Mutator mutations in bacteriophage T4 gene 32 (DNA unwinding protein).

abstract：:Members of the tripartite interaction motif (TRIM) family of E3 ligases are emerging as critical regulators of innate immunity. To identify new regulators, we carried out a screen of 43 human TRIM proteins for the ability to activate NF-κB, AP-1, and interferon, hallmarks of many innate immune signaling pathways. We i...

journal_title：Journal of virology

authors： Uchil PD,Hinz A,Siegel S,Coenen-Stass A,Pertel T,Luban J,Mothes W

更新日期：2013-01-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is treated with interferon (IFN)-based therapy. The mechanisms by which IFN suppresses HCV replication are not known, and only limited efficacy is achieved with therapy because the virus directs mechanisms to resist the host IFN response. In the present study we characterized the effe...

journal_title：Journal of virology

authors： Wang C,Pflugheber J,Sumpter R Jr,Sodora DL,Hui D,Sen GC,Gale M Jr

更新日期：2003-04-01 00:00:00

abstract：:Production of human papillomavirus type 16 (HPV-16) virus particles is totally dependent on the differentiation-dependent induction of viral L1 and L2 late gene expression. The early polyadenylation signal in HPV-16 plays a major role in the switch from the early to the late, productive stage of the viral life cycle. ...

journal_title：Journal of virology

authors： Oberg D,Fay J,Lambkin H,Schwartz S

更新日期：2005-07-01 00:00:00

abstract：:We previously identified two novel endogenous murine leukemia virus proviruses, PreXMRV-1 and PreXMRV-2, and showed that they most likely recombined during xenograft passaging of a human prostate tumor in mice to generate xenotropic murine leukemia virus-related virus (XMRV). To determine the recombination potential o...

journal_title：Journal of virology

authors： Delviks-Frankenberry K,Paprotka T,Cingöz O,Wildt S,Hu WS,Coffin JM,Pathak VK

更新日期：2013-11-01 00:00:00

abstract：:A chimeric poliovirus type 1 (PV1) genome was constructed in which the 3D RNA polymerase (3D(pol)) coding sequences were replaced with those from coxsackievirus B3 (CVB3). No infectious virus was produced from HeLa cells transfected with the chimeric RNA. Processing of the PV1 capsid protein precursor was incomplete, ...

journal_title：Journal of virology

authors： Bell YC,Semler BL,Ehrenfeld E

更新日期：1999-11-01 00:00:00

abstract：:We demonstrate that the S4 genome segment of baboon reovirus (BRV) contains two sequential partially overlapping open reading frames (ORFs), both of which are functional in vitro and in virus-infected cells. The 15-kDa gene product (p15) of the 5"-proximal ORF induces efficient cell-cell fusion when expressed by itsel...

journal_title：Journal of virology

authors： Dawe S,Duncan R

更新日期：2002-03-01 00:00:00

abstract：:The potential role of T cells in the control of human papillomavirus type 6 (HPV-6) infections is an appealing premise, but their actual role has been sparsely investigated. Since HPV-6 infections are confined to the epithelium, such an investigation should focus on the T cells present at the site of infection (i.e., ...

journal_title：Journal of virology

authors： Hong K,Greer CE,Ketter N,Van Nest G,Paliard X

更新日期：1997-09-01 00:00:00

abstract：:The enzymatic activity of recombinant influenza virus RNA polymerase is strictly dependent on the addition of a template RNA containing 5' and 3' viral sequences. Here we report the analysis of the binding specificity and physical characterization of the complex by using gel shift, modification interference, and densi...

journal_title：Journal of virology

authors： Tiley LS,Hagen M,Matthews JT,Krystal M

更新日期：1994-08-01 00:00:00

abstract：:The objective of this investigation was to examine by electron microscopy the replicative ribonucleoprotein (RNP) structures synthesized in vesicular stomatitis virus-infected HeLa cells. Pulse-labeled in vivo products of vesicular stomatitis virus replication and transcription can be separated by centrifugation in Re...

journal_title：Journal of virology

authors： Naeve CW,Summers DF

更新日期：1980-06-01 00:00:00

abstract：UNLABELLED:The measles virus (MeV) membrane fusion apparatus consists of a fusion protein trimer and an attachment protein tetramer. To trigger membrane fusion, the heads of the MeV attachment protein, hemagglutinin (H), bind cellular receptors while the 96-residue-long H stalk transmits the triggering signal. Structur...

journal_title：Journal of virology

authors： Navaratnarajah CK,Kumar S,Generous A,Apte-Sengupta S,Mateo M,Cattaneo R

更新日期：2014-06-01 00:00:00

abstract：:Envelope (Env) glycoprotein of human immunodeficiency virus type 1 (HIV-1) is an important target for the development of an HIV vaccine. Extensive glycosylation of Env is an important feature that both protects the virus from antibody responses and serves as a target for some highly potent broadly neutralizing antibod...

journal_title：Journal of virology

authors： Wang S,Voronin Y,Zhao P,Ishihara M,Mehta N,Porterfield M,Chen Y,Bartley C,Hu G,Han D,Wells L,Tiemeyer M,Lu S

更新日期：2020-03-17 00:00:00

abstract：:We have demonstrated that Epstein-Barr virus (EBV) confers enhanced growth capability in soft agarose, tumorigenesis in the SCID mouse, and resistance to apoptosis in the Burkitt's lymphoma cell line Akata. Subsequently, we have shown that EBV-encoded small RNAs (EBERs) are responsible for these phenotypes. We constan...

journal_title：Journal of virology

authors： Komano J,Takada K

更新日期：2001-02-01 00:00:00

abstract：:The distantly related lentiviruses human immunodeficiency virus type 1 (HIV-1) and visna virus each encode a posttranscriptional regulatory protein, termed Rev, that is critical for expression of the viral structural proteins. We genetically mapped the cis-acting target sequence for visna virus Rev, the visna virus Re...

journal_title：Journal of virology

authors： Tiley LS,Cullen BR

更新日期：1992-06-01 00:00:00

abstract：:Sequences of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) domain were determined by direct sequencing of HIV-1 RNA in successive plasma samples from eight seroconverting patients infected with virus bearing the T215Y/F amino acid substitution associated with zidovudine (ZDV) resistance. A...

journal_title：Journal of virology

authors： Yerly S,Rakik A,De Loes SK,Hirschel B,Descamps D,Brun-Vézinet F,Perrin L

更新日期：1998-05-01 00:00:00

abstract：:Aluminum (Al)-based salts are widely used adjuvants in ruminants and other species to strengthen the immune response elicited against vaccine antigen(s). However, they can lead to the formation of long-lasting granulomas composed of abundant activated macrophages. Small ruminant lentiviruses (SRLV) are widely distribu...

journal_title：Journal of virology

authors： Echeverría I,de Miguel R,Asín J,Rodríguez-Largo A,Fernández A,Pérez M,de Andrés D,Luján L,Reina R

更新日期：2020-12-22 00:00:00

abstract：:The 5' untranslated region (UTR) of hepatitis C virus (HCV), which is composed of four domains (I, II, III, and IV) and a pseudoknot, is essential for translation and viral replication. Equine nonprimate hepacivirus (EHcV) harbors a 5' UTR consisting of a large 5'-terminal domain (I); three additional domains (I', II,...

journal_title：Journal of virology

authors： Tanaka T,Otoguro T,Yamashita A,Kasai H,Fukuhara T,Matsuura Y,Moriishi K

更新日期：2018-03-14 00:00:00

abstract：:By superinfection of human immunodeficiency virus type 2 (HIV-2) strain HIV-2ben-infected macaques with simian immunodeficiency virus (SIV) strain SIVmac, we investigated the mutual influences of an apathogenic and a pathogenic virus in vivo. Four rhesus and two cynomolgus monkeys were infected with HIV-2ben in 1988 a...

journal_title：Journal of virology

authors： Petry H,Dittmer U,Stahl-Hennig C,Coulibaly C,Makoschey B,Fuchs D,Wachter H,Tolle T,Morys-Wortmann C,Kaup FJ

更新日期：1995-03-01 00:00:00

abstract：:Newcastle disease virus (NDV) belongs to serotype 1 of the avian paramyxoviruses (APMV-1) and causes severe disease in chickens. Current live attenuated NDV vaccines are not fully satisfactory. An alternative is to use a viral vector vaccine that infects chickens but does not cause disease. APMV serotype 3 infects a w...

journal_title：Journal of virology

authors： Kumar S,Nayak B,Collins PL,Samal SK

更新日期：2011-07-01 00:00:00

abstract：:We have previously shown that the herpes simplex virus immediate-early regulatory protein ICP27 acts posttranscriptionally to affect mRNA processing (R. M. Sandri-Goldin and G. E. Mendoza, Genes Dev. 6:848-863, 1992). Specifically, in the presence of ICP27, spliced target mRNAs were decreased 5- to 10-fold in transfec...

journal_title：Journal of virology

authors： Hardwicke MA,Sandri-Goldin RM

更新日期：1994-08-01 00:00:00

abstract：:The efficiency and specificity of gene transfer with human adenovirus (hAd)-derived gene transfer vectors would be improved if the native viral tropism could be modified. Here, we demonstrate that the minor capsid protein IX (pIX), which is present in 240 copies in the Ad capsid, can be exploited as an anchor for hete...

journal_title：Journal of virology

authors： Vellinga J,Rabelink MJ,Cramer SJ,van den Wollenberg DJ,Van der Meulen H,Leppard KN,Fallaux FJ,Hoeben RC

更新日期：2004-04-01 00:00:00

abstract：:The major human tRNA(Lys) isoacceptors, and, are selectively packaged into human immunodeficiency virus type 1 (HIV-1) during assembly, where acts as a primer for reverse transcription. Lysyl-tRNA synthetase (LysRS) is also incorporated into HIV-1, independently of tRNA(Lys), via its interaction with Gag, and is a str...

journal_title：Journal of virology

authors： Guo F,Cen S,Niu M,Javanbakht H,Kleiman L

更新日期：2003-09-01 00:00:00

abstract：:The unit-length genome of human herpesvirus 6 (HHV-6) consists of a single unique component (U) bounded by direct repeats DRL and DRR and forms head-to-tail concatemers during productive infection. cis-elements which mediate cleavage and packaging of progeny virions (a sequences) are found at the termini of all herpes...

journal_title：Journal of virology

authors： Thomson BJ,Dewhurst S,Gray D

更新日期：1994-05-01 00:00:00

abstract：:Human papillomavirus type 1 (HPV1) E4 protein is associated with cytoplasmic and nuclear inclusions in productively infected keratinocytes. Here we have used transient expression of HPV1 E4 (also known as E1E4) protein in keratinocytes to reproduce formation of E4 inclusions. Immunofluorescence analysis showed that pr...

journal_title：Journal of virology

authors： Roberts S,Hillman ML,Knight GL,Gallimore PH

更新日期：2003-01-01 00:00:00

abstract：:A virulent porcine epidemic diarrhea virus (PEDV) strain, DR13, was obtained from suckling pigs suspected of having porcine epidemic diarrhea in 1999 in Korea, and its attenuated counterpart was derived from virulent strain DR13 by serial propagation in Vero cells. This report describes the first complete genome seque...

journal_title：Journal of virology

authors： Park SJ,Kim HK,Song DS,An DJ,Park BK

更新日期：2012-05-01 00:00:00

abstract：:By marker rescue of bacteriophage SP02 sus mutants with purified bacteriophage SP02 DNA fragments, 11 of the 17 known bacteriophage SP02 sus loci were assigned to discrete DNA fragments. The left-most genetic locus, susA, was found to reside near one bacteriophage SP02 terminus (EcoRI-C1 fragment), whereas the right-m...

journal_title：Journal of virology

authors： Graham S,Sutton S,Yoneda Y,Young FE

更新日期：1982-04-01 00:00:00

abstract：:The persistence of measles virus in selected areas of the brains of four patients with subacute sclerosing panencephalitis (SSPE) was characterized by immunohistological and biochemical techniques. The five measles virus structural proteins were never simultaneously detectable in any of the brain sections. Nucleocapsi...

journal_title：Journal of virology

authors： Baczko K,Liebert UG,Billeter M,Cattaneo R,Budka H,ter Meulen V

更新日期：1986-08-01 00:00:00

abstract：:The gene encoding the precursor polypeptide of the Marek's disease herpesvirus (MDHV) secretory glycoprotein gp57-65 (formerly identified as A antigen) has been sequenced. Previous results had localized the gene to a 4.6-kilobase (kb) segment of the BamHI B fragment in the unique long region of the MDHV genome. S1 nuc...

journal_title：Journal of virology

authors： Coussens PM,Velicer LF

更新日期：1988-07-01 00:00:00

abstract：:Coevolution of virus and host is a process that emerges in persistent virus infections. Here we studied the coevolutionary development of coxsackievirus B3 (CVB3) and cardiac myocytes representing the major target cells of CVB3 in the heart in a newly established persistently CVB3-infected murine cardiac myocyte cell ...

journal_title：Journal of virology

authors： Pinkert S,Klingel K,Lindig V,Dörner A,Zeichhardt H,Spiller OB,Fechner H

更新日期：2011-12-01 00:00:00

abstract：:Disruption of Epstein-Barr virus (EBV) latency is mediated by ZEBRA, the protein product of the immediate-early EBV gene, BZLF1. In vitro, phorbol 12-myristate 13-acetate (PMA), a potent activator of protein kinase C (PKC), induces reactivation of EBV. However, the physiological stimuli responsible for the disruption ...

journal_title：Journal of virology

authors： Fahmi H,Cochet C,Hmama Z,Opolon P,Joab I

更新日期：2000-07-01 00:00:00

abstract：:In herpes simplex virus type 2, the mRNAs of ICP4 and ICP22/47 are divergently transcribed and their transcription initiation sites are separated by 750 base pairs (L. J. Whitton and J. B. Clements, Nucleic Acids Res. 12:2061-2078, 1984). This 750-base-pair region contains many recognized cis-acting elements, includin...

journal_title：Journal of virology

authors： Smith CA,Marchetti ME,Edmonson P,Schaffer PA

更新日期：1989-05-01 00:00:00