Activity increase in respiratory chain complexes by rubella virus with marginal induction of oxidative stress.

abstract：:In 2002, severe acute respiratory syndrome (SARS)-coronavirus (CoV) appeared as a novel human virus with high similarity to bat coronaviruses. However, while SARS-CoV uses the human angiotensin-converting enzyme 2 (ACE2) receptor for cellular entry, no coronavirus isolated from bats appears to use ACE2. Here we show t...

journal_title：Journal of virology

authors： Demogines A,Farzan M,Sawyer SL

更新日期：2012-06-01 00:00:00

abstract：:Our ability to rapidly respond to an emerging influenza pandemic is hampered somewhat by the lack of a susceptible small-animal model. To develop a more sensitive model, we pathotyped 18 low-pathogenic non-mouse-adapted influenza A viruses of human and avian origin in DBA/2 and C57BL/6 mice. The majority of the isolat...

journal_title：Journal of virology

authors： Boon AC,deBeauchamp J,Krauss S,Rubrum A,Webb AD,Webster RG,McElhaney J,Webby RJ

更新日期：2010-08-01 00:00:00

abstract：:African green monkeys can maintain long-term persistent infection with simian immunodeficiency viruses (SIVagm) without developing AIDS and thus provide an important model for understanding mechanisms of natural host resistance to disease. This study assessed the levels and anatomic distribution of SIVagm in healthy, ...

journal_title：Journal of virology

authors： Broussard SR,Staprans SI,White R,Whitehead EM,Feinberg MB,Allan JS

更新日期：2001-03-01 00:00:00

abstract：:Tetherin/BST-2 is a host-encoded protein that restricts a wide diversity of viruses at the stage of virion release. However, viruses have evolved antagonists of Tetherin, including the Vpu and Nef proteins of primate lentiviruses. Like other host genes subject to viral antagonism, primate Tetherin genes have evolved u...

journal_title：Journal of virology

authors： Lim ES,Malik HS,Emerman M

更新日期：2010-07-01 00:00:00

abstract：:A restriction map was constructed for the 17.5-kilobase SalI C fragment of SP82 DNA. Unfractionated SP82 DNA, the SalI C fragment, and restriction fragments derived from SalI-C were used as templates for in vitro synthesis by the Bacillus subtilis RNA polymerase, and the resulting transcripts were analyzed by gel elec...

journal_title：Journal of virology

authors： Panganiban AT,Whiteley HR

更新日期：1981-01-01 00:00:00

abstract：:The three primary capsid proteins (A, B, and C) of adeno-associated viruses have been shown previously to contain overlapping amino acid sequences (R. McPherson and J. Rose, J. Virol. 46:523-529, 1983). In the present study we demonstrate definitively that these proteins are encoded in the right half of the adeno-asso...

journal_title：Journal of virology

authors： Janik JE,Huston MM,Rose JA

更新日期：1984-11-01 00:00:00

abstract：:Although adeno-associated virus type 2 (AAV) has gained attention as a potentially useful vector for human gene therapy, the transduction efficiencies of AAV vectors vary greatly in different cells and tissues in vitro and in vivo. We have documented that a cellular tyrosine phosphoprotein, designated the single-stran...

journal_title：Journal of virology

authors： Qing K,Hansen J,Weigel-Kelley KA,Tan M,Zhou S,Srivastava A

更新日期：2001-10-01 00:00:00

abstract：UNLABELLED:Next-generation sequence analysis of virus-like particles (VLPs) produced during agroinfiltration of cucumber necrosis virus (CNV) coat protein (CP) and of authentic CNV virions was conducted to assess if host RNAs can be encapsidated by CNV CP. VLPs containing host RNAs were found to be produced during agro...

journal_title：Journal of virology

authors： Ghoshal K,Theilmann J,Reade R,Maghodia A,Rochon D

更新日期：2015-11-01 00:00:00

abstract：:Proteolytic processing of the picornaviral polyprotein mediated by the differential action of virus-encoded proteinase(s) is pivotal to both RNA genome replication and capsid formation. Possibly to enlarge the array of viral proteins, picornaviral polyprotein processing results in intermediate and mature products whic...

journal_title：Journal of virology

authors： Probst C,Jecht M,Gauss-Müller V

更新日期：1998-10-01 00:00:00

abstract：:Replication of the human herpesvirus Epstein-Barr virus drastically impairs cellular protein synthesis. This shutoff phenotype results from mRNA degradation upon expression of the early lytic-phase protein BGLF5. Interestingly, BGLF5 is the viral DNase, or alkaline exonuclease, homologues of which are present througho...

journal_title：Journal of virology

authors： Horst D,Burmeister WP,Boer IG,van Leeuwen D,Buisson M,Gorbalenya AE,Wiertz EJ,Ressing ME

更新日期：2012-09-01 00:00:00

abstract：:As part of the continuing effort to develop an effective HIV vaccine, we generated a poxviral vaccine vector (previously described) designed to improve on the results of the RV144 phase III clinical trial. The construct, NYVAC-KC, is a replication-competent, attenuated recombinant of the vaccinia virus strain NYVAC. N...

journal_title：Journal of virology

authors： Kibler KV,Asbach B,Perdiguero B,García-Arriaza J,Yates NL,Parks R,Stanfield-Oakley S,Ferrari G,Montefiori DC,Tomaras GD,Roederer M,Foulds KE,Forthal DN,Seaman MS,Self S,Gottardo R,Phogat S,Tartaglia J,Barnett S,Cris

更新日期：2019-01-17 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) establishes a lifelong latent infection in peripheral nerve ganglia. Periodically, the virus reactivates from this latent reservoir and is transported to the original site of infection. Strains of HSV-1 have been noted to vary greatly in their virulence and reactivation efficiencies in a...

journal_title：Journal of virology

authors： Grams TR,Edwards TG,Bloom DC

更新日期：2020-07-16 00:00:00

abstract：:Hepatitis C virus (HCV) nonstructural protein 5B (NS5B) is an RNA-dependent RNA polymerase (RdRp) that acts as a key player in the HCV replication complex. Understanding the interplay between the viral and cellular components of the HCV replication complex could provide new insight for prevention of the progression of...

journal_title：Journal of virology

authors： Huang JT,Tseng CP,Liao MH,Lu SC,Yeh WZ,Sakamoto N,Chen CM,Cheng JC

更新日期：2013-05-01 00:00:00

abstract：:The core promoter mutants of hepatitis B virus (HBV) emerge as the dominant viral population at the late HBeAg and the anti-HBe stages of HBV infection, with the A1762T/G1764A substitutions as the hotspot mutations. The double core promoter mutations were found by many investigators to moderately enhance viral genome ...

journal_title：Journal of virology

authors： Parekh S,Zoulim F,Ahn SH,Tsai A,Li J,Kawai S,Khan N,Trépo C,Wands J,Tong S

更新日期：2003-06-01 00:00:00

abstract：:Tegument is a unique structure of herpesvirus, which surrounds the capsid and interacts with the envelope. Morphogenesis of gammaherpesvirus is poorly understood due to lack of efficient lytic replication for Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8, which are etiologically as...

journal_title：Journal of virology

authors： Guo H,Wang L,Peng L,Zhou ZH,Deng H

更新日期：2009-10-01 00:00:00

abstract：:The mechanism of cellular src (c-src) transduction by a transformation-defective deletion mutant, td109, of Rous sarcoma virus was studied by sequence analysis of the recombinational junctions in three td109-derived recovered sarcoma viruses (rASVs). Our results show that two rASVs have been generated by recombination...

journal_title：Journal of virology

authors： Soong MM,Iijima S,Wang LH

更新日期：1986-09-01 00:00:00

abstract：:The immunosuppressant drug rapamycin blocks progression of the cell cycle at G1 in mammalian cells and yeast. We recently showed that rapamycin inhibits both in vitro and in vivo cap-dependent, but not cap-independent, translation. This inhibition is causally related to reduced phosphorylation and consequent activatio...

journal_title：Journal of virology

authors： Beretta L,Svitkin YV,Sonenberg N

更新日期：1996-12-01 00:00:00

abstract：:Flock house virus is a small insect virus with a bipartite RNA genome consisting of RNA1 and RNA2. RNA3 is a subgenomic element encoded by RNA1, the genomic segment required for viral RNA synthesis (T. M. Gallagher, P. D. Friesen, and R. R. Rueckert, J. Virol. 46:481-489, 1983). Synthesis of RNA3 is strongly inhibited...

journal_title：Journal of virology

authors： Zhong W,Rueckert RR

更新日期：1993-05-01 00:00:00

abstract：:Viral attenuation may be due to lowered efficiency of certain steps essential for viral multiplication. For the construction of less neurovirulent strains of poliovirus in vitro, we introduced deletions into the 5' noncoding sequence (742 nucleotides long) of the genomes of the Mahoney and Sabin 1 strains of polioviru...

journal_title：Journal of virology

authors： Iizuka N,Kohara M,Hagino-Yamagishi K,Abe S,Komatsu T,Tago K,Arita M,Nomoto A

更新日期：1989-12-01 00:00:00

abstract：:Half of the world's population is exposed to the risk of dengue virus infection. Although a vaccine for dengue virus is now available in a few countries, its reported overall efficacy of about 60% is not ideal. Protective immune correlates following natural dengue virus infection remain undefined, which makes it diffi...

journal_title：Journal of virology

authors： Xu M,Züst R,Toh YX,Pfaff JM,Kahle KM,Davidson E,Doranz BJ,Velumani S,Tukijan F,Wang CI,Fink K

更新日期：2016-11-28 00:00:00

abstract：:The spikes of alphaviruses are composed of three copies of an E2-E1 heterodimer. The E1 protein possesses membrane fusion activity, and the E2 protein, or its precursor form, p62 (sometimes called PE2), controls this function. Both proteins are, together with the viral capsid protein, translated from a common C-p62-E1...

journal_title：Journal of virology

authors： Andersson H,Barth BU,Ekström M,Garoff H

更新日期：1997-12-01 00:00:00

abstract：:A cloned segment of the polyoma virus genome encoding the small T antigen has been fused, in the correct phase for translation, to the 5' end of the beta-galactosidase gene. The hybrid gene, cloned in Escherichia coli, produces a protein resembling the small T antigen. ...

journal_title：Journal of virology

authors： Horwich A,Koop AH,Eckhart W

更新日期：1980-10-01 00:00:00

abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent of PRRS, which has important impacts on the pig industry. PRRSV infection results in disruption of the swine leukocyte antigen class I (SLA-I) antigen presentation pathway. In this study, highly pathogenic PRRSV (HP-PRRSV) infection inh...

journal_title：Journal of virology

authors： Qi P,Liu K,Wei J,Li Y,Li B,Shao D,Wu Z,Shi Y,Tong G,Qiu Y,Ma Z

更新日期：2017-02-14 00:00:00

abstract：:Murine cytomegalovirus (MCMV) proteins m142 and m143 are essential for viral replication. They bind double-stranded RNA and prevent protein kinase R-induced protein synthesis shutoff. Whether the two viral proteins have additional functions such as their homologs in human cytomegalovirus do remained unknown. We show t...

journal_title：Journal of virology

authors： Ostermann E,Warnecke G,Waibler Z,Brune W

更新日期：2015-10-28 00:00:00

abstract：:The diverse sequences of viral populations within individual hosts are the starting material for selection and subsequent evolution of RNA viruses such as foot-and-mouth disease virus (FMDV). Using next-generation sequencing (NGS) performed on a Genome Analyzer platform (Illumina), this study compared the viral popula...

journal_title：Journal of virology

authors： Wright CF,Morelli MJ,Thébaud G,Knowles NJ,Herzyk P,Paton DJ,Haydon DT,King DP

更新日期：2011-03-01 00:00:00

abstract：:While epidermal growth factor receptor (EGFR) has been shown to be important in the entry process for multiple viruses, including hepatitis C virus (HCV), the molecular mechanisms by which EGFR facilitates HCV entry are not well understood. Using the infectious cell culture HCV model (HCVcc), we demonstrate that the b...

journal_title：Journal of virology

authors： Diao J,Pantua H,Ngu H,Komuves L,Diehl L,Schaefer G,Kapadia SB

更新日期：2012-10-01 00:00:00

abstract：:A protamine-like protein named P6.9 is thought to play a role in the condensation of genomes of the baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) during an infection. Previous studies have shown that P6.9 is phosphorylated immediately upon synthesis and dephosphorylated upon the entry of th...

journal_title：Journal of virology

authors： Liu X,Zhao H,Fang Z,Yuan M,Yang K,Pang Y

更新日期：2012-11-01 00:00:00

abstract：:Recombinant human cytomegaloviruses that do not express UL97 kinase activity exhibit a distinctive plaque morphology characterized by the formation of highly refractile bodies late in infection. These structures were also observed in infected cells treated with the UL97 kinase inhibitor maribavir. Nuclear inclusions w...

journal_title：Journal of virology

authors： Prichard MN,Britt WJ,Daily SL,Hartline CB,Kern ER

更新日期：2005-12-01 00:00:00

abstract：:Replication of flock house virus (FHV) RNA1 and production of subgenomic RNA3 in the yeast Saccharomyces cerevisiae provide a useful tool for the dissection of FHV molecular biology and host-encoded functions involved in RNA replication. The replication template activity of RNA1 can be separated from its coding potent...

journal_title：Journal of virology

authors： Lindenbach BD,Sgro JY,Ahlquist P

更新日期：2002-04-01 00:00:00

abstract：:The contribution of the hepatitis B virus enhancers I and II in the regulation of the activity of the core and the X promoters was assessed in transgenic mice. Surprisingly, despite the presence of heterologous promoters linked 5' of the X gene, the transgene expression is mostly due to core promoter (Cp) activity pre...

journal_title：Journal of virology

authors： Billet O,Grimber G,Levrero M,Seye KA,Briand P,Joulin V

更新日期：1995-09-01 00:00:00