Vertical transmission of bovine spongiform encephalopathy prions evaluated in a transgenic mouse model.

Abstract:

:In this work we show evidence of mother-to-offspring transmission in a transgenic mouse line expressing bovine PrP (boTg) experimentally infected by intracerebral administration of bovine spongiform encephalopathy (BSE) prions. PrP(res) was detected in brains of newborns from infected mothers only when mating was allowed near to the clinical stage of disease, when brain PrP(res) deposition could be detected by Western blot analysis. Attempts to detect infectivity in milk after intracerebral inoculation in boTg mice were unsuccessful, suggesting the involvement of other tissues as carriers of prion dissemination. The results shown here prove the ability of BSE prions to spread centrifugally from the central nervous system to peripheral tissues and to offspring in a mouse model. Also, these results may complement previous epidemiological data supporting the occurrence of vertical BSE transmission in cattle.

journal_name

J Virol

journal_title

Journal of virology

authors

Castilla J,Brun A,Díaz-San Segundo F,Salguero FJ,Gutiérrez-Adán A,Pintado B,Ramírez MA,del Riego L,Torres JM

doi

10.1128/JVI.79.13.8665-8668.2005

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

8665-8

issue

13

eissn

0022-538X

issn

1098-5514

pii

79/13/8665

journal_volume

79

pub_type

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