Signals that dictate nuclear localization of human papillomavirus type 16 oncoprotein E6 in living cells.

abstract：:When human A431 cells, which carry high numbers of epidermal growth factor (EGF) receptors, are exposed to EGF, the total content of phosphotyrosine in cell protein is increased, the EGF receptor becomes phosphorylated at tyrosine, and new phosphotyrosine-containing 36,000- and 81,000-dalton proteins are detected. We ...

journal_title：Journal of virology

authors： Cooper JA,Scolnick EM,Ozanne B,Hunter T

更新日期：1983-12-01 00:00:00

abstract：:Previous in vitro analyses have shown that the human immunodeficiency virus type 1 (HIV-1) integrase uses either manganese or magnesium to assemble as a stable complex on the donor substrate and to catalyze strand transfer. We now demonstrate that subsequent to assembly, catalysis of both 3' end processing and strand ...

journal_title：Journal of virology

authors： Hazuda DJ,Felock PJ,Hastings JC,Pramanik B,Wolfe AL

更新日期：1997-09-01 00:00:00

abstract：:The mouse hind footpad inoculation model has served as a standard laboratory system for the study of the neuropathogenesis of herpes simplex virus type 1 (HSV-1) infection. The temporal and spatial distribution of viral antigen, known as the transneuronal spread phenotype, has not previously been described; nor is it ...

journal_title：Journal of virology

authors： Engel JP,Madigan TC,Peterson GM

更新日期：1997-03-01 00:00:00

abstract：:The ability of vaccinia virus to replicate in HeLa cells which had been previously infected with adenovirus type 2 (Ad2) was studied in order to gain insight into the mechanism by which adenovirus inhibits the expression of host cell functions. Vaccinia virus was employed in these studies because it replicates in the ...

journal_title：Journal of virology

authors： Giorno R,Kates JR

更新日期：1971-02-01 00:00:00

abstract：:The combination of an amino acid deletion at codon 67 (delta 67) and Thr-to-Gly change at codon 69 (T69G) in the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) is associated with high-level resistance to multiple RT inhibitors. To determine the relative contributions of the delta 67 and T69G...

journal_title：Journal of virology

authors： Imamichi T,Berg SC,Imamichi H,Lopez JC,Metcalf JA,Falloon J,Lane HC

更新日期：2000-12-01 00:00:00

abstract：:Dendritic cells (DCs) play a central role in instructing antiviral immune responses. DCs, however, can become targeted by different viruses themselves. We recently demonstrated that human DCs can be productively infected with echoviruses (EVs), but not coxsackie B viruses (CVBs), both of which are RNA viruses belongin...

journal_title：Journal of virology

authors： Kramer M,Schulte BM,Toonen LW,Barral PM,Fisher PB,Lanke KH,Galama JM,van Kuppeveld FJ,Adema GJ

更新日期：2008-03-01 00:00:00

abstract：:Sequences of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) domain were determined by direct sequencing of HIV-1 RNA in successive plasma samples from eight seroconverting patients infected with virus bearing the T215Y/F amino acid substitution associated with zidovudine (ZDV) resistance. A...

journal_title：Journal of virology

authors： Yerly S,Rakik A,De Loes SK,Hirschel B,Descamps D,Brun-Vézinet F,Perrin L

更新日期：1998-05-01 00:00:00

abstract：:The human cytomegalovirus UL47 open reading frame encodes a 110-kDa protein that is a component of the virion tegument. We have constructed a cytomegalovirus mutant, ADsubUL47, in which the central portion of the UL47 open reading frame has been replaced by two marker genes. The mutant replicated to titers 100-fold lo...

journal_title：Journal of virology

authors： Bechtel JT,Shenk T

更新日期：2002-02-01 00:00:00

abstract：:The use of pathogen recognition receptor (PRR) agonists and the molecular mechanisms involved have been the major focus of research in individual vaccine development. West Nile virus (WNV) nonstructural (NS) 4B-P38G mutant has several features for an ideal vaccine candidate, including significantly reduced neuroinvasi...

journal_title：Journal of virology

authors： Luo H,Winkelmann E,Xie G,Fang R,Peng BH,Li L,Lazear HM,Paessler S,Diamond MS,Gale M Jr,Barrett AD,Wang T

更新日期：2017-02-28 00:00:00

abstract：:We have reinvestigated the subcellular distribution of the duck hepatitis B virus (DHBV) core protein in infected duck hepatocytes and in transfected cells. By using indirect immunofluorescence, the protein was found to be localized not only in the cytoplasm, as described previously, but also within the cell nucleus, ...

journal_title：Journal of virology

authors： Mabit H,Knaust A,Breiner KM,Schaller H

更新日期：2003-02-01 00:00:00

abstract：:DNA vaccines have recently emerged at the forefront of approaches to harness the immune system in the prevention and treatment of viral infections, as well as the prevention and treatment of cancers. However, these vaccines suffer from limited efficacy since they often fail to produce significant antigen-specific CD8(...

journal_title：Journal of virology

authors： Mao CP,Hung CF,Kang TH,He L,Tsai YC,Wu CY,Wu TC

更新日期：2010-03-01 00:00:00

abstract：:After the contagion measles virus (MV) crosses the respiratory epithelium within myeloid cells that express the primary receptor signaling lymphocytic activation molecule (SLAM), it replicates briskly in SLAM-expressing cells in lymphatic organs. Later, the infection spreads to epithelia expressing nectin-4, an adhere...

journal_title：Journal of virology

authors： Frenzke M,Sawatsky B,Wong XX,Delpeut S,Mateo M,Cattaneo R,von Messling V

更新日期：2013-03-01 00:00:00

abstract：:Influenza A virus (IAV) is a highly transmissible respiratory pathogen and a major cause of morbidity and mortality around the world. Nucleoprotein (NP) is an abundant IAV protein essential for multiple steps of the viral life cycle. Our recent proteomic study of the IAV-host interaction network found that TRIM41 (tri...

journal_title：Journal of virology

authors： Patil G,Zhao M,Song K,Hao W,Bouchereau D,Wang L,Li S

更新日期：2018-07-31 00:00:00

abstract：:While a diversity of immunogens that elicit qualitatively different cellular immune responses are being assessed in clinical human immunodeficiency virus vaccine trials, the consequences of those varied responses for viral control remain poorly understood. In the present study, we evaluated the induction of virus-spec...

journal_title：Journal of virology

authors： Sun Y,Santra S,Schmitz JE,Roederer M,Letvin NL

更新日期：2008-09-01 00:00:00

abstract：:ev 2 is one of seven recently described genetic loci of chickens which contain structural genes for endogenous virus. ev 2 is present exclusively in line 72 chickens, an inbred strain of white Leghorns which is homozygous for the capacity to produce Rous-associated virus type 0 (RAV-0), a subgroup E virus. This phenot...

journal_title：Journal of virology

authors： Astrin SM,Crittenden LB,Buss EG

更新日期：1980-01-01 00:00:00

abstract：:IgG1 b12 is a broadly neutralizing antibody against human immunodeficiency virus type 1 (HIV-1). The epitope recognized by b12 overlaps the CD4 receptor-binding site (CD4bs) on gp120 and has been a target for vaccine design. Determination of the three-dimensional structure of immunoglobulin G1 (IgG1) b12 allowed model...

journal_title：Journal of virology

authors： Zwick MB,Parren PW,Saphire EO,Church S,Wang M,Scott JK,Dawson PE,Wilson IA,Burton DR

更新日期：2003-05-01 00:00:00

abstract：:Measles virus (MV) interacts with cellular receptors on the surface of peripheral blood lymphocytes (PBL) which mediate virus binding and uptake. Simultaneously, the direct contact of the viral glycoproteins with the cell surface induces a negative signal blocking progression to the S phase of the cell cycle, resultin...

journal_title：Journal of virology

authors： Erlenhoefer C,Wurzer WJ,Löffler S,Schneider-Schaulies S,ter Meulen V,Schneider-Schaulies J

更新日期：2001-05-01 00:00:00

abstract：:The gamma(1)34.5 protein, a virulence factor of herpes simplex viruses, redirects protein phosphatase 1 to dephosphorylate the alpha subunit of translation initiation factor 2 (eIF2alpha). Additionally, it inhibits the induction of antiviral genes by TANK-binding kinase 1. Nevertheless, its precise role in vivo remain...

journal_title：Journal of virology

authors： Verpooten D,Feng Z,Valyi-Nagy T,Ma Y,Jin H,Yan Z,Zhang C,Cao Y,He B

更新日期：2009-12-01 00:00:00

abstract：:Treatment of polyoma virions with ethyleneglycol-bil-N,N'-tetraacetic acid (EGTA) and dithiothreitol (DTT) at pH 8.5 resulted in the dissociation of the virions into a DNA-protein complex and individual structural capsomere subunits. The sedimentation value of the DNA-protein complex in sucrose gradients was approxima...

journal_title：Journal of virology

authors： Brady JN,Winston VD,Consigli RA

更新日期：1978-07-01 00:00:00

abstract：:Viruses display a wide range of genomic profiles and, consequently, a variety of gene expression strategies. Specific sequences associated with transcriptional processes have been described in viruses, and putative promoter motifs have been elucidated for some nucleocytoplasmic large DNA viruses (NCLDV). Among NCLDV, ...

journal_title：Journal of virology

authors： Oliveira GP,Lima MT,Arantes TS,Assis FL,Rodrigues RAL,da Fonseca FG,Bonjardim CA,Kroon EG,Colson P,La Scola B,Abrahão JS

更新日期：2017-10-13 00:00:00

abstract：:The Vpr accessory gene product of human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus is believed to play a role in permitting entry of the viral core into the nucleus of nondividing cells. A second role for Vpr was recently suggested by Rogel et al. (M. E. Rogel, L. I. Wu, and M. Emerman, J. ...

journal_title：Journal of virology

authors： He J,Choe S,Walker R,Di Marzio P,Morgan DO,Landau NR

更新日期：1995-11-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) is an oncogenic human herpesvirus. EBV latent membrane protein 1 (LMP-1) is a viral oncogene that manifests its oncogenic phenotype through activation of cellular signaling pathways involved in cell growth, survival, differentiation, and transformation. Lytic LMP-1 (lyLMP-1) is a related E...

journal_title：Journal of virology

authors： Pandya J,Walling DM

更新日期：2006-08-01 00:00:00

abstract：:In wild aquatic birds and poultry around the world, influenza A viruses carrying 15 antigenic subtypes of hemagglutinin (HA) and 9 antigenic subtypes of neuraminidase (NA) have been described. Here we describe a previously unidentified antigenic subtype of HA (H16), detected in viruses circulating in black-headed gull...

journal_title：Journal of virology

authors： Fouchier RA,Munster V,Wallensten A,Bestebroer TM,Herfst S,Smith D,Rimmelzwaan GF,Olsen B,Osterhaus AD

更新日期：2005-03-01 00:00:00

abstract：:Wild-type herpes simplex virus 1 (HSV-1) multiplies, spreads, and rapidly destroys cells of the murine central nervous system (CNS). In contrast, mutants lacking both copies of the gamma(1)34.5- gene have been shown to be virtually lacking in virulence even after direct inoculation of high-titered virus into the CNS o...

journal_title：Journal of virology

authors： Markovitz NS,Baunoch D,Roizman B

更新日期：1997-07-01 00:00:00

abstract：:The fusion (F) protein of simian virus 5 (strain W3A) induced extensive cell fusion in BHK cells when expressed alone, while that of strain WR did not. Mutational analysis demonstrated that the fusing activity can be transferred to the WR F protein by a proline residue at position 22 of subunit W3A F2. ...

journal_title：Journal of virology

authors： Ito M,Nishio M,Kawano M,Kusagawa S,Komada H,Ito Y,Tsurudome M

更新日期：1997-12-01 00:00:00

abstract：:Fusion of the membrane of the Moloney murine leukemia virus (Mo-MLV) Env protein is facilitated by cleavage of the R peptide from the cytoplasmic tail of its TM subunit, but the mechanism for this effect has remained obscure. The fusion is also controlled by the isomerization of the intersubunit disulfide of the Env S...

journal_title：Journal of virology

authors： Löving R,Li K,Wallin M,Sjöberg M,Garoff H

更新日期：2008-03-01 00:00:00

abstract：:The Ebola virus glycoprotein mucin-like domain (MLD) is implicated in Ebola virus cell entry and immune evasion. Using cryo-electron tomography of Ebola virus-like particles, we determined a three-dimensional structure for the full-length glycoprotein in a near-native state and compared it to that of a glycoprotein la...

journal_title：Journal of virology

authors： Tran EE,Simmons JA,Bartesaghi A,Shoemaker CJ,Nelson E,White JM,Subramaniam S

更新日期：2014-09-01 00:00:00

abstract：:The complete genomic sequence of a new Muscovy duck-origin reovirus (N-MDRV), strain J18 from China, was determined. The virus has a tricistronic S1 genome segment that is distinct from the originally described MDRV, which possesses a bicistronic S4 genome segment. Pairwise comparisons and phylogenetic analyses sugges...

journal_title：Journal of virology

authors： Wang D,Xu F,Ma G,Zhang C,Huang Y,Li H,Zhang D

更新日期：2012-11-01 00:00:00

abstract：:The envelope of human parainfluenza virus type 3 (HPF3) contains two viral glycoproteins, the hemagglutinin-neuraminidase (HN) and the fusion protein (F). HN, which is responsible for receptor attachment and for promoting F-mediated fusion, also possesses neuraminidase (receptor-destroying) activity. We reported previ...

journal_title：Journal of virology

authors： Porotto M,Greengard O,Poltoratskaia N,Horga MA,Moscona A

更新日期：2001-08-01 00:00:00

abstract：UNLABELLED:To investigate the molecular mechanism(s) by which herpes simplex virus 1 (HSV-1) tegument protein UL51 promotes viral replication, we screened for viral proteins that interact with UL51 in infected cells. Affinity purification of tagged UL51 in HSV-1-infected Vero cells was coupled with immunoblotting of th...

journal_title：Journal of virology

authors： Oda S,Arii J,Koyanagi N,Kato A,Kawaguchi Y

更新日期：2016-09-12 00:00:00