PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion.

abstract：:Virus-like particles were purified from stools of patients in an epidemic of hepatitis A in Germany. When reference MS-1 chimpanzee pre-inoculation and convalescent sera were used, the close serological relationship of the purified particles to well-known isolates of hepatitis A could be established. On the other hand...

journal_title：Journal of virology

authors： Siegl G,Frösner GG

更新日期：1978-04-01 00:00:00

abstract：:Seneca Valley virus (SVV) is an oncolytic RNA virus belonging to the Picornaviridae family. Its nucleotide sequence is highly similar to those of members of the Cardiovirus genus. SVV is also a neuroendocrine cancer-selective oncolytic picornavirus that can be used for anticancer therapy. However, the interaction betw...

journal_title：Journal of virology

authors： Qian S,Fan W,Liu T,Wu M,Zhang H,Cui X,Zhou Y,Hu J,Wei S,Chen H,Li X,Qian P

更新日期：2017-07-27 00:00:00

abstract：:Viral infection triggers host innate immune responses through cellular sensor molecules which activate multiple signaling cascades that induce the production of interferons (IFN) and other cytokines. The recent identification of mammalian cytoplasmic viral RNA sensors, such as retinoic acid-inducible gene I (RIG-I)-li...

journal_title：Journal of virology

authors： Biacchesi S,LeBerre M,Lamoureux A,Louise Y,Lauret E,Boudinot P,Brémont M

更新日期：2009-08-01 00:00:00

abstract：:Betanodaviruses, the causal agents of viral nervous necrosis in marine fish, have bipartite positive-sense RNAs as genomes. The larger genomic segment, RNA1 (3.1 kb), encodes an RNA-dependent RNA polymerase, and the smaller genomic segment, RNA2 (1.4 kb), codes for the coat protein. Betanodaviruses have marked host sp...

journal_title：Journal of virology

authors： Iwamoto T,Okinaka Y,Mise K,Mori K,Arimoto M,Okuno T,Nakai T

更新日期：2004-02-01 00:00:00

abstract：:Inflammasomes are cytosolic protein complexes that regulate caspase-1 activation and the secretion of interleukin-1β (IL-1β) and IL-18. Several different inflammasome complexes have been identified, but the NLRP3 inflammasome is particularly notable because of its central role in diseases of inflammation. Recent work ...

journal_title：Journal of virology

authors： Rajan JV,Rodriguez D,Miao EA,Aderem A

更新日期：2011-05-01 00:00:00

abstract：:Serial serum specimens from 22 herpes simplex virus (HSV)-seronegative recipients of an HSV type 2 (HSV-2) glycoprotein subunit vaccine were analyzed by radioimmunoprecipitation and polyacrylamide gel electrophoresis for the development of antibodies to HSV-2 gB, gD, and g80, a complex of gC and gE. Volunteers receive...

journal_title：Journal of virology

authors： Ashley R,Mertz G,Clark H,Schick M,Salter D,Corey L

更新日期：1985-11-01 00:00:00

abstract：:The K15 gene of Kaposi's sarcoma-associated herpesvirus (also known as human herpesvirus 8) consists of eight alternatively spliced exons and has been predicted to encode membrane proteins with a variable number of transmembrane regions and a common C-terminal cytoplasmic domain with putative binding sites for SH2 and...

journal_title：Journal of virology

authors： Brinkmann MM,Glenn M,Rainbow L,Kieser A,Henke-Gendo C,Schulz TF

更新日期：2003-09-01 00:00:00

abstract：UNLABELLED:The increasing number of zoonotic infections caused by influenza A virus (IAV) subtypes of avian origin (e.g., H5N1 and H7N9) in recent years underscores the need to better understand the factors driving IAV evolution and diversity. To evaluate the current feasibility of global analyses to contribute to this...

journal_title：Journal of virology

authors： Rejmanek D,Hosseini PR,Mazet JA,Daszak P,Goldstein T

更新日期：2015-11-01 00:00:00

abstract：:Small interfering RNAs (siRNAs) processed from double-stranded RNA (dsRNA) of virus origins mediate potent antiviral defense through a process referred to as RNA interference (RNAi) or RNA silencing in diverse organisms. In the simple invertebrate Caenorhabditis elegans, the RNAi process is initiated by a single Dicer...

journal_title：Journal of virology

authors： Guo X,Zhang R,Wang J,Lu R

更新日期：2013-10-01 00:00:00

abstract：:The hemagglutinin-neuraminidase (HN) glycoprotein plays a critical role in parainfluenza virus replication. We recently found that in addition to the catalytic binding site, HN of human parainfluenza virus type 1 (hPIV-1) may have a second receptor-binding site covered by an N-linked glycan at residue 173, which is ne...

journal_title：Journal of virology

authors： Mishin VP,Watanabe M,Taylor G,Devincenzo J,Bose M,Portner A,Alymova IV

更新日期：2010-03-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) are important for the control of virus replication during respiratory infections. For human metapneumovirus (hMPV), an H-2(d)-restricted CTL epitope in the M2-2 protein has been described. In this study, we screened the hMPV F, G, N, M, M2-1, and M2-2 proteins using three independent alg...

journal_title：Journal of virology

authors： Melendi GA,Zavala F,Buchholz UJ,Boivin G,Collins PL,Kleeberger SR,Polack FP

更新日期：2007-10-01 00:00:00

abstract：:Human immunodeficiency virus infection in humans and simian immunodeficiency virus (SIV) infection in rhesus macaques (RM) leads to a generalized loss of immune responses involving perturbations in T-cell receptor (TCR) signaling. In contrast, naturally SIV-infected sooty mangabeys (SM) remain asymptomatic and retain ...

journal_title：Journal of virology

authors： Bostik P,Wu P,Dodd GL,Villinger F,Mayne AE,Bostik V,Grimm BD,Robinson D,Kung HJ,Ansari AA

更新日期：2001-12-01 00:00:00

abstract：:Varicella-zoster virus (VZV) encodes within its unique long region a gene product with protein kinase motifs. In a previous study, we demonstrated that immunoprecipitated VZV open reading frame (ORF) 47 protein was associated with a functional protein kinase activity, on the basis of its ability to both autophosphoryl...

journal_title：Journal of virology

authors： Ng TI,Keenan L,Kinchington PR,Grose C

更新日期：1994-03-01 00:00:00

abstract：:High-risk human papillomaviruses (HPVs), including HPV-16 and HPV-18, are the causative agents of cervical carcinomas and are linked to several other tumors of the anogenital and oropharyngeal regions. The majority of HPV-induced tumors contain integrated copies of the normally episomal HPV genome that invariably reta...

journal_title：Journal of virology

authors： Kennedy EM,Kornepati AV,Goldstein M,Bogerd HP,Poling BC,Whisnant AW,Kastan MB,Cullen BR

更新日期：2014-10-01 00:00:00

abstract：:We previously described a preleukemic state induced by Moloney murine leukemia virus (Mo-MuLV) characterized by hematopoietic hyperplasia in the spleen. Further experiments suggested that splenic hyperplasia results from inhibitory effects in the bone marrow, leading to compensatory extramedullary hematopoiesis. An en...

journal_title：Journal of virology

authors： Li QX,Fan H

更新日期：1991-08-01 00:00:00

abstract：:Equine herpesvirus 1 (EHV-1, Kentucky A strain) preparations enriched for defective interfering particles (DIPs) can readily establish persistent infection. The UL1 gene, which is conserved in the genome of DIPs that mediate persistent infection, maps between nucleotides 1418 and 2192 (258 amino acids) from the L (lon...

journal_title：Journal of virology

authors： Harty RN,Caughman GB,Holden VR,O'Callaghan DJ

更新日期：1993-07-01 00:00:00

abstract：:Human papillomavirus type 1 (HPV1) E4 protein is associated with cytoplasmic and nuclear inclusions in productively infected keratinocytes. Here we have used transient expression of HPV1 E4 (also known as E1E4) protein in keratinocytes to reproduce formation of E4 inclusions. Immunofluorescence analysis showed that pr...

journal_title：Journal of virology

authors： Roberts S,Hillman ML,Knight GL,Gallimore PH

更新日期：2003-01-01 00:00:00

abstract：:To determine which sequences or structures in the poliovirus 5' noncoding region (5'NCR) are involved in binding proteins used for internal ribosome binding and protein synthesis initiation, translation competition assays were performed in rabbit reticulocyte lysates in the presence and absence of HeLa cell extract. T...

journal_title：Journal of virology

authors： Gebhard JR,Ehrenfeld E

更新日期：1992-05-01 00:00:00

abstract：:CD81 has been described as a putative receptor for hepatitis C virus (HCV); however, its role in HCV cell entry has not been characterized due to the lack of an efficient cell culture system. We have examined the role of CD81 in HCV glycoprotein-dependent entry by using a recently developed retroviral pseudotyping sys...

journal_title：Journal of virology

authors： Zhang J,Randall G,Higginbottom A,Monk P,Rice CM,McKeating JA

更新日期：2004-02-01 00:00:00

abstract：:The ability of HIV-1 to establish a latent infection presents a barrier to curing HIV. The best-studied reservoir of latent virus in vivo is resting memory CD4(+) T cells, but it has recently been shown that CD34(+) hematopoietic progenitor cells (HPCs) can also become latently infected by HIV-1 in vitro and in vivo. ...

journal_title：Journal of virology

authors： McNamara LA,Ganesh JA,Collins KL

更新日期：2012-09-01 00:00:00

abstract：:Natural killer (NK) cells are an important component in the control of influenza virus infection, acting to both clear virus-infected cells and release antiviral cytokines. Engagement of CD16 on NK cells by antibody-coated influenza virus-infected cells results in antibody-dependent cellular cytotoxicity (ADCC). Incre...

journal_title：Journal of virology

authors： Jegaskanda S,Vanderven HA,Tan HX,Alcantara S,Wragg KM,Parsons MS,Chung AW,Juno JA,Kent SJ

更新日期：2019-02-19 00:00:00

abstract：:The putative envelope 2 (E2) gene of hepatitis C virus (HCV) contains a highly variable region referred to as hypervariable region 1 (HVR1). We hypothesized that this genetic variability is driven by immune selection pressure, rather than representing the accumulation of random mutations in a region with relatively li...

journal_title：Journal of virology

authors： Ray SC,Mao Q,Lanford RE,Bassett S,Laeyendecker O,Wang YM,Thomas DL

更新日期：2000-04-01 00:00:00

abstract：:Herpesvirus ateles is an agent indigenous to spider monkeys (Ateles spp.) and causes fulminant lymphomas in various New World primates. Structural and genetic relatedness led to the classification of this virus as a member of the genus Rhadinovirus. It is most closely related to Herpesvirus saimiri. The 108,409-bp lig...

journal_title：Journal of virology

authors： Albrecht JC

更新日期：2000-01-01 00:00:00

abstract：:The first 86 residues of the Rous sarcoma virus (RSV) Gag protein form a membrane-binding (M) domain that directs Gag to the plasma membrane during budding. Unlike other retroviral Gag proteins, RSV Gag is not myristylated; however, the RSV M domain does contain 11 basic residues that could potentially interact with a...

journal_title：Journal of virology

authors： Callahan EM,Wills JW

更新日期：2000-12-01 00:00:00

abstract：:Virus entry into host cells is a complex process that is largely regulated by access to specific cellular receptors. Human adenoviruses (HAdVs) and many other viruses use cell adhesion molecules such as the coxsackievirus and adenovirus receptor (CAR) for attachment to and entry into target cells. These molecules are ...

journal_title：Journal of virology

authors： Persson BD,Lenman A,Frängsmyr L,Schmid M,Ahlm C,Plückthun A,Jenssen H,Arnberg N

更新日期：2020-07-01 00:00:00

abstract：:In this work we show evidence of mother-to-offspring transmission in a transgenic mouse line expressing bovine PrP (boTg) experimentally infected by intracerebral administration of bovine spongiform encephalopathy (BSE) prions. PrP(res) was detected in brains of newborns from infected mothers only when mating was allo...

journal_title：Journal of virology

authors： Castilla J,Brun A,Díaz-San Segundo F,Salguero FJ,Gutiérrez-Adán A,Pintado B,Ramírez MA,del Riego L,Torres JM

更新日期：2005-07-01 00:00:00

abstract：:To study fundamental aspects of RNA recombination, an in vivo RNA recombination system was established. This system allowed the efficient generation of recombinant cytopathogenic pestiviruses after transfection of synthetic, nonreplicatable, subgenomic transcripts in cells infected with a replicating noncytopathogenic...

journal_title：Journal of virology

authors： Gallei A,Pankraz A,Thiel HJ,Becher P

更新日期：2004-06-01 00:00:00

abstract：:H5N1 and H9N2 avian influenza virus subtypes top the World Health Organization's list for the greatest pandemic potential. Inactivated H5N1 vaccines induce limited immune responses and, in the case of live-attenuated influenza virus vaccines (LAIV), there are safety concerns regarding the possibility of reassortment b...

journal_title：Journal of virology

authors： Pena L,Sutton T,Chockalingam A,Kumar S,Angel M,Shao H,Chen H,Li W,Perez DR

更新日期：2013-05-01 00:00:00

abstract：:In an effort to develop a useful AIDS vaccine or vaccine component, we have generated a combinatorial library of chimeric viruses in which the sequence IGPGRAFYTTKN from the V3 loop of the MN strain of human immunodeficiency virus type 1 (HIV-1) is displayed in many conformations on the surface of human rhinovirus 14 ...

journal_title：Journal of virology

authors： Smith AD,Geisler SC,Chen AA,Resnick DA,Roy BM,Lewi PJ,Arnold E,Arnold GF

更新日期：1998-01-01 00:00:00

abstract：:To analyze intrauterine transmission, MT-2 cells, a human T-cell line producing human T-cell leukemia virus type I (HTLV-I), were injected into eight pregnant F344 rats, and cesarean section was performed at day 23 of pregnancy. HTLV-I provirus was detected by PCR in the liver and spleen taken from one of the eight fe...

journal_title：Journal of virology

authors： Hori M,Ami Y,Kushida S,Kobayashi M,Uchida K,Abe T,Miwa M

更新日期：1995-02-01 00:00:00