Mapping and characterization of the primary and anamnestic H-2(d)-restricted cytotoxic T-lymphocyte response in mice against human metapneumovirus.

abstract：:The herpesvirus saimiri (HVS) immediate-early gene product encoded by open reading frame (ORF) 57 shares limited amino acid homology with HSV-1 ICP27 and Epstein-Barr virus BMLF1, both regulatory proteins. The ORF 57 gene has been proposed to be spliced based on the genome sequence, and here we confirm the intron-exon...

journal_title：Journal of virology

authors： Whitehouse A,Cooper M,Meredith DM

更新日期：1998-01-01 00:00:00

abstract：:Rigorous investigation of many functions encoded by cytomegaloviruses (CMVs) requires analysis in the context of virus-host interactions. To facilitate the construction of rhesus CMV (RhCMV) mutants for in vivo studies, a bacterial artificial chromosome (BAC) containing an enhanced green fluorescent protein (EGFP) cas...

journal_title：Journal of virology

authors： Chang WL,Barry PA

更新日期：2003-05-01 00:00:00

abstract：:The mechanism by which simian virus 40 converts the abortive adenovirus type 7 infection of monkey cells into an efficient lytic infection has been investigated. Analysis of ribonucleic acid (RNA) synthesis during unenhanced and enhanced infection of monkey cells has shown that adenovirus RNA synthesized in the aborti...

journal_title：Journal of virology

authors： Fox RI,Baum SG

更新日期：1972-08-01 00:00:00

abstract：:The mechanism whereby picornaviruses inhibit host protein synthesis while their own synthetic processes proceed unabated has remained elusive. One of our approaches to this problem was to study the ability of cell-free extracts derived from uninfected and mengovirus-infected Ehrlich ascites tumor cells to translate vi...

journal_title：Journal of virology

authors： Abreu SL,Lucas-Lenard J

更新日期：1976-04-01 00:00:00

abstract：UNLABELLED:We have recently shown in both herpesviruses and phages that packaged viral DNA creates a pressure of tens of atmospheres pushing against the interior capsid wall. For the first time, using differential scanning microcalorimetry, we directly measured the energy powering the release of pressurized DNA from th...

journal_title：Journal of virology

authors： Bauer DW,Li D,Huffman J,Homa FL,Wilson K,Leavitt JC,Casjens SR,Baines J,Evilevitch A

更新日期：2015-09-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) efficiently enters cells of Old World monkeys but encounters a block before reverse transcription. This restriction is mediated by a dominant repressive factor. Recently, a member of the tripartite motif (TRIM) family proteins, TRIM5alpha, was identified as a blocking factor...

journal_title：Journal of virology

authors： Nakayama EE,Miyoshi H,Nagai Y,Shioda T

更新日期：2005-07-01 00:00:00

abstract：:Geminiviruses package circular single-stranded DNA and replicate in the nucleus via a double-stranded intermediate. This intermediate also serves as a template for bidirectional transcription by polymerase II. Here, we map promoters and transcripts and characterize regulatory proteins of Mungbean yellow mosaic virus-V...

journal_title：Journal of virology

authors： Shivaprasad PV,Akbergenov R,Trinks D,Rajeswaran R,Veluthambi K,Hohn T,Pooggin MM

更新日期：2005-07-01 00:00:00

abstract：:A tetracycline-regulated gene expression system and a panel of novel monoclonal antibodies were used to examine the subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus (HCV) NS3-NS4A complex in inducible cell lines. The NS3 serine protease domain and the full-length NS3 protein ...

journal_title：Journal of virology

authors： Wölk B,Sansonno D,Kräusslich HG,Dammacco F,Rice CM,Blum HE,Moradpour D

更新日期：2000-03-01 00:00:00

abstract：:Herpes simplex virus (HSV) entry is dependent on the interaction of virion glycoprotein D (gD) with one of several cellular receptors. We previously showed that gD binds specifically to two structurally dissimilar receptors, HveA and HveC. We have continued our studies by using (i) a panel of baculovirus-produced gD m...

journal_title：Journal of virology

authors： Whitbeck JC,Muggeridge MI,Rux AH,Hou W,Krummenacher C,Lou H,van Geelen A,Eisenberg RJ,Cohen GH

更新日期：1999-12-01 00:00:00

abstract：:Treatment of human immunodeficiency virus type 1 (HIV-1)-infected CEM cell cultures with escalating concentrations of the quinoxaline S-2720 resulted in an ordered appearance of single and multiple mutant virus strains that gradually became resistant to the quinoxaline and other nonnucleoside reverse transcriptase (RT...

journal_title：Journal of virology

authors： Pelemans H,Esnouf R,Dunkler A,Parniak MA,Vandamme AM,Karlsson A,De Clercq E,Kleim JP,Balzarini J

更新日期：1997-11-01 00:00:00

abstract：:Proteins located in the tegument layer of herpesvirus particles play important roles in the replicative cycle at both early and late times after infection. As major constituents of the virion, they execute important functions in particular during formation of progeny virions. These functions have mostly been elucidate...

journal_title：Journal of virology

authors： Michael K,Klupp BG,Mettenleiter TC,Karger A

更新日期：2006-02-01 00:00:00

abstract：:Phylogenetic analyses demonstrate significant diversity in worldwide circulating strains of human immunodeficiency virus type 1 (HIV-1). Detailed studies have revealed a complex pattern of intersubtype recombinations, as well as evidence of sub-subtypes circulating in various populations. In this study, we characteriz...

journal_title：Journal of virology

authors： Meloni ST,Kim B,Sankalé JL,Hamel DJ,Tovanabutra S,Mboup S,McCutchan FE,Kanki PJ

更新日期：2004-11-01 00:00:00

abstract：:We previously observed that when human immunodeficiency virus (HIV)-infected T lymphocytes are added to epithelial cells, they adhere, polarize, and secrete virions unidirectionally onto the epithelium. Epithelial cells subsequently take up virus and become productively infected. We report here that colchicine treatme...

journal_title：Journal of virology

authors： Pearce-Pratt R,Malamud D,Phillips DM

更新日期：1994-05-01 00:00:00

abstract：:The ascomycete Botrytis porri causes clove rot and leaf blight of garlic worldwide. We report here the biological and molecular features of a novel bipartite double-stranded RNA (dsRNA) mycovirus named Botrytis porri RNA virus 1 (BpRV1) from the hypovirulent strain GarlicBc-72 of B. porri. The BpRV1 genome comprises t...

journal_title：Journal of virology

authors： Wu M,Jin F,Zhang J,Yang L,Jiang D,Li G

更新日期：2012-06-01 00:00:00

abstract：:A characterization of the antigenic determinants (epitopes) of the glycoprotein (G) of infectious hematopoietic necrosis virus was made by expressing different regions of the G gene in Escherichia coli. A cDNA copy of the G gene was divided into four fragments by TaqI digestion, and the fragments were subcloned into p...

journal_title：Journal of virology

authors： Xu L,Mourich DV,Engelking HM,Ristow S,Arnzen J,Leong JC

更新日期：1991-03-01 00:00:00

abstract：:Simian virus 40 (SV40) large T antigen (SVT) interferes with normal cell regulation and thus has been used to identify cellular components controlling proliferation and homeostasis. We have previously shown that SVT-mediated transformation requires interaction with the histone acetyltransferases (HATs) CBP/p300 and no...

journal_title：Journal of virology

authors： Sáenz Robles MT,Shivalila C,Wano J,Sorrells S,Roos A,Pipas JM

更新日期：2013-12-01 00:00:00

abstract：:The Epstein-Barr virus latent membrane protein (LMP) is an integral membrane protein that is expressed in cells latently infected with the virus. LMP is believed to play an important role in Epstein-Barr virus transformation and has been shown to induce expression of several cellular proteins. We performed a series of...

journal_title：Journal of virology

authors： Hammarskjöld ML,Simurda MC

更新日期：1992-11-01 00:00:00

abstract：:Domains required late in the virus budding process (L domains) have been identified in the Gag proteins of a number of retroviruses. Here we show that the human T-cell leukemia virus type 1 candidate L domain motif PPPY is indeed required for virus production. Strikingly, however, mutation of this motif arrested virus...

journal_title：Journal of virology

authors： Le Blanc I,Prévost MC,Dokhélar MC,Rosenberg AR

更新日期：2002-10-01 00:00:00

abstract：UNLABELLED:The discovery that measles virus (MV) uses the adherens junction protein nectin-4 as its epithelial receptor provides a new vantage point from which to characterize its rapid spread in the airway epithelium. We show here that in well-differentiated primary cultures of airway epithelial cells from human donor...

journal_title：Journal of virology

authors： Singh BK,Hornick AL,Krishnamurthy S,Locke AC,Mendoza CA,Mateo M,Miller-Hunt CL,Cattaneo R,Sinn PL

更新日期：2015-07-01 00:00:00

abstract：:The adenovirus type 2 L1 region, which is located at 30.7 to 39.2 map units on the viral genome, is transcribed from the major late promoter during both early and late stages of virus replication, and a 52,000-Mr (52K) protein-55K protein doublet has been translated in vitro on L1-specific RNA. To investigate the bios...

journal_title：Journal of virology

authors： Lucher LA,Symington JS,Green M

更新日期：1986-03-01 00:00:00

abstract：:After herpes simplex virus infection of hamster kidney cells there is an induction of nucleoside phosphotransferase activity which can utilize AMP as phosphate donor. The activity is immunologically specific for the infected cell and is induced concomitantly with the virus-coded pyrimidine deoxynucleoside kinase activ...

journal_title：Journal of virology

authors： Jamieson AT,Hay J,Subak-Sharpe JH

更新日期：1976-03-01 00:00:00

abstract：:Human T-cell leukemia virus (HTLV) Tax protein has been implicated in the HTLV oncogenic process, primarily due to its pleiotropic effects on cellular genes involved in growth regulation and cell cycle control. To date, several approaches attempting to correlate Tax activation of the CREB/activating transcription fact...

journal_title：Journal of virology

authors： Ross TM,Narayan M,Fang ZY,Minella AC,Green PL

更新日期：2000-03-01 00:00:00

abstract：:Apoptin, a viral death protein derived from chicken anemia virus, displays a number of tumor-specific behaviors. In particular, apoptin is phosphorylated, translocates to the nucleus, and induces apoptosis specifically in tumor or transformed cells, whereas it is nonphosphorylated and remains primarily inactive in the...

journal_title：Journal of virology

authors： Zhang YH,Kooistra K,Pietersen A,Rohn JL,Noteborn MH

更新日期：2004-09-01 00:00:00

abstract：:The structural proteins of mature LPP-1 particles and the patterns of protein synthesis after LPP-1 infection have been examined by electrophoresis on sodium dodecyl sulfate polyacrylamide gels. Structural proteins account for 35% of the LPP-1 genome, and proteins that would require about 65% of the total coding capac...

journal_title：Journal of virology

authors： Sherman LA,Haselkorn R

更新日期：1970-12-01 00:00:00

abstract：:Nef, an accessory protein of human and simian immunodeficiency viruses, is a critical determinant of pathogenesis that promotes the progression from infection to AIDS. The pathogenic effects of Nef are in large part dependent on its ability to downregulate the macrophage and T-cell coreceptor, CD4. It has been propose...

journal_title：Journal of virology

authors： Chaudhuri R,Lindwasser OW,Smith WJ,Hurley JH,Bonifacino JS

更新日期：2007-04-01 00:00:00

abstract：:Mice and cattle injected with plasmids encoding bovine herpesvirus 1 (BHV-1) glycoproteins developed gene-specific antibody responses capable of neutralizing BHV-1. The ability of animals to respond serologically to DNA injections was in part dependent on the quantity of DNA injected and was also negatively affected b...

journal_title：Journal of virology

authors： Cox GJ,Zamb TJ,Babiuk LA

更新日期：1993-09-01 00:00:00

abstract：:Single-envelope human immunodeficiency virus (HIV) vaccines have been studied for more than a decade, with some successes in homologous challenge experiments in nonhuman primates but with no clear successes in clinical trials. To gain insight into the breadth of the immunity elicited by such vaccines, we have dissecte...

journal_title：Journal of virology

authors： Zhan X,Slobod KS,Surman S,Brown SA,Lockey TD,Coleclough C,Doherty PC,Hurwitz JL

更新日期：2003-04-01 00:00:00

abstract：:Regulation of immediate-early gene expression in human cytomegalovirus is subject to complex controls. The major immediate-early (mIE) gene is regulated by both positive and negative regulatory signals, including autoregulation mediated by a cis-repressive sequence. A second immediate-early gene, the US3 gene, is tran...

journal_title：Journal of virology

authors： Biegalke BJ

更新日期：1995-09-01 00:00:00

abstract：:Viral particles infecting some stocks of the protozoan parasite Leishmania braziliensis subsp. guyanensis contain a double-stranded RNA genome of ca. 5 kbp and are associated with an RNA-dependent RNA polymerase which synthesizes in vitro double-stranded and single-stranded, genome-length transcripts. The majority of ...

journal_title：Journal of virology

authors： Widmer G,Patterson JL

更新日期：1991-08-01 00:00:00

abstract：:Discovery of genetically distinct hantaviruses in multiple species of shrews (order Soricomorpha, family Soricidae) and moles (family Talpidae) contests the conventional view that rodents (order Rodentia, families Muridae and Cricetidae) are the principal reservoir hosts and suggests that the evolutionary history of h...

journal_title：Journal of virology

authors： Kang HJ,Bennett SN,Hope AG,Cook JA,Yanagihara R

更新日期：2011-08-01 00:00:00