Poorly lytic bacteriophage from Dactylosporangium thailandensis (Actinomycetales).

abstract：:Viral interference studies have demonstrated the existence of four distinct murine leukemia virus (MuLV) receptors on NIH 3T3 mouse cells. The four viral interference groups are ecotropic MuLV; mink cell focus inducing virus (MCF); amphotropic MuLV; and 10A1, a recombinant derivative of amphotropic MuLV that uses a un...

journal_title：Journal of virology

authors： Ott D,Friedrich R,Rein A

更新日期：1990-02-01 00:00:00

abstract：:In vitro mapping studies of the MD145 norovirus (Caliciviridae) ORF1 polyprotein identified two stable cleavage products containing the viral RNA-dependent RNA polymerase (RdRp) domains: ProPol (a precursor comprised of both the proteinase and polymerase) and Pol (the mature polymerase). The goal of this study was to ...

journal_title：Journal of virology

authors： Belliot G,Sosnovtsev SV,Chang KO,Babu V,Uche U,Arnold JJ,Cameron CE,Green KY

更新日期：2005-02-01 00:00:00

abstract：:We have studied protein synthesis in cultured cells infected with the six noncytopathic (nc) mutants of the Australia-Victoria strain (AV-WT) of Newcastle disease virus and their plaque-forming revertants. Virus-specific polypeptides accumulated at 30 to 63% of wild-type levels in nc mutant-infected cells and between ...

journal_title：Journal of virology

authors： Madansky CH,Bratt MA

更新日期：1981-12-01 00:00:00

abstract：:The VP7 and VP4 genes of seven antigenic mutants of simian rotavirus SA11 4fM (serotype 3) selected after 39 passages in the presence of SA11 4fM hyperimmune antiserum, were sequenced. Nucleotide sequence analysis indicated the following. (i) Twice as many amino acid substitutions occurred in the VP7 protein than in V...

journal_title：Journal of virology

authors： Gorziglia M,Larralde G,Ward RL

更新日期：1990-09-01 00:00:00

abstract：:WUH4 is a highly pathogenic North American porcine reproductive and respiratory syndrome virus (PRRSV). Unlike previous PRRSV isolates, which were mainly recovered from sera or tissues, WUH4 was isolated from a piglet stool sample. Here we announce its complete genome sequence. ...

journal_title：Journal of virology

authors： Song T,Fang L,Zeng S,Li B,Chen H,Xiao S

更新日期：2012-04-01 00:00:00

abstract：:Domains required late in the virus budding process (L domains) have been identified in the Gag proteins of a number of retroviruses. Here we show that the human T-cell leukemia virus type 1 candidate L domain motif PPPY is indeed required for virus production. Strikingly, however, mutation of this motif arrested virus...

journal_title：Journal of virology

authors： Le Blanc I,Prévost MC,Dokhélar MC,Rosenberg AR

更新日期：2002-10-01 00:00:00

abstract：:The E4orf6 protein of group C adenovirus is an oncoprotein that, in association with the E1B 55-kDa protein and by E1B-independent means, promotes virus replication. An arginine-faced amphipathic alpha-helix in the E4orf6 protein is required for the E4orf6 protein to direct nuclear localization of the E1B 55-kDa prote...

journal_title：Journal of virology

authors： Orlando JS,Ornelles DA

更新日期：2002-02-01 00:00:00

abstract：:Previous studies with simian virus 40-transformed mouse 3T3 cells which are temperature sensitive for the expression of the transformed phenotype (ts SV3T3 cells) have shown that T-antigen expression and viral DNA transcription are under cell cycle control. Using these ts SV3T3 cells, we studied the expression of the ...

journal_title：Journal of virology

authors： Zouzias D,Basilico C

更新日期：1979-06-01 00:00:00

abstract：:Infections of fungi by mycoviruses are often symptomless but sometimes also fatal, as they perturb sporulation, growth, and, if applicable, virulence of the fungal host. Hypovirulence-inducing mycoviruses, therefore, represent a powerful means to defeat fungal epidemics on crop plants. Infection with Fusarium graminea...

journal_title：Journal of virology

authors： Bormann J,Heinze C,Blum C,Mentges M,Brockmann A,Alder A,Landt SK,Josephson B,Indenbirken D,Spohn M,Plitzko B,Loesgen S,Freitag M,Schäfer W

更新日期：2018-08-16 00:00:00

abstract：UNLABELLED:Reactivation of human cytomegalovirus (HCMV) is a significant cause of disease and death in immunocompromised patients, underscoring the need to understand how latency is controlled. Here we demonstrate that HCMV has evolved to utilize cellular microRNAs (miRNAs) in cells that promote latency to regulate exp...

journal_title：Journal of virology

authors： O'Connor CM,Vanicek J,Murphy EA

更新日期：2014-05-01 00:00:00

abstract：:Bovine spongiform encephalopathy (BSE) is a fatal, transmissible, neurodegenerative disease of cattle. BSE can be transmitted experimentally between cattle through the oral route, and in this study, brain tissue samples from animals at different time points postinoculation were analyzed for changes in gene expression....

journal_title：Journal of virology

authors： Tang Y,Xiang W,Hawkins SA,Kretzschmar HA,Windl O

更新日期：2009-09-01 00:00:00

abstract：:The lymphocytic choriomeningitis virus (LCMV) genome consists of a large RNA segment and a small RNA segment. The three major structural proteins of this virus are an internal nucleoprotein and two surface glycoproteins. Intertypic reassortants between the Armstrong and WE strains of LCMV were made to map proteins enc...

journal_title：Journal of virology

authors： Riviere Y,Ahmed R,Southern PJ,Buchmeier MJ,Dutko FJ,Oldstone MB

更新日期：1985-03-01 00:00:00

abstract：:Tetherin (CD317/BST-2), an interferon-induced membrane protein, restricts the release of nascent retroviral particles from infected cell surfaces. While human immunodeficiency virus type 1 (HIV-1) encodes the accessory gene vpu to overcome the action of tetherin, the lineage of primate lentiviruses that gave rise to H...

journal_title：Journal of virology

authors： Le Tortorec A,Neil SJ

更新日期：2009-11-01 00:00:00

abstract：:We assessed the prediction that access of the viral NS1 protein to cellular PDZ domain protein networks enhances the virulence of highly pathogenic avian influenza A viruses. The NS1 proteins of most avian influenza viruses bear the C-terminal ligand sequence Glu-Ser-Glu-Val (ESEV) for PDZ domains present in multiple ...

journal_title：Journal of virology

authors： Zielecki F,Semmler I,Kalthoff D,Voss D,Mauel S,Gruber AD,Beer M,Wolff T

更新日期：2010-10-01 00:00:00

abstract：UNLABELLED:The measles virus (MeV) membrane fusion apparatus consists of a fusion protein trimer and an attachment protein tetramer. To trigger membrane fusion, the heads of the MeV attachment protein, hemagglutinin (H), bind cellular receptors while the 96-residue-long H stalk transmits the triggering signal. Structur...

journal_title：Journal of virology

authors： Navaratnarajah CK,Kumar S,Generous A,Apte-Sengupta S,Mateo M,Cattaneo R

更新日期：2014-06-01 00:00:00

abstract：UNLABELLED:Major histocompatibility complex class II (MHC-II) molecules play a central role in adaptive antiviral immunity by presenting viral peptides to CD4(+) T cells. Due to their key role in adaptive immunity, many viruses, including Kaposi's sarcoma-associated herpesvirus (KSHV), have evolved multiple strategies ...

journal_title：Journal of virology

authors： Thakker S,Purushothaman P,Gupta N,Challa S,Cai Q,Verma SC

更新日期：2015-05-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is a herpesvirus commonly associated with several malignancies, particularly in immunocompromised hosts. As a strategy for stimulating immunity against EBV for the treatment of EBV-associated tumors, we have genetically engineered dendritic cells (DC) to express EBV antigens, such as latent me...

journal_title：Journal of virology

authors： Ranieri E,Herr W,Gambotto A,Olson W,Rowe D,Robbins PD,Kierstead LS,Watkins SC,Gesualdo L,Storkus WJ

更新日期：1999-12-01 00:00:00

abstract：:All herpesviruses encode a homolog of glycoprotein M (gM), which appears to function in virion morphogenesis. Despite its conservation, gM is inessential for the lytic replication of alphaherpesviruses. In order to address the importance of gM in gammaherpesviruses, we disrupted it in the murine gammaherpesvirus 68 (M...

journal_title：Journal of virology

authors： May JS,Colaco S,Stevenson PG

更新日期：2005-03-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is a cellular enzyme in the eicosanoid synthetic pathway that mediates the synthesis of prostaglandins from arachidonic acid. The eicosanoids function as critical regulators of a number of cellular processes, including the acute and chronic inflammatory response, hemostasis, and the innate imm...

journal_title：Journal of virology

authors： Rue CA,Jarvis MA,Knoche AJ,Meyers HL,DeFilippis VR,Hansen SG,Wagner M,Früh K,Anders DG,Wong SW,Barry PA,Nelson JA

更新日期：2004-11-01 00:00:00

abstract：:Multiple mutations were found in the human immunodeficiency virus pol gene following treatment of an AIDS patient with antiretroviral drugs. After approximately 2.5 years of monthly alternating therapy with 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC), most of the pol sequences amplified from the p...

journal_title：Journal of virology

authors： Fitzgibbon JE,Farnham AE,Sperber SJ,Kim H,Dubin DT

更新日期：1993-12-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) G protein deletion mutants replicate effectively in vitro but have not been detected in nature. Subtyping of RSV strains in hospitalized children in South Africa identified G protein PCR amplicons significantly reduced in size in 2 out of 209 clinical specimens screened over 4 years. ...

journal_title：Journal of virology

authors： Venter M,van Niekerk S,Rakgantso A,Bent N

更新日期：2011-08-01 00:00:00

abstract：:Vaccinia virus DNA fragments that have been denatured by alkali and then neutralized contain a fraction that rapidly reforms duplex structures. The fraction is enriched by fractionating on hydroxyapatite columns and serves as as substrate for digestion by two restriction endonucleases isolated from Hemophilus parainfl...

journal_title：Journal of virology

authors： DeFilippes F

更新日期：1975-01-01 00:00:00

abstract：:Adenovirus type 2 (Ad2)-transformed hamster and rat cells are susceptible to lysis by natural killer (NK) cells from the host of origin and are nontumorigenic in immunocompetent hamsters and rats, respectively. These NK-cell-susceptible, virus-transformed cells are, however, highly tumorigenic in athymic (nude) mice--...

journal_title：Journal of virology

authors： Cook JL,Lewis AM Jr

更新日期：1987-07-01 00:00:00

abstract：:Merkel cell carcinoma (MCC) is the most aggressive skin cancer. Recently, it was demonstrated that human Merkel cell polyomavirus (MCV) is clonally integrated in approximately 80% of MCC tumors. However, direct evidence for whether oncogenic viral proteins are needed for the maintenance of MCC cells is still missing. ...

journal_title：Journal of virology

authors： Houben R,Shuda M,Weinkam R,Schrama D,Feng H,Chang Y,Moore PS,Becker JC

更新日期：2010-07-01 00:00:00

abstract：:A series of plasmids containing hepatitis A virus (HAV) cDNA was constructed such that positive-strand HAV RNA could be transcribed with T7 RNA polymerase. The plasmids differed in the number of 5'-terminal nucleotides representing the junctions between vectors and HAV sequences that were present in the transcripts. W...

journal_title：Journal of virology

authors： Harmon SA,Richards OC,Summers DF,Ehrenfeld E

更新日期：1991-05-01 00:00:00

abstract：:Arenaviruses are rodent-borne viruses, with five members of the family capable of causing severe hemorrhagic fevers if transmitted to humans. To date, two distinct cellular receptors have been identified that are used by different pathogenic viruses, alpha-dystroglycan by Lassa fever virus and transferrin receptor 1 (...

journal_title：Journal of virology

authors： Flanagan ML,Oldenburg J,Reignier T,Holt N,Hamilton GA,Martin VK,Cannon PM

更新日期：2008-01-01 00:00:00

abstract：:Boid inclusion body disease (BIBD) is a transmissible viral disease of captive snakes that causes severe losses in snake collections worldwide. It is caused by reptarenavirus infection, which can persist over several years without overt signs but is generally associated with the eventual death of the affected snakes. ...

journal_title：Journal of virology

authors： Argenta FF,Hepojoki J,Smura T,Szirovicza L,Hammerschmitt ME,Driemeier D,Kipar A,Hetzel U

更新日期：2020-05-18 00:00:00

abstract：:Hepatitis B virus (HBV) DNA integration has been shown to occur frequently in human hepatocellular carcinomas. We have investigated whether common cellular DNA domains might be rearranged, possibly by HBV integration, in human primary liver tumors. Unique cellular DNA sequences adjacent to an HBV integration site were...

journal_title：Journal of virology

authors： Pasquinelli C,Garreau F,Bougueleret L,Cariani E,Grzeschik KH,Thiers V,Croissant O,Hadchouel M,Tiollais P,Bréchot C

更新日期：1988-02-01 00:00:00

abstract：:Efforts to develop a vaccine against human immunodeficiency virus type 1 (HIV-1) are complicated by resistance of virus to neutralization. The neutralization resistance phenotype of HIV-1 has been linked to high infectivity. We studied the mechanisms determining this phenotype using clones of the T-cell-line-adapted (...

journal_title：Journal of virology

authors： Leavitt M,Park EJ,Sidorov IA,Dimitrov DS,Quinnan GV Jr

更新日期：2003-01-01 00:00:00

abstract：:The adenovirus E1A 243R oncoprotein is capable of transactivating the expression of the human proliferating cell nuclear antigen (PCNA) promoter. Mutational analysis of the E1A 243R protein suggested that both its p300/CBP- and p107-binding regions are required for optimal induction of the PCNA promoter (C. Kannabiran...

journal_title：Journal of virology

authors： Lee BH,Liu M,Mathews MB

更新日期：1998-02-01 00:00:00