Identification of protein kinases dysregulated in CD4(+) T cells in pathogenic versus apathogenic simian immunodeficiency virus infection.

abstract：:Replication of the genomic RNA of severe acute respiratory syndrome coronavirus (SARS-CoV) is mediated by replicase polyproteins that are processed by two viral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro). Previously, we showed that SARS-CoV PLpro processes the replicase polyprotein at three ...

journal_title：Journal of virology

authors： Barretto N,Jukneliene D,Ratia K,Chen Z,Mesecar AD,Baker SC

更新日期：2005-12-01 00:00:00

abstract：:Porcine reproductive and respiratory syndrome (PRRS) consistently elevates the frequency of disease and mortality in young pigs. Many different secondary bacterial diseases occur in PRRS virus (PRRSV)-infected pigs. However, to date, establishing a reproducible experimental model of PRRSV infection in weaned pigs, wit...

journal_title：Journal of virology

authors： Feng W,Laster SM,Tompkins M,Brown T,Xu JS,Altier C,Gomez W,Benfield D,McCaw MB

更新日期：2001-05-01 00:00:00

abstract：:Antiserum against murine cytomegalovirus produced in the rabbit contained complement (C')-requiring neutralizing (CRN) antibody. The proportion of CRN was extremely high (up to 98%) during the early portion of an immunization procedure, whereas the antisera produced late had a much lower proportion that required C'. T...

journal_title：Journal of virology

authors： Kim KS,Carp RI

更新日期：1973-12-01 00:00:00

abstract：:Purified Friend viruses obtained from chronically infected tissue cultures were studied under the electron microscope in an effort to correlate the fine structure of the particles to their leukemogenic activity under varied experimental conditions, i.e., temperature treatments and exposure to Tween 80, amyl acetate, o...

journal_title：Journal of virology

authors： De Tkaczevski L,De Harven E,Friend C

更新日期：1968-04-01 00:00:00

abstract：:The genomic RNA of an alphavirus encodes four different nonstructural proteins, nsP1, nsP2, nsP3, and nsP4. The polyprotein P123 is produced when translation terminates at an opal termination codon between nsP3 and nsP4. The polyprotein P1234 is produced when translational readthrough occurs or when the opal terminati...

journal_title：Journal of virology

authors： Myles KM,Kelly CL,Ledermann JP,Powers AM

更新日期：2006-05-01 00:00:00

abstract：:Marek's disease virus (MDV) is an alphaherpesvirus for which infection is strictly cell associated in permissive cell culture systems. In contrast to most other alphaherpesviruses, no comprehensive ultrastructural study has been published to date describing the different stages of MDV morphogenesis. To circumvent prob...

journal_title：Journal of virology

authors： Denesvre C,Blondeau C,Lemesle M,Le Vern Y,Vautherot D,Roingeard P,Vautherot JF

更新日期：2007-11-01 00:00:00

abstract：:Echovirus 1 (EV1) is a human pathogen which belongs to the Picornaviridae family of RNA viruses. We have analyzed the early events of infection after EV1 binding to its receptor alpha 2 beta 1 integrin and elucidated the route by which EV1 gains access to the host cell. EV1 binding onto the cell surface and subsequent...

journal_title：Journal of virology

authors： Marjomäki V,Pietiäinen V,Matilainen H,Upla P,Ivaska J,Nissinen L,Reunanen H,Huttunen P,Hyypiä T,Heino J

更新日期：2002-02-01 00:00:00

abstract：:Epstein-Barr virus (EBV) latent membrane protein 2A (LMP2A) is widely expressed in EBV-infected cells within the infected human host and EBV-associated malignancies, suggesting that LMP2A is important for EBV latency, persistence, and EBV-associated tumorigenesis. Previously, we demonstrated that LMP2A provides an ant...

journal_title：Journal of virology

authors： Fukuda M,Longnecker R

更新日期：2007-09-01 00:00:00

abstract：:Newcastle disease virus (NDV) edits its P-gene mRNA by inserting a nontemplated G residue(s) at a conserved editing site (3'-UUUUUCCC-template strand). In the wild-type virus, three amino-coterminal P-gene-derived proteins, P, V, and W, are produced at frequencies of approximately 68, 29, and 2%, respectively. By appl...

journal_title：Journal of virology

authors： Mebatsion T,Verstegen S,De Vaan LT,Römer-Oberdörfer A,Schrier CC

更新日期：2001-01-01 00:00:00

abstract：:Poliovirus mutants in neutralizing antigenic site 3B were constructed by replacing the glutamic acid residue at amino acid 74 of capsid protein VP2 (VP2074E), using site-specific mutagenesis methods. All viable mutants display small-plaque phenotypes. Characterization of these mutants indicates that capsid assembly is...

journal_title：Journal of virology

authors： Reynolds C,Birnby D,Chow M

更新日期：1992-03-01 00:00:00

abstract：:The rarely identified influenza A viruses of the H15 hemagglutinin subtype have been isolated exclusively in Australia. Here we report the isolation of an H15N4 influenza A virus (A/teal/Chany/7119/2008) in Western Siberia, Russia. Phylogenetic analysis demonstrated that the internal genes of the A/teal/Chany/7119/200...

journal_title：Journal of virology

authors： Sivay MV,Baranovich T,Marchenko VY,Sharshov KA,Govorkova EA,Shestopalov AM,Webby RJ

更新日期：2013-03-01 00:00:00

abstract：:Early stages of infection by the mouse polyomavirus have been studied using HeLa cells stably expressing small interfering RNA to protein disulfide isomerase (PDI). Infectibility measured by nuclear T antigen expression was reduced commensurately with the degree of PDI downregulation. Infectibility was restored by tra...

journal_title：Journal of virology

authors： Gilbert J,Ou W,Silver J,Benjamin T

更新日期：2006-11-01 00:00:00

abstract：:Radioactive DNA complementary to nucleotide sequences in Moloney murine sarcoma virus (MSV) and Moloney leukemia virus (M-MuLV) complex was made by the endogenous reverse transcriptase reaction. These virus stocks contained a threefold excess of MSV over M-MuLV as measured by biological assay. The complementary DNA wa...

journal_title：Journal of virology

authors： Frankel AE,Neubauer RL,Fischinger PJ

更新日期：1976-05-01 00:00:00

abstract：:A deletion mutant of severe acute respiratory syndrome coronavirus (SARS-CoV) has been engineered by deleting the structural E gene in an infectious cDNA clone that was constructed as a bacterial artificial chromosome (BAC). The recombinant virus lacking the E gene (rSARS-CoV-DeltaE) was rescued in Vero E6 cells. The ...

journal_title：Journal of virology

authors： DeDiego ML,Alvarez E,Almazán F,Rejas MT,Lamirande E,Roberts A,Shieh WJ,Zaki SR,Subbarao K,Enjuanes L

更新日期：2007-02-01 00:00:00

abstract：:The promoter of the murine thymidine kinase gene contains a binding site for transcription factor E2F. Using cell lines (3T3-LT) conditionally expressing polyomavirus large T antigen from a hormone-responsive promoter and reporter gene constructs carrying the thymidine kinase promoter with intact or mutated E2F sites,...

journal_title：Journal of virology

authors： Ogris E,Rotheneder H,Mudrak I,Pichler A,Wintersberger E

更新日期：1993-04-01 00:00:00

abstract：:Influenza A H9N2 viruses are common poultry pathogens that occasionally infect swine and humans. It has been shown previously with H9N2 viruses that reassortment can generate novel viruses with increased transmissibility. Here, we demonstrate the modeling power of a novel transfection-based inoculation system to selec...

journal_title：Journal of virology

authors： Kimble JB,Angel M,Wan H,Sutton TC,Finch C,Perez DR

更新日期：2014-01-01 00:00:00

abstract：:Respiratory syncytial (RS) virus infects the epithelium of the respiratory tract. We examined the replication and maturation of RS virus in two polarized epithelial cell lines, Vero C1008 and MDCK. Electron microscopy of RS virus-infected Vero C1008 cells revealed the presence of pleomorphic viral particles budding ex...

journal_title：Journal of virology

authors： Roberts SR,Compans RW,Wertz GW

更新日期：1995-04-01 00:00:00

abstract：:The genome-length, dicistronic mRNA of the double-stranded RNA fungal virus Helminthosporium victoriae virus 190S (genus Victorivirus, family Totiviridae) contains two long open reading frames (ORFs) that overlap in the tetranucleotide AUGA. Translation of the downstream ORF, which encodes the RNA-dependent RNA polyme...

journal_title：Journal of virology

authors： Li H,Havens WM,Nibert ML,Ghabrial SA

更新日期：2011-07-01 00:00:00

abstract：:We previously reported that the expression of rotavirus phenotypes by reassortants was affected by recipient genetic background and proposed specific interactions between the outer capsid proteins VP4 and VP7 as the basis for the phenotypic effects (D. Chen, J. W. Burns, M. K. Estes, and R. F. Ramig, Proc. Natl. Acad....

journal_title：Journal of virology

authors： Chen DY,Estes MK,Ramig RF

更新日期：1992-01-01 00:00:00

abstract：:We have previously described several helper independent vector constructions (S. Hughes and E. Kosik, Virology 136:89-99, 1984; J. Sorge and S. H. Hughes, J. Mol. Appl. Genet. 1:547-599, 1982; J. Sorge, B. Ricci, and S. Hughes, J. Virol. 48:667-675, 1983), all of which derive from Rous sarcoma virus. In this report we...

journal_title：Journal of virology

authors： Hughes SH,Greenhouse JJ,Petropoulos CJ,Sutrave P

更新日期：1987-10-01 00:00:00

abstract：:Accumulation of the interferon-stimulated gene 15 (ISG15) protein product, which is reversibly conjugated to numerous polypeptide targets, impacts the proteome and physiology of uninfected and infected cells. While many viruses, including human cytomegalovirus (HCMV), blunt host antiviral defenses by limiting ISG expr...

journal_title：Journal of virology

authors： Bianco C,Mohr I

更新日期：2017-04-13 00:00:00

abstract：:HLA-B*57-mediated selection pressure leads to a typical escape pathway in human immunodeficiency virus type 1 (HIV-1) CD8 epitopes such as TW10. Whether this T242N pathway is shared by all clades remains unknown. We therefore assessed the nature of HLA-B*57 selection in a large, observational Kenyan cohort where clade...

journal_title：Journal of virology

authors： McKinnon LR,Capina R,Peters H,Mendoza M,Kimani J,Wachihi C,Kariri A,Kimani M,Richmond M,Kiazyk SK,Fowke KR,Jaoko W,Luo M,Ball TB,Plummer FA

更新日期：2009-12-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) remains latent throughout the life of the carrier, with cells containing the provirus and viral gene expression efficiently down-regulated. On a molecular level, exactly how viruses are down-regulated in vivo remains unresolved. We described here the possibility that down-re...

journal_title：Journal of virology

authors： Saiga A,Orita S,Minoura-Tada N,Maeda M,Aono Y,Asakawa M,Nakahara K,Kubota R,Osame M,Igarashi H

更新日期：1997-06-01 00:00:00

abstract：:Several point mutations in the simian virus 40 (SV40) small-t antigen have been analyzed for their effects on protein stability, transformation, transactivation, and binding of two cellular proteins. All mutations which affected cysteine residues in two cysteine clusters produced highly unstable small-t antigens. Four...

journal_title：Journal of virology

authors： Jog P,Joshi B,Dhamankar V,Imperiale MJ,Rutila J,Rundell K

更新日期：1990-06-01 00:00:00

abstract：:Processes by which human herpesviruses penetrate and are released from polarized epithelial cells, which have distinct apical and basolateral membrane domains differing in protein and lipid content, are poorly understood. We recently reported that human cytomegalovirus (CMV) mutants with deletions of the gene US9 form...

journal_title：Journal of virology

authors： Maidji E,Tugizov S,Abenes G,Jones T,Pereira L

更新日期：1998-07-01 00:00:00

abstract：:Human papillomavirus (HPV) type 16 E6 (16E6) is an oncogenic, multifunctional nuclear protein that induces p53 degradation and perturbs normal cell cycle control, leading to immortalization and transformation of infected keratinocytes and epithelial cells. Although it is unclear how 16E6 disrupts the epigenetic profil...

journal_title：Journal of virology

authors： Tao M,Kruhlak M,Xia S,Androphy E,Zheng ZM

更新日期：2003-12-01 00:00:00

abstract：:Drug resistance remains a major concern for human immunodeficiency virus (HIV) treatment. To date, very few resistance mutations have emerged in first-line combination therapy that includes the integrase strand transfer inhibitor (INSTI) dolutegravir (DTG). In vitro, DTG selects for several primary mutations that indu...

journal_title：Journal of virology

authors： Van Rompay KKA,Hassounah S,Keele BF,Lifson JD,Ardeshir A,Watanabe J,Pham HT,Chertova E,Sowder R,Balzarini J,Mesplède T,Wainberg MA

更新日期：2019-01-04 00:00:00

abstract：:Klebsiella pneumoniae is a member of the family Enterobacteriaceae, opportunistic pathogens that are among the eight most prevalent infectious agents in hospitals. The emergence of multidrug-resistant strains of K. pneumoniae has became a public health problem globally. To develop an effective antimicrobial agent, we ...

journal_title：Journal of virology

authors： Cui Z,Shen W,Wang Z,Zhang H,Me R,Wang Y,Zeng L,Zhu Y,Qin J,He P,Guo X

更新日期：2012-12-01 00:00:00

abstract：:The relatively small package capacity (less than 5 kb) of adeno-associated virus (AAV) vectors has been effectively doubled with the development of dual-vector heterodimerization approaches. However, the efficiency of such dual-vector systems is limited not only by the extent to which intermolecular recombination occu...

journal_title：Journal of virology

authors： Yan Z,Zak R,Zhang Y,Engelhardt JF

更新日期：2005-01-01 00:00:00

abstract：:Antigens derived from host cells are detectable in the envelope of human immunodeficiency virus type 1 (HIV-1) and result in a distinctive viral phenotype reflecting that of the host cell. An immunomagnetic capture assay targeting discriminatory host proteins was developed to differentiate between HIV-1 derived from m...

journal_title：Journal of virology

authors： Lawn SD,Roberts BD,Griffin GE,Folks TM,Butera ST

更新日期：2000-01-01 00:00:00