Herpes simplex virus type 1-specific cytotoxic T lymphocytes recognize virus nonstructural proteins.

abstract：:Marek's disease virus DNA appears to be wound around a central structure connecting the two inner poles of the capsid. Based on electron micrographs of Marek's disease virions, a diagram of spatial configuration of virus DNA is presented. This diagram may explain the pleomorphic character of the herpesvirus core obser...

journal_title：Journal of virology

authors： Nazerian K

更新日期：1974-05-01 00:00:00

abstract：:The protein kinase inhibitor H7 blocks influenza virus replication, inhibits production of the matrix protein (M1), and leads to a retention of the viral ribonucleoproteins (vRNPs) in the nucleus at late times of infection (K. Martin and A. Helenius, Cell 67:117-130, 1991). We show here that production of assembled vR...

journal_title：Journal of virology

authors： Bui M,Wills EG,Helenius A,Whittaker GR

更新日期：2000-02-01 00:00:00

abstract：:Epstein-Barr virus (EBV) in vivo is known to establish persistent infection in resting, circulating memory B cells and to productively replicate in plasma cells. Until now, the molecular mechanism of how EBV switches from latency to lytic replication in vivo was not known. Here, we report that the plasma cell differen...

journal_title：Journal of virology

authors： Sun CC,Thorley-Lawson DA

更新日期：2007-12-01 00:00:00

abstract：:Experimental reverse genetic replacement of Epstein-Barr virus nuclear antigen 3A (EBNA3A) with a conditional mutant EBNA3A revealed that EBNA3A is critical for continued lymphoblastoid cell (LCL) growth. Wild-type (wt) EBNA3A expressed in the LCLs specifically sustained growth under nonpermissive conditions, whereas ...

journal_title：Journal of virology

authors： Maruo S,Johannsen E,Illanes D,Cooper A,Zhao B,Kieff E

更新日期：2005-08-01 00:00:00

abstract：:The rescue of influenza viruses by reverse genetics has been described only for the influenza A and B viruses. Based on a similar approach, we developed a reverse-genetics system that allows the production of influenza C viruses entirely from cloned cDNA. The complete sequences of the 3' and 5' noncoding regions of ty...

journal_title：Journal of virology

authors： Crescenzo-Chaigne B,van der Werf S

更新日期：2007-10-01 00:00:00

abstract：:Historically, coronaviruses were predominantly associated with mild upper respiratory disease in humans. More recently, three novel coronaviruses associated with severe human respiratory disease were found, including (i) the severe acute respiratory syndrome coronavirus, associated with a significant atypical pneumoni...

journal_title：Journal of virology

authors： Donaldson EF,Yount B,Sims AC,Burkett S,Pickles RJ,Baric RS

更新日期：2008-12-01 00:00:00

abstract：:While cytomegalovirus (CMV) infections are often limited in host range by lengthy coevolution with a single host species, a few CMVs are known to deviate from this rule. For example, rhesus macaque CMV (RhCMV), a model for human CMV (HCMV) pathogenesis and vaccine development, can replicate in human cells, as well as ...

journal_title：Journal of virology

authors： Child SJ,Hickson SE,Bayer A,Malouli D,Früh K,Geballe AP

更新日期：2018-02-26 00:00:00

abstract：:Cell-mediated immunity depends in part on appropriate migration and localization of cytotoxic T lymphocytes (CTL), a process regulated by chemokines and adhesion molecules. Many viruses, including human immunodeficiency virus type 1 (HIV-1), encode chemotactically active proteins, suggesting that dysregulation of immu...

journal_title：Journal of virology

authors： Brainard DM,Tharp WG,Granado E,Miller N,Trocha AK,Ren XH,Conrad B,Terwilliger EF,Wyatt R,Walker BD,Poznansky MC

更新日期：2004-05-01 00:00:00

abstract：:A series of contiguous 30-bp deletions were introduced into the regions upstream of the p19 and p40 promoters of adeno-associated virus (AAV), and the effects of these deletions on induction of AAV transcription by the rep gene products was evaluated. A novel complementation system was devised for supplying wild-type ...

journal_title：Journal of virology

authors： McCarty DM,Christensen M,Muzyczka N

更新日期：1991-06-01 00:00:00

abstract：:Naturally occurring bovine-human reassortant rotaviruses with a P[11] VP4 genotype exhibit a tropism for neonates. Interaction of the VP8* domain of the spike protein VP4 with sialic acid was thought to be the key mediator for rotavirus infectivity. However, recent studies have indicated a role for nonsialylated glyco...

journal_title：Journal of virology

authors： Ramani S,Cortes-Penfield NW,Hu L,Crawford SE,Czako R,Smith DF,Kang G,Ramig RF,Le Pendu J,Prasad BV,Estes MK

更新日期：2013-07-01 00:00:00

abstract：:Wide application of the gene-targeting technique has been hampered by its low level of efficiency. A replication-defective adenovirus vector was used for efficient delivery of donor DNA in order to bypass this problem. Homologous recombination was selected between a donor neo gene inserted in the adenovirus vector and...

journal_title：Journal of virology

authors： Fujita A,Sakagami K,Kanegae Y,Saito I,Kobayashi I

更新日期：1995-10-01 00:00:00

abstract：:The wild mouse ecotropic retrovirus, Cas-Br-E, induces progressive, noninflammatory spongiform neurodegenerative disease in susceptible mice. Functional genetic analysis of the Cas-Br-E genome indicates that neurovirulence maps to the env gene, which encodes the surface glycoprotein responsible for binding and fusion ...

journal_title：Journal of virology

authors： Lynch WP,Sharpe AH

更新日期：2000-02-01 00:00:00

abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent of PRRS, which has important impacts on the pig industry. PRRSV infection results in disruption of the swine leukocyte antigen class I (SLA-I) antigen presentation pathway. In this study, highly pathogenic PRRSV (HP-PRRSV) infection inh...

journal_title：Journal of virology

authors： Qi P,Liu K,Wei J,Li Y,Li B,Shao D,Wu Z,Shi Y,Tong G,Qiu Y,Ma Z

更新日期：2017-02-14 00:00:00

abstract：:Previously, the cyclophilin inhibitors cyclosporine (CsA) and alisporivir (ALV) were shown to inhibit the replication of diverse RNA viruses, including arteriviruses and coronaviruses, which both belong to the order Nidovirales In this study, we aimed to identify arterivirus proteins involved in the mode of action of ...

journal_title：Journal of virology

authors： de Wilde AH,Boomaars-van der Zanden AL,de Jong AWM,Bárcena M,Snijder EJ,Posthuma CC

更新日期：2019-08-28 00:00:00

abstract：:We have previously shown that two inhibitors specific for cellular cyclin-dependent kinases (cdks), Roscovitine (Rosco) and Olomoucine (Olo), block the replication of herpes simplex virus (HSV). Based on these results, we demonstrated that HSV replication requires cellular cdks that are sensitive to these drugs (L. M....

journal_title：Journal of virology

authors： Schang LM,Rosenberg A,Schaffer PA

更新日期：2000-03-01 00:00:00

abstract：:We have measured growth of West Nile virus in mouse primary peritoneal macrophages (resident, thioglycolate elicited, and Mycobacterium bovis BCG activated) and in macrophagelike (P338D1) and nonmacrophage (L929, PS clone D) cell lines infected in the absence or presence of specific antibodies (immunoglobulin G ([IgG]...

journal_title：Journal of virology

authors： Cardosa MJ,Gordon S,Hirsch S,Springer TA,Porterfield JS

更新日期：1986-03-01 00:00:00

abstract：UNLABELLED:There are nine subtypes of influenza A virus neuraminidase (NA), N1 to N9. In addition, influenza B virus also contains NA, and there are two influenza virus NA-like molecules, N10 and N11, which were recently identified from bats. Crystal structures for all of these proteins have been solved, with the excep...

journal_title：Journal of virology

authors： Sun X,Li Q,Wu Y,Wang M,Liu Y,Qi J,Vavricka CJ,Gao GF

更新日期：2014-08-01 00:00:00

abstract：:Five regions of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) have been shown to be important in the transcriptional regulation of HIV in HeLa cells. These include the negative regulatory, enhancer, SP1, TATA, and TAR regions. Previous studies in which purified SP1 was used showed that the...

journal_title：Journal of virology

authors： Harrich D,Garcia J,Wu F,Mitsuyasu R,Gonazalez J,Gaynor R

更新日期：1989-06-01 00:00:00

abstract：:Intrarectal simian immunodeficiency virus (SIV) infection in rhesus macaques is a model for sexual transmission of primate retroviruses. Phylogenetic studies on envelope gene sequences that were present in blood following intrarectal SIV inoculation provided evidence for selective amplification of a subset of viruses ...

journal_title：Journal of virology

authors： Trivedi P,Horejsh D,Hinds SB,Hinds PW II,Wu MS,Salvato MS,Pauza CD

更新日期：1996-10-01 00:00:00

abstract：:The molecular defect in the nonconditional B-tropic MuLV pol mutant, clone 23 (Gerwin et al., J. Virol. 31:741-751, 1979), has been characterized by recombinant DNA technology. The entire mutant genome was cloned from an EcoRI digest of integrated cellular DNA into bacteriophage lambda Charon 4A and then subcloned at ...

journal_title：Journal of virology

authors： Levin JG,Hu SC,Rein A,Messer LI,Gerwin BI

更新日期：1984-08-01 00:00:00

abstract：:Signal transducers and activators of transcription (STATs) relay signals from activated cell surface receptors directly to the nucleus. Previously, a protein required for T-cell transformation by the DNA tumor virus herpesvirus saimiri (HVS) and designated tyrosine kinase interacting protein (Tip-484) was shown to int...

journal_title：Journal of virology

authors： Lund TC,Garcia R,Medveczky MM,Jove R,Medveczky PG

更新日期：1997-09-01 00:00:00

abstract：:Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) transactivates EBV genes in latently infected B cells. We have shown that mitotic hyperphosphorylation of EBNA2 suppresses its ability to transactivate the latent membrane protein 1 (LMP1) promoter. In this follow-up study, we identify EBNA2 Ser243 as a phosphorylatio...

journal_title：Journal of virology

authors： Yue W,Shackelford J,Pagano JS

更新日期：2006-02-01 00:00:00

abstract：:China is facing a rapid upsurge in cases of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) infection due to large numbers of paid blood donors (PBD), injection drug users (IDU), and sexual partners of infected individuals. In this report, a total of 236 HIV-1-positive blood samples were collec...

journal_title：Journal of virology

authors： Zhang L,Chen Z,Cao Y,Yu J,Li G,Yu W,Yin N,Mei S,Li L,Balfe P,He T,Ba L,Zhang F,Lin HH,Yuen MF,Lai CL,Ho DD

更新日期：2004-12-01 00:00:00

abstract：:Therapeutic strategies for the treatment of acute retroviral infections have relied mainly on antiviral drugs. In this study we used the Friend virus model system to demonstrate that enhancement of the immune system can also have dramatic therapeutic effects. Since resistance to Friend virus-induced leukemia in mice i...

journal_title：Journal of virology

authors： Olbrich AR,Schimmer S,Heeg K,Schepers K,Schumacher TN,Dittmer U

更新日期：2002-11-01 00:00:00

abstract：:NF-kappaB signaling is critical to the survival and transformation of cells infected by the human gammaherpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus. Here we have examined how elimination of the NF-kappaB transcription factor p50 from mice affects the life cycle of murine gammaherpesviru...

journal_title：Journal of virology

authors： Krug LT,Collins CM,Gargano LM,Speck SH

更新日期：2009-05-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) Tat protein has a critical role in viral transcription, but this study focuses on its additional role as an extracellular effector of lymphocyte cell death. It is well known that Tat induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL) in peripheral blood mononu...

journal_title：Journal of virology

authors： Yang Y,Tikhonov I,Ruckwardt TJ,Djavani M,Zapata JC,Pauza CD,Salvato MS

更新日期：2003-06-01 00:00:00

abstract：:A promoter-trap retrovirus has been constructed in which a promoterless polyomavirus middle T antigen gene was inserted in the U3 region of the long terminal repeat of a replication-competent Moloney murine leukemia virus. The resulting virus, designated PyT, was used to infect mouse mammary glands in situ. As expecte...

journal_title：Journal of virology

authors： Coulombe J,Avis Y,Gray DA

更新日期：1996-10-01 00:00:00

abstract：:The human T-cell leukemia virus type 1 (HTLV-1) transforming protein, Tax, is a potent transactivator of both viral and cellular gene expression. The ability of Tax to transform cells is believed to depend on its transactivation of cellular-growth-regulatory genes. Expression of proliferating cell nuclear antigen (PCN...

journal_title：Journal of virology

authors： Ressler S,Morris GF,Marriott SJ

更新日期：1997-02-01 00:00:00

abstract：:The beginning of the second century of research in the field of virology (the first virus was discovered in 1898) was marked by its amalgamation with bioinformatics, resulting in the birth of a new domain--viroinformatics. The availability of more than 100 Web servers and databases embracing all or specific viruses (f...

journal_title：Journal of virology

authors： Sharma D,Priyadarshini P,Vrati S

更新日期：2015-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is treated with interferon (IFN)-based therapy. The mechanisms by which IFN suppresses HCV replication are not known, and only limited efficacy is achieved with therapy because the virus directs mechanisms to resist the host IFN response. In the present study we characterized the effe...

journal_title：Journal of virology

authors： Wang C,Pflugheber J,Sumpter R Jr,Sodora DL,Hui D,Sen GC,Gale M Jr

更新日期：2003-04-01 00:00:00