Epstein-Barr virus transcription in nasopharyngeal carcinoma.

abstract：:The potential use of the modified vaccinia virus Ankara (MVA) strain as a live recombinant vector to deliver antigens and elicit protective immune responses against infectious diseases demands a comprehensive understanding of the effect of MVA infection on human host gene expression. We used microarrays containing mor...

journal_title：Journal of virology

authors： Guerra S,López-Fernández LA,Conde R,Pascual-Montano A,Harshman K,Esteban M

更新日期：2004-06-01 00:00:00

abstract：:A human cytomegalovirus (CMV) UL54 pol exonuclease domain II mutation, D413A, found in a clinical specimen, conferred ganciclovir (GCV) and cidofovir resistance but not foscarnet resistance when incorporated into laboratory strain T2294. After several passages without drug, mutation was observed in five of eight plaqu...

journal_title：Journal of virology

authors： Chou S,Marousek GI

更新日期：2008-01-01 00:00:00

abstract：:Measles virus has two glycoproteins. The larger glycoprotein (HA) is composed of 76,000-dalton subunits that are bound by disulfide bonds. The smaller glycoprotein (F) appears to contain a glucosamine-rich portion that is linked to an unglycosylated protein by disulfide bonds. ...

journal_title：Journal of virology

authors： Hardwick JM,Bussell RH

更新日期：1978-02-01 00:00:00

abstract：:The mechanism of action of hepatitis B virus (HBV) X protein in transcriptional transactivation and in tumorigenesis remains obscure. We have used the yeast two-hybrid system to identify a cellular protein that can interact with HBV X protein. This protein, designated X-associated protein 1 (XAP-1), is a human homolog...

journal_title：Journal of virology

authors： Lee TH,Elledge SJ,Butel JS

更新日期：1995-02-01 00:00:00

abstract：:A bacteriophage with a contractile tail which shows very similar features to R-type pyocins was isolated and characterized. This phage, named PS17,was purified by DEAE-cellulose chromatography and CsCl density gradient centrifugation. It was a DNA-containing phage, and the density of the purified particles in CsCl was...

journal_title：Journal of virology

authors： Kageyama M,Shinomiya T,Aihara Y,Kobayashi M

更新日期：1979-12-01 00:00:00

abstract：:The genome of infectious bursal disease virus consists of two segments of double-stranded RNA of 2.5 X 10(6) and 2.2 X 10(6) molecular weight. Polyacrylamide gel electrophoresis of purified virus resolved four structural polypeptides: VP-1 (90,000), VP-2 (41,000), VP-3 (35,000), and VP-4 (28,000). Peptide map comparis...

journal_title：Journal of virology

authors： Dobos P

更新日期：1979-12-01 00:00:00

abstract：:Bacteriophage T4 gene 32 encodes a DNA unwinding protein required for DNA replication, repair, and recombination. Gene 32 temperature-sensitive mutations enhance virtually all base pair substitution mutation rates. ...

journal_title：Journal of virology

authors： Koch RE,McGaw MK,Drake JW

更新日期：1976-08-01 00:00:00

abstract：:Wild-type clones of reovirus serotypes 1 (Lang), 2 (Jones), and 3 (Dearing) were serially passaged in L cells at a high multiplicity of infection, and the virus population was examined at passage levels 2, 5, and 11 for the presence of temperature-sensitive (ts) mutants. By passage 11 all three serotypes contained ts ...

journal_title：Journal of virology

authors： Ahmed R,Chakraborty PR,Fields BN

更新日期：1980-04-01 00:00:00

abstract：:The influenza A virus nucleoprotein (NP) is a multifunctional polypeptide which plays a pivotal role in virus replication. To get information on the domains and specific residues involved in the different NP activities, we describe here the preparation and characterization of 20 influenza A virus mutant NPs. The mutat...

journal_title：Journal of virology

authors： Mena I,Jambrina E,Albo C,Perales B,Ortín J,Arrese M,Vallejo D,Portela A

更新日期：1999-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a single-stranded positive-sense RNA hepatotropic virus. Despite cellular defenses, HCV is able to replicate in hepatocytes and to establish a chronic infection that could lead to severe complications and hepatocellular carcinoma. An important player in subverting the host response to HCV in...

journal_title：Journal of virology

authors： Çevik RE,Cesarec M,Da Silva Filipe A,Licastro D,McLauchlan J,Marcello A

更新日期：2017-08-24 00:00:00

abstract：:Mitochondria are important for the viral life cycle, mainly by providing the energy required for viral replication and assembly. A highly complex interaction with mitochondria is exerted by rubella virus (RV), which includes an increase in the mitochondrial membrane potential as a general marker for mitochondrial acti...

journal_title：Journal of virology

authors： Claus C,Schönefeld K,Hübner D,Chey S,Reibetanz U,Liebert UG

更新日期：2013-08-01 00:00:00

abstract：:The mechanism of cellular src (c-src) transduction by a transformation-defective deletion mutant, td109, of Rous sarcoma virus was studied by sequence analysis of the recombinational junctions in three td109-derived recovered sarcoma viruses (rASVs). Our results show that two rASVs have been generated by recombination...

journal_title：Journal of virology

authors： Soong MM,Iijima S,Wang LH

更新日期：1986-09-01 00:00:00

abstract：:The host cell-specific factor 1 gene (hcf-1) of the baculovirus Autographa californica nuclear polyhedrosis virus (AcMNPV) is required for the efficient replication and/or stability of reporter plasmids carrying an AcMNPV-derived origin of DNA replication in a cell-specific manner; hcf-1 is required for reporter plasm...

journal_title：Journal of virology

authors： Lu A,Miller LK

更新日期：1996-08-01 00:00:00

abstract：UNLABELLED:The measles virus (MeV) membrane fusion apparatus consists of a fusion protein trimer and an attachment protein tetramer. To trigger membrane fusion, the heads of the MeV attachment protein, hemagglutinin (H), bind cellular receptors while the 96-residue-long H stalk transmits the triggering signal. Structur...

journal_title：Journal of virology

authors： Navaratnarajah CK,Kumar S,Generous A,Apte-Sengupta S,Mateo M,Cattaneo R

更新日期：2014-06-01 00:00:00

abstract：:In patients with impaired cell-mediated immune responses (e.g., lung transplant recipients and AIDS patients), cytomegalovirus (CMV) infection causes severe disease such as pneumonitis. However, although immunocompetency in the host can protect from CMV disease, the virus persists by evading the host immune defenses. ...

journal_title：Journal of virology

authors： Billstrom MA,Johnson GL,Avdi NJ,Worthen GS

更新日期：1998-07-01 00:00:00

abstract：:Despite being able to use the Bonzo coreceptor as efficiently as CCR5 in transfected cells, pediatric human immunodeficiency virus type 1 isolate P6 was unable to replicate in peripheral blood mononuclear cells (PBMC) lacking the CCR5 receptor. Furthermore, its replication in wild-type PBMC was completely inhibited by...

journal_title：Journal of virology

authors： Zhang YJ,Moore JP

更新日期：1999-04-01 00:00:00

abstract：:The nonpathogenic human adeno-associated virus (AAV) has developed a mechanism to integrate its genome into human chromosome 19 at 19q13.4 (termed AAVS1), thereby establishing latency. Here, we provide evidence that the chromosomal signals required for site-specific integration are conserved in the mouse genome proxim...

journal_title：Journal of virology

authors： Dutheil N,Yoon-Robarts M,Ward P,Henckaerts E,Skrabanek L,Berns KI,Campagne F,Linden RM

更新日期：2004-08-01 00:00:00

abstract：:Recombinant myxoma virus (MYXV) can be produced without a loss of infectivity, and its highly specific host range makes it an ideal vaccine vector candidate, although careful examination of its interaction with the immune system is necessary. Similar to rabbit bone marrow-derived dendritic cells (BM-DCs), ovine dendri...

journal_title：Journal of virology

authors： Top S,Foulon E,Pignolet B,Deplanche M,Caubet C,Tasca C,Bertagnoli S,Meyer G,Foucras G

更新日期：2011-12-01 00:00:00

abstract：:The complete genome sequences of two Sulfolobus spindle-shaped viruses (SSVs) from acidic hot springs in Kamchatka (Russia) and Yellowstone National Park (United States) have been determined. These nonlytic temperate viruses were isolated from hyperthermophilic Sulfolobus hosts, and both viruses share the spindle-shap...

journal_title：Journal of virology

authors： Wiedenheft B,Stedman K,Roberto F,Willits D,Gleske AK,Zoeller L,Snyder J,Douglas T,Young M

更新日期：2004-02-01 00:00:00

abstract：:A restriction map was constructed for the 17.5-kilobase SalI C fragment of SP82 DNA. Unfractionated SP82 DNA, the SalI C fragment, and restriction fragments derived from SalI-C were used as templates for in vitro synthesis by the Bacillus subtilis RNA polymerase, and the resulting transcripts were analyzed by gel elec...

journal_title：Journal of virology

authors： Panganiban AT,Whiteley HR

更新日期：1981-01-01 00:00:00

abstract：:The recently developed subgenomic hepatitis C virus (HCV) replicons were limited by the fact that the sequence encoding the structural proteins was missing. Therefore, important information about a possible influence of these proteins on replication and pathogenesis and about the mechanism of virus formation could not...

journal_title：Journal of virology

authors： Pietschmann T,Lohmann V,Kaul A,Krieger N,Rinck G,Rutter G,Strand D,Bartenschlager R

更新日期：2002-04-01 00:00:00

abstract：:Viral recombination has been postulated to play two roles in the development of human immunodeficiency virus (HIV) resistance to antiretroviral drugs. First, recombination has the capacity to associate resistance mutations expressed by distinct viruses, thereby contributing to the development of viruses with improved ...

journal_title：Journal of virology

authors： Nora T,Charpentier C,Tenaillon O,Hoede C,Clavel F,Hance AJ

更新日期：2007-07-01 00:00:00

abstract：:Viral particles purified from species of the protozoan parasite Leishmania braziliensis subsp. guyanensis by centrifugation in CsCl gradients were examined for the presence of viral polymerase. We demonstrated that RNA-dependent RNA polymerase is associated with viral particles. Viral transcription was studied in vitr...

journal_title：Journal of virology

authors： Widmer G,Keenan MC,Patterson JL

更新日期：1990-08-01 00:00:00

abstract：:Viral infection triggers host innate immune responses through cellular sensor molecules which activate multiple signaling cascades that induce the production of interferons (IFN) and other cytokines. The recent identification of mammalian cytoplasmic viral RNA sensors, such as retinoic acid-inducible gene I (RIG-I)-li...

journal_title：Journal of virology

authors： Biacchesi S,LeBerre M,Lamoureux A,Louise Y,Lauret E,Boudinot P,Brémont M

更新日期：2009-08-01 00:00:00

abstract：:Enterovirus 71 (EV71) (genus Enterovirus, family Picornaviridae), a common cause of hand, foot, and mouth disease (HFMD), may also cause severe neurological diseases, such as encephalitis and poliomyelitis-like paralysis. To examine the genetic diversity and rate of evolution of EV71, we have determined and analyzed c...

journal_title：Journal of virology

authors： Brown BA,Oberste MS,Alexander JP Jr,Kennett ML,Pallansch MA

更新日期：1999-12-01 00:00:00

abstract：:The various strains of BK virus (BKV) exhibit a remarkable degree of heterogeneity in the transcriptional control region, which may affect the biological characteristics of a BKV strain. We describe the detection and sequencing of BKV control regions directly from urine samples and after propagation in cell culture. A...

journal_title：Journal of virology

authors： Sundsfjord A,Johansen T,Flaegstad T,Moens U,Villand P,Subramani S,Traavik T

更新日期：1990-08-01 00:00:00

abstract：:Herpes simplex virus DNA replication proteins localize in characteristic patterns corresponding to viral DNA replication structures in the infected cell nucleus. The intranuclear spatial organization of the HSV DNA replication structures and the factors regulating their nuclear location remain to be defined. We have u...

journal_title：Journal of virology

authors： de Bruyn Kops A,Knipe DM

更新日期：1994-06-01 00:00:00

abstract：:We have found that the replicative helicase E1 of bovine papillomavirus type 1 (BPV-1) interacts with a key cell cycle regulator of S phase, the cyclin E-Cdk2 kinase. The E1 helicase, which interacts with cyclin E and not with Cdk2, presents the highest affinity for catalytically active kinase complexes. In addition, ...

journal_title：Journal of virology

authors： Cueille N,Nougarede R,Mechali F,Philippe M,Bonne-Andrea C

更新日期：1998-09-01 00:00:00

abstract：:Virus-specific cytotoxic T lymphocytes (CTL) exert intense selection pressure on replicating simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) in infected individuals. The immunodominant Mamu-A(*)01-restricted Gag p11C, C-M epitope is highly conserved among all sequenced isolates of S...

journal_title：Journal of virology

authors： Peyerl FW,Barouch DH,Yeh WW,Bazick HS,Kunstman J,Kunstman KJ,Wolinsky SM,Letvin NL

更新日期：2003-12-01 00:00:00

abstract：:A variant of human T-cell leukemia virus subgroup I (HTLV-I), designated HTLV-Ib, has been isolated from a transformed T-lymphocytic cell line established from a Zairian patient with adult T-cell lymphoma. A recombinant phage clone of the variant provirus, denoted lambda MC-1, hybridizes under high stringency to HTLV-...

journal_title：Journal of virology

authors： Ratner L,Josephs SF,Starcich B,Hahn B,Shaw GM,Gallo RC,Wong-Staal F

更新日期：1985-06-01 00:00:00