Abstract:
:The salivary glands of scrapie-affected sheep and healthy controls were investigated for the presence of the pathological prion protein (PrP(Sc)). PrP(Sc) was detected in major (parotid and mandibular) and minor (buccal, labial, and palatine) salivary glands of naturally and experimentally infected sheep. Using Western blotting, the PrP(Sc) concentration in glands was estimated to be 0.02 to 0.005% of that in brain. Immunohistochemistry revealed intracellular depositions of PrP(Sc) in ductal and acinar epithelia and occasional labeling in the lumina of salivary ducts. The presence of PrP(Sc) in salivary glands highlights the possible role of saliva in the horizontal transmission of scrapie.
journal_name
J Viroljournal_title
Journal of virologyauthors
Vascellari M,Nonno R,Mutinelli F,Bigolaro M,Di Bari MA,Melchiotti E,Marcon S,D'Agostino C,Vaccari G,Conte M,De Grossi L,Rosone F,Giordani F,Agrimi Udoi
10.1128/JVI.02148-06subject
Has Abstractpub_date
2007-05-01 00:00:00pages
4872-6issue
9eissn
0022-538Xissn
1098-5514pii
JVI.02148-06journal_volume
81pub_type
杂志文章abstract::Cylindrical projections surrounding the fivefold-symmetry axes in minute virus of mice (MVM) harbor central pores that penetrate through the virion shell. In newly released DNA-containing particles, these pores contain residues 28 to 38 belonging to a single copy of VP2, disposed so that its extreme N-terminal domain ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.80.1.161-171.2006
更新日期:2006-01-01 00:00:00
abstract:UNLABELLED:Reactivation of human cytomegalovirus (HCMV) is a significant cause of disease and death in immunocompromised patients, underscoring the need to understand how latency is controlled. Here we demonstrate that HCMV has evolved to utilize cellular microRNAs (miRNAs) in cells that promote latency to regulate exp...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00481-14
更新日期:2014-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.10.6099-6106.1992
更新日期:1992-10-01 00:00:00
abstract::Experimental reverse genetic replacement of Epstein-Barr virus nuclear antigen 3A (EBNA3A) with a conditional mutant EBNA3A revealed that EBNA3A is critical for continued lymphoblastoid cell (LCL) growth. Wild-type (wt) EBNA3A expressed in the LCLs specifically sustained growth under nonpermissive conditions, whereas ...
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pub_type: 杂志文章
doi:10.1128/JVI.79.16.10171-10179.2005
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01094-19
更新日期:2019-12-12 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.54.2.311-316.1985
更新日期:1985-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.78.7.3704-3709.2004
更新日期:2004-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.1.3.591-598.1967
更新日期:1967-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.80.7.3225-3237.2006
更新日期:2006-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00808-15
更新日期:2015-07-01 00:00:00
abstract::Here we present the first complete genomic sequence of Marek's disease virus serotype 3 (MDV3), also known as turkey herpesvirus (HVT). The 159,160-bp genome encodes an estimated 99 putative proteins and resembles alphaherpesviruses in genomic organization and gene content. HVT is very similar to MDV1 and MDV2 within ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.2.971-978.2001
更新日期:2001-01-01 00:00:00
abstract::The experimental infection of newborn calves with bovine norovirus was used as a homologous large animal model to study the pathogenesis of norovirus infection and to determine target cells for viral replication. Six newborn calves were inoculated orally with Jena virus (JV), a bovine norovirus GIII.1 strain, and six ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.05342-11
更新日期:2011-11-01 00:00:00
abstract::Swine influenza viruses (SIV) naturally infect pigs and can be transmitted to humans. In the pig, genetic reassortment to create novel influenza subtypes by mixing avian, human, and swine influenza viruses is possible. An SIV vaccine inducing cross-protective immunity between different subtypes and strains circulating...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00787-06
更新日期:2006-11-01 00:00:00
abstract:UNLABELLED:The Nairovirus genus of the Bunyaviridae family contains serious human and animal pathogens classified within multiple serogroups and species. Of these serogroups, the Crimean-Congo hemorrhagic fever virus (CCHFV) serogroup comprises sole members CCHFV and Hazara virus (HAZV). CCHFV is an emerging zoonotic v...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00661-16
更新日期:2016-09-29 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00430-15
更新日期:2015-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.35.1.249-251.1980
更新日期:1980-07-01 00:00:00
abstract::We previously reported that a recombinant pantothenate auxotroph of Mycobacterium bovis BCG expressing human immunodeficiency virus type 1 (HIV-1) subtype C Gag (rBCGpan-Gag) efficiently primes the mouse immune system for a boost with a recombinant modified vaccinia virus Ankara (rMVA) vaccine. In this study, we furth...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.03178-12
更新日期:2013-05-01 00:00:00
abstract::The chimpanzee is the only animal model for investigating the pathogenesis of viral hepatitis types A through E in humans. Studies of the host response, including microarray analyses, have relied on the close relationship between these two primate species: chimpanzee samples are commonly tested with human-based reagen...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01205-10
更新日期:2010-11-01 00:00:00
abstract::The objective of this investigation was to examine by electron microscopy the replicative ribonucleoprotein (RNP) structures synthesized in vesicular stomatitis virus-infected HeLa cells. Pulse-labeled in vivo products of vesicular stomatitis virus replication and transcription can be separated by centrifugation in Re...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.34.3.764-771.1980
更新日期:1980-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.10.6070-6075.2003
更新日期:2003-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.4.1.31-35.1969
更新日期:1969-07-01 00:00:00
abstract::The genome of the simian virus 40 (SV40) temperature-sensitive (ts) mutant tsD202 rescued by passage on transformed permissive monkey lines (see accompanying paper [Y. Gluzman et al., J. Virol. 24:534-540, 1977]) was analyzed by restriction endonuclease cleavage mapping to obtain biochemical evidence that the rescue o...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.24.2.541-550.1977
更新日期:1977-11-01 00:00:00
abstract::The cocultivation of a lung cell line from the Southeast Asian mouse Mus cervicolor with cells from heterologous species has resulted in the isolation of two new distinct type C viruses. Both viruses are endogenous to M. cervicolor and are present in multiple copies in the cellular DNA of these mice. One of the viruse...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.21.3.849-862.1977
更新日期:1977-03-01 00:00:00
abstract::Replication of the plus-stranded RNA genome of hepatitis C virus (HCV) occurs in a membrane-bound replication complex consisting of viral and cellular proteins and viral RNA. NS5B, the RNA polymerase of HCV, is anchored to the membranes via a C-terminal 20-amino-acid-long hydrophobic domain, which is flanked on each s...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02072-05
更新日期:2006-11-01 00:00:00
abstract::The replication of many positive-strand RNA viruses [(+)RNA viruses] depends on the cellular protein GBF1, but its role in the replication process is not clear. In uninfected cells, GBF1 activates small GTPases of the Arf family and coordinates multiple steps of membrane metabolism, including functioning of the cellul...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00856-19
更新日期:2019-10-15 00:00:00
abstract::Mouse cytomegalovirus (MCMV) encodes two potential seven-transmembrane-spanning proteins with homologies to cellular chemokine receptors, M33 and M78. While these virus-encoded chemokine receptors are necessary for the in vivo pathogenesis of MCMV, the function of these proteins is unknown. Since vascular smooth muscl...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.16.10788-10795.2005
更新日期:2005-08-01 00:00:00
abstract::The hepatitis C virus (HCV) causes chronic hepatitis in most infected individuals by evading host immune defenses. In this investigation, we show that HCV-infected cells may go undetected in the immune system by suppressing major histocompatibility complex (MHC) class I antigen presentation to cytotoxic T lymphocytes....
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.21.11644-11650.2003
更新日期:2003-11-01 00:00:00
abstract::A cloned segment of the polyoma virus genome encoding the small T antigen has been fused, in the correct phase for translation, to the 5' end of the beta-galactosidase gene. The hybrid gene, cloned in Escherichia coli, produces a protein resembling the small T antigen. ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.36.1.125-132.1980
更新日期:1980-10-01 00:00:00
abstract::Clones of virogenic simian virus 40 (SV40)-transformed hamster kidney cells were exposed to medium deficient in the essential amino acids leucine, arginine, or methionine. Infectious virus was induced after deprivation periods of from 24 to 32 hr. The highest yields of infectious SV40 were obtained from cultures depri...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.9.3.448-453.1972
更新日期:1972-03-01 00:00:00
abstract::Smallpox was eradicated more than 10 years ago, but infection with another Orthopoxvirus, monkeypox virus, can result in a clinical picture resembling smallpox. Human infection with monkeypox virus is extremely rare, not easily transmitted, and confined to the rain forest belt of Africa (Z. Jezek and F. Fenner, p. 81-...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.12.7565-7567.1992
更新日期:1992-12-01 00:00:00