Protection of chimpanzees from type B hepatitis by immunization with woodchuck hepatitis virus surface antigen.

abstract：:In some type C retroviruses, translation of the pol gene appears to require translational suppression of the proximal gag amber codon. To identify the region of the viral nucleic acid responsible for synthesis of the pol gene products, a 300-base-pair DNA fragment containing the stop codon from a type C murine virus (...

journal_title：Journal of virology

authors： Panganiban AT

更新日期：1988-10-01 00:00:00

abstract：:Inoculation of 3-day-old (3D) or 3-week-old (3W) ducklings with duck hepatitis B virus results in chronic or transient infection, respectively. We previously showed that rapid production of neutralizing antibody following inoculation of 3W ducklings prevents virus from spreading in the liver and leads to a transient i...

journal_title：Journal of virology

authors： Zhang YY,Theele DP,Summers J

更新日期：2005-08-01 00:00:00

abstract：:Nonstructural protein 5B (NS5B) of hepatitis C virus (HCV) possesses an RNA-dependent RNA polymerase activity responsible for viral genome RNA replication. Despite several reports on the characterization of this essential viral enzyme, little is known about the reaction pathway of NS5B-catalyzed nucleotide incorporati...

journal_title：Journal of virology

authors： Zhong W,Ferrari E,Lesburg CA,Maag D,Ghosh SK,Cameron CE,Lau JY,Hong Z

更新日期：2000-10-01 00:00:00

abstract：:Epstein-Barr virus (EBV)-specific T-cell lines generated by repeated stimulation with EBV-immortalized lymphoblastoid B-cell lines (LCL) have been successfully used to treat EBV-associated posttransplant lymphoproliferative disease (PTLD) in hematopoietic stem cell transplant recipients. However, PTLD in solid-organ t...

journal_title：Journal of virology

authors： Adhikary D,Behrends U,Feederle R,Delecluse HJ,Mautner J

更新日期：2008-04-01 00:00:00

abstract：:Since the number of human cases of infection with avian H5N1 influenza viruses is ever increasing, a pandemic outbreak caused by these viruses is feared. Therefore, in addition to virus-specific antibodies, there is considerable interest in immune correlates of protection against these viruses, which could be a target...

journal_title：Journal of virology

authors： Kreijtz JH,de Mutsert G,van Baalen CA,Fouchier RA,Osterhaus AD,Rimmelzwaan GF

更新日期：2008-06-01 00:00:00

abstract：:Homozygous human immunodeficiency virus type 1 (HIV-1)-transgenic mice (Tg26) appear normal at birth but die within 3 to 4 weeks. The skin of these animals shows diffuse scaling and high-level expression of both HIV-1 mRNA and gp120. Previous experiments showed that treatment with human chorionic gonadatropin (hCG) pr...

journal_title：Journal of virology

authors： De SK,Devadas K,Notkins AL

更新日期：2002-11-01 00:00:00

abstract：:Evidence is presented that the herpes simplex virus type 2 glycoprotein previously designated gF is antigenically related to herpes simplex virus type 1 gC (gC-1). An antiserum prepared against type 1 virion envelope proteins immunoprecipitated gF of type 2 (gF-2), and competition experiments revealed that the anti-gC...

journal_title：Journal of virology

authors： Zezulak KM,Spear PG

更新日期：1983-09-01 00:00:00

abstract：:Inhibition of histone deacetylase (HDAC) activity induces growth arrest, differentiation, and, in certain cell types, apoptosis. FR901228, FK228, or depsipeptide, is an HDAC inhibitor effective in T-cell lymphomas. Adult T-cell leukemia (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1) and remains incurab...

journal_title：Journal of virology

authors： Mori N,Matsuda T,Tadano M,Kinjo T,Yamada Y,Tsukasaki K,Ikeda S,Yamasaki Y,Tanaka Y,Ohta T,Iwamasa T,Tomonaga M,Yamamoto N

更新日期：2004-05-01 00:00:00

abstract：:The development of resistance to host defense mechanisms such as tumor necrosis factor (TNF)- and Fas-mediated apoptosis of transformed or virus-infected cells may be a critical component in the development of disease. To find genes that protect cells from apoptosis, we used an expression cloning strategy and identifi...

journal_title：Journal of virology

authors： Foghsgaard L,Jäättelä M

更新日期：1997-10-01 00:00:00

abstract：:Transgenic (Tg) mice expressing full-length bovine prion protein (BoPrP) serially propagate bovine spongiform encephalopathy (BSE) prions without posing a transmission barrier. These mice also posed no transmission barrier for Suffolk sheep scrapie prions, suggesting that cattle may be highly susceptible to some sheep...

journal_title：Journal of virology

authors： Scott MR,Peretz D,Nguyen HO,Dearmond SJ,Prusiner SB

更新日期：2005-05-01 00:00:00

abstract：:We have previously demonstrated that open reading frame (ORF) 50 and ORF 57 encode transcriptional regulating genes in herpesvirus saimiri. ORF 50, a homolog of Epstein-Barr virus R protein, is a sequence-specific transactivator, whereas ORF 57 acts posttranscriptionally. In this report, we demonstrate that the ORF 57...

journal_title：Journal of virology

authors： Whitehouse A,Cooper M,Hall KT,Meredith DM

更新日期：1998-03-01 00:00:00

abstract：:We describe respiratory syncytial virus (RSV)-specific cytotoxic T-cell (CTL) lines and clones developed from the spleens of C57BL/6 and BALB/c mice. Line 7 and clones derived from it were H-2Kb restricted, whereas line 12 had both Kb and Db components. Both lines, and all the clones except one, could lyse targets inf...

journal_title：Journal of virology

authors： Muñoz JL,McCarthy CA,Clark ME,Hall CB

更新日期：1991-08-01 00:00:00

abstract：:T-antigen-induced DNA distortion was studied in a series of simian virus 40 (SV40) plasmid constructs whose relative replication efficiency ranges from 0.2 to 36. Bending was detected in the wild-type SV40 regulatory region consisting of three copies of the GC-rich 21-bp repeat but not in constructs with only one or t...

journal_title：Journal of virology

authors： Okuley S,Call M,Mitchell T,Hu B,Woodworth ME

更新日期：2003-10-01 00:00:00

abstract：:This paper reports the use of zonal ultracentrifuge techniques to conduct biophysical studies of rhinoviruses grown with WI-38 cells. Good clean-out of infectivity from rhinovirus harvests was obtained with the continuous-flow B-V and B-IX rotors. Use of the B-V rotor resulted in the successful concentration of rhinov...

journal_title：Journal of virology

authors： Gerin JL,Richter WR,Fenters JD,Holper JC

更新日期：1968-09-01 00:00:00

abstract：:Assembly of hepatitis delta virus (HDV) in infected human hepatocytes involves association of the 1,679- nucleotide single-stranded genomic RNA (deltaRNA) with multiple copies of both small and large forms of the delta protein (deltaAg) to form a ribonucleoprotein particle which in turn interacts with envelope protein...

journal_title：Journal of virology

authors： Gudima S,Chang J,Moraleda G,Azvolinsky A,Taylor J

更新日期：2002-04-01 00:00:00

abstract：:The region of the UL component of the herpes simplex virus type 1 genome between nucleotides 17,793 and 25,150 includes three open reading frames that code for the protein products of the UL8, UL9, and UL10 genes (D.J. McGeogh, M.A. Dalrymple, A.J. Davison, A. Dolan, M.C. Frame, D. McNab, L.J. Perry, J.E. Scott, and P...

journal_title：Journal of virology

authors： Baradaran K,Dabrowski CE,Schaffer PA

更新日期：1994-07-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) requires that its genome be reverse transcribed into double-stranded DNA for productive infection of cells. This process requires not only reverse transcriptase but also the nucleocapsid protein (NC), which functions as a nucleic acid chaperone. Reverse transcription general...

journal_title：Journal of virology

authors： Thomas JA,Bosche WJ,Shatzer TL,Johnson DG,Gorelick RJ

更新日期：2008-10-01 00:00:00

abstract：UNLABELLED:Broadly neutralizing antibodies (bNAbs) specific for conserved epitopes on the HIV-1 envelope (Env) are believed to be essential for protection against multiple HIV-1 clades. However, vaccines capable of stimulating the production of bNAbs remain a major challenge. Given that polyreactivity and autoreactivit...

journal_title：Journal of virology

authors： Gupta S,Clark ES,Termini JM,Boucher J,Kanagavelu S,LeBranche CC,Abraham S,Montefiori DC,Khan WN,Stone GW

更新日期：2015-04-01 00:00:00

abstract：:Biological and genetic variability is a prominent feature of human immunodeficiency virus (HIV) strains, especially in tropism, syncytium formation, and replicative capacity. To determine whether there were variable host cell effects on HIV replication in monocytes, three different strains of low-passage-number monocy...

journal_title：Journal of virology

authors： Chang J,Naif HM,Li S,Sullivan JS,Randle CM,Cunningham AL

更新日期：1996-11-01 00:00:00

abstract：:In eukaryotic cells, cell growth and division occur in a stepwise, orderly fashion described by a process known as the cell cycle. The relationship between positive-strand RNA viruses and the cell cycle and the concomitant effects on virus replication are not clearly understood. We have shown that infection of asynchr...

journal_title：Journal of virology

authors： Dove B,Brooks G,Bicknell K,Wurm T,Hiscox JA

更新日期：2006-04-01 00:00:00

abstract：:PLC/PRF/5, a tissue culture cell line isolated from a human hepatocellular carcinoma and producing hepatitis B surface antigen, was studied for the presence of hepatitis B virus (HBV)-specific DNA and RNA. PLC/PRF/5 cell DNA accelerated the rate of reassociation of HBV [32P]DNA, and quantitative experiments indicated ...

journal_title：Journal of virology

authors： Marion PL,Salazar FH,Alexander JJ,Robinson WS

更新日期：1980-02-01 00:00:00

abstract：:In the influenza H5N1 virus incident in Hong Kong in 1997, viruses that are closely related to H5N1 viruses initially isolated in a severe outbreak of avian influenza in chickens were isolated from humans, signaling the possibility of an incipient pandemic. However, it was not possible to prepare a vaccine against the...

journal_title：Journal of virology

authors： Takada A,Kuboki N,Okazaki K,Ninomiya A,Tanaka H,Ozaki H,Itamura S,Nishimura H,Enami M,Tashiro M,Shortridge KF,Kida H

更新日期：1999-10-01 00:00:00

abstract：:Since its detection in swine, influenza D virus (IDV) has been shown to be present in multiple animal hosts, and bovines have been identified as its natural reservoir. However, it remains unclear how IDVs emerge, evolve, spread, and maintain in bovine populations. Through multiple years of virological and serological ...

journal_title：Journal of virology

authors： Wan XF,Ferguson L,Oliva J,Rubrum A,Eckard L,Zhang X,Woolums AR,Lion A,Meyer G,Murakami S,Ma W,Horimoto T,Webby R,Ducatez MF,Epperson W

更新日期：2020-08-31 00:00:00

abstract：:The spindles of Anomala cuprea entomopoxvirus (AncuEPV), which are composed of glycoprotein fusolin, are known to enhance the peroral infectivity of AncuEPV itself and of nucleopolyhedroviruses. This has been demonstrated to involve the disruption of intestinal peritrophic membrane (PM), composed of chitin matrix, gly...

journal_title：Journal of virology

authors： Takemoto Y,Mitsuhashi W,Murakami R,Konishi H,Miyamoto K

更新日期：2008-12-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma and is associated with a variety of immunoregulatory disorders. HTLV-1 has been shown to bind to and infect a variety of hematopoietic and nonhematopoietic cells. However, both in vivo and in vitro, the provirus is mos...

journal_title：Journal of virology

authors： Newbound GC,Andrews JM,O'Rourke JP,Brady JN,Lairmore MD

更新日期：1996-04-01 00:00:00

abstract：:The cytotoxic T-lymphocyte (CTL) response to lymphocytic choriomeningitis virus infection determines the outcome of infection. Here we show that this response in BALB/c mice (H-2d), when analyzed both at the primary CTL level and using CTL clones, is predominantly monospecific. The vast majority of CTL have a common s...

journal_title：Journal of virology

authors： Whitton JL,Tishon A,Lewicki H,Gebhard J,Cook T,Salvato M,Joly E,Oldstone MB

更新日期：1989-10-01 00:00:00

abstract：:Gammaherpesviruses are important human and animal pathogens. Infection control has proven difficult because the key process of transmission is ill understood. Murid herpesvirus 4 (MuHV-4), a gammaherpesvirus of mice, is transmitted sexually. We show that this depends on the major virion envelope glycoprotein gp150. gp...

journal_title：Journal of virology

authors： Zeippen C,Javaux J,Xiao X,Ledecq M,Mast J,Farnir F,Vanderplasschen A,Stevenson P,Gillet L

更新日期：2017-06-09 00:00:00

abstract：:A number of avocado (Persea americana) cultivars are known to contain high-molecular-weight double-stranded RNA (dsRNA) molecules for which a viral nature has been suggested, although sequence data are not available. Here we report the cloning and complete sequencing of a 13.5-kbp dsRNA virus isolated from avocado and...

journal_title：Journal of virology

authors： Villanueva F,Sabanadzovic S,Valverde RA,Navas-Castillo J

更新日期：2012-01-01 00:00:00

abstract：:Type I interferon (IFN-I) inhibits the replication of different viruses. However, the effect of IFN-I on the human T-lymphotropic virus type 1 (HTLV-1) viral cycle is controversial. Here, we investigated the consequences of IFN-α addition for different steps of HTLV-1 and HTLV-2 infection. We first show that alpha int...

journal_title：Journal of virology

authors： Cachat A,Chevalier SA,Alais S,Ko NL,Ratner L,Journo C,Dutartre H,Mahieux R

更新日期：2013-12-01 00:00:00

abstract：:PEPSCAN analysis has been used to characterize the immunogenic regions of the capsid protein (CP) in virions of plum pox potyvirus (PPV). In addition to the well-known highly immunogenic N- and C-terminal domains of CP, regions within the core domain of the protein have also shown high immunogenicity. Moreover, the N ...

journal_title：Journal of virology

authors： Fernández-Fernández MR,Martínez-Torrecuadrada JL,Roncal F,Domínguez E,García JA

更新日期：2002-12-01 00:00:00