Abstract:
:To analyze intrauterine transmission, MT-2 cells, a human T-cell line producing human T-cell leukemia virus type I (HTLV-I), were injected into eight pregnant F344 rats, and cesarean section was performed at day 23 of pregnancy. HTLV-I provirus was detected by PCR in the liver and spleen taken from one of the eight fetuses. Moreover, 71 offspring were delivered by cesarean section from the remaining seven dams and fostered by seven normal rats. HTLV-I provirus was detected in peripheral blood mononuclear cells in 2 of the 71 offspring 4 weeks after cesarean section. These results indicate for the first time the intrauterine transmission of HTLV-I. To confirm the postnatal transmission, MT-2 cells were injected into a dam within 24 h after delivery, and six offspring were fostered by this dam. HTLV-I provirus was detected in peripheral blood mononuclear cells of all six offspring. This animal model may be useful for analysis and prevention of mother-to-child transmission of HTLV-I.
journal_name
J Viroljournal_title
Journal of virologyauthors
Hori M,Ami Y,Kushida S,Kobayashi M,Uchida K,Abe T,Miwa Mdoi
10.1128/JVI.69.2.1302-1305.1995subject
Has Abstractpub_date
1995-02-01 00:00:00pages
1302-5issue
2eissn
0022-538Xissn
1098-5514journal_volume
69pub_type
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