A three-helix junction is the interface between two functional domains of prohead RNA in 29 DNA packaging.

abstract：:Five urea-resistant and two heat-resistant mutants of poliovirus types 1 and 2 were isolated and their structural and nonstructural polypeptides compared to those of their wild-type, parental strains in an attempt to correlate mutant phenotypes with alterations in specific capsid polypeptides. Four of the seven mutant...

journal_title：Journal of virology

authors： Fennell R,Phillips BA

更新日期：1974-10-01 00:00:00

abstract：:T-cell responses of pigs to hog cholera virus (HCV) have reportedly been absent or difficult to detect. Therefore, little is known about cellular immunity to HCV. In this study, we used an attenuated strain of pseudorabies virus expressing the envelope glycoprotein E1 of HCV and purified recombinant E1 to examine whet...

journal_title：Journal of virology

authors： Kimman TG,Bianchi AT,Wensvoort G,de Bruin TG,Meliefste C

更新日期：1993-05-01 00:00:00

abstract：:Inhibition of hepatitis B virus (HBV) replication and viral clearance from an infected host requires both the innate and adaptive immune responses. Expression of interferon (IFN)-inducible proteasome catalytic and regulatory subunits correlates with the IFN-alpha/beta- and IFN-gamma-mediated noncytopathic inhibition o...

journal_title：Journal of virology

authors： Robek MD,Garcia ML,Boyd BS,Chisari FV

更新日期：2007-01-01 00:00:00

abstract：:In this study, we have identified an internal ribosome entry site (IRES) from the highly infectious herpesvirus Marek's disease virus (MDV). The IRES was mapped to the intercistronic region (ICR) of a bicistronic mRNA that we cloned from the MDV-transformed CD4(+) T-cell line MSB-1. The transcript is a member of a fam...

journal_title：Journal of virology

authors： Tahiri-Alaoui A,Smith LP,Baigent S,Kgosana L,Petherbridge LJ,Lambeth LS,James W,Nair V

更新日期：2009-06-01 00:00:00

abstract：:R325-beta TK+, a herpes simplex virus 1 mutant carrying a 500-base-pair deletion in the alpha 22 gene and the wild-type (beta) thymidine kinase (TK) gene, was previously shown to grow efficiently in HEp-2 and Vero cell lines. We report that in rodent cell lines exemplified by the Rat-1 line, plating efficiency was red...

journal_title：Journal of virology

authors： Sears AE,Halliburton IW,Meignier B,Silver S,Roizman B

更新日期：1985-08-01 00:00:00

abstract：:Previous studies have established that chlorella viruses encode K(+) channels with different structural and functional properties. In the current study, we exploit the different sensitivities of these channels to Cs(+) to determine if the membrane depolarization observed during virus infection is caused by the activit...

journal_title：Journal of virology

authors： Frohns F,Käsmann A,Kramer D,Schäfer B,Mehmel M,Kang M,Van Etten JL,Gazzarrini S,Moroni A,Thiel G

更新日期：2006-03-01 00:00:00

abstract：:By using T1 oligonucleotide fingerprinting and mapping techniques, we analyzed the genomic structure of retroviruses produced by thymocytes and splenocytes of reciprocal bone marrow-and thymus-grafted chimeras. We found that the genetic factor(s) derived from NZB mice that suppresses the development of thymic leukemia...

journal_title：Journal of virology

authors： Datta SK,Thomas CY,Nicklas JA,Coffin JM

更新日期：1983-07-01 00:00:00

abstract：UNLABELLED:Respiratory syncytial virus (RSV) is the most important cause of lower respiratory tract infection in young children and the leading cause of infant hospitalization worldwide. Uncontrolled response to RSV is mediated by a toll-like receptor (TLR)-mediated immune response. Resveratrol possesses anti-RSV activ...

journal_title：Journal of virology

authors： Liu T,Zang N,Zhou N,Li W,Xie X,Deng Y,Ren L,Long X,Li S,Zhou L,Zhao X,Tu W,Wang L,Tan B,Liu E

更新日期：2014-04-01 00:00:00

abstract：:Mononuclear phagocytes (MP) and T lymphocytes play a pivotal role in the host immune response to human immunodeficiency virus type 1 (HIV-1) infection. Regulation of such immune responses can be mediated, in part, through the interaction of the T-lymphocyte-expressed molecule CD40 ligand (CD40L) with its receptor on M...

journal_title：Journal of virology

authors： Cotter RL,Zheng J,Che M,Niemann D,Liu Y,He J,Thomas E,Gendelman HE

更新日期：2001-05-01 00:00:00

abstract：:Northern (RNA) blot analysis was used to determine the spatial and temporal distribution of bovine herpesvirus 1 (BHV-1) transcripts. Total RNA was isolated from Madin-Darby bovine kidney cells which had been infected with BHV-1.2b strain K22 or BHV-1.1 strain Jura in the presence or absence of metabolic inhibitors. C...

journal_title：Journal of virology

authors： Wirth UV,Gunkel K,Engels M,Schwyzer M

更新日期：1989-11-01 00:00:00

abstract：:The matrix (M) protein of vesicular stomatitis virus (VSV) is a potent inhibitor in vivo of transcription by all three host RNA polymerases (RNAP). In the case of host RNA polymerase II (RNAPII), the inhibition is due to lack of activity of the TATA-binding protein (TBP), which is a subunit of the basal transcription ...

journal_title：Journal of virology

authors： Yuan H,Puckett S,Lyles DS

更新日期：2001-05-01 00:00:00

abstract：:Hepatitis C virus (HCV)-specific CD8 cell exhaustion may represent a mechanism of HCV persistence. The inhibitory receptor PD-1 has been reported to be up-regulated in exhausted CD8 cells. Therefore, we studied PD-1 expression longitudinally during acute HCV infection. Most HCV-specific CD8 cells expressed PD-1 at the...

journal_title：Journal of virology

authors： Urbani S,Amadei B,Tola D,Massari M,Schivazappa S,Missale G,Ferrari C

更新日期：2006-11-01 00:00:00

abstract：:The smallest capsid proteins (SCPs) of the human herpesviruses differ substantially in size and sequence and are thought to impart some unique aspects of infection to their respective viruses. We used electron cryomicroscopy and antibody labeling to show that the 8-kDa SCP of human cytomegalovirus is attached only to ...

journal_title：Journal of virology

authors： Yu X,Shah S,Atanasov I,Lo P,Liu F,Britt WJ,Zhou ZH

更新日期：2005-01-01 00:00:00

abstract：:Plasmid lambdadv1, which is in a dimeric form, was converted to a linear monomer duplex by the action of EcoRI restriction endonuclease that incises at a unique site in this plasmid genome. The resulting products were then joined by Escherichia coli DNA ligase to produce molecules with various oligomeric forms, and fr...

journal_title：Journal of virology

authors： Matsubara K,Takagi Y,Mukai T

更新日期：1975-09-01 00:00:00

abstract：:The presence or absence of the receptor CD4 and the coreceptors CCR5 and CXCR4 restrict the cell tropism of human immunodeficiency virus type 1 (HIV-1). Despite the importance of thymic infection by HIV-1, conflicting reports regarding the expression of HIV-1 coreceptors on human thymocytes have not been resolved. We ...

journal_title：Journal of virology

authors： Taylor JR Jr,Kimbrell KC,Scoggins R,Delaney M,Wu L,Camerini D

更新日期：2001-09-01 00:00:00

abstract：:The coding capacity of human cytomegalovirus (HCMV) for glycoproteins by far exceeds that of other herpesviruses. Few of these proteins have been characterized so far. We have investigated the gene product of reading frame UL132. The putative protein product of UL132 is a glycoprotein with a theoretical mass of 29.8 k...

journal_title：Journal of virology

authors： Spaderna S,Kropff B,Ködel Y,Shen S,Coley S,Lu S,Britt W,Mach M

更新日期：2005-09-01 00:00:00

abstract：:Molluscum contagiosum virus (MCV), a member of the human poxvirus family, encodes the MC159 protein that inhibits Fas-, tumor necrosis factor (TNF)-, and TNF-related apoptosis-inducing ligant (TRAIL)-induced apoptosis. We used site-directed mutagenesis to change charged or hydrophobic amino acid residues to alanines t...

journal_title：Journal of virology

authors： Garvey TL,Bertin J,Siegel RM,Wang GH,Lenardo MJ,Cohen JI

更新日期：2002-01-01 00:00:00

abstract：:We report here the isolation by molecular cloning and the analysis by heteroduplex and restriction enzyme mapping of seven distinct DNA fragments containing hepatitis B virus (HBV) sequences from genomic DNA of the PLC/PRF/5 human liver carcinoma cell line (the Alexander cell). No intact full-length HBV genomes were p...

journal_title：Journal of virology

authors： Shaul Y,Ziemer M,Garcia PD,Crawford R,Hsu H,Valenzuela P,Rutter WJ

更新日期：1984-09-01 00:00:00

abstract：:We performed live cell visualization assays to directly assess the interaction between competing adeno-associated virus (AAV) and herpes simplex virus type 1 (HSV-1) DNA replication. Our studies reveal the formation of separate AAV and HSV-1 replication compartments and the inhibition of HSV-1 replication compartment ...

journal_title：Journal of virology

authors： Glauser DL,Strasser R,Laimbacher AS,Saydam O,Clément N,Linden RM,Ackermann M,Fraefel C

更新日期：2007-05-01 00:00:00

abstract：:We have established a genetic assay for the multimerization of retroviral gag polyproteins. This assay is based on the GAL4 two-hybrid system for studying protein-protein interactions (S. Fields and O. Song, Nature (London) 340:245-246, 1989). In our initial experiments, we generated Saccharomyces cerevisiae plasmids ...

journal_title：Journal of virology

authors： Luban J,Alin KB,Bossolt KL,Humaran T,Goff SP

更新日期：1992-08-01 00:00:00

abstract：:Disease-associated PrP fragments produced upon in vitro or in vivo proteolysis can provide significant insight into the causal strain of prion disease. Here we describe a novel molecular strain typing assay that used thermolysin digestion of caudal medulla samples to produce PrPres signatures on Western blots that rea...

journal_title：Journal of virology

authors： Owen JP,Rees HC,Maddison BC,Terry LA,Thorne L,Jackman R,Whitelam GC,Gough KC

更新日期：2007-10-01 00:00:00

abstract：:We describe a modification of the polymerase chain reaction technique which allows amplification of cellular DNA adjacent to an integrated provirus given sequence information for the provirus only. The modified technique should be generally useful for studies of insertional mutagenesis and other situations in which on...

journal_title：Journal of virology

authors： Silver J,Keerikatte V

更新日期：1989-05-01 00:00:00

abstract：:Using gel shift assays, we found that the human immunodeficiency virus type 1 (HIV-1) Tat protein (Tat-1) bound both HIV-1 and HIV-2 TAR RNAs with similar high affinities. In contrast, the HIV-2 Tat protein (Tat-2) bound only TAR-2 RNA with high affinity. We conclude that the weak in vivo activity of Tat-2 on the HIV-...

journal_title：Journal of virology

authors： Rhim H,Rice AP

更新日期：1993-02-01 00:00:00

abstract：UNLABELLED:Hepatitis C virus (HCV) requires proteins from the NS3-NS5B polyprotein to create a replicase unit for replication of its genome. The replicase proteins form membranous compartments in cells to facilitate replication, but little is known about their functional organization within these structures. We recentl...

journal_title：Journal of virology

authors： Gomes RG,Isken O,Tautz N,McLauchlan J,McCormick CJ

更新日期：2015-12-30 00:00:00

abstract：:Hepatitis E virus (HEV) is a common cause of acute viral hepatitis worldwide. Most HEV infections are asymptomatic, but immunocompromised patients infected with HEV genotype 3 (HEV3), HEV4, or HEV7 may develop chronic infections. The HEV particles in stools are naked (nHEV), while those in the serum and culture supern...

journal_title：Journal of virology

authors： Capelli N,Marion O,Dubois M,Allart S,Bertrand-Michel J,Lhomme S,Abravanel F,Izopet J,Chapuy-Regaud S

更新日期：2019-02-05 00:00:00

abstract：:Five gibbon ape leukemia virus substrains (two from gibbons with lymphocytic leukemia and three from gibbons with myelogenous leukemia) were examined for unique genomic sequences specific for each form of leukemia. By using sequential adsorption procedures, the genome from each gibbon ape leukemia virus was fractionat...

journal_title：Journal of virology

authors： Sun L,Kawakami TG

更新日期：1980-08-01 00:00:00

abstract：:A number of avocado (Persea americana) cultivars are known to contain high-molecular-weight double-stranded RNA (dsRNA) molecules for which a viral nature has been suggested, although sequence data are not available. Here we report the cloning and complete sequencing of a 13.5-kbp dsRNA virus isolated from avocado and...

journal_title：Journal of virology

authors： Villanueva F,Sabanadzovic S,Valverde RA,Navas-Castillo J

更新日期：2012-01-01 00:00:00

abstract：:The effects of avian reovirus (ARV) p17 protein on cell cycle progression and host cellular protein translation were studied. ARV infection and ARV p17 transfection resulted in the accumulation of infected and/or transfected cells in the G(2)/M phase of the cell cycle. The accumulation of cells in the G(2)/M phase was...

journal_title：Journal of virology

authors： Chulu JL,Huang WR,Wang L,Shih WL,Liu HJ

更新日期：2010-08-01 00:00:00

abstract：:Homologous recombination is an important biological process that facilitates genome rearrangement and repair of DNA double-strand breaks (DSBs). The induction of Epstein-Barr virus (EBV) lytic replication induces ataxia telangiectasia-mutated (ATM)-dependent DNA damage checkpoint signaling, leading to the clustering o...

journal_title：Journal of virology

authors： Kudoh A,Iwahori S,Sato Y,Nakayama S,Isomura H,Murata T,Tsurumi T

更新日期：2009-07-01 00:00:00

abstract：:Adult T-cell leukemia (ATL) occurs in a small population of human T-cell leukemia virus type 1 (HTLV-1)-infected individuals. Although the critical risk factor for ATL development is not clear, it has been noted that ATL is incidentally associated with mother-to-child infection, elevated proviral loads, and weakness i...

journal_title：Journal of virology

authors： Hasegawa A,Ohashi T,Hanabuchi S,Kato H,Takemura F,Masuda T,Kannagi M

更新日期：2003-03-01 00:00:00