Abstract:
:Measles virus has two glycoproteins. The larger glycoprotein (HA) is composed of 76,000-dalton subunits that are bound by disulfide bonds. The smaller glycoprotein (F) appears to contain a glucosamine-rich portion that is linked to an unglycosylated protein by disulfide bonds.
journal_name
J Viroljournal_title
Journal of virologyauthors
Hardwick JM,Bussell RHdoi
10.1128/JVI.25.2.687-692.1978subject
Has Abstractpub_date
1978-02-01 00:00:00pages
687-92issue
2eissn
0022-538Xissn
1098-5514journal_volume
25pub_type
杂志文章abstract::Transgenic mice containing the complete human immunodeficiency virus (HIV) coding sequences fused to the mouse mammary tumor virus long terminal repeat were generated. They were found to produce high levels of authentic gag and env HIV proteins in several tissues known to support mouse mammary tumor virus-driven trans...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.6.3904-3908.1992
更新日期:1992-06-01 00:00:00
abstract::The regressing and conventional strains of Friend virus were compared by neutralization assays, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and tryptic peptide mapping of the individual viral components. Neutralization rates of the two viruses differed in the presence of monospecific anti-gp70 antiserum...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.33.3.1083-1096.1980
更新日期:1980-03-01 00:00:00
abstract::Nondefective reticuloendotheliosis virus induces chicken bursal lymphoma in a manner similar to that of avian leukosis virus. The provirus integrates in the c-myc locus and uses a promoter insertion mechanism to activate c-myc expression. We cloned a provirus involved in c-myc activation from a B lymphoma. Detailed st...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.61.7.2084-2090.1987
更新日期:1987-07-01 00:00:00
abstract::The double-stranded-DNA bacteriophages employ powerful molecular motors to translocate genomic DNA into preformed capsids during the packaging step in phage assembly. Bacillus subtilis bacteriophage 29 has an oligomeric prohead RNA (pRNA) that is an essential component of its packaging motor. The crystal structure of ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01370-12
更新日期:2012-11-01 00:00:00
abstract::A poliovirus-specific polyuridylic acid [poly(U)] polymerase that copies a polyadenylic acid template complexed to an oligouridylic acid primer was isolated from the membrane fraction of infected HeLa cells and was found to sediment at 4 to 5S on a linear 5 to 20% glycerol gradient. When the poly(U) polymerase was iso...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.29.1.352-360.1979
更新日期:1979-01-01 00:00:00
abstract::Rhesus cytomegalovirus (RhCMV) infection of macaques exhibits strong similarities to human CMV (HCMV) persistence and pathogenesis. The immunogenicity of DNA vaccines encoding three RhCMV proteins (a truncated version of glycoprotein B lacking the transmembrane region and endodomain [gBDeltaTM], phosphoprotein 65-2 [p...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01708-06
更新日期:2007-02-01 00:00:00
abstract::Herpes simplex virus (HSV) glycoprotein D (gD) is modified with mannose 6-phosphate (M6P) and binds to M6P receptors (MPRs). MPRs are involved in the well-characterized pathway by which lysosomal enzymes are directed to lysosomes via a network of endosomal membranes. Based on the impaired ability of HSV to form plaque...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.4.3330-3339.1998
更新日期:1998-04-01 00:00:00
abstract::The unit-length genome of human herpesvirus 6 (HHV-6) consists of a single unique component (U) bounded by direct repeats DRL and DRR and forms head-to-tail concatemers during productive infection. cis-elements which mediate cleavage and packaging of progeny virions (a sequences) are found at the termini of all herpes...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.5.3007-3014.1994
更新日期:1994-05-01 00:00:00
abstract::Apoptosis of virus-infected cells occurs either as a direct response to viral infection or upon recognition of infection by the host immune response. Apoptosis reduces production of new virus from these cells, and therefore viruses have evolved inhibitory mechanisms. We previously showed that laboratory strains of her...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.11.8950-8957.1999
更新日期:1999-11-01 00:00:00
abstract::Herpes simplex virus type 1 (HSV-1) DNA and RNA have been detected in peripheral nervous system (PNS) and central nervous system (CNS) tissues of latently infected mice. However, explant methods are successful in reactivating HSV-1 only from latently infected PNS tissues. In this report, latent herpesvirus infections ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.62.3.749-756.1988
更新日期:1988-03-01 00:00:00
abstract::Differential effect of various metabolic inhibitors on the development of hemadsorption activity and virus formation in cells infected with Newcastle disease virus (NDV) was investigated. It was found that, in BHK-21 cells infected with NDV, cycloheximide did not prevent the development of hemadsorption activity, wher...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.11.4.479-486.1973
更新日期:1973-04-01 00:00:00
abstract::The HXLF (HindIII-X left reading frame) gene family is a group of five genes that share one or two regions of homology and are arranged in tandem within the short unique component of the human cytomegalovirus genome (K. Weston and B.G. Barrell, J. Mol. Biol. 192:177-208, 1986). These genes were cloned into an SP6 expr...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.62.6.1956-1962.1988
更新日期:1988-06-01 00:00:00
abstract::An unusual human retrovirus was isolated from two patients with persistent generalized lymphadenopathy who originate from West-Central Africa and are currently residing in Belgium. Although the virus shared a number of the same biological and morphological properties as human immunodeficiency retrovirus type 1 (HIV-1)...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.3.1207-1216.1990
更新日期:1990-03-01 00:00:00
abstract::Influenza virus enters its host cell by receptor-mediated endocytosis followed by acid-activated membrane fusion in endosomes. The viral ribonucleoprotein particles (vRNPs) delivered into the cytosol then dissociate from the matrix protein, M1, and from each other, after which they are individually imported into the n...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.12.8391-8401.1996
更新日期:1996-12-01 00:00:00
abstract::Influenza virus infection initiates transcription of a variety of genes for cytokines such as tumor necrosis factor alpha (TNF-alpha), TNF-beta, interleukin 1 alpha, (IL-1 alpha), IL-1 beta, IL-2, IL-4, IL-6, IL-10, granulocyte macrophage colony-stimulating factor, and gamma interferon. However, the mechanism by which...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.3.1480-1484.1995
更新日期:1995-03-01 00:00:00
abstract::Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is indispensable for viral DNA replication and episome maintenance in latency. Four promoters, Cp, Wp, Qp, and Fp, are known to drive EBNA1 expression. Here we show that the TATA-less Qp is constitutively active in a variety of EBV-positive [EBV(+)] tumors and cell li...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.9.7075-7083.1998
更新日期:1998-09-01 00:00:00
abstract::The simian picornaviruses were isolated from various primate tissues during the development of general tissue culture methods in the 1950s to 1970s or from specimens derived from primates used in biomedical research. Twenty simian picornavirus serotypes are recognized, and all are presently classified within the Enter...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.3.1244-1251.2002
更新日期:2002-02-01 00:00:00
abstract::A number of avocado (Persea americana) cultivars are known to contain high-molecular-weight double-stranded RNA (dsRNA) molecules for which a viral nature has been suggested, although sequence data are not available. Here we report the cloning and complete sequencing of a 13.5-kbp dsRNA virus isolated from avocado and...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.06572-11
更新日期:2012-01-01 00:00:00
abstract::Hepatitis C virus (HCV) nonstructural protein 5B (NS5B) is an RNA-dependent RNA polymerase (RdRp) that acts as a key player in the HCV replication complex. Understanding the interplay between the viral and cellular components of the HCV replication complex could provide new insight for prevention of the progression of...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02526-12
更新日期:2013-05-01 00:00:00
abstract::In this study, we have identified an internal ribosome entry site (IRES) from the highly infectious herpesvirus Marek's disease virus (MDV). The IRES was mapped to the intercistronic region (ICR) of a bicistronic mRNA that we cloned from the MDV-transformed CD4(+) T-cell line MSB-1. The transcript is a member of a fam...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02602-08
更新日期:2009-06-01 00:00:00
abstract::Murine cytomegalovirus encodes three regulators of antigen presentation to antiviral CD8 T cells. According to current paradigms, all three regulators are committed to the inhibition of the presentation of antigenic peptides. Whereas m152/gp40 catalyzes the retention of peptide-loaded major histocompatibility complex ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00723-06
更新日期:2006-08-01 00:00:00
abstract::Alternative splicing has been recognized as a major mechanism for creating proteomic diversity from a limited number of genes. However, not all determinants regulating this process have been characterized. Using subviral human immunodeficiency virus (HIV) env constructs we observed an enhanced splicing of the RNA when...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02105-06
更新日期:2007-04-01 00:00:00
abstract::Several lines of evidence indicate that cutaneous human papillomavirus (HPV) types belonging to the beta genus of the HPV phylogenetic tree synergize with UV radiation in the development of skin cancer. Accordingly, the E6 and E7 oncoproteins from some beta HPV types are able to deregulate pathways related to immune r...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01123-17
更新日期:2017-09-12 00:00:00
abstract::Specific cleavage of BK virus (MM) DNA with restriction endonuclease MboI gives rise to 10 fragments. Two techniques were used to determine the location of these fragments on the viral genome with respect to the three known sites for HindIII cleavage. In the first method, reciprocal digestion, individual MboI fragment...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.27.3.700-712.1978
更新日期:1978-09-01 00:00:00
abstract::The genome sequence of a hypervirulent novirhabdovirus, viral hemorrhagic septicemia virus (VHSV) French strain 23-75, was determined. Compared to the genome of the prototype Fil3 strain, a number of substitutions, deletions, and insertions were observed. Following the establishment of a plasmid-based minigenome repli...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00343-10
更新日期:2010-10-01 00:00:00
abstract::Several members of the APOBEC3 DNA cytosine deaminase family can potently inhibit Vif-deficient human immunodeficiency virus type 1 (HIV-1) by catalyzing cytosine deamination in viral cDNA and impeding reverse transcription. HIV-1 counteracts restriction with the virally encoded Vif protein, which targets relevant APO...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00447-18
更新日期:2018-05-29 00:00:00
abstract::Mouse mammary tumor virus (MTV) was isolated from the milk of RIII mice by density-gradient centrifugation in Ficoll. The homogeneity of the preparation was demonstrated in electron micrographs. The nucleic acid was extracted with phenol in the presence of Pronase. Its viral origin was attested by failure of ribo-nucl...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.5.2.230-236.1970
更新日期:1970-02-01 00:00:00
abstract::Six overlapping viral RNAs are synthesized in cells infected with the avian coronavirus infectious bronchitis virus (IBV). These RNAs contain a 3'-coterminal nested sequence set and were assumed to be viral mRNAs. The seven major IBV virion proteins are all produced by processing of three polypeptides of ca. 23, 51, a...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.50.1.22-29.1984
更新日期:1984-04-01 00:00:00
abstract::A number of human immunodeficiency type 1 (HIV-1)-based vectors have recently been shown to transduce nondividing cells in vivo as well as in vitro. However, if these vectors are to be considered for eventual clinical use, a major consideration is to reduce the probability of unintended generation of replication-compe...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.3.1828-1834.1999
更新日期:1999-03-01 00:00:00
abstract:UNLABELLED:Kaposi's sarcoma-associated herpesvirus (KSHV, also called human herpesvirus 8) is linked to the development of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD). KSHV expresses several proteins that modulate host cell signaling pathways. One of these proteins...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00511-14
更新日期:2014-08-01 00:00:00