Adaptation of pandemic H2N2 influenza A viruses in humans.

abstract：:The human immunodeficiency virus type 1 (HIV-1) Tat protein is essential for viral replication and stimulates transcription of the integrated provirus by recruiting the kinase complex TAK/P-TEFb, composed of cyclin T1 (CycT1) and Cdk9, to the viral TAR RNA element. TAK/P-TEFb phosphorylates the RNA polymerase II compl...

journal_title：Journal of virology

authors： Liou LY,Herrmann CH,Rice AP

更新日期：2002-11-01 00:00:00

abstract：UNLABELLED:Aspects of intrinsic antiviral immunity are mediated by promyelocytic leukemia nuclear body (PML-NB) constituent proteins. During herpesvirus infection, these antiviral proteins are independently recruited to nuclear domains that contain infecting viral genomes to cooperatively promote viral genome silencing...

journal_title：Journal of virology

authors： Brown JR,Conn KL,Wasson P,Charman M,Tong L,Grant K,McFarlane S,Boutell C

更新日期：2016-06-10 00:00:00

abstract：:Recent studies of varicella-zoster virus (VZV) DNA sequence variation, involving large numbers of globally distributed clinical isolates, suggest that this virus has diverged into at least three distinct genotypes designated European (E), Japanese (J), and mosaic (M). In the present study, we determined and analyzed t...

journal_title：Journal of virology

authors： Norberg P,Liljeqvist JA,Bergström T,Sammons S,Schmid DS,Loparev VN

更新日期：2006-10-01 00:00:00

abstract：:Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus termed SARS-CoV. We and others have previously shown that the replication of SARS-CoV can be suppressed by exogenously added interferon (IFN), a cytokine which is normally synthesized by cells as a reaction to virus infection. Here, we demonstra...

journal_title：Journal of virology

authors： Spiegel M,Pichlmair A,Martínez-Sobrido L,Cros J,García-Sastre A,Haller O,Weber F

更新日期：2005-02-01 00:00:00

abstract：:BCX 2798 (4-azido-5-isobutyrylamino-2,3-didehydro-2,3,4,5-tetradeoxy-d-glycero-d-galacto-2-nonulopyranosic acid) effectively inhibited the activities of the hemagglutinin-neuraminidase (HN) of human parainfluenza viruses (hPIV) in vitro and protected mice from lethal infection with a recombinant Sendai virus whose HN ...

journal_title：Journal of virology

authors： Alymova IV,Taylor G,Mishin VP,Watanabe M,Murti KG,Boyd K,Chand P,Babu YS,Portner A

更新日期：2008-09-01 00:00:00

abstract：:LA3382 is a temperature-sensitive replication-defective mutant of Rous sarcoma virus that contains four active mutations. In this study we performed experiments to determine the biochemical defect that blocks the synthesis of infections virus late in the replication cycle. At the nonpermissive temperature (41 degrees ...

journal_title：Journal of virology

authors： Hardwick JM,Hunter E

更新日期：1981-12-01 00:00:00

abstract：:Vesicular stomatitis virus (VSV) is a negative-strand RNA virus with intrinsic oncolytic specificity due to substantially attenuated antiviral responses in many tumors. We have recently reported that recombinant VSV vector can be used as an effective oncolytic agent to safely treat multifocal hepatocellular carcinoma ...

journal_title：Journal of virology

authors： Shinozaki K,Ebert O,Suriawinata A,Thung SN,Woo SL

更新日期：2005-11-01 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) and HSV-2 are large, double-stranded DNA viruses that cause lifelong persistent infections characterized by periods of quiescence and recurrent disease. How HSV evolves within an infected individual experiencing multiple episodes of recurrent disease over time is not known. We determined...

journal_title：Journal of virology

authors： Minaya MA,Jensen TL,Goll JB,Korom M,Datla SH,Belshe RB,Morrison LA

更新日期：2017-11-14 00:00:00

abstract：:For viruses with segmented genomes, genetic diversity is generated by genetic drift, reassortment, and recombination. Recombination produces RNA populations distinct from full-length gene segments and can influence viral population dynamics, persistence, and host immune responses. Viruses in the Reoviridae family, inc...

journal_title：Journal of virology

authors： Smith SC,Gribble J,Diller JR,Wiebe MA,Thoner TW Jr,Denison MR,Ogden KM

更新日期：2021-01-20 00:00:00

abstract：:Herpesvirus saimiri (HVS) is a T-cell-specific transforming and oncogenic virus. A protein encoded by HVS known as Tip-484 (for tyrosine kinase interacting protein from HVS strain 484) is required for this transformation. Tip-484 binds specifically to the nonreceptor protein tyrosine kinase p56lck. By transfecting Tip...

journal_title：Journal of virology

authors： Lund T,Medveczky MM,Medveczky PG

更新日期：1997-01-01 00:00:00

abstract：:Human noroviruses are the most common nonbacterial cause of gastroenteritis outbreaks, with new variants and genotypes frequently emerging. The origin of these new viruses is unknown; however, animals have been proposed as a potential source, as human noroviruses have been detected in animal species. Here, we investig...

journal_title：Journal of virology

authors： Villabruna N,Schapendonk CME,Aron GI,Koopmans MPG,de Graaf M

更新日期：2021-01-13 00:00:00

abstract：:The addition of 25 mug of protamine sulfate per ml to lysozyme-ethylenediamine-tetraacetic acid spheroplasts of Escherichia coli stimulates transfection not only for T1 phage deoxyribonucleic acid (DNA; Hotz and Mauser, 1969) but also for the following phage DNA species: lambda, 10,000-fold to an efficiency of 10(-3) ...

journal_title：Journal of virology

authors： Benzinger R,Kleber I,Huskey R

更新日期：1971-05-01 00:00:00

abstract：:We have developed a high-throughput sequencing (HTS) workflow for investigating paramyxovirus transcription and replication. We show that sequencing of oligo(dT)-selected polyadenylated mRNAs, without considering the orientation of the RNAs from which they had been generated, cannot accurately be used to analyze the a...

journal_title：Journal of virology

authors： Wignall-Fleming EB,Hughes DJ,Vattipally S,Modha S,Goodbourn S,Davison AJ,Randall RE

更新日期：2019-08-13 00:00:00

abstract：:A promoter-trap retrovirus has been constructed in which a promoterless polyomavirus middle T antigen gene was inserted in the U3 region of the long terminal repeat of a replication-competent Moloney murine leukemia virus. The resulting virus, designated PyT, was used to infect mouse mammary glands in situ. As expecte...

journal_title：Journal of virology

authors： Coulombe J,Avis Y,Gray DA

更新日期：1996-10-01 00:00:00

abstract：:The major DNA-binding protein encoded by several temperature-sensitive mutants of herpes simplex virus type 1 was thermolabile for binding to intracellular viral DNA. The ability of DNase I to release this protein from isolated nuclei was used as a measure of the amount of protein bound to viral DNA. This assay was ba...

journal_title：Journal of virology

authors： Lee CK,Knipe DM

更新日期：1983-06-01 00:00:00

abstract：:Differential effect of various metabolic inhibitors on the development of hemadsorption activity and virus formation in cells infected with Newcastle disease virus (NDV) was investigated. It was found that, in BHK-21 cells infected with NDV, cycloheximide did not prevent the development of hemadsorption activity, wher...

journal_title：Journal of virology

authors： Nagai Y

更新日期：1973-04-01 00:00:00

abstract：:Naked DNA vaccines expressing the prM and E genes of two tick-borne flaviviruses, Russian spring summer encephalitis (RSSE) virus and Central European encephalitis (CEE) virus were evaluated in mice. The vaccines were administered by particle bombardment of DNA-coated gold beads by Accell gene gun inoculation. Two imm...

journal_title：Journal of virology

authors： Schmaljohn C,Vanderzanden L,Bray M,Custer D,Meyer B,Li D,Rossi C,Fuller D,Fuller J,Haynes J,Huggins J

更新日期：1997-12-01 00:00:00

abstract：:The U(S)3 open reading frame of herpes simplex virus 1 (HSV-1) was reported to encode two mRNAs each directing the synthesis of the same protein. We report that the U(S)3 gene encodes two proteins. The predominant U(S)3 protein is made in wild-type HSV-1-infected cells. The truncated mRNA and a truncated protein desig...

journal_title：Journal of virology

authors： Poon AP,Roizman B

更新日期：2005-07-01 00:00:00

abstract：:P-element-induced wimpy-like (Piwil) proteins restrict the replication of mobile genetic elements in the germ line. They are also expressed in many transformed cell lines. In this study, we discovered that the human Piwil 2 (Hili) protein can also inhibit HIV replication, especially in activated CD4+ T cells that are ...

journal_title：Journal of virology

authors： Peterlin BM,Liu P,Wang X,Cary D,Shao W,Leoz M,Hong T,Pan T,Fujinaga K

更新日期：2017-05-12 00:00:00

abstract：:Hpt-13 is a Chinese hamster cell line deficient in hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) and sensitive to a medium containing 10(-4) M hypoxanthine, 5.5 X 10(-6) M aminopterin, and 10(-4) M thymidine. In this cell line there is a high incidence of cells resistant to this selective medium after an incubat...

journal_title：Journal of virology

authors： Marengo C,Mbikay M,Weber J,Thirion JP

更新日期：1981-04-01 00:00:00

abstract：:The early proteins of simian virus 40 (SV40) large T and small t antigen (T/t antigen) can each cause the transcriptional activation of a variety of cellular and viral promoters. We showed previously that simian cellular DNA-binding factors (the Band A factors) bind to sequences within the SV40 late promoter which are...

journal_title：Journal of virology

authors： Gallo GJ,Gruda MC,Manuppello JR,Alwine JC

更新日期：1990-01-01 00:00:00

abstract：:Regulatory T (T(R)) cells maintain tolerance to self-antigens and control immune responses to alloantigens after organ transplantation. Here, we show that CD4(+) CD25(+) human T(R) cells suppress virus-specific T-cell responses. Depletion of T(R) cells from peripheral blood mononuclear cells enhances T-cell responses ...

journal_title：Journal of virology

authors： Aandahl EM,Michaëlsson J,Moretto WJ,Hecht FM,Nixon DF

更新日期：2004-03-01 00:00:00

abstract：:The adenovirus major late promoter (MLP) is active during both the early and late phases of infection. During the early phase the activity of the MLP is similar to those of the other early viral promoters, but during the late phase the rate of transcription from the MLP becomes much greater by comparison. We report he...

journal_title：Journal of virology

authors： Leong K,Lee W,Berk AJ

更新日期：1990-01-01 00:00:00

abstract：:Infection of quiescent cells by human cytomegalovirus (HCMV) elicits severe cell cycle deregulation, resulting in a G(1)/S arrest, which can be partly attributed to the inactivation of the anaphase-promoting complex (APC). As we previously reported, the premature phosphorylation of its coactivator Cdh1 and/or the diss...

journal_title：Journal of virology

authors： Tran K,Kamil JP,Coen DM,Spector DH

更新日期：2010-10-01 00:00:00

abstract：:Infection of mice with Moloney murine leukemia virus (M-MuLV) as well as with a nonpathogenic variant, Mo+PyF101 M-MuLV, was studied. Mo+PyF101 M-MuLV differs from wild-type M-MuLV by the addition of enhancer sequences from polyomavirus in the long terminal repeat. Previous experiments indicated that Mo+PyF101 establi...

journal_title：Journal of virology

authors： Davis BR,Chandy KG,Brightman BK,Gupta S,Fan H

更新日期：1986-11-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) integrase protein (IN) catalyzes two reactions required to integrate HIV DNA into the human genome: 3' processing of the viral DNA ends and integration. IN has three domains, the N-terminal zinc-binding domain, the catalytic core, and the C-terminal SH3 domain. Previously, it was...

journal_title：Journal of virology

authors： van den Ent FM,Vos A,Plasterk RH

更新日期：1999-04-01 00:00:00

abstract：:Vaccinia extracellular enveloped virus (EEV) is critical for cell-to-cell and long-range virus spread both in vitro and in vivo. The B5R gene encodes an EEV-specific type I membrane protein that is essential for efficient EEV formation. The majority of the B5R ectodomain consists of four domains with homology to short...

journal_title：Journal of virology

authors： Aldaz-Carroll L,Whitbeck JC,Ponce de Leon M,Lou H,Hirao L,Isaacs SN,Moss B,Eisenberg RJ,Cohen GH

更新日期：2005-05-01 00:00:00

abstract：:Barley stripe mosaic virus (BSMV) encodes three movement proteins in an overlapping triple gene block (TGB), but little is known about the physical interactions of these proteins. We have characterized a ribonucleoprotein (RNP) complex consisting of the TGB1 protein and plus-sense BSMV RNAs from infected barley plants...

journal_title：Journal of virology

authors： Lim HS,Bragg JN,Ganesan U,Lawrence DM,Yu J,Isogai M,Hammond J,Jackson AO

更新日期：2008-05-01 00:00:00

abstract：:Foamy viruses (FVs) are the least known retroviruses commonly found in primates, cats, horses, and cattle. Although FVs are considered apathogenic, simian and feline FVs have been shown to be associated with some transient health abnormalities in animal models. Currently, data regarding the course of infection with bo...

journal_title：Journal of virology

authors： Materniak M,Hechler T,Löchelt M,Kuzmak J

更新日期：2013-03-01 00:00:00

abstract：:Synthesis of viral ribonucleic acid (RNA) polymerase, maturation protein, and coat protein in Escherichia coli infected with bacteriophage R17 occurs mainly on polysomes containing four or more ribosomes. The 30S ribosomal subunits through trimer-size polysomes, which are associated with all of the R17-specific protei...

journal_title：Journal of virology

authors： Truden JL,Franklin RM

更新日期：1972-01-01 00:00:00