Ancient adaptive evolution of tetherin shaped the functions of Vpu and Nef in human immunodeficiency virus and primate lentiviruses.

abstract：:Two poliovirus mutants were isolated that contain an oligonucleotide linker insertion in the 2C-coding region of the viral genome. One, 2C-31, has a strongly temperature-sensitive phenotype and the other, 2C-32, forms small plaques on HeLa cell monolayers at all temperatures. Both mutants have a severe temperature-sen...

journal_title：Journal of virology

authors： Li JP,Baltimore D

更新日期：1988-11-01 00:00:00

abstract：:CD4+ T-cell depletion in AIDS patients involves induction of apoptosis in human immunodeficiency virus (HIV)-infected and noninfected T cells. The HIV type 1 (HIV-1)-transactivating protein Tat enhances apoptosis and activation-induced cell death (AICD) of human T cells. This effect is mediated by the CD95 (APO-1/Fas)...

journal_title：Journal of virology

authors： Ehret A,Westendorp MO,Herr I,Debatin KM,Heeney JL,Frank R,Krammer PH

更新日期：1996-09-01 00:00:00

abstract：:Interferons (IFNs) are a critical component of the first line of antiviral defense. The activation of Toll-like receptors (TLRs) expressed by dendritic cells triggers different signaling cascades that result in the production of large amounts of IFNs. However, the functional consequences of TLR activation and differen...

journal_title：Journal of virology

authors： Ioannidis I,Ye F,McNally B,Willette M,Flaño E

更新日期：2013-03-01 00:00:00

abstract：:We found that recircularized high-risk (type 16 and 18) and low-risk mucosal (type 6b and 11) and cutaneous (type 5 and 8) human papillomavirus (HPV) genomes replicate readily when delivered into U2OS cells by electroporation. The replication efficiency is dependent on the amount of input HPV DNA and can be followed f...

journal_title：Journal of virology

authors： Geimanen J,Isok-Paas H,Pipitch R,Salk K,Laos T,Orav M,Reinson T,Ustav M Jr,Ustav M,Ustav E

更新日期：2011-04-01 00:00:00

abstract：:The entire genome of the reference strain of bluetongue virus (BTV) serotype 16 (strain RSArrrr/16) was sequenced (a total of 23,518 base pairs). The virus was obtained from the Orbivirus Reference Collection (ORC) at IAH, Pirbright, United Kingdom. The virus strain, which was previously provided by the Onderstepoort ...

journal_title：Journal of virology

authors： Maan S,Maan NS,Singh KP,Belaganahalli MN,Guimera M,Pullinger G,Nomikou K,Mertens PP

更新日期：2012-09-01 00:00:00

abstract：:We have studied the functions of the intracellular RNAs of mouse mammary tumor virus (MMTV) by purification and translation in vitro. Two major size classes of MMTV RNA, 35S and 24S RNA, were isolated from MMTV-infected rat (XC) cells and cultured mammary tumor cells by preparative hybridization of whole cell or polya...

journal_title：Journal of virology

authors： Dudley JP,Varmus HE

更新日期：1981-07-01 00:00:00

abstract：:Porcine circovirus 2 (PCV2) is a T=1 nonenveloped icosahedral virus that has had severe impact on the swine industry. Here we report the crystal structure of an N-terminally truncated PCV2 virus-like particle at 2.3-Å resolution, and the cryo-electron microscopy (cryo-EM) image reconstruction of a full-length PCV2 vir...

journal_title：Journal of virology

authors： Khayat R,Brunn N,Speir JA,Hardham JM,Ankenbauer RG,Schneemann A,Johnson JE

更新日期：2011-08-01 00:00:00

abstract：:The effect of bacteriophage SPO1 infection of Bacillus subtilis and a deoxyribonucleic acid (DNA) polymerase-deficient (pol(-)) mutant of this microorganism on the synthesis of DNA has been examined. Soon after infection, the incorporation of deoxyribonucleoside triphosphates into acid-insoluble material by cell lysat...

journal_title：Journal of virology

authors： Yehle CO,Ganesan AT

更新日期：1972-02-01 00:00:00

abstract：:Human coronavirus NL63 (HCoV-NL63), a common human respiratory pathogen, is associated with both upper and lower respiratory tract disease in children and adults. Currently, no antiviral drugs are available to treat CoV infections; thus, potential drug targets need to be identified and characterized. Here, we identify...

journal_title：Journal of virology

authors： Chen Z,Wang Y,Ratia K,Mesecar AD,Wilkinson KD,Baker SC

更新日期：2007-06-01 00:00:00

abstract：:The barley stripe mosaic virus (BSMV) beta(b) gene product is the major viral nonstructural protein synthesized during early stages of the infection cycle and is required for systemic movement of the virus. To examine the biochemical properties of beta(b), a histidine tag was engineered at the amino terminus and the p...

journal_title：Journal of virology

authors： Donald RG,Lawrence DM,Jackson AO

更新日期：1997-02-01 00:00:00

abstract：:While RNA silencing is a potent antiviral defense in plants, well-adapted plant viruses are known to encode suppressors of RNA silencing (VSR) that can neutralize the effectiveness of RNA silencing. As a result, most plant genes involved in antiviral silencing were identified by using debilitated viruses lacking silen...

journal_title：Journal of virology

authors： Zhang X,Zhang X,Singh J,Li D,Qu F

更新日期：2012-06-01 00:00:00

abstract：:Storage of the dimeric (alphabeta) form of avian myeloblastosis virus (AMV) DNA polymerase in glycerol resulted in the release of the smaller alpha subunit, as detected by glycerol gradient sedimentation. Analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis of enzyme stored in glycerol showed the conc...

journal_title：Journal of virology

authors： Papas TS,Marciani DJ,Samuel K,Chirikjian JG

更新日期：1976-06-01 00:00:00

abstract：:The v-rel oncogene encoded by reticuloendotheliosis virus strain T is the acutely transforming member of the Rel/NF-kappaB family of transcription factors. In v-Rel-transformed cells, v-Rel exists as homodimers or heterodimers with the endogenous Rel/NF-kappaB proteins c-Rel, NF-kappaB1, NF-kappaB2, and RelA. To exami...

journal_title：Journal of virology

authors： Liss AS,Bose HR Jr

更新日期：2002-05-01 00:00:00

abstract：:Similar to other positive-sense, single-stranded RNA viruses, hepatitis C virus (HCV) replicates its genome in a remodeled intracellular membranous structure known as the membranous web (MW). To date, the process of MW formation remains unclear. It is generally acknowledged that HCV nonstructural protein 4B (NS4B) can...

journal_title：Journal of virology

authors： Xu S,Pei R,Guo M,Han Q,Lai J,Wang Y,Wu C,Zhou Y,Lu M,Chen X

更新日期：2012-12-01 00:00:00

abstract：:Endogenous viral elements derived from nonretroviral RNA viruses have been described in various animal genomes. Whether they have a biological function, such as host immune protection against related viruses, is a field of intense study. Here, we investigated the repertoire of endogenous flaviviral elements (EFVEs) in...

journal_title：Journal of virology

authors： Suzuki Y,Frangeul L,Dickson LB,Blanc H,Verdier Y,Vinh J,Lambrechts L,Saleh MC

更新日期：2017-07-12 00:00:00

abstract：:When mouse L cells are infected for 22 hr with vesicular stomatitis virus (VSV), a ribonucleic acid-containing enveloped virus, greater than 70% of the major histocompatibility antigen (H-2), is no longer detectable by the method of inhibition of immune cytolysis. Infected cells prelabeled with (14)C-glucosamine also ...

journal_title：Journal of virology

authors： Hecht TT,Summers DF

更新日期：1972-10-01 00:00:00

abstract：:Previous findings of low levels of reverse transcriptase (RT) activity in chick cell-derived measles and mumps vaccines showed this activity to be associated with virus particles containing RNA of both subgroup E endogenous avian leukosis viruses (ALV-E) and endogenous avian viruses (EAV). These particles originate fr...

journal_title：Journal of virology

authors： Johnson JA,Heneine W

更新日期：2001-04-01 00:00:00

abstract：:Equine herpesvirus type 1 (EHV-1), a member of the Alphaherpesviridae, displays a broad host range in vitro, allowing for detailed study of the mechanisms of productive infection, including attachment and entry, in various cell culture systems. Previously, we showed that EHV-1 infects Chinese hamster ovary (CHO-K1) ce...

journal_title：Journal of virology

authors： Frampton AR Jr,Stolz DB,Uchida H,Goins WF,Cohen JB,Glorioso JC

更新日期：2007-10-01 00:00:00

abstract：:In Epstein-Barr virus (EBV)-carrying nonproducer Raji cells, the induction of the viral replicative cycle by chemical treatment is limited to only the early stage and viral DNA synthesis is totally inhibited. We previously showed the absence of two messenger RNAs that are encoded by the BamHI-A fragment of the EBV gen...

journal_title：Journal of virology

authors： Decaussin G,Leclerc V,Ooka T

更新日期：1995-11-01 00:00:00

abstract：:Analysis of six monoclonal antibody-resistant (mar) mutants in herpes simplex virus type 1 glycoprotein B identified two type-common (II and III) and two type-specific (I and IV) antigenic sites on this molecule. To derive additional information on the location of these sites, mar mutations were mapped and nucleotide ...

journal_title：Journal of virology

authors： Highlander SL,Dorney DJ,Gage PJ,Holland TC,Cai W,Person S,Levine M,Glorioso JC

更新日期：1989-02-01 00:00:00

abstract：:Pretreatment with two biological response modifiers (BRM), OK-432 and PS-K, protected mice from lethal infection by murine cytomegalovirus (MCMV). This was evidenced by an increase in 50% lethal doses and a decrease in titers of infectious viruses replicated in the liver and spleen. Spleen cells from the BRM-treated m...

journal_title：Journal of virology

authors： Ebihara K,Minamishima Y

更新日期：1984-07-01 00:00:00

abstract：:Two foot-and-mouth disease virus (FMDV) genome sequences have been determined for isolates collected from recent field outbreaks in North Africa (Egypt) and the Middle East (Palestinian Autonomous Territories). These data represent the first examples of complete genomic sequences for the FMDV SAT 2 topotype VII, which...

journal_title：Journal of virology

authors： Valdazo-González B,Knowles NJ,Hammond J,King DP

更新日期：2012-08-01 00:00:00

abstract：:The RV144 HIV-1 vaccine trial (Thailand, 2003 to 2009), using immunogens genetically matched to the regional epidemic, demonstrated the first evidence of efficacy for an HIV-1 vaccine. Here we studied the molecular evolution of the HIV-1 epidemic from the time of immunogen selection to the execution of the efficacy tr...

journal_title：Journal of virology

authors： Kijak GH,Tovanabutra S,Rerks-Ngarm S,Nitayaphan S,Eamsila C,Kunasol P,Khamboonruang C,Thongcharoen P,Namwat C,Premsri N,Benenson M,Morgan P,Bose M,Sanders-Buell E,Paris R,Robb ML,Birx DL,De Souza MS,McCutchan FE,Mic

更新日期：2013-07-01 00:00:00

abstract：:A closed circular, double-stranded infectious DNA of Moloney leukemia virus has been described previously. The present report characterizes a second type of infectious, unintegrated viral DNA which is linear, largely double stranded, and of mass comparable to that of the closed circular viral DNA. The linear form is o...

journal_title：Journal of virology

authors： Smotkin D,Yoshimura FK,Weinberg RA

更新日期：1976-12-01 00:00:00

abstract：:The complete nucleotide sequence of the NS mRNA of vesicular stomatitis virus (New Jersey serotype) was established from two cDNA clones spanning the entire coding region of the mRNA. The gene is 856 nucleotides long and can code for a polypeptide of 274 amino acids. Comparison with the nucleotide sequence of the NS g...

journal_title：Journal of virology

authors： Gill DS,Banerjee AK

更新日期：1985-07-01 00:00:00

abstract：:Retroviruses use RNA as their genetic material within viral particles and DNA (provirus) as their genetic material within cells. The rate of recombination during reverse transcription between two identical sequences within the same RNA molecule is very high. In this study, we have developed a sensitive system to study...

journal_title：Journal of virology

authors： Li T,Zhang J

更新日期：2000-08-01 00:00:00

abstract：:Human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines constitutively produce high levels of biologically active lymphotoxin (LT; tumor necrosis factor-beta) protein and LT mRNA. To understand the regulation of LT transcription by HTLV-I, we analyzed the ability of a series of deletions of the LT promoter t...

journal_title：Journal of virology

authors： Paul NL,Lenardo MJ,Novak KD,Sarr T,Tang WL,Ruddle NH

更新日期：1990-11-01 00:00:00

abstract：:Transient transfection assays indicated that A2L is one of three vaccinia virus intermediate genes that are required for the transcriptional transactivation of viral late genes. We have expressed the A2L open reading frame in Escherichia coli and shown by blotting experiments that the 26-kDa protein binds zinc, a prop...

journal_title：Journal of virology

authors： Keck JG,Feigenbaum F,Moss B

更新日期：1993-10-01 00:00:00

abstract：:Virus-infected cells secrete a broad range of interferons (IFN) which confer resistance to yet uninfected cells by triggering the synthesis of antiviral factors. The relative contributions of the various IFN subtypes to innate immunity against virus infections remain elusive. IFN-alpha, IFN-beta, and other type I IFN ...

journal_title：Journal of virology

authors： Mordstein M,Neugebauer E,Ditt V,Jessen B,Rieger T,Falcone V,Sorgeloos F,Ehl S,Mayer D,Kochs G,Schwemmle M,Günther S,Drosten C,Michiels T,Staeheli P

更新日期：2010-06-01 00:00:00

abstract：:Apoptosis is a type of controlled cell death that is essential for development and tissue homeostasis. It also serves as a robust host response against infection by many viruses. The capacity of neurotropic viruses to induce apoptosis strongly correlates with virulence. However, the precise function of apoptosis in vi...

journal_title：Journal of virology

authors： Pruijssers AJ,Hengel H,Abel TW,Dermody TS

更新日期：2013-12-01 00:00:00