Abstract:
:Fusion of the membrane of the Moloney murine leukemia virus (Mo-MLV) Env protein is facilitated by cleavage of the R peptide from the cytoplasmic tail of its TM subunit, but the mechanism for this effect has remained obscure. The fusion is also controlled by the isomerization of the intersubunit disulfide of the Env SU-TM complex. In the present study, we used several R-peptide-cleavage-inhibited virus mutants to show that the R peptide suppresses the isomerization reaction in both in vitro and in vivo assays. Thus, the R peptide affects early steps in the activation pathway of murine leukemia virus Env.
journal_name
J Viroljournal_title
Journal of virologyauthors
Löving R,Li K,Wallin M,Sjöberg M,Garoff Hdoi
10.1128/JVI.02039-07subject
Has Abstractpub_date
2008-03-01 00:00:00pages
2594-7issue
5eissn
0022-538Xissn
1098-5514pii
JVI.02039-07journal_volume
82pub_type
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