Prophylactic alpha interferon treatment increases the therapeutic index of oncolytic vesicular stomatitis virus virotherapy for advanced hepatocellular carcinoma in immune-competent rats.

abstract：:The ability of the 3A protein of coxsackievirus B (CVB) to inhibit protein secretion was investigated for this study. Here we show that the ectopic expression of CVB 3A blocked the transport of both the glycoprotein of vesicular stomatitis virus, a membrane-bound secretory marker, and the alpha-1 protease inhibitor, a...

journal_title：Journal of virology

authors： Wessels E,Duijsings D,Notebaart RA,Melchers WJ,van Kuppeveld FJ

更新日期：2005-04-01 00:00:00

abstract：:The physical map locations of 62 temperature-sensitive mutations of vaccinia virus WR have been determined by marker rescue experiments, using cloned HindIII fragments of wild-type DNA. Since vaccinia virus DNA is not infectious, marker rescue was performed by infecting monolayers of cells at the nonpermissive tempera...

journal_title：Journal of virology

authors： Ensinger MJ,Rovinsky M

更新日期：1983-11-01 00:00:00

abstract：:Adenovirus (Ad) gene transfer vectors can be used to transfer and express antigens and function as strong adjuvants and thus are useful platforms for the development of genetic vaccines. Based on the hypothesis that Ad vectors with enhanced infectibility of dendritic cells (DC) may be able to evoke enhanced immune res...

journal_title：Journal of virology

authors： Worgall S,Busch A,Rivara M,Bonnyay D,Leopold PL,Merritt R,Hackett NR,Rovelink PW,Bruder JT,Wickham TJ,Kovesdi I,Crystal RG

更新日期：2004-03-01 00:00:00

abstract：:H.-H. Lu and E. Wimmer (Proc. Natl. Acad. Sci. USA 93:1412-1417, 1996) have demonstrated that the internal ribosomal entry site (IRES) of poliovirus (PV) can be functionally replaced by the related genetic element from hepatitis C virus (HCV). One important finding of this study was that open reading frame sequences 3...

journal_title：Journal of virology

authors： Zhao WD,Wimmer E,Lahser FC

更新日期：1999-02-01 00:00:00

abstract：:A fresh inoculum of human adenovirus type 12 (Ad12) was obtained from the American Type Culture Collection and passaged once on human embryonic kidney cells, and Ad12 DNA was prepared from the first-passage yield to avoid higher passages which might have generated host-virus DNA recombinants. The 18 PstI fragments of ...

journal_title：Journal of virology

authors： Sprengel J,Schmitz B,Heuss-Neitzel D,Zock C,Doerfler W

更新日期：1994-01-01 00:00:00

abstract：:Rotavirus nonstructural protein 4 (NSP4) induces dramatic changes in cellular calcium homeostasis. These include increased endoplasmic reticulum (ER) permeability, resulting in decreased ER calcium stores and activation of plasma membrane (PM) calcium influx channels, ultimately causing a 2- to 4-fold elevation in cyt...

journal_title：Journal of virology

authors： Hyser JM,Utama B,Crawford SE,Broughman JR,Estes MK

更新日期：2013-12-01 00:00:00

abstract：:The in vitro transcription of the genome segments of insect cytoplasmic polyhedrosis virus was examined for a possible mechanism of coordinate control. Initiation of the first transcription cycle, primed by preincubation in the absence of CTP, was synchronous for all 10 viral genome segments. The time required for the...

journal_title：Journal of virology

authors： Smith RE,Furuichi Y

更新日期：1982-01-01 00:00:00

abstract：:Actively replicating endogenous retroviruses entered the human genome millions of years ago and became a stable part of the inherited genetic material. They subsequently acquired multiple mutations, leading to the assumption that these viruses no longer replicate. However, certain human tumor cell lines have been show...

journal_title：Journal of virology

authors： Contreras-Galindo R,Kaplan MH,Leissner P,Verjat T,Ferlenghi I,Bagnoli F,Giusti F,Dosik MH,Hayes DF,Gitlin SD,Markovitz DM

更新日期：2008-10-01 00:00:00

abstract：:As potential targets for human immunodeficiency virus type 1 and simian immunodeficiency virus (HIV-1 and SIV), dendritic cells (DCs) likely play a significant role in the onset and spread of infection as well as in the induction of antiviral immunity. Using the SIV-macaque system to study the very early events in DC-...

journal_title：Journal of virology

authors： Frank I,Piatak M Jr,Stoessel H,Romani N,Bonnyay D,Lifson JD,Pope M

更新日期：2002-03-01 00:00:00

abstract：:Two chimpanzees immunized with woodchuck hepatitis virus (WHV) surface antigen (WHsAg) developed antibodies cross-reactive with hepatitis B virus (HBV) surface antigen (HBsAg). After challenge with HBV, one animal was completely protected and the other experienced a subclinical infection, without evidence of liver dis...

journal_title：Journal of virology

authors： Cote PJ,Shapiro M,Engle RE,Popper H,Purcell RH,Gerin JL

更新日期：1986-12-01 00:00:00

abstract：:We identified the transcriptional coactivator FHL2 as a novel target of the human papillomavirus type 16 (HPV-16) E7 oncoprotein, which plays a major role in cell transformation. The interaction with FHL2 is abolished by mutations in conserved regions 1 and 2 and in the C-terminal zinc finger domain of E7, all require...

journal_title：Journal of virology

authors： Campo-Fernández B,Morandell D,Santer FR,Zwerschke W,Jansen-Dürr P

更新日期：2007-01-01 00:00:00

abstract：:Murine cytomegalovirus propagated in mouse embryo fibroblasts was purified by the following procedures. (i) Extracellular virus was concentrated by centrifugation at 100,000 x g for 90 min. (ii) The concentrated virus was passed through a Bio-Rad Bio-Gel A-15m column to eliminate contaminating materials smaller than 1...

journal_title：Journal of virology

authors： Kim KS,Sapienza VJ,Carp RI,Moon HM

更新日期：1976-03-01 00:00:00

abstract：:RNA silencing is a conserved eukaryotic gene regulatory system in which sequence specificity is determined by small RNAs. Plant RNA silencing also acts as an antiviral mechanism; therefore, viral infection requires expression of a silencing suppressor. The mechanism and the evolution of silencing suppression are still...

journal_title：Journal of virology

authors： Mérai Z,Kerényi Z,Molnár A,Barta E,Válóczi A,Bisztray G,Havelda Z,Burgyán J,Silhavy D

更新日期：2005-06-01 00:00:00

abstract：:Purified preparations of human adenovirus type 12 showed two bands when subjected to isopycnic centrifugation in a density gradient of cesium chloride. Their density difference was about 0.003 g/ml, suggesting a small difference in their deoxyribonucleic acid to protein ratio. Virions with a lighter density can kill h...

journal_title：Journal of virology

authors： Mak S

更新日期：1971-04-01 00:00:00

abstract：:NF-D is a ubiquitous nuclear factor that has been shown to bind specifically to a DNA element in the polyomavirus regulatory region. In this report, we demonstrate that NF-D is either identical or very similar to a transcription factor that has been variously named YY1, delta, NF-E1, UCRBP, or CF1. Moreover, we show t...

journal_title：Journal of virology

authors： Martelli F,Iacobini C,Caruso M,Felsani A

更新日期：1996-03-01 00:00:00

abstract：:Recently, we demonstrated that inverted repeat sequences inserted into first-generation adenovirus (Ad) vector genomes mediate precise genomic rearrangements resulting in vector genomes devoid of all viral genes that are efficiently packaged into functional Ad capsids. As a specific application of this finding, we gen...

journal_title：Journal of virology

authors： Lieber A,Steinwaerder DS,Carlson CA,Kay MA

更新日期：1999-11-01 00:00:00

abstract：:The herpes simplex virus glycoprotein designated VP7(B2) is extracted from virions by nonionic detergent in the form of an oligomer, whereas the other detergent-soluble envelope proteins appear to be extracted as monomers. The subunits of the VP7(B2) oligomer cannot be dissociated by 2-mercaptoethanol and are also res...

journal_title：Journal of virology

authors： Sarmiento M,Spear PG

更新日期：1979-03-01 00:00:00

abstract：:The region of the UL component of the herpes simplex virus type 1 genome between nucleotides 17,793 and 25,150 includes three open reading frames that code for the protein products of the UL8, UL9, and UL10 genes (D.J. McGeogh, M.A. Dalrymple, A.J. Davison, A. Dolan, M.C. Frame, D. McNab, L.J. Perry, J.E. Scott, and P...

journal_title：Journal of virology

authors： Baradaran K,Dabrowski CE,Schaffer PA

更新日期：1994-07-01 00:00:00

abstract：:The major human tRNA(Lys) isoacceptors, and, are selectively packaged into human immunodeficiency virus type 1 (HIV-1) during assembly, where acts as a primer for reverse transcription. Lysyl-tRNA synthetase (LysRS) is also incorporated into HIV-1, independently of tRNA(Lys), via its interaction with Gag, and is a str...

journal_title：Journal of virology

authors： Guo F,Cen S,Niu M,Javanbakht H,Kleiman L

更新日期：2003-09-01 00:00:00

abstract：:The H-DNA repeat unit of Herpesvirus saimiri strain 11 was cloned in plasmid vector pAGO, and the nucleotide sequence was determined by the dideoxy chain termination method. One unit of repetitive DNA has 1,444 base pairs with 70.8% G+C content. The structural features of repeat DNA sequences at the termini of intact ...

journal_title：Journal of virology

authors： Bankier AT,Dietrich W,Baer R,Barrell BG,Colbère-Garapin F,Fleckenstein B,Bodemer W

更新日期：1985-07-01 00:00:00

abstract：:Transgene expression after the administration of recombinant adenovirus with E1 deleted is constantly transient. It is admitted that E1A-substituting activities of cellular or viral origin allow viral antigen synthesis and trigger cytotoxic lymphocyte-mediated clearance of the recipient cells. Our approach to solving ...

journal_title：Journal of virology

authors： Yeh P,Dedieu JF,Orsini C,Vigne E,Denefle P,Perricaudet M

更新日期：1996-01-01 00:00:00

abstract：:A hallmark of infection with herpes simplex virus type 1 (HSV-1) is the establishment of latency in ganglia of the infected individual. During the life of the latently infected individual, the virus can occasionally reactivate, travel back to the eye, and cause recurrent disease. Indeed, a major cause of corneal scarr...

journal_title：Journal of virology

authors： Mott KR,Bresee CJ,Allen SJ,BenMohamed L,Wechsler SL,Ghiasi H

更新日期：2009-03-01 00:00:00

abstract：:Neuraminidase (NA) inhibitors (NAIs) are widely used antiviral drugs for the treatment of humans with influenza virus infections. There have been widespread reports of NAI resistance among seasonal A(H1N1) viruses, and most have been identified in oseltamivir-exposed patients or those treated with other NAIs. Thus, mo...

journal_title：Journal of virology

authors： Lloren KKS,Kwon JJ,Choi WS,Jeong JH,Ahn SJ,Choi YK,Baek YH,Song MS

更新日期：2019-03-05 00:00:00

abstract：:Previous results have indicated that Rous sarcoma virus env gene expression is specifically inhibited by antisense RNA (L.-J. Chang and C. M. Stoltzfus, Mol. Cell. Biol. 5:2341-2348, 1985). In this study, we compare the extents of inhibition by antisense RNA derived from different parts of the Rous sarcoma virus genom...

journal_title：Journal of virology

authors： Chang LJ,Stoltzfus CM

更新日期：1987-03-01 00:00:00

abstract：:It has become evident that naturally occurring CD25(+) regulatory T cells (T(reg) cells) not only influence self-antigen specific immune response but also dampen foreign antigen specific immunity. This report extends our previous findings by demonstrating that immunity to certain herpes simplex virus (HSV) vaccines is...

journal_title：Journal of virology

authors： Toka FN,Suvas S,Rouse BT

更新日期：2004-12-01 00:00:00

abstract：:We sought proof of principle that one of the safest human vaccines, measles virus Edmonston B (MV-Edm), can be genetically modified to allow entry via cell surface molecules other than its receptor CD46. Hybrid proteins consisting of the epidermal growth factor (EGF) or the insulin-like growth factor 1 (IGF1) linked t...

journal_title：Journal of virology

authors： Schneider U,Bullough F,Vongpunsawad S,Russell SJ,Cattaneo R

更新日期：2000-11-01 00:00:00

abstract：:A tumor line (58-2T) was established from a slowly growing tumor in a BALB/c mouse inoculated with M58-2 cells. The latter clonal cell line was isolated after bromodeoxyuridine treatment as a flat variant from nonproducer BALB/3T3 cells transformed by the Kirsten sarcoma virus. The 58-2T cells produced type C virus wi...

journal_title：Journal of virology

authors： Tsuchida N,Shih MS,Gilden RV,Hatanaka M

更新日期：1974-11-01 00:00:00

abstract：:CD8+ T cells were previously shown to be important in preventing lymphoproliferation and immunodeficiency following infection of murine AIDS (MAIDS)-resistant mice with the LP-BM5 mixture of murine leukemia viruses. To further evaluate the mechanisms contributing to MAIDS resistance, we studied mice lacking CD8+ T cel...

journal_title：Journal of virology

authors： Tang Y,Hügin AW,Giese NA,Gabriele L,Chattopadhyay SK,Fredrickson TN,Kägi D,Hartley JW,Morse HC 3rd

更新日期：1997-03-01 00:00:00

abstract：:We have investigated the species-specific replication of polyomavirus DNA in the cell-free system that was established previously (Y. Murakami, T. Eki, M. Yamada, C. Prives, and J. Hurwitz, Proc. Natl. Acad. Sci. USA 83:6347-6351, 1986). Extracts from various species of cells supported polyomavirus DNA replication in ...

journal_title：Journal of virology

authors： Eki T,Enomoto T,Masutani C,Miyajima A,Takada R,Murakami Y,Ohno T,Hanaoka F,Ui M

更新日期：1991-09-01 00:00:00

abstract：UNLABELLED:The ORF45 protein of Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus-specific immediate-early tegument protein. Our previous studies have revealed its crucial roles in both early and late stages of KSHV infection. In this study, we surveyed the interactome of ORF45 using a panel of monoc...

journal_title：Journal of virology

authors： Gillen J,Li W,Liang Q,Avey D,Wu J,Wu F,Myoung J,Zhu F

更新日期：2015-05-01 00:00:00