Abstract:
:Two serologically distinguishable primate herpesviruses, Herpesvirus aotus type 1 and type 3, were examined with regard to their genomes and structural polypeptides. The duplex DNA genomes of these two viruses were found to be essentially identical in molecular weight (Mr approximately equal to 145 X 10(6)) and guanine plus cytosine composition (55%). Both contained unique and inverted repeat nucleotide sequences of the same size and arrangement, which, as judged by DNA-DNA hybridization and restriction enzyme analyses, were at least 95% homologous. In addition, no differences were observed in electrophoretic profiles of virion polypeptides. Because of their great similarity with respect to these criteria, the two viruses ought to be considered independent isolates (or strains) of a single virus, which should be designated H. aotus type 1. The elevated molecular weight and presence of two sets of inverted repeat sequences closely resemble the structure of the human cytomegalovirus genome. However, no sequence homology (less than 5%) nor similarity in virion polypeptides was detected between H. aotus type 1 and human cytomegalovirus.
journal_name
J Viroljournal_title
Journal of virologyauthors
Ebeling A,Keil G,Nowak B,Fleckenstein B,Berthelot N,Sheldrick Pdoi
10.1128/JVI.45.2.715-726.1983subject
Has Abstractpub_date
1983-02-01 00:00:00pages
715-26issue
2eissn
0022-538Xissn
1098-5514journal_volume
45pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.12.6953-6959.1992
更新日期:1992-12-01 00:00:00
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journal_title:Journal of virology
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doi:10.1128/JVI.64.9.4232-4241.1990
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.11.6768-6777.1993
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pub_type: 杂志文章
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