Characterization of a bacteriophage related to R-type pyocins.

abstract：:Strains of Theiler's murine encephalomyelitis virus (TMEV) are divided into two subgroups, TO and GDVII. TMEV strains show subgroup-specific virus growth and cell tropism and induce subgroup-specific diseases. Using site-directed mutagenesis, we demonstrated that the amino acid at position 57 of the leader protein (L(...

journal_title：Journal of virology

authors： Takano-Maruyama M,Ohara Y,Asakura K,Okuwa T

更新日期：2006-12-01 00:00:00

abstract：:Human rhinoviruses (HRVs) were discovered as common cold pathogens over 50 years ago. Recent advances in molecular viral diagnostics have led to an appreciation of their role in more-significant respiratory illnesses, including bronchiolitis in infancy, childhood pneumonia, and acute exacerbations of chronic respirato...

journal_title：Journal of virology

authors： Gern JE

更新日期：2010-08-01 00:00:00

abstract：UNLABELLED:In contrast to many viruses, human cytomegalovirus (HCMV) is unable to productively infect most cancer-derived cell lines. The mechanisms of this restriction are unclear. To explore this issue, we tested whether defined oncogenic alleles, including the simian virus 40 (SV40) T antigen (TAg) and oncogenic H-R...

journal_title：Journal of virology

authors： Xu S,Schafer X,Munger J

更新日期：2016-04-14 00:00:00

abstract：:Beta interferon (IFN-beta) expression is triggered by double-stranded RNA, a common intermediate in the replication of many viruses including hepatitis C virus (HCV). The recent development of cell culture-grown HCV allowed us to analyze the IFN signaling pathway following virus infection. In this study, we have exami...

journal_title：Journal of virology

authors： Kanda T,Steele R,Ray R,Ray RB

更新日期：2007-11-01 00:00:00

abstract：:Prophylactic hepatitis C virus (HCV) vaccine trials with human volunteers are pending. There is an important need for immunological end points which correlate with vaccine efficacy and which do not involve invasive procedures, such as liver biopsies. By using a multicomponent DNA priming-protein boosting vaccine strat...

journal_title：Journal of virology

authors： Rollier C,Depla E,Drexhage JA,Verschoor EJ,Verstrepen BE,Fatmi A,Brinster C,Fournillier A,Whelan JA,Whelan M,Jacobs D,Maertens G,Inchauspé G,Heeney JL

更新日期：2004-01-01 00:00:00

abstract：:Intranuclear and intracytoplasmic inclusions in monkey kidney cells infected with African horsesickness virus were studied with the aid of electron microscopy. ...

journal_title：Journal of virology

authors： Breese SS Jr,Ozawa Y

更新日期：1969-07-01 00:00:00

abstract：:A recombinant capripoxvirus vaccine containing a cDNA of the peste-des-petits-ruminants virus (PPRV) fusion protein gene was constructed. A quick and efficient method was used to select a highly purified recombinant virus clone. A trial showed that a dose of this recombinant as low as 0.1 PFU protected goats against c...

journal_title：Journal of virology

authors： Berhe G,Minet C,Le Goff C,Barrett T,Ngangnou A,Grillet C,Libeau G,Fleming M,Black DN,Diallo A

更新日期：2003-01-01 00:00:00

abstract：:Hepatitis E virus (HEV) replication is not well understood, mainly because the virus does not infect cultured cells efficiently. However, Huh-7 cells transfected with full-length genomes produce open reading frame 2 protein, indicative of genome replication (6). To investigate the role of 3'-terminal sequences in RNA ...

journal_title：Journal of virology

authors： Graff J,Nguyen H,Kasorndorkbua C,Halbur PG,St Claire M,Purcell RH,Emerson SU

更新日期：2005-01-01 00:00:00

abstract：:Infection of newborn Lewis rats with Borna disease virus (neonatal Borna disease [NBD]) results in cerebellar damage without the cellular inflammation associated with infections in later life. Purkinje cell (PC) damage has been reported for several models of early-life viral infection, including NBD; however, the time...

journal_title：Journal of virology

authors： Williams BL,Yaddanapudi K,Hornig M,Lipkin WI

更新日期：2007-03-01 00:00:00

abstract：:Cleavage of varicella-zoster virus DNA with the restriction endonucleases PstI, XbaI, and BglII resulted in 18, 22, and 20 fragments, respectively. Based on the molecular weights and molarities of these fragments, a molecular weight of 84 x 10(6) could be calculated for the varicella-zoster virus genome. In both the X...

journal_title：Journal of virology

authors： Dumas AM,Geelen JL,Weststrate MW,Wertheim P,van der Noordaa J

更新日期：1981-08-01 00:00:00

abstract：:We previously reported that exosomal transfer of hepatitis C virus (HCV) positive-strand RNA from human Huh-7 hepatoma cells to human plasmacytoid dendritic cells (pDCs) triggers pDC alpha/beta interferon (IFN-α/β) production in a Toll-like receptor 7 (TLR7)-dependent, virus-independent manner. Here we show that human...

journal_title：Journal of virology

authors： Wieland SF,Takahashi K,Boyd B,Whitten-Bauer C,Ngo N,de la Torre JC,Chisari FV

更新日期：2014-01-01 00:00:00

abstract：:The 1957 A/H2N2 influenza virus caused an estimated 2 million fatalities during the pandemic. Since viruses of the H2 subtype continue to infect avian species and pigs, the threat of reintroduction into humans remains. To determine factors involved in the zoonotic origin of the 1957 pandemic, we performed analyses on ...

journal_title：Journal of virology

authors： Joseph U,Linster M,Suzuki Y,Krauss S,Halpin RA,Vijaykrishna D,Fabrizio TP,Bestebroer TM,Maurer-Stroh S,Webby RJ,Wentworth DE,Fouchier RA,Bahl J,Smith GJ,CEIRS H2N2 Working Group.

更新日期：2015-02-01 00:00:00

abstract：:Retroviruses, as a result of the presence of two identical genomic RNA molecules in their virions, recombine at a high rate. When nonhomologous RNA is present in the dimer RNA molecules, nonhomologous recombination can occur, although the rate is very low, only 0.1% of the rate of essentially homologous recombination ...

journal_title：Journal of virology

authors： Zhang J,Temin HM

更新日期：1994-04-01 00:00:00

abstract：:Many viral fusion proteins are primed by proteolytic cleavage near their fusion peptides. While the coronavirus (CoV) spike (S) protein is known to be cleaved at the S1/S2 boundary, this cleavage site is not closely linked to a fusion peptide. However, a second cleavage site has been identified in the severe acute res...

journal_title：Journal of virology

authors： Madu IG,Roth SL,Belouzard S,Whittaker GR

更新日期：2009-08-01 00:00:00

abstract：:The major immediate-early (MIE) gene of human cytomegalovirus (HCMV) expresses IE86, IE72, IE55, and IE18 mRNA by differential splicing. Reverse transcription-PCR with IE72-specific primers generated an 0.65-kb cDNA from HCMV-infected fibroblast RNA, which does not correspond to any known MIE cDNA. Nucleotide sequenci...

journal_title：Journal of virology

authors： Shirakata M,Terauchi M,Ablikim M,Imadome K,Hirai K,Aso T,Yamanashi Y

更新日期：2002-04-01 00:00:00

abstract：:Whether a genetic informational nucleic acid is required for the infectivity of transmissible spongiform encephalopathies is central to the debate about the infectious agent. Here we report that an infectious prion formed with bacterially expressed recombinant prion protein plus synthetic polyriboadenylic acid and syn...

journal_title：Journal of virology

authors： Wang F,Zhang Z,Wang X,Li J,Zha L,Yuan CG,Weissmann C,Ma J

更新日期：2012-02-01 00:00:00

abstract：:The early proteins of simian virus 40 (SV40) large T and small t antigen (T/t antigen) can each cause the transcriptional activation of a variety of cellular and viral promoters. We showed previously that simian cellular DNA-binding factors (the Band A factors) bind to sequences within the SV40 late promoter which are...

journal_title：Journal of virology

authors： Gallo GJ,Gruda MC,Manuppello JR,Alwine JC

更新日期：1990-01-01 00:00:00

abstract：:We recently found that a human T-cell leukemia virus type 1-infected cell line, MT-2, could support the replication of hepatitis C virus (HCV) (N. Kato, T. Nakazawa, T. Mizutani, and K. Shimotohno, Biochem. Biophys. Res. Commun. 206:863-869, 1995). In order to develop a culture system in which HCV replicates more effi...

journal_title：Journal of virology

authors： Mizutani T,Kato N,Saito S,Ikeda M,Sugiyama K,Shimotohno K

更新日期：1996-10-01 00:00:00

abstract：:The release of Bluetongue virus (BTV) and other members of the Orbivirus genus from infected host cells occurs predominantly by cell lysis, and in some cases, by budding from the plasma membrane. Two nonstructural proteins, NS3 and NS3A, have been implicated in this process. Here we show that both proteins bind to hum...

journal_title：Journal of virology

authors： Wirblich C,Bhattacharya B,Roy P

更新日期：2006-01-01 00:00:00

abstract：:The simian virus 40 (SV40) large tumor antigen (Tag) is a virus-encoded oncoprotein which is the target of a strong cytotoxic T-lymphocyte (CTL) response. Three immunodominant H-2(b)-restricted epitopes, designated epitopes I, II/III, and IV, have been defined. We investigated whether induction of CTLs directed agains...

journal_title：Journal of virology

authors： Schell TD,Mylin LM,Georgoff I,Teresky AK,Levine AJ,Tevethia SS

更新日期：1999-07-01 00:00:00

abstract：:An in vitro poliovirus RNA-synthesizing system derived from a crude membrane fraction of infected HeLa cells was used to analyze the mechanism of initiation of poliovirus plus-strand RNA synthesis. This system contains an activity that synthesizes the nucleotidyl proteins VPg-pU and VPg-pUpU. These molecules represent...

journal_title：Journal of virology

authors： Takeda N,Kuhn RJ,Yang CF,Takegami T,Wimmer E

更新日期：1986-10-01 00:00:00

abstract：:Foxp3(+) CD4(+) regulatory T cells (Tregs) represent a highly suppressive T cell subset with well-characterized immunosuppressive effects during immune homeostasis and chronic infections, although the role of these cells in acute viral infections is poorly understood. The present study sought to examine the induction ...

journal_title：Journal of virology

authors： Betts RJ,Prabhu N,Ho AW,Lew FC,Hutchinson PE,Rotzschke O,Macary PA,Kemeny DM

更新日期：2012-03-01 00:00:00

abstract：:Hepatitis C virus (HCV) is an important human pathogen associated with chronic liver disease. Recently, based on a genotype 2a isolate, tissue culture systems supporting complete replication and infectious virus production have been developed. In this study, we used cell culture-produced infectious HCV to analyze the ...

journal_title：Journal of virology

authors： Tscherne DM,Jones CT,Evans MJ,Lindenbach BD,McKeating JA,Rice CM

更新日期：2006-02-01 00:00:00

abstract：:In addition to encoding the structural and regulatory proteins, many viruses encode auxiliary proteins, some of which have been shown to play important roles in lytic and latent states of the viruses. The human neurotropic JC virus (JCV) genome encodes an auxiliary protein called Agno whose function remains unknown. H...

journal_title：Journal of virology

authors： Safak M,Barrucco R,Darbinyan A,Okada Y,Nagashima K,Khalili K

更新日期：2001-02-01 00:00:00

abstract：:Nipah virus (NiV), of the family Paramyxoviridae, was isolated in 1999 in Malaysia from a human fatality in an outbreak of severe human encephalitis, when human infections were linked to transmission of the virus from pigs. Consequently, a swine vaccine able to abolish virus shedding is of veterinary and human health ...

journal_title：Journal of virology

authors： Weingartl HM,Berhane Y,Caswell JL,Loosmore S,Audonnet JC,Roth JA,Czub M

更新日期：2006-08-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) evokes a strong immune response, but the virus persists. Polymorphisms within known antigenic sites result in loss of immune recognition and can be positively selected. Amino acid variation outside known HLA class I restricted epitopes can also enable immune escape by interf...

journal_title：Journal of virology

authors： Zimbwa P,Milicic A,Frater J,Scriba TJ,Willis A,Goulder PJ,Pillay T,Gunthard H,Weber JN,Zhang HT,Phillips RE

更新日期：2007-02-01 00:00:00

abstract：:9-([2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) is more potent and has a more prolonged inhibitory effect against Epstein-Barr virus (EBV) in vitro than does acyclovir (ACV). To assess the mechanism of this difference, we first compared the extent of phosphorylation of the two drugs in superinfected Ra...

journal_title：Journal of virology

authors： Lin JC,Nelson DJ,Lambe CU,Choi EI

更新日期：1986-11-01 00:00:00

abstract：:The presence of a high number of activated T cells in the bloodstream and spontaneous proliferation of peripheral blood mononuclear cells in vitro are striking characteristics of human T-cell leukemia virus type I (HTLV-I) infection. The HTLV-I regulatory protein Tax and the envelope protein gp46 have been implicated ...

journal_title：Journal of virology

authors： Kimata JT,Palker TJ,Ratner L

更新日期：1993-06-01 00:00:00

abstract：:Flavopiridol, roscovitine, and other inhibitors of Cyclin-Dependent Kinases (CDK) inhibit the replication of a variety of viruses in vitro while proving nontoxic in human clinical trials of their effects against cancer. Consequently, these and other Pharmacological CDK inhibitors (PCIs) have been proposed as potential...

journal_title：Journal of virology

authors： Diwan P,Lacasse JJ,Schang LM

更新日期：2004-09-01 00:00:00

abstract：:The host cell regulators and substrates of the Rous sarcoma virus transforming protein pp60v-src remain largely unknown. Viral mutants which induce a host-dependent phenotype may result from mutations which affect the interaction of pp60v-src with host cell components. To isolate such mutants and to examine the role o...

journal_title：Journal of virology

authors： DeClue JE,Martin GS

更新日期：1989-02-01 00:00:00