Virus-specific mRNA capping enzyme encoded by hepatitis E virus.

abstract：:Historically, coronaviruses were predominantly associated with mild upper respiratory disease in humans. More recently, three novel coronaviruses associated with severe human respiratory disease were found, including (i) the severe acute respiratory syndrome coronavirus, associated with a significant atypical pneumoni...

journal_title：Journal of virology

authors： Donaldson EF,Yount B,Sims AC,Burkett S,Pickles RJ,Baric RS

更新日期：2008-12-01 00:00:00

abstract：:Transduction of the liver with single-stranded adeno-associated virus serotype 2 (AAV2) vectors is inefficient; less than 10% of hepatocytes are permissive for stable transduction, and transgene expression is characterized by a lag phase of up to 6 weeks. AAV2-based vector genomes packaged inside AAV6 or AAV8 capsids ...

journal_title：Journal of virology

authors： Thomas CE,Storm TA,Huang Z,Kay MA

更新日期：2004-03-01 00:00:00

abstract：:Marek's disease herpesvirus (MDV)-transformed lymphoblastoid tumor cell lines were characterized for the presence of the surface markers. Monoclonal antibodies were used for CD3 (T-cell receptor [TCR] complex), TCR1, TCR2, and TCR3, CD4, CD8, and Ia antigen by indirect fluorescence staining followed by microscopic exa...

journal_title：Journal of virology

authors： Schat KA,Chen CL,Calnek BW,Char D

更新日期：1991-03-01 00:00:00

abstract：:To study the tissue specificity of mouse mammary tumor virus (MMTV) gene expression, we developed two series of transgenic mice, containing the MMTV proviral DNA of mammary (GR) and kidney (C3H-K) origin. The expression pattern in the MMTV(GR) transgenic mice is very similar to that observed in infected animals, e.g.,...

journal_title：Journal of virology

authors： Rollini P,Billotte J,Kolb E,Diggelmann H

更新日期：1992-07-01 00:00:00

abstract：:Herpes simplex virus (HSV) is an important human pathogen with a high worldwide seroprevalence. HSV enters epithelial cells, the primary site of infection, by a low-pH pathway. HSV glycoprotein B (gB) undergoes low pH-induced conformational changes, which are thought to drive membrane fusion. When neutralized back to ...

journal_title：Journal of virology

authors： Weed DJ,Dollery SJ,Komala Sari T,Nicola AV

更新日期：2018-08-16 00:00:00

abstract：:The ability of the 3A protein of coxsackievirus B (CVB) to inhibit protein secretion was investigated for this study. Here we show that the ectopic expression of CVB 3A blocked the transport of both the glycoprotein of vesicular stomatitis virus, a membrane-bound secretory marker, and the alpha-1 protease inhibitor, a...

journal_title：Journal of virology

authors： Wessels E,Duijsings D,Notebaart RA,Melchers WJ,van Kuppeveld FJ

更新日期：2005-04-01 00:00:00

abstract：:Two chimpanzees immunized with woodchuck hepatitis virus (WHV) surface antigen (WHsAg) developed antibodies cross-reactive with hepatitis B virus (HBV) surface antigen (HBsAg). After challenge with HBV, one animal was completely protected and the other experienced a subclinical infection, without evidence of liver dis...

journal_title：Journal of virology

authors： Cote PJ,Shapiro M,Engle RE,Popper H,Purcell RH,Gerin JL

更新日期：1986-12-01 00:00:00

abstract：:The beginning of the second century of research in the field of virology (the first virus was discovered in 1898) was marked by its amalgamation with bioinformatics, resulting in the birth of a new domain--viroinformatics. The availability of more than 100 Web servers and databases embracing all or specific viruses (f...

journal_title：Journal of virology

authors： Sharma D,Priyadarshini P,Vrati S

更新日期：2015-02-01 00:00:00

abstract：:Spleen necrosis virus productively infects avian and rat cells. The average number of molecules of unintegrated and integrated viral DNA in cells at different times after infection was determined by hybridization and transfection assays. Shortly after infection, there was a transient accumulation of an average of abou...

journal_title：Journal of virology

authors： Keshet E,Temin HM

更新日期：1979-08-01 00:00:00

abstract：:The 5'-terminal nucleotide sequence from positions 50 to 130 of vesicular stomatitis virus RNA was determined indirectly by using a defective interfering particle RNA which contains covalently linked genomic minus and antigenomic plus sense RNAs. The last 18 nucleotides of the L gene coding for in the viral polymerase...

journal_title：Journal of virology

authors： Schubert M,Keene JD,Herman RC,Lazzarini RA

更新日期：1980-05-01 00:00:00

abstract：:The NS3 protein of hepatitis C virus contains a bipartite structure consisting of an N-terminal serine protease and a C-terminal DEAD box helicase. We show that the C-terminal domain has ATPase and panhelicase activities. The integrity of the helicase function is dependent on the conserved DEAD motif and can be abolis...

journal_title：Journal of virology

authors： Heilek GM,Peterson MG

更新日期：1997-08-01 00:00:00

abstract：:Mouse mammary tumor virus (MTV) was isolated from the milk of RIII mice by density-gradient centrifugation in Ficoll. The homogeneity of the preparation was demonstrated in electron micrographs. The nucleic acid was extracted with phenol in the presence of Pronase. Its viral origin was attested by failure of ribo-nucl...

journal_title：Journal of virology

authors： Sarkar NH,Moore DH

更新日期：1970-02-01 00:00:00

abstract：:Broadly neutralizing antibodies (bNAbs) are being explored for HIV-1 prevention and cure strategies. However, administration of purified bNAbs poses challenges in resource-poor settings, where the HIV-1 disease burden is greatest. In vivo vector-based production of bNAbs represents an alternative strategy. We investig...

journal_title：Journal of virology

authors： Badamchi-Zadeh A,Tartaglia LJ,Abbink P,Bricault CA,Liu PT,Boyd M,Kirilova M,Mercado NB,Nanayakkara OS,Vrbanac VD,Tager AM,Larocca RA,Seaman MS,Barouch DH

更新日期：2018-03-14 00:00:00

abstract：:The E3 complex transcription unit of adenovirus encodes four major mRNAs (a, c, f, and h) and two minor (d and e) mRNAs with overlapping exons, alternative splice sites, and two polyadenylation sites, termed E3A (upstream) and E3B (downstream). mRNAs a and d use the E3A polyadenylation site, and mRNAs c, e, f, and h u...

journal_title：Journal of virology

authors： Brady HA,Scaria A,Wold WS

更新日期：1992-10-01 00:00:00

abstract：:Evidence is presented by use of radiolabeling and pancreatic and T1 ribonuclease digestion that some of the ribonucleic acid specified by herpes simplex virus contains polyadenylic acid sequences. The polyadenylic sequences are not transcribed from viral DNA. ...

journal_title：Journal of virology

authors： Bachenheimer SL,Roizman B

更新日期：1972-10-01 00:00:00

abstract：:The RNAs of replication-defective murine and primate type C transforming viruses were analyzed for the presence of nucleotide sequences homologous to the genomes of their respective helper type C viruses by using DNAs complementary (cDNA) to either the 5'-terminal (cDNA5') or total (cDNAtotal) nucleotide sequences of ...

journal_title：Journal of virology

authors： Tronick SR,Cabradilla CD,Aaronson SA,Haseltine WA

更新日期：1978-06-01 00:00:00

abstract：:Adult T-cell leukemia (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1). Elevated expression of vascular endothelial growth factor (VEGF) in ATL patients is associated with leukemic cell invasion and infiltration in different organs. The regulatory protein Tax 1 encoded by HTLV-1 plays a pivotal role in T...

journal_title：Journal of virology

authors： Watters KM,Dean J,Gautier V,Hall WW,Sheehy N

更新日期：2010-05-01 00:00:00

abstract：:Paramyxoviruses such as human parainfluenza viruses that bear inserts encoding protective antigens of heterologous viruses can induce an effective immunity against the heterologous viruses in experimental animals. However, vectors based on common human pathogens would be expected to be restricted in replication in the...

journal_title：Journal of virology

authors： Bukreyev A,Huang Z,Yang L,Elankumaran S,St Claire M,Murphy BR,Samal SK,Collins PL

更新日期：2005-11-01 00:00:00

abstract：:Respiratory syncytial (RS) virus infects the epithelium of the respiratory tract. We examined the replication and maturation of RS virus in two polarized epithelial cell lines, Vero C1008 and MDCK. Electron microscopy of RS virus-infected Vero C1008 cells revealed the presence of pleomorphic viral particles budding ex...

journal_title：Journal of virology

authors： Roberts SR,Compans RW,Wertz GW

更新日期：1995-04-01 00:00:00

abstract：:Hepatitis B virus (HBV) is an enveloped DNA virus that presumably buds at intracellular membranes of infected cells. HBV budding involves two endocytic host proteins, the ubiquitin-interacting adaptor gamma 2-adaptin and the Nedd4 ubiquitin ligase. Here, we demonstrate that HBV release also requires the cellular machi...

journal_title：Journal of virology

authors： Lambert C,Döring T,Prange R

更新日期：2007-09-01 00:00:00

abstract：:The VP7 and VP4 genes of seven antigenic mutants of simian rotavirus SA11 4fM (serotype 3) selected after 39 passages in the presence of SA11 4fM hyperimmune antiserum, were sequenced. Nucleotide sequence analysis indicated the following. (i) Twice as many amino acid substitutions occurred in the VP7 protein than in V...

journal_title：Journal of virology

authors： Gorziglia M,Larralde G,Ward RL

更新日期：1990-09-01 00:00:00

abstract：:Retrovirus assembly involves a complex series of events in which a large number of proteins must be targeted to a point on the plasma membrane where immature viruses bud from the cell. Gag polyproteins of most retroviruses assemble an immature capsid on the cytoplasmic side of the plasma membrane during the budding pr...

journal_title：Journal of virology

authors： Parker SD,Hunter E

更新日期：2000-01-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) infected cell protein 0 (ICP0) is a 110-kDa nuclear phosphoprotein that is required for both the efficient initiation of lytic infection and the reactivation of quiescent viral genomes from latency. The ability of ICP0 to act as a potent viral transactivator is mediated by its N-ter...

journal_title：Journal of virology

authors： Boutell C,Everett R,Hilliard J,Schaffer P,Orr A,Davido D

更新日期：2008-11-01 00:00:00

abstract：:We have previously shown that alpha/beta interferon (IFN-alpha/beta) and IFN-gamma inhibit hepatitis B virus (HBV) replication noncytopathically in the livers of HBV transgenic mice and in hepatocyte cell lines derived from these mice. The present study was designed to identify transcriptionally controlled hepatocellu...

journal_title：Journal of virology

authors： Wieland SF,Vega RG,Müller R,Evans CF,Hilbush B,Guidotti LG,Sutcliffe JG,Schultz PG,Chisari FV

更新日期：2003-01-01 00:00:00

abstract：:The herpes simplex virus glycoprotein designated VP7(B2) is extracted from virions by nonionic detergent in the form of an oligomer, whereas the other detergent-soluble envelope proteins appear to be extracted as monomers. The subunits of the VP7(B2) oligomer cannot be dissociated by 2-mercaptoethanol and are also res...

journal_title：Journal of virology

authors： Sarmiento M,Spear PG

更新日期：1979-03-01 00:00:00

abstract：:We used reovirus reassortant genetics and severe combined immunodeficient (SCID) mice to define viral genes important for organ tropism and virulence in the absence of antigen-specific immunity. Adult SCID mice infected with reovirus serotype 1 strain Lang (T1L) died after 20 +/- 6 days, while infection with serotype ...

journal_title：Journal of virology

authors： Haller BL,Barkon ML,Vogler GP,Virgin HW 4th

更新日期：1995-01-01 00:00:00

abstract：:Previous analyses using in situ hybridization alone or together with PCR have yielded conflicting results regarding the cell type in which latent varicella-zoster virus (VZV) resides. We separated human trigeminal ganglia (TG) into neuronal and nonneuronal fractions, followed by primary and nested PCR to quantitate VZ...

journal_title：Journal of virology

authors： LaGuardia JJ,Cohrs RJ,Gilden DH

更新日期：1999-10-01 00:00:00

abstract：:Proteolytic processing of the Rous sarcoma virus (RSV) Gag precursor was altered in vivo through the introduction of amino acid substitutions into either the polyprotein cleavage junctions or the PR coding sequence. Single amino acid substitutions (V(P2)S and P(P4)G), which are predicted from in vitro peptide substrat...

journal_title：Journal of virology

authors： Xiang Y,Ridky TW,Krishna NK,Leis J

更新日期：1997-03-01 00:00:00

abstract：:The neuraminidase inhibitors zanamivir and oseltamivir are marketed for the treatment and prophylaxis of influenza and have been stockpiled by many countries for use in a pandemic. Although recent surveillance has identified a striking increase in the frequency of oseltamivir-resistant seasonal influenza A (H1N1) viru...

journal_title：Journal of virology

authors： Hurt AC,Holien JK,Parker M,Kelso A,Barr IG

更新日期：2009-10-01 00:00:00

abstract：:Although combination therapy allows the suppression of human immunodeficiency virus type 1 (HIV-1) viremia to undetectable levels, eradication has not been achieved because the virus persists in cellular reservoirs, particularly the latent reservoir in resting CD4(+) T lymphocytes. We previously established a simian i...

journal_title：Journal of virology

authors： Shen A,Yang HC,Zhou Y,Chase AJ,Boyer JD,Zhang H,Margolick JB,Zink MC,Clements JE,Siliciano RF

更新日期：2007-02-01 00:00:00