology

authors： Li Y,O'Dell S,Walker LM,Wu X,Guenaga J,Feng Y,Schmidt SD,McKee K,Louder MK,Ledgerwood JE,Graham BS,Haynes BF,Burton DR,Wyatt RT,Mascola JR

更新日期：2011-09-01 00:00:00

abstract：:Tumor progression locus 2 (TPL2) is a serine/threonine kinase that belongs to the mitogen-activated protein 3 kinase (MAP3K) family, and it plays an important role in pathogen infection. The trimer complex of TPL2, p105, and ABIN2 is essential for maintenance of TPL2 steady-state levels and host cell response to patho...

journal_title：Journal of virology

authors： Zhang K,Yan M,Hao J,Shen C,Zhu Z,Zhang D,Hou J,Xu G,Li D,Zheng H,Liu X

更新日期：2020-12-23 00:00:00

abstract：:Prestimulation of the TLR4 pathway with lipopolysaccharide (LPS) protects mice from lethal infection with H5N1 influenza virus. Here, we reveal that the TLR4-TRIF pathway is required for this protective effect by using mice whose TLR4-related molecules were knocked out. Microarray analysis of primary mouse lung cultur...

journal_title：Journal of virology

authors： Shinya K,Ito M,Makino A,Tanaka M,Miyake K,Eisfeld AJ,Kawaoka Y

更新日期：2012-01-01 00:00:00

abstract：:Mouse mammary tumor virus (MMTV)-induced mammary adenocarcinomas can develop from several different premalignant precursors common in GR mice. Insertion mutagenesis of the mammary protooncogenes int-1 and int-2 was studied in this multistep system by analyzing samples from various stages of neoplastic development for ...

journal_title：Journal of virology

authors： Morris DW,Barry PA,Bradshaw HD Jr,Cardiff RD

更新日期：1990-04-01 00:00:00

abstract：:Infectious bursal disease virus (IBDV) is a nonenveloped virus with an icosahedral capsid composed of two proteins, VP2 and VP3, that derive from the processing of the polyprotein NH(2)-pVP2-VP4-VP3-COOH. The virion contains VP1, the viral polymerase, which is both free and covalently linked to the two double-stranded...

journal_title：Journal of virology

authors： Chevalier C,Lepault J,Da Costa B,Delmas B

更新日期：2004-04-01 00:00:00

abstract：:Vertebrates mount a strong innate immune response against viruses, largely by activating the interferon system. Double-stranded RNA (dsRNA), a common intermediate formed during the life cycle of many viruses, is a potent trigger of this response. In contrast, no general inducible antiviral defense mechanism has been r...

journal_title：Journal of virology

authors： Robalino J,Browdy CL,Prior S,Metz A,Parnell P,Gross P,Warr G

更新日期：2004-10-01 00:00:00

abstract：:Lethal, amber mutations in T4 genes 46 and 47 cause incomplete degradation of host DNA, premature arrest of phage DNA synthesis, accumulation of abnormal DNA replication intermediates, and defective recombination. These phenotypes can be explained by the hypothesis that genes 46 and 47 control a DNA exonuclease, but i...

journal_title：Journal of virology

authors： Mickelson C,Wiberg JS

更新日期：1981-10-01 00:00:00

abstract：:We have examined the influence of the V1/V2 region of the human immunodeficiency virus type 1 (HIV-1) gp120 on certain biologic properties of the virus. We observed that on the genomic background of the T-cell-line-tropic strain, HIV-1SF2mc, both the V1 and V2 domains of the macrophage-tropic strain, HIV-1SF162mc, in ...

journal_title：Journal of virology

authors： Koito A,Harrowe G,Levy JA,Cheng-Mayer C

更新日期：1994-04-01 00:00:00

abstract：:In previous reports it was demonstrated that the Nipah virus V and W proteins have interferon (IFN) antagonist activity due to their ability to block signaling from the IFN-alpha/beta receptor (J. J. Rodriguez, J. P. Parisien, and C. M. Horvath, J. Virol. 76:11476-11483, 2002; M. S. Park et al., J. Virol. 77:1501-1511...

journal_title：Journal of virology

authors： Shaw ML,García-Sastre A,Palese P,Basler CF

更新日期：2004-06-01 00:00:00

abstract：:The initiation of human immunodeficiency virus type 1 (HIV-1) reverse transcription occurs at a site in the viral RNA genome which is designated the primer-binding site (PBS). The HIV-1 PBS is an 18-nucleotide sequence that is complementary to the 3'-terminal 18 nucleotides of tRNA(3Lys), which is used as the primer f...

journal_title：Journal of virology

authors： Wakefield JK,Wolf AG,Morrow CD

更新日期：1995-10-01 00:00:00

abstract：:The recent advent of genome sequences as the only source available to classify many newly discovered viruses challenges the development of virus taxonomy by expert virologists who traditionally rely on extensive virus characterization. In this proof-of-principle study, we address this issue by presenting a computation...

journal_title：Journal of virology

authors： Lauber C,Gorbalenya AE

更新日期：2012-04-01 00:00:00

abstract：:The neuraminidase inhibitors zanamivir and oseltamivir are marketed for the treatment and prophylaxis of influenza and have been stockpiled by many countries for use in a pandemic. Although recent surveillance has identified a striking increase in the frequency of oseltamivir-resistant seasonal influenza A (H1N1) viru...

journal_title：Journal of virology

authors： Hurt AC,Holien JK,Parker M,Kelso A,Barr IG

更新日期：2009-10-01 00:00:00

abstract：:Coronaviruses that infect humans belong to the Alpha-coronavirus (including HCoV-229E) and Beta-coronavirus (including SARS-CoV and SARS-CoV-2) genera. In particular, SARS-CoV-2 is currently a major threat to public health worldwide. The spike (S) homotrimers bind to their receptors via the receptor-binding domain (RB...

journal_title：Journal of virology

authors： Shi Y,Shi J,Sun L,Tan Y,Wang G,Guo F,Hu G,Fu Y,Fu ZF,Xiao S,Peng G

更新日期：2021-01-07 00:00:00

abstract：:Production of human papillomavirus type 16 (HPV-16) virus particles is totally dependent on the differentiation-dependent induction of viral L1 and L2 late gene expression. The early polyadenylation signal in HPV-16 plays a major role in the switch from the early to the late, productive stage of the viral life cycle. ...

journal_title：Journal of virology

authors： Oberg D,Fay J,Lambkin H,Schwartz S

更新日期：2005-07-01 00:00:00

abstract：:Four mutants of the virulent Mahoney strain of poliovirus were generated by introducing mutations in nucleotides (nt) 128 to 134 of the genome, a region that contains a part of the stem-loop II (SLII) structure located within the internal ribosomal entry site (IRES; nt 120 to 590) (K. Shiroki, T. Ishii, T. Aoki, Y. Ot...

journal_title：Journal of virology

authors： Ishii T,Shiroki K,Hong DH,Aoki T,Ohta Y,Abe S,Hashizume S,Nomoto A

更新日期：1998-03-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection of CD4-positive lymphocytes is accompanied by acute cytopathic effects, i.e., syncytium formation and single-cell lysis. Syncytium formation involves cell-cell fusion mediated by viral envelope glycoproteins on the surface of infected cells and by CD4 glycoproteins...

journal_title：Journal of virology

authors： Cao J,Park IW,Cooper A,Sodroski J

更新日期：1996-03-01 00:00:00

abstract：:Herpes simplex virus VP22 is a major tegument protein of unknown function. Very recently, we reported that the predominant effect of deleting the VP22 gene was on the expression, localization, and virion incorporation of ICP0. In addition, the Delta22 virus replicated poorly in epithelial MDBK cells. We have also prev...

journal_title：Journal of virology

authors： Potel C,Elliott G

更新日期：2005-11-01 00:00:00

abstract：:To analyze the biological activities of the alphavirus glycoproteins, eight different monoclonal antibodies against the two glycoproteins of western equine encephalitis virus were isolated. Five of the eight monoclonal antibodies were shown to be specific for E1 and three for E2 protein by an enzyme-linked immunosorbe...

journal_title：Journal of virology

authors： Yamamoto K,Hashimoto K,Chiba J,Simizu B

更新日期：1985-09-01 00:00:00

abstract：:Recruitment and extravasation of T cells through the blood-brain barrier are favored by adhesion molecule-mediated interactions of circulating T cells with endothelial cells. Since a common pathological finding in human T-cell leukemia virus type 1 (HTLV-1)-associated diseases is the infiltration of HTLV-1-infected T ...

journal_title：Journal of virology

authors： Valentin H,Lemasson I,Hamaia S,Cassé H,König S,Devaux C,Gazzolo L

更新日期：1997-11-01 00:00:00

abstract：:BK polyomavirus (BKV) establishes persistent, low-level, and asymptomatic infections in most humans and causes polyomavirus-associated nephropathy (PVAN) and other pathologies in some individuals. The activation of BKV replication following kidney transplantation, leading to viruria, viremia, and, ultimately, PVAN, is...

journal_title：Journal of virology

authors： Liang B,Tikhanovich I,Nasheuer HP,Folk WR

更新日期：2012-03-01 00:00:00

abstract：:Gene therapy is proposed as a novel therapeutic strategy for treating glioblastoma multiforme (GBM), a devastating brain cancer. In the clinic, antivector immune responses pose formidable challenges. Herein we demonstrate that high-capacity adenovirus vectors (HC-Ads) carrying the conditional cytotoxic gene herpes sim...

journal_title：Journal of virology

authors： King GD,Muhammad AK,Xiong W,Kroeger KM,Puntel M,Larocque D,Palmer D,Ng P,Lowenstein PR,Castro MG

更新日期：2008-05-01 00:00:00

abstract：:Subgenomic RNAs of both polarities corresponding to rice hoja blanca virus (RHBV) ambisense RNA4 were detected in RHBV-infected rice tissues. Total RNA extracted from RHBV-infected and noninfected rice tissues and RNA4 purified from RHBV ribonucleoprotein particles were used as templates for primer extension studies. ...

journal_title：Journal of virology

authors： Ramirez BC,Garcin D,Calvert LA,Kolakofsky D,Haenni AL

更新日期：1995-03-01 00:00:00

abstract：:The human cytomegalovirus (HCMV) immediate-early 2 (IE2) transactivator has previously been shown to form intranuclear, dot-like accumulations in association with subnuclear structures known as promyelocytic leukemia protein (PML) nuclear bodies or ND10. We recently observed that IE2 can form dot-like structures even ...

journal_title：Journal of virology

authors： Sourvinos G,Tavalai N,Berndt A,Spandidos DA,Stamminger T

更新日期：2007-09-01 00:00:00

abstract：:Human T-cell leukemia virus (HTLV) Tax protein has been implicated in the HTLV oncogenic process, primarily due to its pleiotropic effects on cellular genes involved in growth regulation and cell cycle control. To date, several approaches attempting to correlate Tax activation of the CREB/activating transcription fact...

journal_title：Journal of virology

authors： Ross TM,Narayan M,Fang ZY,Minella AC,Green PL

更新日期：2000-03-01 00:00:00