Mouse cytomegalovirus M33 is necessary and sufficient in virus-induced vascular smooth muscle cell migration.

abstract：UNLABELLED:Generalized immune activation during HIV infection is associated with an increased risk of cardiovascular disease, neurocognitive disease, osteoporosis, metabolic disorders, and physical frailty. The mechanisms driving this immune activation are poorly understood, particularly for individuals effectively tre...

journal_title：Journal of virology

authors： Liang EC,Sceats L,Bayless NL,Strauss-Albee DM,Kubo J,Grant PM,Furman D,Desai M,Katzenstein DA,Davis MM,Zolopa AR,Blish CA

更新日期：2014-08-01 00:00:00

abstract：:Glycoprotein H (gH) is conserved among all herpesviruses and is essential for virus entry and cell fusion along with gL, gB, and, in most alphaherpesviruses, gD. Within the gH/gL heterodimer, it is thought that gH accounts for the fusion function and gL acts as a chaperone for the folding and transport of gH. Here, we...

journal_title：Journal of virology

authors： Cairns TM,Friedman LS,Lou H,Whitbeck JC,Shaner MS,Cohen GH,Eisenberg RJ

更新日期：2007-05-01 00:00:00

abstract：:The virion host shutoff (vhs) protein encoded by herpes simplex virus type 1 (HSV-1) destabilizes both viral and host mRNAs. An HSV-1 strain with a mutation in vhs is attenuated in virulence and induces immune responses in mice that are protective against corneal infection with virulent HSV-1, but it has the capacity ...

journal_title：Journal of virology

authors： Geiss BJ,Smith TJ,Leib DA,Morrison LA

更新日期：2000-12-01 00:00:00

abstract：:Nonstructural protein 5A (NS5A) is a membrane-associated essential component of the hepatitis C virus (HCV) replication complex. An N-terminal amphipathic alpha helix mediates in-plane membrane association of HCV NS5A and at the same time is likely involved in specific protein-protein interactions required for the ass...

journal_title：Journal of virology

authors： Brass V,Pal Z,Sapay N,Deléage G,Blum HE,Penin F,Moradpour D

更新日期：2007-03-01 00:00:00

abstract：:The structure of Bacillus subtilis bacteriophage phi25 and phi25 deoxyribonucleic acid (DNA) were studied by electron microscopy. The head of phi25 is a regular polyhedron measuring 75 nm in diameter. The uncontracted tail of phi25 is 130 nm in length and includes a large, complex tail plate. Phage phi25 DNA is double...

journal_title：Journal of virology

authors： Liljemark WF,Anderson DL

更新日期：1970-07-01 00:00:00

abstract：:Macaques immunized with uninfected human cells have been shown to be protected from challenge with simian immunodeficiency virus (SIV) propagated in human cells. To identify the potential antigens involved in this protection, macaques were immunized with uninfected human cells, sucrose density gradient-purified cultur...

journal_title：Journal of virology

authors： Arthur LO,Bess JW Jr,Urban RG,Strominger JL,Morton WR,Mann DL,Henderson LE,Benveniste RE

更新日期：1995-05-01 00:00:00

abstract：:The reovirus core particle is a molecular machine that mediates synthesis, capping, and export of the viral plus strand RNA transcripts. Its assembly and structure-function relationships remain to be well understood. Following the lead of previous studies with other Reoviridae family members, most notably orbiviruses ...

journal_title：Journal of virology

authors： Kim J,Zhang X,Centonze VE,Bowman VD,Noble S,Baker TS,Nibert ML

更新日期：2002-12-01 00:00:00

abstract：:Varicella-zoster virus (VZV) glycoprotein I (gI) is dispensable in cell culture; the SCIDhu model of VZV pathogenesis was used to determine whether gI is necessary in vivo. The parental and repaired viruses grew in human skin and thymus/liver implants, but the gI deletion mutant was not infectious. Thus, gI is essenti...

journal_title：Journal of virology

authors： Moffat J,Ito H,Sommer M,Taylor S,Arvin AM

更新日期：2002-08-01 00:00:00

abstract：:The parvovirus minute virus of mice (MVM) packages predominantly negative-sense single strands, while its close relative LuIII encapsidates strands of both polarities with equal efficiency. Using genomic chimeras and mutagenesis, we show that the ability to package positive strands maps not, as originally postulated, ...

journal_title：Journal of virology

authors： Cotmore SF,Tattersall P

更新日期：2005-02-01 00:00:00

abstract：UNLABELLED:Inhibitor-of-apoptosis (IAP) proteins are key regulators of the innate antiviral response by virtue of their capacity to respond to signals affecting cell survival. In insects, wherein the host IAP provides a primary restriction to apoptosis, diverse viruses trigger rapid IAP depletion that initiates caspase...

journal_title：Journal of virology

authors： Vandergaast R,Mitchell JK,Byers NM,Friesen PD

更新日期：2015-04-01 00:00:00

abstract：:Although parvoviruses are found throughout the animal kingdom, only the human pathogenic B19 virus has so far been shown to possess a limited host range, with erythroid progenitor cells as the main target cells supporting B19 propagation. The underlying mechanism of such erythroid tropism is still unexplained. Synthes...

journal_title：Journal of virology

authors： Pallier C,Greco A,Le Junter J,Saib A,Vassias I,Morinet F

更新日期：1997-12-01 00:00:00

abstract：:BALB/c mice infected on the scarified cornea with herpes simplex virus type 1 strain 35 [HSV-1(35)] rarely developed ocular disease even at challenge doses as high as 10(7) PFU per eye. In contrast, HSV-1(RE) consistently induced stromal keratitis at an inoculum of 2 x 10(4) PFU. The goal of this study was to determin...

journal_title：Journal of virology

authors： Su YH,Oakes JE,Lausch RN

更新日期：1990-05-01 00:00:00

abstract：:Galectin-9 is a pleiotropic immune modulator affecting numerous cell types of innate and adaptive immunity. Patients with chronic infection with either hepatitis C virus (HCV) or HIV have elevated circulating levels. Limited data exist on the regulation of natural killer (NK) cell function through interaction with gal...

journal_title：Journal of virology

authors： Golden-Mason L,McMahan RH,Strong M,Reisdorph R,Mahaffey S,Palmer BE,Cheng L,Kulesza C,Hirashima M,Niki T,Rosen HR

更新日期：2013-05-01 00:00:00

abstract：:Recent studies suggest the existence of cancer stem cells (CSC) and cancer progenitor cells (CPC), although strict definitions of neither CSC nor CPC have been developed. We have produced evidence that the principal oncoprotein of Epstein-Barr virus (EBV), latent membrane protein 1 (LMP1), which is associated with hum...

journal_title：Journal of virology

authors： Kondo S,Wakisaka N,Muramatsu M,Zen Y,Endo K,Murono S,Sugimoto H,Yamaoka S,Pagano JS,Yoshizaki T

更新日期：2011-11-01 00:00:00

abstract：:The putative role of nitric oxide in the neuropathogenesis of Borna disease was investigated by determining changes in the expression of inducible nitric oxide synthase (iNOS) mRNA and constitutively expressed NOS (cNOS) mRNA in brains of Borna disease virus (BDV)-infected rats. iNOS mRNA was not detected in normal ra...

journal_title：Journal of virology

authors： Zheng YM,Schäfer MK,Weihe E,Sheng H,Corisdeo S,Fu ZF,Koprowski H,Dietzschold B

更新日期：1993-10-01 00:00:00

abstract：:Activated Notch1 (AcN1) alleles cooperate with oncogenes from DNA tumor viruses in transformation of epithelial cells. AcN1 signaling has pleiotropic effects, and suggested oncogenic roles include driving proliferation through cyclin D1 or the generation of resistance to apoptosis on matrix withdrawal through a phosph...

journal_title：Journal of virology

authors： Nair P,Somasundaram K,Krishna S

更新日期：2003-06-01 00:00:00

abstract：:Influenza virus has a set of ribonucleoproteins (RNPs) consisting of viral RNAs, influenza virus polymerase subunits, and nucleoprotein. Intracellular reconstitution of the whole set of RNPs via plasmid transfection results in the generation of influenza virus. By the use of reverse genetics and dual promoters, we con...

journal_title：Journal of virology

authors： Zhang X,Kong W,Ashraf S,Curtiss R 3rd

更新日期：2009-09-01 00:00:00

abstract：:Sequences which encode Epstein-Barr virus (EBV) RNA in nasopharyngeal carcinoma (NPC) tissue have been identified. We utilized human biopsy material directly as well as NPC grown in nude mice. Total RNA was extracted from the tumor material and separated into polyadenylated and nonpolyadenylated fractions by oligodeox...

journal_title：Journal of virology

authors： Raab-Traub N,Hood R,Yang CS,Henry B 2nd,Pagano JS

更新日期：1983-12-01 00:00:00

abstract：:Monoclonal antibodies (MAbs) to human immunodeficiency virus type 1 were produced. Two antibodies reacted with the 17-kilodalton core protein (p17) of the virus and with its polyprotein precursor. To various degrees, each MAb neutralized infection by the cell-free virus. With a series of sequential overlapping hexapep...

journal_title：Journal of virology

authors： Papsidero LD,Sheu M,Ruscetti FW

更新日期：1989-01-01 00:00:00

abstract：:The configuration of latent varicella-zoster virus (VZV) DNA was analyzed by PCR. Template DNA for both internal and terminal VZV primers was present in a 1:1 ratio in ganglionic DNA, compared with a 15:1 ratio in DNA extracted from VZV virions, indicating that the VZV genomic termini are adjacent in latently infected...

journal_title：Journal of virology

authors： Clarke P,Beer T,Cohrs R,Gilden DH

更新日期：1995-12-01 00:00:00

abstract：:By using a series of deletion mutants, we have shown that the stimulation of fibroblast growth by E26 requires the cooperation of the two oncogenes, v-myb and v-ets, fused in the nuclear viral product. Of the two DNA-binding domains, only one must be present to promote anchorage-independent growth, whereas that of v-m...

journal_title：Journal of virology

authors： Ravel-Chapuis P,Leprince D,Pain B,Li R,Domenget C,Stehelin D,Samarut J,Jurdic P

更新日期：1991-07-01 00:00:00

abstract：:TR1.3 is a Friend murine leukemia virus (MLV) that induces selective syncytium induction (SI) of brain capillary endothelial cells (BCEC), intracerebral hemorrhage, and death. Syncytium induction by TR1.3 has been mapped to a single tryptophan-to-glycine conversion at position 102 of the envelope glycoprotein (Env102)...

journal_title：Journal of virology

authors： Murphy SL,Chung-Landers M,Honczarenko M,Gaulton GN

更新日期：2006-05-01 00:00:00

abstract：:The single-stranded DNA containing the Moloney murine leukemia virus origin for plus-strand synthesis was cloned in M13mp2 and used as a template for avian myeloblastosis virus reverse transcriptase in the presence of Moloney RNA which had been treated with pancreatic RNase A. The RNA pieces containing the polypurine ...

journal_title：Journal of virology

authors： Champoux JJ,Gilboa E,Baltimore D

更新日期：1984-03-01 00:00:00

abstract：:Among several proposed cellular receptors for bovine viral diarrhea virus (BVDV), the low-density lipoprotein (LDL) receptor is of special interest because it is also considered a receptor for the related hepatitis C virus. It has been reported that an anti-LDL receptor monoclonal antibody blocked the infection of bov...

journal_title：Journal of virology

authors： Krey T,Moussay E,Thiel HJ,Rümenapf T

更新日期：2006-11-01 00:00:00

abstract：:The 3'-end host-virus junction fragments from two bovine leukemia virus (BLV)-induced lymphoid tumors (tumors 15-4 and 1351), each containing a single provirus, were used as probes to detect large restriction fragments flanking these proviruses. The DNAs from 28 other independent BLV-induced tumors were checked by Sou...

journal_title：Journal of virology

authors： Kettmann R,Deschamps J,Couez D,Claustriaux JJ,Palm R,Burny A

更新日期：1983-07-01 00:00:00

abstract：:Long-acting antiretrovirals could provide a useful alternative to daily oral therapy for HIV-1-infected individuals. Building on a bi-specific molecule with adnectins targeting CD4 and gp41, a potential long-acting biologic, GSK3732394, was developed with three independent and synergistic modes of HIV entry inhibition...

journal_title：Journal of virology

authors： Wensel D,Sun Y,Davis J,Li Z,Zhang S,McDonagh T,Langley D,Mitchell T,Tabruyn S,Nef P,Cockett M,Krystal M

更新日期：2019-09-30 00:00:00

abstract：:We have recently described an intracellular protein, p21, in nonproducer cells transformed by either the Kirsten (Ki-MSV) or Harvey (Ha-MSV) strain of murine sarcoma virus (Shih et al., Virology, in press). The p21 is phosphorylated and has been shown to be coded for by either Ki-MSV or Ha-MSV. In this report, we comp...

journal_title：Journal of virology

authors： Shih TY,Weeks MO,Young HA,Scolnick EM

更新日期：1979-08-01 00:00:00

abstract：:Exosomes are small vesicles secreted from cells that participate in intercellular communication events. Accumulating evidence demonstrates that host exosome pathways are hijacked by viruses and that virally modified exosomes contribute to virus spread and immune evasion. In the case of tumor viruses, recent findings s...

journal_title：Journal of virology

authors： Meckes DG Jr

更新日期：2015-05-01 00:00:00

abstract：:Little is known about the biological significance of human adenovirus type 5 (Ad5) E1A in vivo. However, Ad5 E1A is well defined in vitro and can be detected frequently in the lungs of patients with pulmonary disease. Transgenic expression of the Ad5 E1A gene targeted to the mouse lung reveals distinct biological effe...

journal_title：Journal of virology

authors： Yang Y,McKerlie C,Borenstein SH,Lu Z,Schito M,Chamberlain JW,Buchwald M

更新日期：2002-09-01 00:00:00

abstract：:We have studied initiation and regulation of early transcription of simian virus (SV40) DNA in vitro by eucaryotic RNA polymerase II, using both a crude HeLa cell extract and a partially purified calf thymus polymerase supplemented with a HeLa cell S100 fraction. Analysis of initiation sites by primer-directed cDNA sy...

journal_title：Journal of virology

authors： Lebowitz P,Ghosh PK

更新日期：1982-02-01 00:00:00