Preexisting nuclear architecture defines the intranuclear location of herpesvirus DNA replication structures.

abstract：:The adenovirus major late transcription unit (MLTU) encodes five families of mRNAs, L1 to L5, each distinguished by a unique poly(A) site. Use of the promoter-proximal L1 poly(A) site predominates during early infection, whereas poly(A) site choice shifts to the promoter-distal sites during late infection. A mini-MLTU...

journal_title：Journal of virology

authors： Gilmartin GM,Hung SL,DeZazzo JD,Fleming ES,Imperiale MJ

更新日期：1996-03-01 00:00:00

abstract：:The major adenovirus (Ad) capsid proteins hexon, penton, and fiber influence the efficiency and tropism of gene transduction by Ad vectors. Fiber is the high-affinity receptor binding protein that serves to mediate cell attachment in vitro when using coxsackie-adenovirus receptor (CAR)-containing cell lines. This cont...

journal_title：Journal of virology

authors： Schoggins JW,Nociari M,Philpott N,Falck-Pedersen E

更新日期：2005-09-01 00:00:00

abstract：:Three polyadenylated RNAs, 9, 7.3, and 3.5 kilobases long, of a human endogenous retrovirus, ERV3, are abundant in human placental chorion, representing about 0.03 to 0.05% of the total mRNA. We characterized the structure of these mRNAs by Northern blot and S1 nuclease mapping analyses. We found that all three RNAs w...

journal_title：Journal of virology

authors： Kato N,Pfeifer-Ohlsson S,Kato M,Larsson E,Rydnert J,Ohlsson R,Cohen M

更新日期：1987-07-01 00:00:00

abstract：:Experimental reverse genetic replacement of Epstein-Barr virus nuclear antigen 3A (EBNA3A) with a conditional mutant EBNA3A revealed that EBNA3A is critical for continued lymphoblastoid cell (LCL) growth. Wild-type (wt) EBNA3A expressed in the LCLs specifically sustained growth under nonpermissive conditions, whereas ...

journal_title：Journal of virology

authors： Maruo S,Johannsen E,Illanes D,Cooper A,Zhao B,Kieff E

更新日期：2005-08-01 00:00:00

abstract：:Although iridoviruses vary widely within and among genera with respect to their host range and virulence, variation within iridovirus species has been less extensively characterized. This study explores the nature and extent of intraspecific variation within an emerging iridovirus of North American warm-water fishes, ...

journal_title：Journal of virology

authors： Goldberg TL,Coleman DA,Grant EC,Inendino KR,Philipp DP

更新日期：2003-08-01 00:00:00

abstract：:The insertion of a particular phi X DNA sequence in the plasmid pACYC177 strongly decreased the capacity of Escherichia coli cells containing such a plasmid to propagate bacteriophage phi X174. The smallest DNA sequence tested that showed the effect was the HindII fragment R4. This fragment does not code for a complet...

journal_title：Journal of virology

authors： van der Avoort HG,van Arkel GA,Weisbeek PJ

更新日期：1982-04-01 00:00:00

abstract：UNLABELLED:Enterovirus 71 (EV71) recruits various cellular factors to assist in the replication and translation of its genome. Identification of the host factors involved in the EV71 life cycle not only will enable a better understanding of the infection mechanism but also has the potential to be of use in the developm...

journal_title：Journal of virology

authors： Zhang H,Song L,Cong H,Tien P

更新日期：2015-10-01 00:00:00

abstract：:Two major DNA variants have been isolated from serially propagated stocks of the WR strain of vaccinia virus. Restriction enzyme mapping of the two variants with HindIII, AvaI, XhoI, SstII, and SmaI revealed a 6.3-megadalton deletion in the smaller DNA variant. The deletion was mapped at ca. 6.8 megadaltons in from th...

journal_title：Journal of virology

authors： Panicali D,Davis SW,Mercer SR,Paoletti E

更新日期：1981-03-01 00:00:00

abstract：:The effect of human cytomegalovirus infection on cellular DNA synthesis in human fibroblasts was measured by fluorometry and by incorporation of radiolabeled thymidine. The results show that although HCMV infection stimulates cellular DNA synthesis in both quiescent and serum-stimulated cells, radiolabeled thymidine i...

journal_title：Journal of virology

authors： Morin J,Johann S,O'Hara B,Gluzman Y

更新日期：1996-09-01 00:00:00

abstract：:Abnormal prion protein (PrP(Sc)) plays a central role in the transmission of prion diseases, but the molecular basis of prion strains with distinct biological characteristics remains to be elucidated. We analyzed the characteristics of prion disease by using mice inoculated with the Chandler and Fukuoka-1 strains prop...

journal_title：Journal of virology

authors： Arima K,Nishida N,Sakaguchi S,Shigematsu K,Atarashi R,Yamaguchi N,Yoshikawa D,Yoon J,Watanabe K,Kobayashi N,Mouillet-Richard S,Lehmann S,Katamine S

更新日期：2005-06-01 00:00:00

abstract：:Macrophages perform a central role in the pathogenesis of human immunodeficiency virus type 1 (HIV-1) infection and have been implicated as the cell type most prominent in the development of central nervous system impairment. In this study, we evaluated the effect of interaction between macrophages and endothelial cel...

journal_title：Journal of virology

authors： Gilles PN,Lathey JL,Spector SA

更新日期：1995-04-01 00:00:00

abstract：:The herpes simplex virus type 1 UL6 protein forms a 12-subunit ring structure at a unique capsid vertex which functions as a conduit for encapsidation of the viral genome. To characterize UL6 protein domains that are involved in intersubunit interactions and interactions with other capsid proteins, we engineered a set...

journal_title：Journal of virology

authors： Nellissery JK,Szczepaniak R,Lamberti C,Weller SK

更新日期：2007-09-01 00:00:00

abstract：:Gammaretroviruses, such as murine leukemia virus (MLV), are functionally distinguished from lentiviruses, such as human immunodeficiency virus, by their inability to infect nondividing cells. Attempts to engineer this property into MLV have been hindered by an incomplete understanding of early events in the viral life...

journal_title：Journal of virology

authors： Yu JH,Schaffer DV

更新日期：2006-09-01 00:00:00

abstract：:The E6 oncoproteins encoded by the cancer-associated human papillomaviruses (HPVs) can associate with and promote the degradation of wild-type p53 in vitro. To gain further insight into this process, the ability of HPV-16 E6 to complex with and promote the degradation of mutant forms of p53 was studied. A correlation ...

journal_title：Journal of virology

authors： Scheffner M,Takahashi T,Huibregtse JM,Minna JD,Howley PM

更新日期：1992-08-01 00:00:00

abstract：:Epstein-Barr virus (EBV)-associated membrane antigens have been purified from the plasma membranes of the producer cell line P3HR-1 NONO. The antigens were assayed with a specific rabbit anti-ebv antiserum using an 125I-labeled staphylococcal protein A binding assay. The antigens have been shown to be present on purif...

journal_title：Journal of virology

authors： Thorley-Lawson DA,Edson CM

更新日期：1979-11-01 00:00:00

abstract：:Borna disease virus (BDV) is a neurotropic virus with a broad host and geographic range. Lewis rats were immunized against BDV with a recombinant vaccinia virus expressing the BDV nucleoprotein and were later infected with BDV to evaluate protection against Borna disease (BD). Relative to animals that were not immuniz...

journal_title：Journal of virology

authors： Lewis AJ,Whitton JL,Hatalski CG,Weissenböck H,Lipkin WI

更新日期：1999-03-01 00:00:00

abstract：:To identify the domains of Vpr that are involved nuclear localization, we transfected HeLa cells with a panel of expression vectors that encode mutant Vpr protein with deletions or substitutions within putative domains. Immunofluorescence staining of transfected cells revealed that wild-type Vpr was localized predomin...

journal_title：Journal of virology

authors： Kamata M,Aida Y

更新日期：2000-08-01 00:00:00

abstract：:Integrase of human immunodeficiency virus type 1 (HIVIN) consists of 288 amino acids, and its minimum DNA-binding domain (MDBD) (amino acids [aa] 220 to 270) is required for the integration reaction. We produced and characterized four murine monoclonal antibodies (MAbs) to the MDBD of HIVIN (strain LAI). Immunoblot an...

journal_title：Journal of virology

authors： Ishikawa T,Okui N,Kobayashi N,Sakuma R,Kitamura T,Kitamura Y

更新日期：1999-05-01 00:00:00

abstract：:Human hepatitis B virus (HBV) HBx protein is a multifunctional protein that activates cellular signaling pathways and is thought to be essential for viral infection. Woodchuck HBV mutants that lack HBx are unable to replicate in vivo or are severely impaired. HBV replication in HepG2 cells, a human hepatoblastoma cell...

journal_title：Journal of virology

authors： Bouchard MJ,Puro RJ,Wang L,Schneider RJ

更新日期：2003-07-01 00:00:00

abstract：:Initiation of the Epstein-Barr virus (EBV) lytic cycle is dependent on expression of the viral transactivator Zta, which is encoded by the BZLF1 gene. Described here is an initial mapping of the regions of Zta involved in activating transcription. The data indicate that the amino-terminal 153 amino acids of Zta are im...

journal_title：Journal of virology

authors： Flemington EK,Borras AM,Lytle JP,Speck SH

更新日期：1992-02-01 00:00:00

abstract：UNLABELLED:Generalized immune activation during HIV infection is associated with an increased risk of cardiovascular disease, neurocognitive disease, osteoporosis, metabolic disorders, and physical frailty. The mechanisms driving this immune activation are poorly understood, particularly for individuals effectively tre...

journal_title：Journal of virology

authors： Liang EC,Sceats L,Bayless NL,Strauss-Albee DM,Kubo J,Grant PM,Furman D,Desai M,Katzenstein DA,Davis MM,Zolopa AR,Blish CA

更新日期：2014-08-01 00:00:00

abstract：:Viruses cause about 15% of the cancers that are still the leading causes of human mortality. The discovery of viral oncogenes has enhanced our understanding of viral oncogenesis. However, the underlying molecular mechanisms of virus-induced cancers are complex and require further investigation. The present study has a...

journal_title：Journal of virology

authors： Xu S,Xue C,Li J,Bi Y,Cao Y

更新日期：2011-01-01 00:00:00

abstract：:A method for obtaining large quantities of defective interfering (DI) rabies virus particles that fulfill all the criteria delineated by Huang and Baltimore (1970) is described. The purified rabies DI virion was found to be much shorter (60 to 80 nm) than the complete virion (180 nm) and to have a viral genome of abou...

journal_title：Journal of virology

authors： Wiktor TJ,Dietzschold B,Leamnson RN,Koprowski H

更新日期：1977-02-01 00:00:00

abstract：UNLABELLED:In contrast to many viruses, human cytomegalovirus (HCMV) is unable to productively infect most cancer-derived cell lines. The mechanisms of this restriction are unclear. To explore this issue, we tested whether defined oncogenic alleles, including the simian virus 40 (SV40) T antigen (TAg) and oncogenic H-R...

journal_title：Journal of virology

authors： Xu S,Schafer X,Munger J

更新日期：2016-04-14 00:00:00

abstract：:The adenovirus type 5 mutant dl1520 was engineered previously to be completely defective for E1B-55K functions. Recently, this mutant (also known as ONYX-015) has been suggested to replicate preferentially in p53(-) and some p53(+) tumor cell lines but to be attenuated in primary cultured cells (C. Heise, A. Sampson-J...

journal_title：Journal of virology

authors： Harada JN,Berk AJ

更新日期：1999-07-01 00:00:00

abstract：:Closed circular unintegrated DNA of the SEATO strain of gibbon ape leukemia virus (GaLV-S) was isolated from canine thymus fibroblasts after cocultivation with chronically infected bat lung fibroblasts. Restriction endonuclease HindIII cleaves GaLV-S DNA once, thus allowing isolation and cloning of HindIII-digested un...

journal_title：Journal of virology

authors： Gelmann EP,Trainor CD,Wong-Staal F,Reitz MS

更新日期：1982-10-01 00:00:00

abstract：:CD81 has been described as a putative receptor for hepatitis C virus (HCV); however, its role in HCV cell entry has not been characterized due to the lack of an efficient cell culture system. We have examined the role of CD81 in HCV glycoprotein-dependent entry by using a recently developed retroviral pseudotyping sys...

journal_title：Journal of virology

authors： Zhang J,Randall G,Higginbottom A,Monk P,Rice CM,McKeating JA

更新日期：2004-02-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a cytoplasmic receptor/transcription factor that modulates several cellular and immunological processes following activation by pathogen-associated stimuli, though its role during virus infection is largely unknown. Here, we show that AhR is activated in cells infected with mouse...

journal_title：Journal of virology

authors： Grunewald ME,Shaban MG,Mackin SR,Fehr AR,Perlman S

更新日期：2020-01-17 00:00:00

abstract：:Deoxyribonucleoside triphosphates are incorporated into T4 DNA in infected cells treated with toluene. Under the proper conditions the incorporation is controlled by the known T4 DNA polymerase and proceeds by a semiconservative mechanism. Both strands of the phage DNA are replicated into a high molecular weight proge...

journal_title：Journal of virology

authors： Miller RC Jr,Taylor DM,MacKay K,Smith HW

更新日期：1973-12-01 00:00:00

abstract：:Beta interferon (IFN-beta) expression is triggered by double-stranded RNA, a common intermediate in the replication of many viruses including hepatitis C virus (HCV). The recent development of cell culture-grown HCV allowed us to analyze the IFN signaling pathway following virus infection. In this study, we have exami...

journal_title：Journal of virology

authors： Kanda T,Steele R,Ray R,Ray RB

更新日期：2007-11-01 00:00:00