Recombinant measles viruses efficiently entering cells through targeted receptors.

abstract：:Transcription and replication signals within the negative-sense genomic RNA of vesicular stomatitis virus (VSV) are located at the 3' terminus. To identify these signals, we have used a transcription- and replication-competent minigenome of VSV to generate a series of deletions spanning the first 47 nucleotides at the...

journal_title：Journal of virology

authors： Li T,Pattnaik AK

更新日期：1999-01-01 00:00:00

abstract：:The human cytomegalovirus (HCMV) immediate-early 2 (IE2) transactivator has previously been shown to form intranuclear, dot-like accumulations in association with subnuclear structures known as promyelocytic leukemia protein (PML) nuclear bodies or ND10. We recently observed that IE2 can form dot-like structures even ...

journal_title：Journal of virology

authors： Sourvinos G,Tavalai N,Berndt A,Spandidos DA,Stamminger T

更新日期：2007-09-01 00:00:00

abstract：:The human foamy virus (HFV) contains within the U3 region of its long terminal repeat (LTR) three perfect consensus sequences for the binding of the inducible transcription factor AP-1. Results of DNase I footprint protection and gel retardation assays demonstrated that proteins in extracts of HeLa and BHK-21 cells as...

journal_title：Journal of virology

authors： Maurer B,Serfling E,ter Meulen V,Rethwilm A

更新日期：1991-11-01 00:00:00

abstract：:Polyoma virus particles were purified by equilibrium centrifugation in CsCl. Particles from three regions of the density gradient were examined for infectivity, for their ability to induce expanded pools of deoxyribonucleic acid (DNA) precursors, and for their ability to stimulate the synthesis of DNA. The most infect...

journal_title：Journal of virology

authors： Skoog L,Nordenskjöld BA,Lindberg U

更新日期：1970-07-01 00:00:00

abstract：:Noroviruses (NoVs) are a leading cause of gastroenteritis worldwide, yet host factors that restrict NoV replication are not well understood. Here, we use a CRISPR activation genome-wide screening to identify host genes that can inhibit murine norovirus (MNoV) replication in human cells. Our screens identified with hig...

journal_title：Journal of virology

authors： Orchard RC,Sullender ME,Dunlap BF,Balce DR,Doench JG,Virgin HW

更新日期：2018-12-10 00:00:00

abstract：:Q beta phage RNAs with inactivating insertion (8-base) or deletion (17-base) mutations within their replicase genes were prepared from modified Q beta cDNAs and transfected into Escherichia coli spheroplasts containing Q beta replicase provided in trans by a resident plasmid. Replicase-defective (Rep-) Q beta phage pr...

journal_title：Journal of virology

authors： Palasingam K,Shaklee PN

更新日期：1992-04-01 00:00:00

abstract：:Reoviruses isolated from persistently infected cultures (PI viruses) can grow in the presence of ammonium chloride, a weak base that blocks acid-dependent proteolysis of viral outer-capsid proteins during viral entry into cells. We used reassortant viruses isolated from crosses of wild-type (wt) reovirus strain, type ...

journal_title：Journal of virology

authors： Wetzel JD,Wilson GJ,Baer GS,Dunnigan LR,Wright JP,Tang DS,Dermody TS

更新日期：1997-02-01 00:00:00

abstract：:In our search for novel inhibitors of herpes simplex virus type 1 (HSV-1), a new class of thiourea inhibitors was discovered. N-(4-[3-(5-Chloro-2,4-dimethoxyphenyl)-thioureido]-phenyl)-acetamide and its 2-fluoro-benzamide derivative inhibited HSV-1 replication. HSV-2, human cytomegalovirus, and varicella-zoster virus ...

journal_title：Journal of virology

authors： van Zeijl M,Fairhurst J,Jones TR,Vernon SK,Morin J,LaRocque J,Feld B,O'Hara B,Bloom JD,Johann SV

更新日期：2000-10-01 00:00:00

abstract：:A virus structurally similar to viruses associated with maedi, progressive pneumonia, and visna of sheep has been isolated from buffy coat cells of cattle with chronic lymphocytosis. Electron microscope studies revealed three variants of the virion: (i) an intracytoplasmic form 98 to 116 nm in diameter when occurring ...

journal_title：Journal of virology

authors： Boothe AD,Van der Maaten AJ

更新日期：1974-01-01 00:00:00

abstract：:Dactylosporangiophage A1 has a polygonal head (75 nm) with spherical capsomeres (3 nm) and a noncontractile tail (200 by 10 nm) with cross-striations which is terminated with at least three prongs which are used for attachment. It contains double-stranded deoxyribonucleic acid and produces very little lysis. Intracell...

journal_title：Journal of virology

authors： Higgins ML,Lechevalier MP

更新日期：1969-02-01 00:00:00

abstract：:Human papillomavirus (HPV) infection of the genital tract is common; however, only about 10 to 15% of infections persist, and approximately 10 to 15% of these persistent infections result in cancer. Basal epidermal stem cells are the presumed target cells for HPV infection, providing a reservoir of latently infected c...

journal_title：Journal of virology

authors： Woappi Y,Hosseinipour M,Creek KE,Pirisi L

更新日期：2018-05-14 00:00:00

abstract：:Understanding how viral components collaborate to convert the human immunodeficiency virus type 1 genome from single-stranded RNA into double-stranded DNA is critical to the understanding of viral replication. Not only must the correct reactions be carried out, but unwanted side reactions must be avoided. After minus-...

journal_title：Journal of virology

authors： Driscoll MD,Hughes SH

更新日期：2000-10-01 00:00:00

abstract：:A radioimmunoassay (RIA) has been used to measure the quantity of protein P27 (mol wt 27,000; group specific-1 [gs-1]) of avian leukoviruses in different types of chicken embryos and tissues of adult chickens. The RIA used was 200- to 300-fold more sensitive than the complement fixation test and was able to detect as ...

journal_title：Journal of virology

authors： Chen JH,Hanafusa H

更新日期：1974-02-01 00:00:00

abstract：:While a large number of mosquito-transmitted alphaviruses are known to cause serious human diseases, there are no licensed vaccines that protect against alphavirus infections. The alphavirus chikungunya virus (CHIKV) has caused multiple recent outbreaks of chikungunya fever. This virus has the potential to cause a wor...

journal_title：Journal of virology

authors： Chattopadhyay A,Wang E,Seymour R,Weaver SC,Rose JK

更新日期：2013-01-01 00:00:00

abstract：:The occurrence of genome segment reassortment between two antigenically related orbiviruses was demonstrated in cattle. Individual virus clones were isolated by cell culture plaque assays directly from the blood of a calf infected with two serotypes of bluetongue virus. The majority (89%) of progeny viruses isolated f...

journal_title：Journal of virology

authors： Stott JL,Oberst RD,Channell MB,Osburn BI

更新日期：1987-09-01 00:00:00

abstract：:Further advances are required in understanding protection from AIDS by T-cell immunity. We analyzed a set of multigenic simian/human immunodeficiency virus (SHIV) DNA and fowlpox virus priming and boosting vaccines for immunogenicity and protective efficacy in outbred pigtail macaques. The number of vaccinations requi...

journal_title：Journal of virology

authors： Dale CJ,De Rose R,Stratov I,Chea S,Montefiori DC,Thomson S,Ramshaw IA,Coupar BE,Boyle DB,Law M,Kent SJ

更新日期：2004-12-01 00:00:00

abstract：:Interferon-induced proteins (IFPs) exert multiple functions corresponding to diverse interferon signals. However, the intracellular functions of many IFPs are not fully characterized. Here, we report that IFP35, a member of the IFP family with a molecular mass of 35 kDa, can interact with the bovine Tas (BTas) regulat...

journal_title：Journal of virology

authors： Tan J,Qiao W,Wang J,Xu F,Li Y,Zhou J,Chen Q,Geng Y

更新日期：2008-05-01 00:00:00

abstract：:We provide here new insights into rotavirus (RRV) pathogenicity by showing that RRV infection promotes structural and functional injuries localized at the tight junctions (TJ) in the cell-cell junctional complex of cultured polarized human intestinal Caco-2 cells forming monolayers. RRV infection resulted in a progres...

journal_title：Journal of virology

authors： Obert G,Peiffer I,Servin AL

更新日期：2000-05-01 00:00:00

abstract：:The dynamics of human immunodeficiency virus type 1 (HIV-1) transcription was analyzed in vitro and in vivo by using a specific molecular approach which allows accurate quantitation of the different classes of viral mRNAs. Unspliced (US) and multiply spliced (MS) HIV-1 transcripts were assayed by competitive reverse t...

journal_title：Journal of virology

authors： Bagnarelli P,Valenza A,Menzo S,Sampaolesi R,Varaldo PE,Butini L,Montroni M,Perno CF,Aquaro S,Mathez D,Leibowitch J,Balotta C,Clementi M

更新日期：1996-11-01 00:00:00

abstract：:In the course of our studies on oxidative stress as a component of pathological processes in humans, we showed that microintrusion into cells with microcapillary and ultramicroelectrochemical detection could mimic many types of mechanical intrusion leading to an instant (0.1 s) and high (some femtomoles) burst release...

journal_title：Journal of virology

authors： Lachgar A,Sojic N,Arbault S,Bruce D,Sarasin A,Amatore C,Bizzini B,Zagury D,Vuillaume M

更新日期：1999-02-01 00:00:00

abstract：:Nonstructural protein 5A (NS5A) is a membrane-associated essential component of the hepatitis C virus (HCV) replication complex. An N-terminal amphipathic alpha helix mediates in-plane membrane association of HCV NS5A and at the same time is likely involved in specific protein-protein interactions required for the ass...

journal_title：Journal of virology

authors： Brass V,Pal Z,Sapay N,Deléage G,Blum HE,Penin F,Moradpour D

更新日期：2007-03-01 00:00:00

abstract：:We introduced various mutations into the activation and RNA binding domains of human immunodeficiency virus type 1 (HIV-1) Tat in order to develop a novel and potent transdominant Tat protein and to characterize its mechanism of action. The different mutant Tat proteins were characterized for their abilities to activa...

journal_title：Journal of virology

authors： Orsini MJ,Debouck CM

更新日期：1996-11-01 00:00:00

abstract：:The hepatitis C virus (HCV) causes chronic hepatitis in most infected individuals by evading host immune defenses. In this investigation, we show that HCV-infected cells may go undetected in the immune system by suppressing major histocompatibility complex (MHC) class I antigen presentation to cytotoxic T lymphocytes....

journal_title：Journal of virology

authors： Tardif KD,Siddiqui A

更新日期：2003-11-01 00:00:00

abstract：:Duck hepatitis B virus mutants containing frameshift or stop codon mutations in a portion of the viral pol gene separating the terminal protein and reverse transcriptase domains had a leaky phenotype and, depending on the location and type of mutation, synthesized up to 10% as much viral DNA as did the wild type. This...

journal_title：Journal of virology

authors： Wu TT,Condreay LD,Coates L,Aldrich C,Mason W

更新日期：1991-05-01 00:00:00

abstract：:To understand the roles of heptad repeat 1(HR1) and HR2 of the spike (S) protein of the severe acute respiratory syndrome coronavirus (SARS-CoV) in virus-cell interactions, the conserved Leu or Ile residues located at positions 913, 927, 941, and 955 in HR1 and 1151, 1165, and 1179 in HR2 were individually replaced wi...

journal_title：Journal of virology

authors： Chan WE,Chuang CK,Yeh SH,Chang MS,Chen SS

更新日期：2006-04-01 00:00:00

abstract：:TMC125 is a potent new investigational nonnucleoside reverse transcriptase inhibitor (NNRTI) that is active against human immunodeficiency virus type 1 (HIV-1) with resistance to currently licensed NNRTIs. Sequential passage experiments with both wild-type virus and NNRTI-resistant virus were performed to identify mut...

journal_title：Journal of virology

authors： Vingerhoets J,Azijn H,Fransen E,De Baere I,Smeulders L,Jochmans D,Andries K,Pauwels R,de Béthune MP

更新日期：2005-10-01 00:00:00

abstract：:Lassa fever (LF) is a zoonotic viral hemorrhagic fever caused by Lassa virus (LASV), which is endemic to West African countries. Previous studies have suggested an important role for T-cell-mediated immunopathology in LF pathogenesis, but the mechanisms by which T cells influence disease severity and outcome are not w...

journal_title：Journal of virology

authors： Port JR,Wozniak DM,Oestereich L,Pallasch E,Becker-Ziaja B,Müller J,Rottstegge M,Olal C,Gómez-Medina S,Oyakhliome J,Ighodalo Y,Omomoh E,Olokor T,Adomeh DI,Asogun D,Ogbani-Emovon E,Hartmann K,Krasemann S,Nelson EV,Esc

更新日期：2020-10-14 00:00:00

abstract：:The protein kinase C (PKC) pathway has been considered to be essential for activation of latent Epstein-Barr virus (EBV) into the lytic cycle. The phorbol ester tetradecanoyl phorbol acetate (TPA), a PKC agonist, is one of the best understood activators of EBV lytic replication. Zp, the promoter of the EBV immediate-e...

journal_title：Journal of virology

authors： Gradoville L,Kwa D,El-Guindy A,Miller G

更新日期：2002-06-01 00:00:00

abstract：:Persistent infection with hepatitis C virus (HCV) is a major cause of chronic liver diseases. The aim of this study was to identify host cell factor(s) participating in the HCV replication complex (RC) and to clarify the regulatory mechanisms of viral genome replication dependent on the host-derived factor(s) identifi...

journal_title：Journal of virology

authors： Hara H,Aizaki H,Matsuda M,Shinkai-Ouchi F,Inoue Y,Murakami K,Shoji I,Kawakami H,Matsuura Y,Lai MM,Miyamura T,Wakita T,Suzuki T

更新日期：2009-05-01 00:00:00

abstract：:The hepatitis B virus (HBV) X protein (pX) is implicated in hepatocarcinogenesis by an unknown mechanism. pX variants encoded by HBV genomes found integrated in genomic DNA from liver tumors of patients with hepatocellular carcinoma (HCC) generally lack amino acids 134 to 154. Since deregulation of mitogenic pathways ...

journal_title：Journal of virology

authors： Li H,Chi CY,Lee S,Andrisani OM

更新日期：2006-11-01 00:00:00